RU93052411A - (-) - ENANTIOMER - {([4- (1,4,5,6-TETRAGIDRO-4-METHYL-6-OXO-3-PYRIDAZINYL) PHENYL]) - HYDRAZONE} PROPANDININITRIL - Google Patents
(-) - ENANTIOMER - {([4- (1,4,5,6-TETRAGIDRO-4-METHYL-6-OXO-3-PYRIDAZINYL) PHENYL]) - HYDRAZONE} PROPANDININITRILInfo
- Publication number
- RU93052411A RU93052411A RU93052411/04A RU93052411A RU93052411A RU 93052411 A RU93052411 A RU 93052411A RU 93052411/04 A RU93052411/04 A RU 93052411/04A RU 93052411 A RU93052411 A RU 93052411A RU 93052411 A RU93052411 A RU 93052411A
- Authority
- RU
- Russia
- Prior art keywords
- pyridazinyl
- enantiomer
- oxo
- phenyl
- methyl
- Prior art date
Links
- -1 (1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl) phenyl Chemical group 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 239000000496 cardiotonic agent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000006233 congestive heart failure Diseases 0.000 claims 1
- 125000005638 hydrazono group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
Claims (1)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9100049.7 | 1991-01-03 | ||
GB919100049A GB9100049D0 (en) | 1991-01-03 | 1991-01-03 | (-)-6-(4-(dicyanomethylidenehydrazino)phenyl)-4,5-dihydro-5-methylpyridazin-3(2h)one |
GB9118947.2 | 1991-09-05 | ||
GB919118947A GB9118947D0 (en) | 1991-09-05 | 1991-09-05 | Method for the optical resolution of racemic 6-(4-amino-phenyl)-methyl-pyridazin-3(2h)one and preparation of optically active derivatives thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93052411A true RU93052411A (en) | 1996-06-20 |
RU2118317C1 RU2118317C1 (en) | 1998-08-27 |
Family
ID=26298204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93052411A RU2118317C1 (en) | 1991-01-03 | 1992-01-03 | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phen- -yl]hydrozono]propanedinitrile and its pharmaceutically acceptable salts, pharmaceutical composition based on thereof, method of synthesis of intermediate compound and method of synthesis of end compound |
Country Status (32)
Country | Link |
---|---|
US (3) | US5424428A (en) |
EP (1) | EP0565546B1 (en) |
JP (2) | JP2635445B2 (en) |
KR (1) | KR100207145B1 (en) |
AT (1) | ATE119525T1 (en) |
AU (1) | AU645399B2 (en) |
BG (1) | BG62002B1 (en) |
BR (1) | BR1100737A (en) |
CA (2) | CA2099262C (en) |
CY (1) | CY1878A (en) |
DE (1) | DE69201640T2 (en) |
DK (1) | DK0565546T3 (en) |
EE (1) | EE02946B1 (en) |
ES (1) | ES2070627T3 (en) |
FI (1) | FI105183B (en) |
GB (1) | GB2251615B (en) |
GE (1) | GEP19991868B (en) |
HK (1) | HK117395A (en) |
HR (1) | HRP921251B1 (en) |
HU (1) | HU218659B (en) |
IE (1) | IE72101B1 (en) |
IL (2) | IL100553A (en) |
LU (1) | LU90920I2 (en) |
LV (1) | LV11174B (en) |
NO (2) | NO300682B1 (en) |
NZ (1) | NZ241194A (en) |
PL (2) | PL169435B1 (en) |
RO (1) | RO111847B1 (en) |
RU (1) | RU2118317C1 (en) |
SI (1) | SI9112003A (en) |
WO (1) | WO1992012135A1 (en) |
YU (1) | YU48767B (en) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2251615B (en) * | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
GB2266841A (en) * | 1992-05-06 | 1993-11-17 | Orion Yhtymae Oy | Compounds for use as anti-ischemic medicaments |
JP2806192B2 (en) * | 1992-11-02 | 1998-09-30 | 日本曹達株式会社 | Platelet aggregation inhibitor |
AU3855995A (en) * | 1994-11-11 | 1996-06-06 | Nippon Soda Co., Ltd. | Optically active compound |
GB9606474D0 (en) | 1996-03-27 | 1996-06-05 | Orion Yhytmo Oy | Method for obtaining pure enantiomers of a pyridazinone derivative |
GB9614098D0 (en) | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
FI973804A (en) | 1997-09-26 | 1999-03-27 | Orion Yhtymae Oy | Oral compositions of levosimendan |
FI974578A (en) | 1997-12-19 | 1999-06-20 | Orion Yhtymae Oyj | Method of administering levosimendan |
FI980901A (en) | 1998-04-23 | 1999-10-24 | Orion Yhtymae Oyj | Oral compositions that controlled release the levosimendan |
FI980902A (en) * | 1998-04-23 | 1999-10-24 | Orion Yhtymae Oyj | Stable compositions of levosimendan |
FI104718B (en) * | 1998-06-18 | 2000-03-31 | Orion Yhtymae Oyj | [[4- (2-Azido-3-methyl-5-oxotetrahydrofuran-2-yl) phenyl] hydrazono] propanedonitrile for use as reference substance in the analysis of batches of levosimendan |
US5905078A (en) * | 1998-06-19 | 1999-05-18 | Orion Corporation | Use of a pyridazinone derivative |
FI981473A (en) * | 1998-06-25 | 1999-12-26 | Orion Yhtymae Oyj | A method of treating pulmonary hypertension |
GB9915179D0 (en) * | 1999-06-29 | 1999-09-01 | Orion Corp | A method for the treatment or prevention of coronary graft vasospasm |
FI109659B (en) | 1999-09-10 | 2002-09-30 | Orion Yhtymae Oyj | Pharmaceutical solutions of levosimendan |
DE60016038T2 (en) * | 1999-10-22 | 2005-12-22 | Orion Corp. | NEW USE OF LEVOSIMENDAN |
FI20001542A (en) | 2000-06-29 | 2001-12-30 | Orion Yhtymae Oyj | A method of treating septic shock |
FI20002526A (en) * | 2000-11-17 | 2002-05-18 | Orion Yhtymae Oyj | New use of pyridazinone derivatives |
FI20002525A (en) * | 2000-11-17 | 2002-05-18 | Orion Yhtymae Oyj | Anti-inflammatory substances |
FI20002755A0 (en) * | 2000-12-15 | 2000-12-15 | Orion Yhtymae Oyj | Method of therapy for erectile dysfunction |
FI20010233A0 (en) | 2001-02-08 | 2001-02-08 | Orion Corp | A method for treating heart failure |
FI20011464A0 (en) | 2001-07-04 | 2001-07-04 | Orion Corp | Combination therapy for the treatment of heart failure |
FI20030015A0 (en) * | 2003-01-03 | 2003-01-03 | Orion Corp | A method of treating renal failure |
EP1612204A4 (en) * | 2003-03-31 | 2007-04-11 | Daiichi Seiyaku Co | Hydrazone derivative |
DE102004011512B4 (en) * | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical preparation containing pimobendan |
US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
EP1579862A1 (en) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
FI20040674A0 (en) | 2004-05-12 | 2004-05-12 | Orion Corp | A method of inhibiting thromboembolic diseases |
FI20040675A0 (en) * | 2004-05-12 | 2004-05-12 | Orion Corp | A method of treating and preventing cardiac hypertrophy |
MXPA06013825A (en) * | 2004-05-28 | 2007-03-01 | Abbott Lab | Methods for treating a mammal before, during and after cardiac arrest. |
CA2599575A1 (en) | 2005-03-14 | 2006-09-21 | Orion Corporation | A combination treatment for enhancing diuresis |
EP1951227B1 (en) | 2005-11-14 | 2017-04-12 | Boehringer Ingelheim Vetmedica GmbH | Use of pimobendan for the treatment of asymptomatic (occult) heart failure |
EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
BRPI0806588A2 (en) * | 2007-01-17 | 2014-05-06 | Orion Corp | LEVOSIMENDAN USE FOR TREATMENT OF CHRONIC VALVULAR DISEASE. |
BRPI0921868A2 (en) | 2008-11-25 | 2015-12-29 | Boehringer Ingelheim Vetmed | phosphodiesterase type iii (pde iii) inhibitors or ca2 + sensitizing agents for the treatment of hypertrophic cardiomyopathy |
JP5747030B2 (en) | 2009-07-14 | 2015-07-08 | シプラ・リミテッド | Process for producing levosimendan and intermediate used in the process |
WO2013135852A1 (en) | 2012-03-15 | 2013-09-19 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
EP2970145B1 (en) * | 2013-03-11 | 2020-05-06 | The Broad Institute, Inc. | Compounds and compositions for the treatment of cancer |
CN105377235A (en) | 2013-07-19 | 2016-03-02 | 勃林格殷格翰动物保健有限公司 | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition |
CN104418810A (en) * | 2013-09-04 | 2015-03-18 | 北京博时安泰科技发展有限公司 | New synthetic route of levosimendan |
CN103554033A (en) * | 2013-11-12 | 2014-02-05 | 江苏正大清江制药有限公司 | Splitting method for despinner (+/-)-6-(4-aminophenyl)-4, 5-dihydro-5-methyl-3(2H)-pyridazinone |
CN103554032A (en) * | 2013-11-12 | 2014-02-05 | 江苏正大清江制药有限公司 | Preparation method of high-optical-purity (-)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone |
BR122019024673B1 (en) | 2013-12-04 | 2023-04-11 | Boehringer Ingelheim Vetmedica Gmbh | IMPROVED PHARMACEUTICAL COMPOSITIONS OF PIMOBENDAN |
EP3334404A4 (en) | 2015-08-13 | 2019-02-13 | The Broad Institute, Inc. | Compositions and methods for cancer expressing pde3a or slfn12 |
CN105784895B (en) * | 2015-10-30 | 2018-05-22 | 成都欣捷高新技术开发有限公司 | A kind of method that impurity in Levosimendan is detected with high performance liquid chromatograph |
US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
EP3424908A1 (en) | 2017-07-07 | 2019-01-09 | Melody Healthcare Pvt. Ltd. | Process for preparation of levosimendan |
US9962384B1 (en) * | 2017-09-07 | 2018-05-08 | Korea Institute Of Science And Technology | Levosimendan compound for preventing or treating tau-related diseases |
CN111548310B (en) * | 2020-05-12 | 2021-07-02 | 成都欣捷高新技术开发股份有限公司 | Levosimendan sodium crystal form and preparation method thereof |
CN111718299B (en) * | 2020-07-23 | 2023-03-10 | 成都欣捷高新技术开发股份有限公司 | Levosimendan sodium crystal form B and preparation method thereof |
US11760730B2 (en) | 2021-01-11 | 2023-09-19 | Navinta, Llc | Process for the preparation of high purity Levosimendan |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB228004A (en) * | 1924-01-24 | 1925-01-29 | Daimler Co Ltd | Improvements in locking devices for sliding windows |
JPS58113180A (en) * | 1981-12-28 | 1983-07-05 | Mitsui Toatsu Chem Inc | Pyridazinone derivative |
JPS6193169A (en) * | 1984-10-12 | 1986-05-12 | Sankyo Co Ltd | Pyridazinone derivative and its preparation |
AU581324B2 (en) * | 1985-07-05 | 1989-02-16 | Smith Kline & French Laboratories Limited | Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones |
JPH0629254B2 (en) * | 1986-09-08 | 1994-04-20 | 帝国臓器製薬株式会社 | Pyridazinone derivative |
GB8824458D0 (en) * | 1988-10-19 | 1988-11-23 | Orion Yhtymae Oy | Substituted pyridazinones |
GB8903130D0 (en) * | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
GB2251615B (en) * | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
-
1991
- 1991-12-20 GB GB9127145A patent/GB2251615B/en not_active Revoked
- 1991-12-27 SI SI9112003A patent/SI9112003A/en unknown
- 1991-12-27 YU YU200391A patent/YU48767B/en unknown
- 1991-12-30 IL IL10055391A patent/IL100553A/en active Protection Beyond IP Right Term
- 1991-12-30 IL IL11402891A patent/IL114028A/en not_active IP Right Cessation
-
1992
- 1992-01-03 HU HU9301911A patent/HU218659B/en active Protection Beyond IP Right Term
- 1992-01-03 WO PCT/FI1992/000003 patent/WO1992012135A1/en active IP Right Grant
- 1992-01-03 ES ES92901317T patent/ES2070627T3/en not_active Expired - Lifetime
- 1992-01-03 EP EP92901317A patent/EP0565546B1/en not_active Expired - Lifetime
- 1992-01-03 JP JP4501428A patent/JP2635445B2/en not_active Expired - Lifetime
- 1992-01-03 CA CA002099262A patent/CA2099262C/en not_active Expired - Lifetime
- 1992-01-03 DK DK92901317.5T patent/DK0565546T3/en active
- 1992-01-03 DE DE69201640T patent/DE69201640T2/en not_active Expired - Lifetime
- 1992-01-03 US US08/081,360 patent/US5424428A/en not_active Expired - Lifetime
- 1992-01-03 RU RU93052411A patent/RU2118317C1/en active
- 1992-01-03 GE GEAP19922483A patent/GEP19991868B/en unknown
- 1992-01-03 AU AU11535/92A patent/AU645399B2/en not_active Expired
- 1992-01-03 CA CA002314115A patent/CA2314115C/en not_active Expired - Lifetime
- 1992-01-03 AT AT92901317T patent/ATE119525T1/en active
- 1992-01-03 RO RO93-00896A patent/RO111847B1/en unknown
- 1992-01-03 KR KR1019930701800A patent/KR100207145B1/en not_active IP Right Cessation
- 1992-01-06 NZ NZ241194A patent/NZ241194A/en not_active IP Right Cessation
- 1992-11-12 HR HR921251A patent/HRP921251B1/en not_active IP Right Cessation
-
1993
- 1993-06-09 FI FI932618A patent/FI105183B/en active Protection Beyond IP Right Term
- 1993-06-25 IE IE920002A patent/IE72101B1/en not_active IP Right Cessation
- 1993-06-25 PL PL92299920A patent/PL169435B1/en unknown
- 1993-06-25 PL PL92310250A patent/PL169415B1/en unknown
- 1993-06-28 NO NO932367A patent/NO300682B1/en not_active IP Right Cessation
- 1993-06-29 BG BG97915A patent/BG62002B1/en unknown
-
1994
- 1994-11-17 EE EE9400252A patent/EE02946B1/en unknown
-
1995
- 1995-05-31 US US08/454,856 patent/US5569657A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,035 patent/US5512571A/en not_active Expired - Lifetime
- 1995-07-20 HK HK117395A patent/HK117395A/en not_active IP Right Cessation
- 1995-11-30 LV LVP-95-358A patent/LV11174B/en unknown
-
1996
- 1996-04-05 CY CY187896A patent/CY1878A/en unknown
- 1996-11-19 JP JP8308528A patent/JP3015748B2/en not_active Expired - Lifetime
-
1997
- 1997-05-09 BR BR1100737A patent/BR1100737A/en active IP Right Grant
-
2001
- 2001-11-20 NO NO2001021C patent/NO2001021I1/en unknown
-
2002
- 2002-05-17 LU LU90920C patent/LU90920I2/en unknown
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