RU93004860A - HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PRODUCTION, USE AND PHARMACEUTICAL COMPOSITION - Google Patents

HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PRODUCTION, USE AND PHARMACEUTICAL COMPOSITION

Info

Publication number
RU93004860A
RU93004860A RU93004860/04A RU93004860A RU93004860A RU 93004860 A RU93004860 A RU 93004860A RU 93004860/04 A RU93004860/04 A RU 93004860/04A RU 93004860 A RU93004860 A RU 93004860A RU 93004860 A RU93004860 A RU 93004860A
Authority
RU
Russia
Prior art keywords
production
pharmaceutical composition
heterocyclic compounds
pharmaceutically acceptable
acceptable esters
Prior art date
Application number
RU93004860/04A
Other languages
Russian (ru)
Other versions
RU2114860C1 (en
Inventor
Энтони Кренитский Томас
Рэндольф Эверетт Деврон
Дуглас Вильсон Джеффри
Рэй Мурман Аллан
Доуэс Чэмбэрлэйн Стенли
Вальтер Косзалка Джордж
Портер Дэвид
Уолберг Джеральд
Original Assignee
Дзе Веллкам Фаундейшн Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909015914A external-priority patent/GB9015914D0/en
Application filed by Дзе Веллкам Фаундейшн Лимитед filed Critical Дзе Веллкам Фаундейшн Лимитед
Publication of RU93004860A publication Critical patent/RU93004860A/en
Application granted granted Critical
Publication of RU2114860C1 publication Critical patent/RU2114860C1/en

Links

Claims (1)

Описаны 6-алкоксипроизводные ara G и фармацевтически приемлемые его сложные эфиры в качестве полезных средств для лечения опухолей. Описаны также новые фармацевтически приемлемые сложные эфиры, их получение и фармацевтические формы, содержащие их.The 6-alkoxy derivatives of ara G and its pharmaceutically acceptable esters as useful agents for the treatment of tumors are described. Also described are new pharmaceutically acceptable esters, their preparation and pharmaceutical forms containing them.
RU93004860A 1990-07-19 1991-07-18 MONO-, DI- OR TRICOMPLEX ESTERS OF 2-AMINO-6-(C1-C5-ALKOXY)-9-(β-D-ARABINOFURANOSYL)-9H-PURINE, METHOD OF THEIR SYNTHESIS, USING AND PHARMACEUTICAL COMPOSITION RU2114860C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9015914.6 1990-07-19
GB9015914,6 1990-07-19
GB909015914A GB9015914D0 (en) 1990-07-19 1990-07-19 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
RU93004860A true RU93004860A (en) 1995-11-27
RU2114860C1 RU2114860C1 (en) 1998-07-10

Family

ID=10679359

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93004860A RU2114860C1 (en) 1990-07-19 1991-07-18 MONO-, DI- OR TRICOMPLEX ESTERS OF 2-AMINO-6-(C1-C5-ALKOXY)-9-(β-D-ARABINOFURANOSYL)-9H-PURINE, METHOD OF THEIR SYNTHESIS, USING AND PHARMACEUTICAL COMPOSITION

Country Status (23)

Country Link
US (3) US5492897A (en)
EP (1) EP0539479B1 (en)
JP (1) JP2873086B2 (en)
KR (1) KR100187326B1 (en)
AT (1) ATE151637T1 (en)
CA (1) CA2087543C (en)
CY (1) CY2165B1 (en)
DE (1) DE69125715T2 (en)
DK (1) DK0539479T3 (en)
ES (1) ES2103311T3 (en)
GB (1) GB9015914D0 (en)
GR (1) GR3023776T3 (en)
HU (2) HU9300115D0 (en)
IE (1) IE912513A1 (en)
IL (1) IL98881A (en)
MC (1) MC2289A1 (en)
MY (1) MY111871A (en)
NZ (1) NZ239025A (en)
PT (1) PT98371B (en)
RU (1) RU2114860C1 (en)
TW (1) TW208655B (en)
WO (1) WO1992001456A1 (en)
ZA (1) ZA915656B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
WO1998042352A1 (en) * 1997-03-24 1998-10-01 Glaxo Group Ltd. Method for treating b-cell tumors with ara-g nucleoside derivatives
ES2284256T3 (en) * 1998-07-02 2007-11-01 Kyowa Hakko Kogyo Co., Ltd. MEDICATIONS FOR DIABETES.
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
AU2002365412B2 (en) * 2001-11-27 2008-10-09 Anadys Pharmaceuticals, Inc. 3-Beta-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
WO2004012746A2 (en) * 2002-08-02 2004-02-12 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
ATE465742T1 (en) 2003-09-05 2010-05-15 Anadys Pharmaceuticals Inc TLR7 LIGANDS FOR TREATING HEPATITIS C
GB0321613D0 (en) * 2003-09-15 2003-10-15 Drug Discovery Lab As Compounds
WO2006030217A2 (en) * 2004-09-15 2006-03-23 Drug Discovery Laboratory As Drug conjugates of long chain fatty acid or ester moieties as protein binding prodrugs
US20090082304A1 (en) * 2004-11-12 2009-03-26 Northwestern University Methods of Treating Hematological Malignancies with Nucleoside Analog Drugs
ES2525567T3 (en) 2004-12-17 2014-12-26 Anadys Pharmaceuticals, Inc. Compounds of 3H-oxazolo and 3H-thiazolo [4,5-d] pyrimidin-2-one 3,5-disubstituted and 3,5,7-trisubstituted and prodrugs thereof
US20060189543A1 (en) * 2005-02-23 2006-08-24 Rosenbloom Richard A Compositions and methods for the treatment of leukemia
BRPI0618789A2 (en) 2005-11-21 2016-08-30 Anadys Pharmaceuticals Inc processes for the preparation of 5-amino-3h-thiazol [4,5-d] pyrimidin-2-one, cyclo-condensation of 2,4-diamino-5-halo-pyrimidine and oxidation of 5-amino-3h-thiazole [ 4,5-d] pyrimidin-2-thione
DE602007012247D1 (en) * 2006-06-22 2011-03-10 Anadys Pharmaceuticals Inc PRODRUGS OF 5-AMINO-3- (3'-DEOXY-BETA-D-RIBOFURANOSYL) -THIAZOLA4,5-DUPRYIDIN-2,7-DION
BRPI0714831A2 (en) 2006-07-18 2013-04-02 Anadys Pharmaceuticals Inc compound, pharmaceutical composition and methods of modulating cytokine immune activities in a patient, treating hepatitis virus infection and in a patient, and proliferation-related disorder in a mammal in need thereof
CN101768197A (en) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 Preparation method for nelarabine
EP2658857B1 (en) 2010-12-29 2016-11-02 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
WO2018230479A1 (en) * 2017-06-13 2018-12-20 大原薬品工業株式会社 5'-position silyl ether derivative for nucleoside anti-cancer agent or anti-virus agent
KR20230127294A (en) * 2020-12-30 2023-08-31 서던 유니버시티 오브 사이언스 앤드 테크놀로지 Methods and modified nucleosides for treating coronavirus infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2152486A1 (en) * 1970-11-20 1972-06-29 Akad Wissenschaften Ddr 6-methylmercapto-purine 5'-desoxy-5'-fluoro-riboside - with cytostati activity
US3872084A (en) * 1972-10-10 1975-03-18 Syntex Inc Purine nucleoside 3,5-cyclicphosphate compounds
US4081534A (en) * 1973-09-11 1978-03-28 Burroughs Wellcome Co. Amino purine nucleosides as autoimmune suppressant agents
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
JPS61233696A (en) * 1985-04-08 1986-10-17 Kanegafuchi Chem Ind Co Ltd 7-hydroxyguanine derivative, production thereof, and antitumor agent comprising same as active ingredient
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
CA1317291C (en) * 1987-12-14 1993-05-04 Naeem Botros Hanna Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
US5352669A (en) * 1990-03-13 1994-10-04 The Of The United States Of America As Represented By The Department Of Health And Human Services O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds

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