RU92016314A - DERIVATIVES OF DIPEPTIDES, METHOD OF THEIR RECEPTION AND PHARMACEUTICAL COMPOSITION ON THEIR BASIS - Google Patents
DERIVATIVES OF DIPEPTIDES, METHOD OF THEIR RECEPTION AND PHARMACEUTICAL COMPOSITION ON THEIR BASISInfo
- Publication number
- RU92016314A RU92016314A RU92016314/04A RU92016314A RU92016314A RU 92016314 A RU92016314 A RU 92016314A RU 92016314/04 A RU92016314/04 A RU 92016314/04A RU 92016314 A RU92016314 A RU 92016314A RU 92016314 A RU92016314 A RU 92016314A
- Authority
- RU
- Russia
- Prior art keywords
- lower alkyl
- derivatives
- dipeptides
- reception
- basis
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
включая таутомерные формы, где n представляет собой 0 или целое число от 1 до 3, R представляет собой OH, SH, COOH, NH2, галоген, OR4, SR4, COOR4, NHR или N(R4)2, где R4 принадлежит к ряду, состоящему из возможно замещенного низшего алкила, ароматической или ацильной групп, R1 представляет собой OH, возможно замещенный низший алкоксил, арил-низший алкоксил, арилоксигруппу, или дизамещенную аминогруппу, R2 принадлежит к ряду, состоящему из низшего алкила и амино-низшей алкильной группы, R3 представляет собой галоген, NO2 низший алкил, галоген - низший алкил, арил - низший алкил или ароматический радикал, и пригодные для фармацевтического использования соли указанных соединений. Описанные производные могут использоваться в частности при лечении гипертонии.The invention relates to new derivatives of dipeptides of the General formula:
including tautomeric forms, where n is 0 or an integer from 1 to 3, R is OH, SH, COOH, NH 2 , halogen, OR 4 , SR 4 , COOR 4 , NHR or N (R 4 ) 2 , where R 4 belongs to the series consisting of possibly substituted lower alkyl, aromatic or acyl groups, R 1 represents OH, possibly substituted lower alkoxy, aryl-lower alkoxy, aryloxy group, or disubstituted amino group, R 2 belongs to the series consisting of lower alkyl and amino-lower alkyl group, R 3 represents halogen, NO 2 lower alkyl, halo - lower alkyl, aryl, - izshy alkyl or aromatic radical, and suitable for pharmaceutical use, the salts of these compounds. The described derivatives can be used in particular in the treatment of hypertension.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES92102950.2 | 1991-02-27 | ||
| EP91102950A EP0500989B1 (en) | 1991-02-27 | 1991-02-27 | N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents |
| EP91102950.2 | 1991-02-27 | ||
| PCT/EP1992/000400 WO1992015608A1 (en) | 1991-02-27 | 1992-02-26 | N-(α-SUBSTITUTED-PYRIDINYL)CARBONYL DIPEPTIDE ANTIHYPERTENSIVE AGENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU92016314A true RU92016314A (en) | 1996-03-20 |
| RU2098424C1 RU2098424C1 (en) | 1997-12-10 |
Family
ID=8206465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU9292016314A RU2098424C1 (en) | 1991-02-27 | 1992-02-26 | Dipeptide derivatives or their pharmaceutically acceptable salts, methods of their synthesis, antihypertensive pharmaceutical composition |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5432159A (en) |
| EP (1) | EP0500989B1 (en) |
| JP (1) | JPH05507295A (en) |
| AT (1) | ATE174343T1 (en) |
| AU (1) | AU650954B2 (en) |
| BR (1) | BR9204779A (en) |
| CA (1) | CA2081471A1 (en) |
| CZ (1) | CZ280952B6 (en) |
| DE (1) | DE69130605T2 (en) |
| ES (1) | ES2037613B1 (en) |
| FI (1) | FI924850A0 (en) |
| HU (1) | HUT62313A (en) |
| NO (1) | NO924076L (en) |
| PL (1) | PL167915B1 (en) |
| PT (1) | PT100148B (en) |
| RO (1) | RO111369B1 (en) |
| RU (1) | RU2098424C1 (en) |
| WO (1) | WO1992015608A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5825094A (en) * | 1993-11-19 | 1995-06-06 | Astra Aktiebolag | Novel dipeptide derivatives |
| JP2000510481A (en) * | 1997-04-04 | 2000-08-15 | ファイザー・プロダクツ・インク | Nicotinamide derivatives |
| BR0116850A (en) | 2001-01-31 | 2004-02-25 | Pfizer Prod Inc | Thiazolyl-, oxazolyl-, pyrrolyl- and imidazolyl- amide derivatives useful as inhibitors of pde4 isoenzymes |
| IL156460A0 (en) | 2001-01-31 | 2004-01-04 | Pfizer Prod Inc | Ether derivatives useful as inhibitors of pde4 isozymes |
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| JP2004520386A (en) | 2001-01-31 | 2004-07-08 | ファイザー・プロダクツ・インク | Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes |
| WO2003033471A1 (en) * | 2001-10-17 | 2003-04-24 | Tobishi Pharmaceutical Co.,Ltd | Novel pyridone derivative and remedial agent for circulatory disease containing the same |
| MXPA04007252A (en) * | 2002-01-29 | 2005-03-31 | Wyeth Corp | Compositions and methods for modulating connexin hemichannels. |
| JP2008536850A (en) * | 2005-04-14 | 2008-09-11 | メルク エンド カムパニー インコーポレーテッド | VLA-4 antagonist |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU537592B2 (en) * | 1979-04-02 | 1984-07-05 | E.R. Squibb & Sons, Inc. | Mercaptoacyldipeptides |
| NZ202232A (en) * | 1981-11-06 | 1985-08-16 | Smithkline Beckman Corp | N-carboxyalkylproline-containing tripeptides and pharmaceutical compositions |
| DE3332633A1 (en) * | 1983-09-09 | 1985-04-04 | Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München | Substituted carboxylic acid derivatives, process for their preparation, and pharmaceuticals |
-
1991
- 1991-02-27 EP EP91102950A patent/EP0500989B1/en not_active Expired - Lifetime
- 1991-02-27 AT AT91102950T patent/ATE174343T1/en not_active IP Right Cessation
- 1991-02-27 DE DE69130605T patent/DE69130605T2/en not_active Expired - Fee Related
- 1991-12-16 ES ES9102792A patent/ES2037613B1/en not_active Expired - Fee Related
-
1992
- 1992-02-21 PT PT100148A patent/PT100148B/en not_active IP Right Cessation
- 1992-02-26 JP JP92504931A patent/JPH05507295A/en active Pending
- 1992-02-26 RO RO92-01349A patent/RO111369B1/en unknown
- 1992-02-26 BR BR9204779A patent/BR9204779A/en not_active Application Discontinuation
- 1992-02-26 AU AU12783/92A patent/AU650954B2/en not_active Ceased
- 1992-02-26 US US07/938,248 patent/US5432159A/en not_active Expired - Lifetime
- 1992-02-26 HU HU9203324A patent/HUT62313A/en unknown
- 1992-02-26 CZ CS923220A patent/CZ280952B6/en unknown
- 1992-02-26 RU RU9292016314A patent/RU2098424C1/en active
- 1992-02-26 CA CA002081471A patent/CA2081471A1/en not_active Abandoned
- 1992-02-26 WO PCT/EP1992/000400 patent/WO1992015608A1/en active IP Right Grant
- 1992-02-26 PL PL92296625A patent/PL167915B1/en unknown
- 1992-10-21 NO NO92924076A patent/NO924076L/en unknown
- 1992-10-26 FI FI924850A patent/FI924850A0/en unknown
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