RU33869U1 - Blood-contact device and kit for targeted low-volume hemoperfusion - Google Patents

Description

HEMOCONTACT DEVICE AND SET FOR CARRYING OUT

. - Lg.

TARGET LOW-VOLUME HEMONERFUSION

A useful model can be used in medicine, for example, for the treatment of various diseases during low-volume hemoperfusions.

The procedure for targeted low-volume hemoperfusion involves the collection of blood from an arterial vessel, its activation on the blood-contact preparation contained in the proposed blood-contact device, and the return of activated blood back to the arterial vessel, which supplies a specific organ or region with a focus of the pathological process.

As a prototype, you can choose any column for hemo- or plasma sorption, for example, a column from Excorim, Sweden (1). The column is designed to carry out a standard plasma or hemosorption procedure, depending on which hemosorbent is loaded into the column. The column contains a vessel for loading hemosorbent, in the lower part of which there is a grid, a filter and an opening for the blood duct. The disadvantages of this device compared to the claimed solution include the need for catheterization of the intake and inlet vessels of the patient, heparinization of the whole body, the use of technical devices, in particular peristaltic pumps, etc.

The proposed utility model is intended for the implementation of other therapeutic effects of the blood contact procedure with sorbents. Namely, to ensure the development of activation processes in the humoral and cellular blood systems, which provides a modification of its effector-regulatory potential due to the formation of a wide variety of biologically active products (2,3). The practical implementation of activation effects does not imply perfusion of large volumes of blood. The therapeutic effect in this will be achieved by delivering bioactive products of activated blood to the lesion by the shortest route, i.e. intraarterial hemoperfusion.

The blood contact device contains a container for hemosorbent, in the lower part of which there is a grid, a filter and an opening for the duct 1 of the blood. Compared with the prototype, it is additionally equipped with a piston mounted with the possibility of vertical movement inside the tank. Such a constructive implementation allows the collection and return of blood using a single puncture of the vessel, as well as hemoperfusion through the sorbent in a reciprocating mode, which does not require a1 gicoagent.

To carry out the procedure for targeted low-volume hemoperfusion, a special kit is needed that will allow you to perform the procedure in an operating room or dressing room without involving additional funds. The kit contains a blood contact device, made, for example, as described above, needles for puncture of an arterial vessel, communication tubes, physiological saline, an anticoagulant to block the blood coagulation system, which can be used, for example, heparin, an arterial catheter, syringes and anesthetic, for example, novocaine.

The essence of the utility model is illustrated by the drawings, which represent the bloodong device (Fig. 1), and a kit for conducting targeted low-volume hemoperfusion (Fig. 2).

The blood contact device contains a container (1) for hemosorbent, a mesh (2), which is pressed to the base with a ring (4), a filter (3), and a piston (5) mounted inside the container (1) with the possibility of vertical movement along the walls of the vessel.

To manufacture this device, a syringe (50, 100 ml) is taken, a piston (5) is removed, a filter (3) and a rigid mesh (2) matching the diameter of the syringe are placed in the syringe. The mesh (2) was pressed against the base of the syringe with a ring (4), which fits tightly into the inside of the syringe and prevents the filter (3) and mesh (2) from moving when the piston (5) is mixed. Next, the necessary amount (10-20 ml) of the blood contact drug is loaded into the syringe, which can be used as any hemosorbents that are approved for use in clinical practice. After loading the hemosorbent, it is washed with a 20-fold volume of sterile saline. Then the piston is inserted into the syringe and tightly presses the blood contact drug. After sterilization, the blood contact device is ready for use.

The kit for the procedure of the targeted low-volume hemoperfusion includes: a blood contact device (6), needles for puncture of an arterial vessel - 2 pcs (7), a communication tube (8), sterile phys. 200 ml solution (9), anticoagulant (2.0 ml heparin) (10), arterial catheter (11), 1.0 and 5.0 syringes - 1 pc (12), anesthetic (novocaine) (13).

The kit may additionally include rubber (surgical) gloves - 2 pairs (14), iodine (15), alcohol (16).

The procedure using a kit is as follows;

First of all, you need to bring the kit into working condition. To do this, you must:

- Repeatedly rinse the blood contact device with heparinized saline;

-connect the contact needle, communication tube and hemococcal device;

- Pour 0.2 ml of genarin into the communication tube.

The very nrocephalus of the target low-volume hemoperfusion is performed as follows:

- an arterial vessel is punctured (an arterial catheter can be used);

- a blood contact device is connected through a communication tube;

- Slowly take and slowly return blood to the vessel;

- remove the needle from the arterial trunk.

The procedure for taking and returning blood takes 3-5 minutes. As a result, the blood passes twice through the blood-contact drug, is activated and delivered to the affected areas, which are supplied with this arterial blood vessel.

Thus, the proposed utility model can be used to treat various diseases in which a local effect on the affected organ or a specific vascular region is required.

Sources of information taken into account:

1. Prospectus from Exopsh, Sweden.

2.K5 Netsov S.I. Effector mechanisms of hemoperfusion // Effector therapy. 1998.-T.4.-N4.-C.28-31.

Z. Kuznetsov S.I. Solid-phase contact hemomodulation. (Immunomodulation) // Allergology and Immunology.-2001.-t.2.-K2.-p.17-18.

Claims (3)

1. A blood contact device for conducting targeted low-volume hemoperfusion, including a hemosorbent container, in the lower part of which there is a grid, a filter and a hole for the blood duct, characterized in that it is additionally equipped with a piston mounted with the possibility of vertical movement inside the container. 2. A kit for conducting targeted low-volume hemoperfusion, characterized in that the blood contact device is rigidly connected to a communication tube to which a puncture needle or arterial catheter is attached. 3. The kit according to claim 2, characterized in that it further comprises a syringe with a needle designed to collect the anticoagulant and introduce it into a sterile physiological solution for processing a blood contact device.