RU92016280A - NEW 2-SAKHINOLMETIL- and 4,5,6,7-TETRAFLIDRO-2-SAHARINHYL-METHYLPHOSPHATES, -PHOSPHONATES AND -PHOSPHINATES, USED AS INHIBITORS OF PROTEALITIC AND INHIBITORS, AREA AND IGNITURES, I’m GOTT, I’m GOTT, I’m GET TO BE USED AS INHIBITORS OF PROTEALITIC GASES, AND -PHORPHYLINO-2-SAHARINIL-METHYLETHYPE - Google Patents

NEW 2-SAKHINOLMETIL- and 4,5,6,7-TETRAFLIDRO-2-SAHARINHYL-METHYLPHOSPHATES, -PHOSPHONATES AND -PHOSPHINATES, USED AS INHIBITORS OF PROTEALITIC AND INHIBITORS, AREA AND IGNITURES, I’m GOTT, I’m GOTT, I’m GET TO BE USED AS INHIBITORS OF PROTEALITIC GASES, AND -PHORPHYLINO-2-SAHARINIL-METHYLETHYPE

Info

Publication number
RU92016280A
RU92016280A RU92016280/33A RU92016280A RU92016280A RU 92016280 A RU92016280 A RU 92016280A RU 92016280/33 A RU92016280/33 A RU 92016280/33A RU 92016280 A RU92016280 A RU 92016280A RU 92016280 A RU92016280 A RU 92016280A
Authority
RU
Russia
Prior art keywords
inhibitors
protealitic
gott
phosphinates
phosphonates
Prior art date
Application number
RU92016280/33A
Other languages
Russian (ru)
Other versions
RU2091377C1 (en
Inventor
Чиманлал Десай Ранджит
Джозеф Курт Джон
Джон Хласта Денниз
Субраманьям Чакрапани
Original Assignee
Стерлинг Уинтроп Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/814,741 external-priority patent/US5187173A/en
Application filed by Стерлинг Уинтроп Инк. filed Critical Стерлинг Уинтроп Инк.
Publication of RU92016280A publication Critical patent/RU92016280A/en
Application granted granted Critical
Publication of RU2091377C1 publication Critical patent/RU2091377C1/en

Links

Claims (1)

Новые 4-R1 - R2 - R3 -2- сахаринилметил-, 4 - R4 - 4 - R5 -6- R6 - 4,5,6,7-тетрагидро-2-сахаринилметил- и 4,7-C-4,5,6,7- - тетрагидро - 2 - сахаринилметилфосфаты, -фосфонаты и -фосфинаты, предназначенные для лечения дегенеративных значений, их содержащие композиции и способы их использования для лечения дегенеративных заболеваний, а также способы получения указанных соединений посредством реакции соответствующих 2-галогенметилсахаринов с фосфатом, фосфонатом или фосфиновой кислотой в присутствии акцептора кислоты.The novel 4-R 1 - R 2 - R 3 -2-saccharinylmethyl, 4 - R 4 - 4 - R 5 -6- R 6 - 4,5,6,7-tetrahydro-2-saccharinylmethyl and 4,7 -C-4,5,6,7- - tetrahydro - 2 - saccharinylmethyl phosphates, phosphonates and phosphinates for the treatment of degenerative values, their compositions and methods for using them for the treatment of degenerative diseases, as well as methods for producing these compounds by the reaction the corresponding 2-halomethylsaccharins with phosphate, phosphonate or phosphinic acid in the presence of an acid acceptor.
RU9292016280A 1991-12-27 1992-12-25 2-saccharinylmethyl- or 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, -phosphonates or -phosphinates and pharmaceutical composition based on thereof RU2091377C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/814,741 US5187173A (en) 1991-12-27 1991-12-27 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US814741 1991-12-27

Publications (2)

Publication Number Publication Date
RU92016280A true RU92016280A (en) 1995-06-19
RU2091377C1 RU2091377C1 (en) 1997-09-27

Family

ID=25215883

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9292016280A RU2091377C1 (en) 1991-12-27 1992-12-25 2-saccharinylmethyl- or 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, -phosphonates or -phosphinates and pharmaceutical composition based on thereof

Country Status (22)

Country Link
US (1) US5187173A (en)
EP (1) EP0549073B1 (en)
JP (1) JPH05271262A (en)
AT (1) ATE150755T1 (en)
AU (1) AU648938B2 (en)
CA (1) CA2085427A1 (en)
CZ (1) CZ371692A3 (en)
DE (1) DE69218568T2 (en)
DK (1) DK0549073T3 (en)
ES (1) ES2100274T3 (en)
FI (1) FI925875A (en)
GR (1) GR3023632T3 (en)
HU (1) HUT63630A (en)
IL (3) IL116601A (en)
MX (1) MX9207542A (en)
MY (1) MY106897A (en)
NO (1) NO303639B1 (en)
NZ (1) NZ245585A (en)
RU (1) RU2091377C1 (en)
SG (1) SG48310A1 (en)
SK (1) SK371692A3 (en)
TW (1) TW225538B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236917A (en) * 1989-05-04 1993-08-17 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5296496A (en) * 1991-12-27 1994-03-22 Sterling Winthrop Inc. 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5541168A (en) * 1994-12-02 1996-07-30 Sterling Winthrop Inc. Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof
WO2003080047A1 (en) * 2002-03-20 2003-10-02 Bristol-Myers Squibb Company Phosphate prodrugs of fluorooxindoles
RS52762B (en) * 2005-03-21 2013-08-30 Virobay Inc. Alpha ketoamide compounds as cysteine protease inhibitors

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US3002884A (en) * 1959-04-15 1961-10-03 Rohm & Haas Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases
US3314960A (en) * 1964-08-25 1967-04-18 American Home Prod Benzisothiazol glutarimides
FR1451417A (en) * 1965-07-15 1966-01-07 Roussel Uclaf Novel cyclic acid esters and their preparation process
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4263393A (en) * 1979-09-06 1981-04-21 Eastman Kodak Company Novel electron donor precursors and photographic element containing them
US4350752A (en) * 1980-12-29 1982-09-21 Eastman Kodak Company Photographic elements and film units containing imidomethyl blocked photographic reagents
US4363865A (en) * 1981-03-04 1982-12-14 Eastman Kodak Company Imido methyl blocked photographic dyes and dye releasing compounds
US4410618A (en) * 1982-06-11 1983-10-18 Eastman Kodak Company Blocked photographic reagents
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
US4659855A (en) * 1983-05-09 1987-04-21 Georgia Tech Research Corporation Aryl sulfonyl fluoride compounds
JPH026496A (en) * 1988-06-27 1990-01-10 Ishihara Sangyo Kaisha Ltd Organic phosphoric acid amide compound, its production and harmful animal-controlling agent containing the same compound
US5236917A (en) * 1989-05-04 1993-08-17 Sterling Winthrop Inc. Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof
SG48298A1 (en) * 1989-05-04 1998-04-17 Sterling Winthorp Inc Saccharin deriatives useful as proteolytic enzymeinhibitors and preparation of
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

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