RU93057957A - Бактерии, способ получения бактерий, вакцина - Google Patents

Бактерии, способ получения бактерий, вакцина

Info

Publication number
RU93057957A
RU93057957A RU93057957/13A RU93057957A RU93057957A RU 93057957 A RU93057957 A RU 93057957A RU 93057957/13 A RU93057957/13 A RU 93057957/13A RU 93057957 A RU93057957 A RU 93057957A RU 93057957 A RU93057957 A RU 93057957A
Authority
RU
Russia
Prior art keywords
bacteria
vaccine
producing
promoter
producing bacteria
Prior art date
Application number
RU93057957/13A
Other languages
English (en)
Other versions
RU2126447C1 (ru
Inventor
Джордж Чарльз Ян
Невилле Чэтфилд Стивен
Фрэзер Фейрветер Нейл
Original Assignee
Дзе Веллкам Фаундейшн Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919104596A external-priority patent/GB9104596D0/en
Application filed by Дзе Веллкам Фаундейшн Лимитед filed Critical Дзе Веллкам Фаундейшн Лимитед
Priority claimed from PCT/GB1992/000387 external-priority patent/WO1992015689A1/en
Publication of RU93057957A publication Critical patent/RU93057957A/ru
Application granted granted Critical
Publication of RU2126447C1 publication Critical patent/RU2126447C1/ru

Links

Claims (1)

  1. Предложены бактерии с ослабленной вирулентностью, способные экспрессировать гетерологичные белки, причем экспрессия гетерологичного белка происходит под контролем промотка, переход которого в активное состояние вызывается анаэробными условиями. Указанные бактерии можно использовать в качестве вакцины. Подходящим промотором является nirВ-промотор.
RU93057957A 1991-03-05 1992-03-05 Способ получения аттенуированного штамма бактерий salmonella и вакцина RU2126447C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9104596.3 1991-03-05
GB919104596A GB9104596D0 (en) 1991-03-05 1991-03-05 Production of recombinant proteins
GB9121208.4 1991-10-04
PCT/GB1992/000387 WO1992015689A1 (en) 1991-03-05 1992-03-05 Expression of recombinant proteins in attenuated bacteria

Publications (2)

Publication Number Publication Date
RU93057957A true RU93057957A (ru) 1997-02-10
RU2126447C1 RU2126447C1 (ru) 1999-02-20

Family

ID=10690995

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93057957A RU2126447C1 (ru) 1991-03-05 1992-03-05 Способ получения аттенуированного штамма бактерий salmonella и вакцина

Country Status (3)

Country Link
GB (1) GB9104596D0 (ru)
RU (1) RU2126447C1 (ru)
WO (1) WO1992015688A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0574466T3 (da) * 1991-03-05 1999-11-08 Wellcome Found Udtrykkelse af rekombinante proteiner i svækkede bakterier
US6585975B1 (en) * 1998-04-30 2003-07-01 Acambis, Inc. Use of Salmonella vectors for vaccination against helicobacter infection
CN102477440A (zh) * 2010-11-29 2012-05-30 南京大学 治疗基因在厌氧组织靶向递送和选择性稳定表达方法及应用
US20160206666A1 (en) * 2014-12-22 2016-07-21 Synlogic, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3926076A1 (de) * 1989-04-21 1990-10-25 Boehringer Mannheim Gmbh Rekombinante dna und expressionsvektor

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