FR2248028A1 - 2,6-Dimethyl-3,5-dicarbonyl (or dicyano)-1,4-dihydropyridine prepns - used in treatment of hepatic diseases caused by peroxidative damage of biological membranes - Google Patents

2,6-Dimethyl-3,5-dicarbonyl (or dicyano)-1,4-dihydropyridine prepns - used in treatment of hepatic diseases caused by peroxidative damage of biological membranes

Info

Publication number
FR2248028A1
FR2248028A1 FR7337234A FR7337234A FR2248028A1 FR 2248028 A1 FR2248028 A1 FR 2248028A1 FR 7337234 A FR7337234 A FR 7337234A FR 7337234 A FR7337234 A FR 7337234A FR 2248028 A1 FR2248028 A1 FR 2248028A1
Authority
FR
France
Prior art keywords
dimethyl
biological membranes
dicarbonyl
dicyano
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7337234A
Other languages
French (fr)
Other versions
FR2248028B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ORDENA TRUDOVOGO KRASNOGO ZNAMEN SU
Original Assignee
ORDENA TRUDOVOGO KRASNOGO ZNAMEN SU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ORDENA TRUDOVOGO KRASNOGO ZNAMEN SU filed Critical ORDENA TRUDOVOGO KRASNOGO ZNAMEN SU
Priority to FR7337234A priority Critical patent/FR2248028A1/en
Publication of FR2248028A1 publication Critical patent/FR2248028A1/en
Application granted granted Critical
Publication of FR2248028B1 publication Critical patent/FR2248028B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparations containing as active component a 2, 6-dimethyl-3, 5-dicarbonyl (or 3, 5-dicyano)-1, 4-dihydro pyridine of general formula (I): (where R - alkyl, opt. substd. carbalkoxy, substd. carbamoyl or cyano; R1 = H, alkyl, aryl or beta-pyridyl) are new. Named cpd. (I) is 2,6-dimethyl-3, 5-dicarbethoxy-1, 4-dihydropyridine(ethydine). Ethydine (I) inhibits peroxidative processes in biological membranes in organs esp. the liver and may be used in the treatment of those liver diseases such as necrotic liver alterations, fatty hepatosis, virus hepatitis etc. (I) has anti-oxidative activity and may also be used as a stabilising agent for biological membranes or other tissues in the organism. (I) has high specific activity and no side-effectS. It is stable in closed containers.
FR7337234A 1973-10-18 1973-10-18 2,6-Dimethyl-3,5-dicarbonyl (or dicyano)-1,4-dihydropyridine prepns - used in treatment of hepatic diseases caused by peroxidative damage of biological membranes Granted FR2248028A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7337234A FR2248028A1 (en) 1973-10-18 1973-10-18 2,6-Dimethyl-3,5-dicarbonyl (or dicyano)-1,4-dihydropyridine prepns - used in treatment of hepatic diseases caused by peroxidative damage of biological membranes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7337234A FR2248028A1 (en) 1973-10-18 1973-10-18 2,6-Dimethyl-3,5-dicarbonyl (or dicyano)-1,4-dihydropyridine prepns - used in treatment of hepatic diseases caused by peroxidative damage of biological membranes

Publications (2)

Publication Number Publication Date
FR2248028A1 true FR2248028A1 (en) 1975-05-16
FR2248028B1 FR2248028B1 (en) 1977-03-11

Family

ID=9126614

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7337234A Granted FR2248028A1 (en) 1973-10-18 1973-10-18 2,6-Dimethyl-3,5-dicarbonyl (or dicyano)-1,4-dihydropyridine prepns - used in treatment of hepatic diseases caused by peroxidative damage of biological membranes

Country Status (1)

Country Link
FR (1) FR2248028A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456091A1 (en) * 1979-05-11 1980-12-05 Inst Organicheskogo Sinteza Ak 1,4-Di:hydro-pyridine-3-thiocarboxylic acid ester derivs. - useful as coronary vasodilators
EP0044262A1 (en) * 1980-07-16 1982-01-20 Rhone-Poulenc Agrochimie Aniline derivatives, process for their preparation and their application as a selective weedkiller
FR2486938A1 (en) * 1980-07-16 1982-01-22 Rhone Poulenc Agrochimie 3-Phenyl:carbamoyl 5-carboxy or carbalkoxy 2,6-lutidine derivs. - and corresp. 1,4-di:hydro cpds., are selective herbicides esp. for cotton and sunflower crops
FR2508446A1 (en) * 1981-06-25 1982-12-31 Rhone Poulenc Agrochimie PYRIDINE-DERIVED AMIDE AND ESTER FUNCTION HERBICIDES AND THEIR PREPARATION PROCESS AND APPLICATION THEREOF
EP0149475A2 (en) * 1984-01-13 1985-07-24 Yamanouchi Pharmaceutical Co. Ltd. Medicaments for the treatment and prevention of liver damage

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456091A1 (en) * 1979-05-11 1980-12-05 Inst Organicheskogo Sinteza Ak 1,4-Di:hydro-pyridine-3-thiocarboxylic acid ester derivs. - useful as coronary vasodilators
EP0044262A1 (en) * 1980-07-16 1982-01-20 Rhone-Poulenc Agrochimie Aniline derivatives, process for their preparation and their application as a selective weedkiller
FR2486938A1 (en) * 1980-07-16 1982-01-22 Rhone Poulenc Agrochimie 3-Phenyl:carbamoyl 5-carboxy or carbalkoxy 2,6-lutidine derivs. - and corresp. 1,4-di:hydro cpds., are selective herbicides esp. for cotton and sunflower crops
US4493729A (en) * 1980-07-16 1985-01-15 Rhone-Poulenc Agrochimie N-Phenylcarbamoyl-pyridine compounds
FR2508446A1 (en) * 1981-06-25 1982-12-31 Rhone Poulenc Agrochimie PYRIDINE-DERIVED AMIDE AND ESTER FUNCTION HERBICIDES AND THEIR PREPARATION PROCESS AND APPLICATION THEREOF
EP0069033A1 (en) * 1981-06-25 1983-01-05 Rhone-Poulenc Agrochimie Herbicidal amide and ester derivatives of pyridine, process for their preparation and their application
US4556414A (en) * 1981-06-25 1985-12-03 Rhone-Poulenc Agrochimie Herbicidal dihydropyridine amides
EP0149475A2 (en) * 1984-01-13 1985-07-24 Yamanouchi Pharmaceutical Co. Ltd. Medicaments for the treatment and prevention of liver damage
EP0149475A3 (en) * 1984-01-13 1985-09-18 Yamanouchi Pharmaceutical Co. Ltd. Medicaments for the treatment and prevention of liver damage

Also Published As

Publication number Publication date
FR2248028B1 (en) 1977-03-11

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