ES8300337A1 - A procedure for the preparation of derivatives of phosphinic and phosphonic acid. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of derivatives of phosphinic and phosphonic acid. (Machine-translation by Google Translate, not legally binding)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of ES8300337A1publicationCriticalpatent/ES8300337A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Procedure for the obtaining of derivatives of phosphonic and phosphine acids and of their salts, of formula (I), in which r is lower rent; r together with the carbon to which they are united form a cyclomaccanic ring c <003>; and x is hydrogen, hydroxyl, rent or aril. It consists in the dissociation reaction of the tiazolidinic ring of a compound of formula (II) or (III), in which r and r are lower rent and the other symbols have the same meaning as in formula (I). The reaction is carried out by heating the ebullition of a suspension of the compound in water, in the presence of a halohidic acid. These compounds have pharmacological applications for the treatment of inflammatory states, degenerative articular diseases and wilson's disease. (Machine-translation by Google Translate, not legally binding)
ES508362A1981-12-281981-12-28A procedure for the preparation of derivatives of phosphinic and phosphonic acid. (Machine-translation by Google Translate, not legally binding)
ExpiredES8300337A1
(en)