RU93057957A - Бактерии, способ получения бактерий, вакцина - Google Patents
Бактерии, способ получения бактерий, вакцинаInfo
- Publication number
- RU93057957A RU93057957A RU93057957/13A RU93057957A RU93057957A RU 93057957 A RU93057957 A RU 93057957A RU 93057957/13 A RU93057957/13 A RU 93057957/13A RU 93057957 A RU93057957 A RU 93057957A RU 93057957 A RU93057957 A RU 93057957A
- Authority
- RU
- Russia
- Prior art keywords
- bacteria
- vaccine
- producing
- promoter
- producing bacteria
- Prior art date
Links
- 241000894006 Bacteria Species 0.000 title claims 4
- 229960005486 vaccines Drugs 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 101700005294 nasB Proteins 0.000 claims 1
- 101700065275 nasD Proteins 0.000 claims 1
- 230000008506 pathogenesis Effects 0.000 claims 1
- 230000017613 viral reproduction Effects 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
Claims (1)
- Предложены бактерии с ослабленной вирулентностью, способные экспрессировать гетерологичные белки, причем экспрессия гетерологичного белка происходит под контролем промотка, переход которого в активное состояние вызывается анаэробными условиями. Указанные бактерии можно использовать в качестве вакцины. Подходящим промотором является nirВ-промотор.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9104596.3 | 1991-03-05 | ||
GB919104596A GB9104596D0 (en) | 1991-03-05 | 1991-03-05 | Production of recombinant proteins |
GB9121208.4 | 1991-10-04 | ||
PCT/GB1992/000387 WO1992015689A1 (en) | 1991-03-05 | 1992-03-05 | Expression of recombinant proteins in attenuated bacteria |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93057957A true RU93057957A (ru) | 1997-02-10 |
RU2126447C1 RU2126447C1 (ru) | 1999-02-20 |
Family
ID=10690995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93057957A RU2126447C1 (ru) | 1991-03-05 | 1992-03-05 | Способ получения аттенуированного штамма бактерий salmonella и вакцина |
Country Status (3)
Country | Link |
---|---|
GB (1) | GB9104596D0 (ru) |
RU (1) | RU2126447C1 (ru) |
WO (1) | WO1992015688A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0574466T3 (da) * | 1991-03-05 | 1999-11-08 | Wellcome Found | Udtrykkelse af rekombinante proteiner i svækkede bakterier |
US6585975B1 (en) * | 1998-04-30 | 2003-07-01 | Acambis, Inc. | Use of Salmonella vectors for vaccination against helicobacter infection |
CN102477440A (zh) * | 2010-11-29 | 2012-05-30 | 南京大学 | 治疗基因在厌氧组织靶向递送和选择性稳定表达方法及应用 |
US20160206666A1 (en) * | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3926076A1 (de) * | 1989-04-21 | 1990-10-25 | Boehringer Mannheim Gmbh | Rekombinante dna und expressionsvektor |
-
1991
- 1991-03-05 GB GB919104596A patent/GB9104596D0/en active Pending
-
1992
- 1992-03-05 RU RU93057957A patent/RU2126447C1/ru active
- 1992-03-05 WO PCT/GB1992/000386 patent/WO1992015688A1/en active Application Filing
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