RU93005286A - GRISEOLIC ACID DERIVATIVES - Google Patents
GRISEOLIC ACID DERIVATIVESInfo
- Publication number
- RU93005286A RU93005286A RU93005286/04A RU93005286A RU93005286A RU 93005286 A RU93005286 A RU 93005286A RU 93005286/04 A RU93005286/04 A RU 93005286/04A RU 93005286 A RU93005286 A RU 93005286A RU 93005286 A RU93005286 A RU 93005286A
- Authority
- RU
- Russia
- Prior art keywords
- acid derivatives
- griseolic acid
- agents
- treatment
- griseolic
- Prior art date
Links
- IAPZXUKYTCQQFE-UHFFFAOYSA-N 2-(6-aminopurin-9-yl)-5-[carboxy(hydroxy)methyl]-3-hydroxy-3,3a-dihydro-2H-furo[3,2-b]furan-5-carboxylic acid Chemical class NC1=NC=NC2=C1N=CN2C1C(O)C2OC(C(O)=O)(C(O)C(O)=O)C=C2O1 IAPZXUKYTCQQFE-UHFFFAOYSA-N 0.000 title claims 2
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 1
- 210000004556 Brain Anatomy 0.000 claims 1
- 208000008787 Cardiovascular Disease Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 230000036740 Metabolism Effects 0.000 claims 1
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000000924 antiasthmatic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000002490 cerebral Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 230000035786 metabolism Effects 0.000 claims 1
- 239000003076 neurotropic agent Substances 0.000 claims 1
- 101710031992 pRL90232 Proteins 0.000 claims 1
- 101710035540 plaa2 Proteins 0.000 claims 1
- 239000004089 psychotropic agent Substances 0.000 claims 1
- 239000000050 smooth muscle relaxant Substances 0.000 claims 1
Claims (1)
и ее сложным эфирам, обладающим ингибирующей фосфодиэстеразу (ФДЭ) активностью и используемым, например, при лечении сердечно-сосудистых заболеваний, в качестве противоастматических агентов, как релаксанты гладкой мускулатуры, в качестве психотропных или невротропных агентов, в качестве противовоспалительных агентов при лечении рака и диабетов, при различных церебральных циркуляторных расстройствах и в качестве активаторов метаболизма в мозге.The invention relates to a number of new derivatives of griseolic acid of the formula
and its esters having phosphodiesterase inhibiting (PDE) activity and used, for example, in the treatment of cardiovascular diseases, as anti-asthma agents, as smooth muscle relaxants, as psychotropic or neurotropic agents, as anti-inflammatory agents in the treatment of cancer and diabetes , with various cerebral circulatory disorders and as activators of metabolism in the brain.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60-91987 | 1985-04-27 | ||
| JP9198785 | 1985-04-27 |
Related Parent Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU4027478 Division | |||
| RU4355448 Division |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2056424C1 RU2056424C1 (en) | 1996-03-20 |
| RU93005286A true RU93005286A (en) | 1996-12-20 |
Family
ID=14041818
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU4355448 RU2021282C1 (en) | 1985-04-27 | 1988-03-30 | Method of synthesis of griseolic acid derivative or its ester |
| RU93005286/04A RU2056424C1 (en) | 1985-04-27 | 1993-05-14 | Derivative of griseolic acid or its esters |
| RU93005243/04A RU2073000C1 (en) | 1985-04-27 | 1993-06-07 | Derivatives of griseolic acid or their pharmaceutically acceptable salts or their esters (variants) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU4355448 RU2021282C1 (en) | 1985-04-27 | 1988-03-30 | Method of synthesis of griseolic acid derivative or its ester |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93005243/04A RU2073000C1 (en) | 1985-04-27 | 1993-06-07 | Derivatives of griseolic acid or their pharmaceutically acceptable salts or their esters (variants) |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPH072747B2 (en) |
| RU (3) | RU2021282C1 (en) |
| SU (1) | SU1766259A3 (en) |
-
1986
- 1986-04-18 JP JP61089240A patent/JPH072747B2/en not_active Expired - Fee Related
-
1987
- 1987-04-20 SU SU4202394A patent/SU1766259A3/en active
-
1988
- 1988-03-30 RU SU4355448 patent/RU2021282C1/en not_active IP Right Cessation
-
1993
- 1993-05-14 RU RU93005286/04A patent/RU2056424C1/en not_active IP Right Cessation
- 1993-06-07 RU RU93005243/04A patent/RU2073000C1/en not_active IP Right Cessation
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