CA2075366A1 - Immunologically active peptides or polypeptides from the parvovirus b19 - Google Patents
Immunologically active peptides or polypeptides from the parvovirus b19Info
- Publication number
- CA2075366A1 CA2075366A1 CA002075366A CA2075366A CA2075366A1 CA 2075366 A1 CA2075366 A1 CA 2075366A1 CA 002075366 A CA002075366 A CA 002075366A CA 2075366 A CA2075366 A CA 2075366A CA 2075366 A1 CA2075366 A1 CA 2075366A1
- Authority
- CA
- Canada
- Prior art keywords
- genetic engineering
- parvovirus
- antigens
- produced
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 241000702617 Human parvovirus B19 Species 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 238000010353 genetic engineering Methods 0.000 abstract 3
- 108090000565 Capsid Proteins Proteins 0.000 abstract 1
- 102100023321 Ceruloplasmin Human genes 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 1
- 108010052285 Membrane Proteins Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14211—Erythrovirus, e.g. B19 virus
- C12N2750/14222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Immunologically active peptides or polypeptides with a partial amino-acid sequence of the capsid proteins VP1 and VP2 of parvovirus B19 which permit tests to be carried out at low cost, sensitively and specifically for the determination of antibodies against human parvovirus B19 are made available. Short peptide sequences which, employed as antigen, serve to identify anti-B19 IgG-positive sera are identified. Furthermore, the production of these peptides using genetic engineering measures is disclosed. Other antigens which are produced by genetic engineering and which can be stably produced in a high yield in E.coli and subsequently purified therefrom are used as additional antigens for IgG detection. Finally, a set of antigens permits tests to be carried out to determine IgM antibodies against the virus.
In addition, the components, produced by genetic engineering, of the surface proteins represent substances which can be used for prophylactic immunisation.
In addition, the components, produced by genetic engineering, of the surface proteins represent substances which can be used for prophylactic immunisation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4003826.2 | 1990-02-08 | ||
| DE4003826A DE4003826C2 (en) | 1990-02-08 | 1990-02-08 | Peptides of the capsid proteins VP1 or VP2 of the parvovirus B19 |
| PCT/EP1991/000106 WO1991011895A1 (en) | 1990-01-29 | 1991-01-21 | Holder for the application of microwave fields to items to be treated |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2075366A1 true CA2075366A1 (en) | 1991-08-09 |
| CA2075366C CA2075366C (en) | 2003-02-18 |
Family
ID=6399718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002075366A Expired - Lifetime CA2075366C (en) | 1990-02-08 | 1991-02-08 | Immunologically active peptides or polypeptides from the parvovirus b19 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0514413B1 (en) |
| JP (2) | JP3061196B2 (en) |
| AT (1) | ATE105303T1 (en) |
| AU (1) | AU650864B2 (en) |
| CA (1) | CA2075366C (en) |
| DE (2) | DE4003826C2 (en) |
| DK (1) | DK0514413T3 (en) |
| ES (1) | ES2052370T3 (en) |
| WO (1) | WO1991012269A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3149116B2 (en) * | 1992-10-28 | 2001-03-26 | 信越化学工業株式会社 | Epitope-related peptide of human parvovirus |
| AU680264B2 (en) * | 1993-01-23 | 1997-07-24 | Inmunologia Y Genetica Aplicada, S.A. | Synthetic peptides and vaccines against parvovirus |
| DK0725837T3 (en) * | 1993-10-28 | 2000-06-13 | Deutsches Krebsforsch | Adeno-associated virus - its diagnostic use in early miscarriage |
| AU5103396A (en) * | 1995-03-08 | 1996-09-23 | Klaus Hedman | Method for the diagnosis of injections |
| JPH0910000A (en) | 1995-06-26 | 1997-01-14 | Nippon Sekijiyuujishiya | Method for detecting human parvovirus and reagent therefor |
| FR2771751B1 (en) * | 1997-12-03 | 2000-05-26 | Assist Publ Hopitaux De Paris | ERYTHROVIRUS AND ITS APPLICATIONS |
| RU2146372C1 (en) * | 1998-04-16 | 2000-03-10 | Гематологический научный центр РАМН | Method of assay of parvovirus b 19 |
| US6238860B1 (en) | 1998-11-05 | 2001-05-29 | Dyax Corp. | Binding moieties for human parvovirus B19 |
| US6818612B2 (en) | 1998-11-24 | 2004-11-16 | Kristina Broliden | Use of parvovirus capsid particles in the inhibition of cell proliferation and migration |
| US6743772B1 (en) | 1998-11-24 | 2004-06-01 | Kristina Broliden | Use of parovirus capsid particles in the inhibition of cell proliferation and migration |
| BRPI0211191B8 (en) | 2001-06-28 | 2021-07-27 | Chiron Corp | nucleic acid-based assays to accurately diagnose parvovirus b19 infection and initiators and markers for use in these assays |
| CA2456715A1 (en) | 2001-08-31 | 2003-03-13 | Gen-Probe Incorporated | Assay for detection of human parvovirus b19 nucleic acid |
| WO2007096199A2 (en) * | 2006-02-22 | 2007-08-30 | Ikdt Institut Kardiale Diagnostik Und Therapie Gmbh | Differential diagnostics and therapy of virally induced heart muscle disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7966987A (en) * | 1986-09-08 | 1988-04-07 | Applied Biotechnology, Inc. | Empty viral capsid vaccines |
| DE3939470A1 (en) * | 1989-11-29 | 1991-06-06 | Biochrom Beteiligungs Gmbh & C | Diagnosis and prevention of human parvovirus B19 infection - using synthetic penta- and higher peptide(s) and antibodies |
-
1990
- 1990-02-08 DE DE4003826A patent/DE4003826C2/en not_active Expired - Fee Related
-
1991
- 1991-02-08 DE DE59101577T patent/DE59101577D1/en not_active Expired - Lifetime
- 1991-02-08 AT AT9191903270T patent/ATE105303T1/en not_active IP Right Cessation
- 1991-02-08 DK DK91903270.6T patent/DK0514413T3/en active
- 1991-02-08 ES ES91903270T patent/ES2052370T3/en not_active Expired - Lifetime
- 1991-02-08 JP JP3503659A patent/JP3061196B2/en not_active Expired - Lifetime
- 1991-02-08 EP EP91903270A patent/EP0514413B1/en not_active Expired - Lifetime
- 1991-02-08 CA CA002075366A patent/CA2075366C/en not_active Expired - Lifetime
- 1991-02-08 AU AU72115/91A patent/AU650864B2/en not_active Expired
- 1991-02-08 WO PCT/DE1991/000106 patent/WO1991012269A1/en active IP Right Grant
-
2000
- 2000-01-24 JP JP2000017931A patent/JP3130024B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000184889A (en) | 2000-07-04 |
| AU650864B2 (en) | 1994-07-07 |
| DE59101577D1 (en) | 1994-06-09 |
| ATE105303T1 (en) | 1994-05-15 |
| AU7211591A (en) | 1991-09-03 |
| JP3130024B2 (en) | 2001-01-31 |
| EP0514413A1 (en) | 1992-11-25 |
| DK0514413T3 (en) | 1994-06-06 |
| JPH05504143A (en) | 1993-07-01 |
| ES2052370T3 (en) | 1994-07-01 |
| WO1991012269A1 (en) | 1991-08-22 |
| JP3061196B2 (en) | 2000-07-10 |
| EP0514413B1 (en) | 1994-05-04 |
| CA2075366C (en) | 2003-02-18 |
| DE4003826A1 (en) | 1991-08-14 |
| DE4003826C2 (en) | 1995-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |