RU92004487A -
DNA, POLIPEPTID, VACCINE, VECTOR, MICROORGANISM, INSECTED CELL, REAGENT, METHODS OF TREATMENT AND PREVENTION, METHOD OF DETECTING ANTIGENES
- Google Patents
DNA, POLIPEPTID, VACCINE, VECTOR, MICROORGANISM, INSECTED CELL, REAGENT, METHODS OF TREATMENT AND PREVENTION, METHOD OF DETECTING ANTIGENES
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RU92004487A
RU92004487ARU92004487/13ARU92004487ARU92004487ARU 92004487 ARU92004487 ARU 92004487ARU 92004487/13 ARU92004487/13 ARU 92004487/13ARU 92004487 ARU92004487 ARU 92004487ARU 92004487 ARU92004487 ARU 92004487A
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Application filed by Американ Хоум Продактс Корпорейшн, Amerikan Khoum Prodakts KorporejshnfiledCriticalАмерикан Хоум Продактс Корпорейшн
Publication of RU92004487ApublicationCriticalpatent/RU92004487A/en
Предложены фрагменты химерической ДНК, включающие нуклеотидную последовательность, почти такую же, что кодирует поверхностный протеин НA вируса гриппа А с пятью иммунодоминантными антигенными участками, где нуклеотидная последовательность почти такая же, что кодирует чужеродный эпитон, вставлена в нуклеотидную последовательность антигенного участка. Также предложены соответствующие химерические полипептиды, векторы экспрессии и трансформированные клетки-хозяева. Эти пептиды полезны при получении вакцин против соответствующих антигенов, а также применимы в диагностических препаратах, предназначенных для обнаружения факта заражения подобными антигенами. Кроме того, указанные пептиды или соответствующие им антитела полезны при осуществлении методов лечения и профилактики (включая иммунотерапевтические методы) в случае заражения такими антигенами.Chimeric DNA fragments, including the nucleotide sequence, are almost the same as those that encode the influenza A virus surface protein HA with five immunodominant antigenic regions, where the nucleotide sequence is almost the same as that of the foreign epiton, inserted into the nucleotide sequence of the antigenic region. Corresponding chimeric polypeptides, expression vectors and transformed host cells are also proposed. These peptides are useful in obtaining vaccines against the corresponding antigens, and are also applicable in diagnostic preparations designed to detect the fact of infection with similar antigens. In addition, these peptides or their corresponding antibodies are useful in the implementation of treatment and prevention methods (including immunotherapy methods) in the event of infection with such antigens.
RU92004487/13A1991-12-111992-12-10
DNA, POLIPEPTID, VACCINE, VECTOR, MICROORGANISM, INSECTED CELL, REAGENT, METHODS OF TREATMENT AND PREVENTION, METHOD OF DETECTING ANTIGENES
RU92004487A
(en)
Induction of protective immunity and modulation of granulomatous hypersensitivity in mice using PIII, an anionic fraction of Schistosoma mansoni adult worm
An isolated polynucleotide (VARIANTS) of polynucleotides (OPTIONS), VECTOR (VARIANTS) host cell (VARIANTS) recovering the polypeptide (VARIANTS), METHOD FOR ITS PREPARATION (VARIANTS) vaccine composition (VARIANTS) method for the therapeutic or prophylactic treatment of streptococcal bacterial infection ANIMAL (OPTIONS), APPLICATION (VARIANTS)
VACCINE CONTAINING AT LEAST ONE PARTICULATE IMMUNOGEN AND ADJUVANTING AMOUNT OF SUBUNITS OF e. COLI HEAT-LABILE ENTEROTOXIN (LTB) FREE FROM CONTAMINATING A SUBUNITS OR TOXIC HOLOTOXIN, ITS USE FOR INDUCTION OF LOCAL AND SYSTEMIC PROTECTIVE RESPONSE AGAINST PARTICULATE IMMUNOGEN UPON MUCOSAL ADMINISTRATION
Synthesis of an antigenic determinant of the HSV gD that stimulates the induction of virus-neutralizing antibodies and confers protection against a lethal challenge of HSV.