RU93058417A - Pyridone Carboxylic Acid Derivatives, Antimicrobial Agent - Google Patents

Pyridone Carboxylic Acid Derivatives, Antimicrobial Agent

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Publication number
RU93058417A
RU93058417A RU93058417/04A RU93058417A RU93058417A RU 93058417 A RU93058417 A RU 93058417A RU 93058417/04 A RU93058417/04 A RU 93058417/04A RU 93058417 A RU93058417 A RU 93058417A RU 93058417 A RU93058417 A RU 93058417A
Authority
RU
Russia
Prior art keywords
carboxylic acid
mixture
diastereomers
acid derivatives
pyridone carboxylic
Prior art date
Application number
RU93058417/04A
Other languages
Russian (ru)
Other versions
RU2100351C1 (en
Inventor
Хаякава Йоуити Кимура Исао
Такахаси Хисаси
Original Assignee
Дайити Фармасьютикал Ко, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайити Фармасьютикал Ко, Лтд. filed Critical Дайити Фармасьютикал Ко, Лтд.
Priority claimed from PCT/JP1992/000687 external-priority patent/WO1992021659A1/en
Publication of RU93058417A publication Critical patent/RU93058417A/en
Application granted granted Critical
Publication of RU2100351C1 publication Critical patent/RU2100351C1/en

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Claims (1)

Хинолоновые производные известны как синтетические антимикробные агенты, имеющие скелет конденсированной пиридонкарбоновой кислоты; также известны те из них, которые обладают заместителями в различных замещенных положениях названного скелета. В частности, если существуют диастереомеры, то имеется 4 или более видов стереоизомеров. Смесь диастереомеров является смесью изомеров, имеющих различные физические свойства, и применение такой смеси в качестве лекарства затруднительно. Настоящее изобретение представляет антимикробное 1-(1,2-цис-2-фторциклопропил)-замещенное хинолоновое производное, представленное формулой, которое, хотя и заключает в себе диастереомеры, состоит из единственного стереоизомера
Figure 00000001

где R1 представляет метиловую группу, дифторметиловую группу и др.; R2 представляет насыщенную азотосодержащую гетероциклическую группу; А представляет С-Х3 или атом азота; каждый из Х1 и Х2 представляет атом галогена; Х3 и Z представляет атом водорода и др.Quinolone derivatives are known as synthetic antimicrobial agents having a skeleton of a fused pyridone carboxylic acid; also known are those which have substituents at various substituted positions of the named skeleton. In particular, if diastereomers exist, then there are 4 or more kinds of stereoisomers. A mixture of diastereomers is a mixture of isomers having different physical properties, and the use of such a mixture as a medicine is difficult. The present invention provides an antimicrobial 1- (1,2-cis-2-fluorocyclopropyl) -substituted quinolone derivative represented by the formula, which, although containing diastereomers, consists of a single stereoisomer
Figure 00000001

where R 1 represents a methyl group, a difluoromethyl group, and others; R 2 represents a saturated nitrogen-containing heterocyclic group; A represents CX 3 or a nitrogen atom; each of X 1 and X 2 represents a halogen atom; X 3 and Z represents a hydrogen atom, etc.
RU93058417/04A 1991-05-28 1992-05-27 Pyridone carboxylic acid derivatives and composition based on thereof RU2100351C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22542591 1991-05-28
JP3-225425 1991-05-28
PCT/JP1992/000687 WO1992021659A1 (en) 1991-05-28 1992-05-27 Pyridonecarboxylic acid derivative

Publications (2)

Publication Number Publication Date
RU93058417A true RU93058417A (en) 1996-12-27
RU2100351C1 RU2100351C1 (en) 1997-12-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU93058417/04A RU2100351C1 (en) 1991-05-28 1992-05-27 Pyridone carboxylic acid derivatives and composition based on thereof

Country Status (16)

Country Link
US (1) US5696132A (en)
EP (1) EP0593766B1 (en)
JP (1) JP3215500B2 (en)
KR (1) KR100232937B1 (en)
AT (1) ATE196135T1 (en)
AU (1) AU661999B2 (en)
CA (1) CA2110260C (en)
DE (1) DE69231422T2 (en)
DK (1) DK0593766T3 (en)
ES (1) ES2151488T3 (en)
FI (1) FI109201B (en)
GR (1) GR3034966T3 (en)
NO (1) NO180780C (en)
RU (1) RU2100351C1 (en)
TW (1) TW212179B (en)
WO (1) WO1992021659A1 (en)

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