RU2764175C1 - Бифункциональные композиции для лечения рака - Google Patents

Бифункциональные композиции для лечения рака Download PDF

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RU2764175C1
RU2764175C1 RU2021100818A RU2021100818A RU2764175C1 RU 2764175 C1 RU2764175 C1 RU 2764175C1 RU 2021100818 A RU2021100818 A RU 2021100818A RU 2021100818 A RU2021100818 A RU 2021100818A RU 2764175 C1 RU2764175 C1 RU 2764175C1
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cancer
pnd
dna
cells
cell
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RU2021100818A
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Russian (ru)
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Ренато Агилеро
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Армасьютика Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2021100818A 2018-06-19 2019-06-19 Бифункциональные композиции для лечения рака RU2764175C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUAU20180902181 2018-06-19
AU2018902181A AU2018902181A0 (en) 2018-06-19 Bifunctional compositions for the treatment of cancer
PCT/IB2019/055130 WO2019244050A1 (en) 2018-06-19 2019-06-19 Bifunctional compositions for the treatment of cancer

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Publication Number Publication Date
RU2764175C1 true RU2764175C1 (ru) 2022-01-14

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EP (1) EP3793544B1 (enExample)
JP (1) JP7510411B2 (enExample)
CN (1) CN112672741A (enExample)
AU (1) AU2019291491B2 (enExample)
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RU (1) RU2764175C1 (enExample)
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WO2020248075A1 (en) * 2019-06-12 2020-12-17 The Governors Of The University Of Alberta Targeting dna repair in tumor cells via inhibition of ercc1-xpf
US12486274B2 (en) 2020-01-13 2025-12-02 Verge Analytics, Inc. Substituted pyrazolo-pyrimidines and uses thereof
CN115317625B (zh) * 2021-12-24 2023-08-08 南通大学附属医院 一种小干扰rna在制备改善鼻咽癌预后的药物中的应用
CN114511462B (zh) * 2022-02-11 2023-04-18 电子科技大学 一种视觉图像增强方法
WO2025251699A1 (zh) * 2024-06-07 2025-12-11 北京三博脑科医院有限公司 一种硝唑尼特及其药学上可接受的盐在制备抗造釉细胞型颅咽管瘤药物中的应用
CN119064582B (zh) * 2024-09-02 2025-05-27 南方医科大学南方医院 RIPK1 O-GlcNAc糖基化抑制剂在制备增强肾细胞癌舒尼替尼敏感性药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013826A1 (en) * 2000-08-02 2002-02-21 Keum Ki Chang Anti-cancer composition composed of anti-cancer and anti-malarial drugs
US20110300137A1 (en) * 2010-06-03 2011-12-08 Mckenzie Douglas Tyler Use of lumefantrine and related compounds in the treatment of cancer
WO2016196614A1 (en) * 2015-06-01 2016-12-08 University Of Kentucky Research Foundation Chloroquine induction of par-4 and treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1135977C (zh) * 1999-07-19 2004-01-28 中国医学科学院中国协和医科大学血液学研究所血液病医院 咯萘啶在制备抗肿瘤药物和逆转肿瘤多药耐药性的药物中的应用
US20120172292A1 (en) 2009-09-10 2012-07-05 New York University Method for protection of antimicrobial and anticancer drugs from inactivation by nitric oxide
CN103570711B (zh) * 2012-07-24 2016-08-03 中国科学院上海药物研究所 一种咯萘啶类化合物及其用途
US20200215074A1 (en) 2017-06-22 2020-07-09 Cipla Limited Method of Treatment of Cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002013826A1 (en) * 2000-08-02 2002-02-21 Keum Ki Chang Anti-cancer composition composed of anti-cancer and anti-malarial drugs
US20110300137A1 (en) * 2010-06-03 2011-12-08 Mckenzie Douglas Tyler Use of lumefantrine and related compounds in the treatment of cancer
WO2016196614A1 (en) * 2015-06-01 2016-12-08 University Of Kentucky Research Foundation Chloroquine induction of par-4 and treatment of cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KRITSIRIWUTHINAN R et al. Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine. Malaria Journal, 2011, volume 10, article number: 242, . *
KRITSIRIWUTHINAN R et al. Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine. Malaria Journal, 2011, volume 10, article number: 242, реферат. *
QI J et al. Function and mechanism of pyronaridine: a new inhibitor of P- glycoprotein-mediated multidrug resistance. Acta Pharmacol Sin, 2002, 23(6), p.544-50. *

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US12201626B2 (en) 2025-01-21
CN112672741A (zh) 2021-04-16
US20250073225A1 (en) 2025-03-06
GB2587172A (en) 2021-03-17
WO2019244050A1 (en) 2019-12-26
MX2020014096A (es) 2021-03-09
US20210361643A1 (en) 2021-11-25
CL2020003306A1 (es) 2021-05-07
SG11202011503YA (en) 2020-12-30
JP7510411B2 (ja) 2024-07-03
IL279609B2 (en) 2025-02-01
MY206540A (en) 2024-12-20
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EP3793544B1 (en) 2023-09-20
IL279609A (en) 2021-03-01
BR112020025946A2 (pt) 2021-03-23
CA3102051A1 (en) 2019-12-26
JP2021528496A (ja) 2021-10-21
EP3793544A4 (en) 2021-08-18
EP3793544C0 (en) 2023-09-20
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PH12020552171A1 (en) 2021-06-07
GB2587172B (en) 2021-09-22
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AU2019291491B2 (en) 2020-05-21
AU2019291491A1 (en) 2020-03-05

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