RU92014370A - DRUG FOR TREATMENT OF SEVERE SKIN DISEASES BASED ON 13-CIS-RETINOIC ACID - Google Patents

DRUG FOR TREATMENT OF SEVERE SKIN DISEASES BASED ON 13-CIS-RETINOIC ACID

Info

Publication number
RU92014370A
RU92014370A RU92014370/14A RU92014370A RU92014370A RU 92014370 A RU92014370 A RU 92014370A RU 92014370/14 A RU92014370/14 A RU 92014370/14A RU 92014370 A RU92014370 A RU 92014370A RU 92014370 A RU92014370 A RU 92014370A
Authority
RU
Russia
Prior art keywords
cis
retinoic acid
emulsifier
treatment
drug
Prior art date
Application number
RU92014370/14A
Other languages
Russian (ru)
Other versions
RU2004240C1 (en
Inventor
В.И. Ноздрин
К.С. Гузев
Original Assignee
Государственное малое научно-производственное предприятие "Ретиноиды"
Filing date
Publication date
Application filed by Государственное малое научно-производственное предприятие "Ретиноиды" filed Critical Государственное малое научно-производственное предприятие "Ретиноиды"
Priority to RU92014370A priority Critical patent/RU2004240C1/en
Priority claimed from RU92014370A external-priority patent/RU2004240C1/en
Application granted granted Critical
Publication of RU2004240C1 publication Critical patent/RU2004240C1/en
Publication of RU92014370A publication Critical patent/RU92014370A/en

Links

Claims (1)

Изобретение относится к медицине и может быть использовано в производстве лекарственных средств, непосредственно касается препарата для наружного применения, а именно мази, содержащей 13-цис-ретиноевую кислоту. Препарат, содержащий ретиноиды, жировую основу, антиоксиданты и эмульгаторы, отличается тем, что в качестве активного соединения содержит 13-цис-ретиноевую кислоту, в качестве эмульгатора смесь поверхностно-активных веществ, выпускаемую Нижегородским химико-фармацевтическим заводом под названием "Эмульгатор N 1" в качестве стабилизаторов бутилокситолуол и бутилоксианизол, в качестве жировой основы вазелиновое масло, кроме того содержит глицерин, этиловый спирт 96o и воду, при следующем соотношении компонентов, мас.%: 13-цис-ретиноевая кислота (в пересчете на 100% препарат) 0,1 0,05 0,01; эмульгатор N 1 10 10 10; бутилокситолуол 0,1 0,05 0,05; бутилоксианизол 0,1 0,05 0,05; вазелиновое масло 10 10 10; глицерин 10 10 10; спирт этиловый 96o 10 10 10; вода дистиллированная до 100 до 100 до 100. Высокоэффективный, малотоксичный стабильный, экономически выгодный препарат предназначен для лечения тяжелых дерматологических заболеваний.The invention relates to medicine and can be used in the manufacture of medicines, directly relates to a preparation for external use, namely an ointment containing 13-cis-retinoic acid. A preparation containing retinoids, a fat base, antioxidants and emulsifiers, is characterized in that it contains 13-cis-retinoic acid as an active compound, and a surfactant mixture produced by the Nizhny Novgorod Chemical and Pharmaceutical Plant under the name Emulsifier N 1 as an emulsifier as stabilizers butylhydroxytoluene and butylhydroxyanisole as fat base mineral oil, furthermore comprising glycerol, ethyl alcohol 96 o and water in the following ratio, wt.%: 13-cis-retinoic sour w (based on the 100% formulation) 0.1 0.05 0.01; emulsifier N 1 10 10 10; butyloxytoluene 0.1 0.05 0.05; butyloxyanisole 0.1 0.05 0.05; petroleum jelly oil 10 10 10; glycerol 10 10 10; ethyl alcohol 96 o 10 10 10; distilled water to 100 to 100 to 100. Highly effective, low-toxic stable, cost-effective drug is intended for the treatment of severe dermatological diseases.
RU92014370A 1992-12-24 1992-12-24 Preparation for treatment of conglobate form of acne disease and skin disease caused by keratinization insufficiency RU2004240C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU92014370A RU2004240C1 (en) 1992-12-24 1992-12-24 Preparation for treatment of conglobate form of acne disease and skin disease caused by keratinization insufficiency

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU92014370A RU2004240C1 (en) 1992-12-24 1992-12-24 Preparation for treatment of conglobate form of acne disease and skin disease caused by keratinization insufficiency

Publications (2)

Publication Number Publication Date
RU2004240C1 RU2004240C1 (en) 1993-12-15
RU92014370A true RU92014370A (en) 1997-04-10

Family

ID=20134233

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92014370A RU2004240C1 (en) 1992-12-24 1992-12-24 Preparation for treatment of conglobate form of acne disease and skin disease caused by keratinization insufficiency

Country Status (1)

Country Link
RU (1) RU2004240C1 (en)

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