RU93005182A - DERIVATIVES OF OCTAGIDRONAPTALINOXIMA, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, METHOD OF THEIR PREPARATION, METHODS OF OBTAINING INITIAL MATERIALS AND CULTURE OF MICROORGANISMS - Google Patents
DERIVATIVES OF OCTAGIDRONAPTALINOXIMA, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, METHOD OF THEIR PREPARATION, METHODS OF OBTAINING INITIAL MATERIALS AND CULTURE OF MICROORGANISMSInfo
- Publication number
- RU93005182A RU93005182A RU93005182/04A RU93005182A RU93005182A RU 93005182 A RU93005182 A RU 93005182A RU 93005182/04 A RU93005182/04 A RU 93005182/04A RU 93005182 A RU93005182 A RU 93005182A RU 93005182 A RU93005182 A RU 93005182A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- octagidronaptalinoxima
- microorganisms
- culture
- derivatives
- Prior art date
Links
- 239000000463 material Substances 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N (3β)-Cholest-5-en-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 229940107161 Cholesterol Drugs 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 210000004369 Blood Anatomy 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 230000037348 biosynthesis Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 0 CC(C(CCC(CC(CC(O)=O)O)=O)C(C(C1)C(C(*)C2)[N+](**)[O-])C2OC(*)=O)C1=O Chemical compound CC(C(CCC(CC(CC(O)=O)O)=O)C(C(C1)C(C(*)C2)[N+](**)[O-])C2OC(*)=O)C1=O 0.000 description 1
Claims (1)
в которой R представляет водород, метил или гидрокси; X представляет алкил, алкенил, циклоалкил, арил, аралкил или гетероциклическую группу; А представляет одинарную связь, или алкиленовую, алкениленовую, алкиниленовую группу или алкадиениленовую группу; Y представляет водород, арил, циклоалкил или гетероциклическую группу; обладают способностью ингибировать биосинтез холестерина, и таким образом, могут использоваться для лечения и профилактики заболеваний, связанных с высокими уровнями холестерина в крови.The compounds of the formula:
in which R represents hydrogen, methyl or hydroxy; X represents alkyl, alkenyl, cycloalkyl, aryl, aralkyl or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene group or an alkadienylene group; Y represents hydrogen, aryl, cycloalkyl or a heterocyclic group; have the ability to inhibit cholesterol biosynthesis, and thus, can be used for the treatment and prevention of diseases associated with high levels of cholesterol in the blood.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4-122476 | 1992-05-15 | ||
| JP12247692 | 1992-05-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93005182A true RU93005182A (en) | 1996-04-27 |
| RU2125043C1 RU2125043C1 (en) | 1999-01-20 |
Family
ID=14836794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93005182/04A RU2125043C1 (en) | 1992-05-15 | 1993-05-14 | Derivatives of octahydronaphthalene oxime, pharmaceutical composition, method of their synthesis, method of patient treatment |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5604256A (en) |
| EP (1) | EP0570245B1 (en) |
| JP (1) | JPH0641040A (en) |
| KR (2) | KR0177840B1 (en) |
| CN (1) | CN1034498C (en) |
| AT (1) | ATE144768T1 (en) |
| AU (1) | AU656855B2 (en) |
| CA (1) | CA2096281A1 (en) |
| CZ (1) | CZ281151B6 (en) |
| DE (1) | DE69305684T2 (en) |
| DK (1) | DK0570245T3 (en) |
| ES (1) | ES2096208T3 (en) |
| FI (1) | FI932188A (en) |
| GR (1) | GR3022095T3 (en) |
| HK (1) | HK31797A (en) |
| HU (1) | HU221854B1 (en) |
| IL (1) | IL105708A (en) |
| MX (1) | MX9302870A (en) |
| NO (1) | NO180443C (en) |
| NZ (1) | NZ247617A (en) |
| RU (1) | RU2125043C1 (en) |
| ZA (1) | ZA933359B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9320597D0 (en) * | 1993-10-06 | 1993-11-24 | Proteus Molecular Design | Improvements in and realting to vaccines |
| US5461049A (en) * | 1994-05-27 | 1995-10-24 | Warner-Lambert Company | Amide tetrazole ACAT inhibitors |
| WO2000056328A1 (en) * | 1999-03-19 | 2000-09-28 | Enos Pharmaceuticals, Inc. | Increasing cerebral bioavailability of drugs |
| EP1562555A2 (en) * | 2002-10-24 | 2005-08-17 | Enos Pharmaceuticals, Inc. | Sustained release l-arginine formulations and methods of manufacture and use |
| US20080145424A1 (en) * | 2002-10-24 | 2008-06-19 | Enos Phramaceuticals, Inc. | Sustained release L-arginine formulations and methods of manufacture and use |
| EP1675619A4 (en) * | 2003-09-29 | 2010-10-06 | Palmetto Pharmaceuticals Llc | Sustained release l-arginine formulations and methods of manufacture and use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (en) | 1974-06-07 | 1981-03-18 | ||
| JPS5925599B2 (en) | 1979-02-20 | 1984-06-19 | 三共株式会社 | New physiologically active substance monacolin K and its production method |
| JPS5612114A (en) | 1979-07-11 | 1981-02-06 | Tdk Corp | Manufacture of piezoelectric body resonator |
| MX7065E (en) | 1980-06-06 | 1987-04-10 | Sankyo Co | A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B |
| JPS5855443A (en) * | 1981-09-25 | 1983-04-01 | Sankyo Co Ltd | Octahydronaphthalene derivative and its preparation |
| CA1327360C (en) | 1983-11-14 | 1994-03-01 | William F. Hoffman | Oxo-analogs of mevinolin-like antihypercholesterolemic agents |
| JPS6113699A (en) | 1984-06-28 | 1986-01-21 | 三菱電機株式会社 | Shield of electric device |
| JPH0687664B2 (en) | 1987-06-22 | 1994-11-02 | 株式会社東芝 | Circulating current control type cycloconverter control device |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| JP2542429B2 (en) | 1987-10-27 | 1996-10-09 | 三共株式会社 | Octahydronaphthalene substituted oxime derivative |
-
1993
- 1993-05-13 NZ NZ247617A patent/NZ247617A/en unknown
- 1993-05-13 ZA ZA933359A patent/ZA933359B/en unknown
- 1993-05-13 FI FI932188A patent/FI932188A/en unknown
- 1993-05-14 AU AU38581/93A patent/AU656855B2/en not_active Ceased
- 1993-05-14 IL IL105708A patent/IL105708A/en not_active IP Right Cessation
- 1993-05-14 NO NO931752A patent/NO180443C/en not_active IP Right Cessation
- 1993-05-14 DK DK93303757.4T patent/DK0570245T3/en active
- 1993-05-14 EP EP93303757A patent/EP0570245B1/en not_active Expired - Lifetime
- 1993-05-14 DE DE69305684T patent/DE69305684T2/en not_active Expired - Fee Related
- 1993-05-14 ES ES93303757T patent/ES2096208T3/en not_active Expired - Lifetime
- 1993-05-14 AT AT93303757T patent/ATE144768T1/en not_active IP Right Cessation
- 1993-05-14 CZ CZ93896A patent/CZ281151B6/en not_active IP Right Cessation
- 1993-05-14 CA CA002096281A patent/CA2096281A1/en not_active Abandoned
- 1993-05-14 RU RU93005182/04A patent/RU2125043C1/en not_active IP Right Cessation
- 1993-05-14 HU HU9301415A patent/HU221854B1/en not_active IP Right Cessation
- 1993-05-15 CN CN93107589A patent/CN1034498C/en not_active Expired - Fee Related
- 1993-05-15 KR KR1019930008370A patent/KR0177840B1/en not_active IP Right Cessation
- 1993-05-17 MX MX9302870A patent/MX9302870A/en not_active IP Right Cessation
- 1993-05-17 JP JP5114817A patent/JPH0641040A/en active Pending
-
1994
- 1994-12-14 US US08/357,062 patent/US5604256A/en not_active Expired - Fee Related
-
1996
- 1996-12-18 GR GR960403543T patent/GR3022095T3/en unknown
-
1997
- 1997-03-13 HK HK31797A patent/HK31797A/en not_active IP Right Cessation
-
1998
- 1998-08-12 KR KR1019980032741A patent/KR100187482B1/en not_active IP Right Cessation
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