EP0227799A1 - Allyl isothiocyanate and use thereof to inhibit hair loss - Google Patents
Allyl isothiocyanate and use thereof to inhibit hair lossInfo
- Publication number
- EP0227799A1 EP0227799A1 EP86904525A EP86904525A EP0227799A1 EP 0227799 A1 EP0227799 A1 EP 0227799A1 EP 86904525 A EP86904525 A EP 86904525A EP 86904525 A EP86904525 A EP 86904525A EP 0227799 A1 EP0227799 A1 EP 0227799A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- allyl isothiocyanate
- composition
- hair loss
- weight
- aitc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Definitions
- This application is concerned with pharmaceutical compositions allyl isothiocyanate (AITC) , and the use of such compositions of AITC itself to inhibit hair loss from the human scalp.
- AITC allyl isothiocyanate
- Allyl isothiocyanate is a known compound. It may be prepared by reaction between allyl iodide and potassium thiocyanate as described by Duliere J. Pharm. Belg. 2 j _ 981 (1920).
- AITC topical application of AITC to the human scalp, preferably in a pharmaceutically acceptable carrier will assist in the prevention of hair loss.
- the AITC may be applied, generally by massage, in any of a variety of compositions including liquids, and viscous bases such as creams, lotions, emollients, and other compositions generally employed for topical application.
- Useful compositions will contain from about 0.01% to 5%, preferably 0.1% to 2% by weight based on the total weight of the composition of the active ingredient.
- shampoos may be considered as pharmaceutical compositions.
- AITC may be used in dilute solution in water, but because of its low solubility in this carrier it will be generally employed in liquid compositions which are mixtures of water and a water miscible alkanol such as methyl, ethyl, propyl or isopropyl alcohol.
- AITC may be compounded with vaseline, petrolatum, hydrocarbon waxes, vegetable oils such as safflower, almond or peanut oil, or other inert, pharmaceutically acceptable carriers.
- the compositions may contain other active ingredients such as antiseptics, germicides or anti-dandruff compounds.
- a liquid composition useful for inhibiting hair, loss is prepared by dissolving 0.5 ml. or AITC in 100 ml. of 70% ethanol-water.
- An ointment composition of the invention is prepared by thoroughly mixing the following ingredients:
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Isothiocyanate allylique destiné à empêcher la chute des cheveux chez l'homme.Allyl isothiocyanate intended to prevent hair loss in humans.
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74696585A | 1985-06-20 | 1985-06-20 | |
US746965 | 1985-06-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0227799A1 true EP0227799A1 (en) | 1987-07-08 |
EP0227799A4 EP0227799A4 (en) | 1987-10-05 |
Family
ID=25003099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19860904525 Withdrawn EP0227799A4 (en) | 1985-06-20 | 1986-06-16 | Allyl isothiocyanate and use thereof to inhibit hair loss. |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0227799A4 (en) |
JP (1) | JPS63500520A (en) |
WO (1) | WO1986007536A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2826261B1 (en) * | 2001-06-26 | 2005-03-25 | Lmd | TOPICAL COMPOSITION COMPRISING A CYTOTOXIC PRODUCT AND ITS USE IN THE TREATMENT OF ALOPECHE |
CN101897691B (en) * | 2009-05-31 | 2013-06-05 | 无锡杰西医药科技有限公司 | Application of isothiocyanate compounds in promoting hair growth |
CA3090188A1 (en) * | 2018-02-02 | 2019-08-08 | Commonwealth Scientific And Industrial Research Organisation | Protecting a bioactive and/or precursor thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB473769A (en) * | 1936-05-08 | 1937-10-20 | Hans Haag | Process for the production of a preparation for the destruction of vermin |
GB2088714A (en) * | 1980-11-26 | 1982-06-16 | Marinello Rosolino | Pharmaceutical compositions containing allyl isothiocyanate |
US4440783A (en) * | 1983-02-24 | 1984-04-03 | Bernard Weiss | Composition for repelling animals from garbage and the like |
-
1986
- 1986-06-16 WO PCT/US1986/001305 patent/WO1986007536A1/en not_active Application Discontinuation
- 1986-06-16 JP JP50371286A patent/JPS63500520A/en active Pending
- 1986-06-16 EP EP19860904525 patent/EP0227799A4/en not_active Withdrawn
Non-Patent Citations (2)
Title |
---|
No relevant documents have been disclosed. * |
See also references of WO8607536A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1986007536A1 (en) | 1986-12-31 |
EP0227799A4 (en) | 1987-10-05 |
JPS63500520A (en) | 1988-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
17P | Request for examination filed |
Effective date: 19870821 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19871005 |
|
17Q | First examination report despatched |
Effective date: 19890712 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19900504 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: DARKO, LASZLO, L. |