RU93051787A - ELIMINATING ISOMER 6- (5-CHLOR-2-PYRIDIL) - (4-METHYL-1-PIPERAZINYL) -5-CARBONYLOXY-7-OXO-6,7-DIHYDRO-5H-PYRRO- [3,4-V] Pyrazyl , METHOD FOR ITS OBTAINING, PHARMACEUTICAL COMPOSITION BASED ON IT AND METHOD OF IMPROVING SLEEP - Google Patents
ELIMINATING ISOMER 6- (5-CHLOR-2-PYRIDIL) - (4-METHYL-1-PIPERAZINYL) -5-CARBONYLOXY-7-OXO-6,7-DIHYDRO-5H-PYRRO- [3,4-V] Pyrazyl , METHOD FOR ITS OBTAINING, PHARMACEUTICAL COMPOSITION BASED ON IT AND METHOD OF IMPROVING SLEEPInfo
- Publication number
- RU93051787A RU93051787A RU93051787/04A RU93051787A RU93051787A RU 93051787 A RU93051787 A RU 93051787A RU 93051787/04 A RU93051787/04 A RU 93051787/04A RU 93051787 A RU93051787 A RU 93051787A RU 93051787 A RU93051787 A RU 93051787A
- Authority
- RU
- Russia
- Prior art keywords
- carbonyloxy
- piperazinyl
- isomer
- dihydro
- oxo
- Prior art date
Links
- -1 4-METHYL-1-PIPERAZINYL Chemical class 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 125000005412 pyrazyl group Chemical group 0.000 title 1
- 239000003326 hypnotic agent Substances 0.000 claims 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9100490A FR2671800B1 (en) | 1991-01-17 | 1991-01-17 | OPTICALLY ACTIVE 5H-PYRROLO [3,4-B] PYRAZINE DERIVATIVE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT. |
FR9100490 | 1991-01-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93051787A true RU93051787A (en) | 1996-02-27 |
RU2110519C1 RU2110519C1 (en) | 1998-05-10 |
Family
ID=9408772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93051787A RU2110519C1 (en) | 1991-01-17 | 1992-01-16 | Dextrorotatory isomer of 6-(5-chloro-2-pyridyl)-(4-methyl-1- -piperazinyl)-5-carbonyloxy-7-oxo-6,7-dihydro-5h-pyrrolo- -[3,4-b]-pyrazine and its pharmaceutically acceptable acid-additive salt, method of their synthesis and pharmaceutical composition based on thereof |
Country Status (29)
Country | Link |
---|---|
US (5) | US6319926B1 (en) |
EP (2) | EP0495717A1 (en) |
JP (1) | JPH06504548A (en) |
AR (1) | AR248024A1 (en) |
AT (1) | ATE121089T1 (en) |
AU (2) | AU671797B2 (en) |
CA (1) | CA2099782C (en) |
CZ (1) | CZ281011B6 (en) |
DE (1) | DE69202060T2 (en) |
DK (1) | DK0609210T3 (en) |
ES (1) | ES2071486T3 (en) |
FI (1) | FI100331B (en) |
FR (1) | FR2671800B1 (en) |
HU (1) | HU218928B (en) |
IE (1) | IE66110B1 (en) |
IL (1) | IL100677A (en) |
MA (1) | MA22392A1 (en) |
MX (1) | MX9200180A (en) |
NO (1) | NO179911C (en) |
NZ (1) | NZ241313A (en) |
OA (1) | OA09807A (en) |
PH (1) | PH30982A (en) |
PL (1) | PL166976B1 (en) |
RU (1) | RU2110519C1 (en) |
SK (1) | SK279060B6 (en) |
TN (1) | TNSN92004A1 (en) |
WO (1) | WO1992012980A1 (en) |
YU (1) | YU48878B (en) |
ZA (1) | ZA92302B (en) |
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US5786357A (en) | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
ES2101653B1 (en) * | 1995-07-10 | 1998-04-01 | Asturpharma S A | (+) - 6- (5-CHLOROPIRID-2-IL) -7-OXO-VINYLOXICARBONYLLOXI-5,6-DIHYDROPYROL (3,4B) PIRAZINE AND ITS USE FOR A PREPARATION PROCEDURE FOR (+) - 6- (5 -CHLOROPIRID-2-IL) -5- (4-METHYLPIPERAZIN-1-IL) -CARBONYLLOXI-7-OXO-5,6-DIHYDROPYROL (3,4B) PYRAZINE. |
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EP1904066B1 (en) | 2005-07-06 | 2018-05-23 | Sunovion Pharmaceuticals Inc. | COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS |
CN101257898A (en) * | 2005-07-06 | 2008-09-03 | 塞普拉科公司 | Combinations of eszopiclone and O-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
US20070098788A1 (en) * | 2005-10-28 | 2007-05-03 | Gore Subhash P | Non-benzodiazepine hypnotic compositions |
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US20080027223A1 (en) * | 2006-03-23 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Polymorphs of eszopiclone malate |
US20070270590A1 (en) * | 2006-04-20 | 2007-11-22 | Marioara Mendelovici | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
EP1904499A1 (en) * | 2006-06-26 | 2008-04-02 | Teva Pharmaceutical Industries Ltd | Process for the preparation of zopiclone |
US7786304B2 (en) * | 2006-11-06 | 2010-08-31 | Centaur Pharmaceutical Pvt. Ltd. | Process for the preparation of eszopiclone |
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ATE515259T1 (en) * | 2007-05-29 | 2011-07-15 | Lek Pharmaceuticals | PHARMACEUTICAL COMPOSITION CONTAINING ESZOPICLONE |
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US20090198058A1 (en) * | 2007-08-06 | 2009-08-06 | Dhananjay Govind Sathe | Process for Preparation of Dextrorotatory Isomer of 6-(5- chloro-pyrid-2-yl)-5-[(4-methyl -1-piperazinyl) carbonyloxy] -7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b] pyrazine (Eszopiclone) |
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US20100196286A1 (en) * | 2008-12-01 | 2010-08-05 | Armer Thomas A | Inhalation delivery methods and devices |
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JP2020007252A (en) * | 2018-07-05 | 2020-01-16 | アクティブファーマ株式会社 | Method for producing eszopiclone dibenzoyl-D-tartrate, method for producing eszopiclone, and crystal of eszopiclone dibenzoyl-D-tartrate |
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OA04285A (en) * | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | New derivatives of pyrrolo (3,4-b) pyrazine and their preparation. |
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US4962124A (en) | 1987-11-17 | 1990-10-09 | Analgesic Associates | Onset-hastened/enhanced antipyretic response |
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US5102890A (en) | 1989-09-05 | 1992-04-07 | Rhone-Poulenc Sante | Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them |
FR2671800B1 (en) | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | OPTICALLY ACTIVE 5H-PYRROLO [3,4-B] PYRAZINE DERIVATIVE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT. |
AU3275993A (en) | 1991-12-02 | 1993-06-28 | Sepracor, Inc. | Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone |
US5786357A (en) * | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
US5331000A (en) | 1992-03-09 | 1994-07-19 | Sepracor Inc. | Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen |
US6436926B1 (en) * | 1999-05-10 | 2002-08-20 | Medpointe, Inc. | Compositions and methods for treating superficial fungal infections |
US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
AR059296A1 (en) * | 2006-02-03 | 2008-03-26 | Synthon Bv | S-ZOPICLONE L-TARTRATE COMPOSITE AND PROCESS TO RESOLVE ZOPICLONA ENANTIOMERS. |
-
1991
- 1991-01-17 FR FR9100490A patent/FR2671800B1/en not_active Expired - Fee Related
-
1992
- 1992-01-15 NZ NZ241313A patent/NZ241313A/en not_active IP Right Cessation
- 1992-01-15 ZA ZA92302A patent/ZA92302B/en unknown
- 1992-01-15 MA MA22677A patent/MA22392A1/en unknown
- 1992-01-16 AR AR92321649A patent/AR248024A1/en active
- 1992-01-16 DE DE69202060T patent/DE69202060T2/en not_active Expired - Lifetime
- 1992-01-16 WO PCT/FR1992/000031 patent/WO1992012980A1/en active IP Right Grant
- 1992-01-16 MX MX9200180A patent/MX9200180A/en unknown
- 1992-01-16 JP JP4504006A patent/JPH06504548A/en active Pending
- 1992-01-16 CZ CS931380A patent/CZ281011B6/en not_active IP Right Cessation
- 1992-01-16 PH PH43784A patent/PH30982A/en unknown
- 1992-01-16 CA CA002099782A patent/CA2099782C/en not_active Expired - Fee Related
- 1992-01-16 DK DK92903994.9T patent/DK0609210T3/en active
- 1992-01-16 IL IL10067792A patent/IL100677A/en not_active IP Right Cessation
- 1992-01-16 EP EP92400111A patent/EP0495717A1/en active Pending
- 1992-01-16 HU HU9302063A patent/HU218928B/en unknown
- 1992-01-16 AT AT92903994T patent/ATE121089T1/en not_active IP Right Cessation
- 1992-01-16 EP EP92903994A patent/EP0609210B1/en not_active Expired - Lifetime
- 1992-01-16 AU AU12264/92A patent/AU671797B2/en not_active Expired
- 1992-01-16 RU RU93051787A patent/RU2110519C1/en active
- 1992-01-16 SK SK719-93A patent/SK279060B6/en not_active IP Right Cessation
- 1992-01-16 IE IE920126A patent/IE66110B1/en not_active IP Right Cessation
- 1992-01-16 ES ES92903994T patent/ES2071486T3/en not_active Expired - Lifetime
- 1992-01-16 PL PL92299834A patent/PL166976B1/en unknown
- 1992-01-17 YU YU5592A patent/YU48878B/en unknown
- 1992-01-17 TN TNTNSN92004A patent/TNSN92004A1/en unknown
-
1993
- 1993-05-26 NO NO931919A patent/NO179911C/en not_active IP Right Cessation
- 1993-06-17 OA OA60387A patent/OA09807A/en unknown
- 1993-07-16 FI FI933248A patent/FI100331B/en active
-
1995
- 1995-08-30 AU AU30321/95A patent/AU3032195A/en not_active Abandoned
-
1998
- 1998-07-29 US US09/124,651 patent/US6319926B1/en not_active Expired - Fee Related
-
2000
- 2000-11-28 US US09/722,438 patent/US6444673B1/en not_active Expired - Lifetime
-
2002
- 2002-07-23 US US10/200,510 patent/US6864257B2/en not_active Expired - Fee Related
-
2004
- 2004-09-28 US US10/951,844 patent/US7125874B2/en not_active Expired - Fee Related
-
2006
- 2006-05-03 US US11/416,570 patent/US7381724B2/en not_active Expired - Fee Related
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