RU2761457C2 - N1-(4-(5-(циклопропилметил)-1-метил-1h-пиразол-4-ил)пиридин-2-ил)циклогексан-1,4-диаминовые производные и родственные соединения в качестве ингибиторов сk1 и/или irak1 для лечения рака - Google Patents
N1-(4-(5-(циклопропилметил)-1-метил-1h-пиразол-4-ил)пиридин-2-ил)циклогексан-1,4-диаминовые производные и родственные соединения в качестве ингибиторов сk1 и/или irak1 для лечения рака Download PDFInfo
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- RU2761457C2 RU2761457C2 RU2019127038A RU2019127038A RU2761457C2 RU 2761457 C2 RU2761457 C2 RU 2761457C2 RU 2019127038 A RU2019127038 A RU 2019127038A RU 2019127038 A RU2019127038 A RU 2019127038A RU 2761457 C2 RU2761457 C2 RU 2761457C2
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762453192P | 2017-02-01 | 2017-02-01 | |
| US62/453,192 | 2017-02-01 | ||
| PCT/IL2018/050100 WO2018142393A1 (en) | 2017-02-01 | 2018-01-30 | N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer |
Publications (3)
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| EP3331877B1 (en) * | 2015-08-04 | 2021-09-22 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Pyrazole pyrimidine derivative and uses thereof |
| AU2019219678A1 (en) * | 2018-02-08 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use |
| CN114127058B (zh) * | 2019-07-04 | 2024-06-25 | 深圳国顺康医药科技有限公司 | 一种杂环化合物、其药物组合物及用途 |
| KR20230069169A (ko) * | 2020-09-17 | 2023-05-18 | 얀센 파마슈티카 엔.브이. | 카제인 키나제 1 델타 조절제 |
| CA3215697A1 (en) * | 2021-04-28 | 2022-11-03 | Cornell University | Soluble adenylyl cyclase (sac) inhibitors and uses thereof |
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| EP2651405A2 (en) * | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
| RU2604062C2 (ru) * | 2010-07-13 | 2016-12-10 | Ф.Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА И ТИЕНО[3,2-b]ПИРИМИДИНА В КАЧЕСТВЕ МОДУЛЯТОРОВ IRAK-4 |
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| WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| ES2629690T3 (es) | 2011-11-04 | 2017-08-14 | Jasco Pharmaceuticals, LLC | Inhibidores de aminopirimidina quinasa |
| US9518065B2 (en) | 2013-09-27 | 2016-12-13 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| CN105849099B (zh) * | 2013-10-18 | 2020-01-17 | 达纳-法伯癌症研究所股份有限公司 | 周期蛋白依赖性激酶7(cdk7)的多环抑制剂 |
| HUE047586T2 (hu) | 2014-11-20 | 2020-04-28 | Merck Patent Gmbh | Heteroaril vegyületek mint IRAK inhibitorok és alkalmazásaik |
| CN107847480B (zh) | 2015-03-23 | 2021-06-25 | 墨尔本大学 | 呼吸性疾病的治疗 |
| EP3331877B1 (en) * | 2015-08-04 | 2021-09-22 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Pyrazole pyrimidine derivative and uses thereof |
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| EP2651405A2 (en) * | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
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| ES2902885T3 (es) | 2022-03-30 |
| MX2019009083A (es) | 2019-09-10 |
| JP2020505468A (ja) | 2020-02-20 |
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| CA3052247A1 (en) | 2018-08-09 |
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| US11072599B2 (en) | 2021-07-27 |
| RU2019127038A3 (instruction) | 2021-03-17 |
| IL268128B (en) | 2022-11-01 |
| US20220017493A1 (en) | 2022-01-20 |
| EP3577108A1 (en) | 2019-12-11 |
| TW201837027A (zh) | 2018-10-16 |
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| IL268128A (en) | 2019-09-26 |
| AU2018215809B2 (en) | 2021-12-23 |
| RU2019127038A (ru) | 2021-03-02 |
| IL268128B2 (en) | 2023-03-01 |
| JP7142646B2 (ja) | 2022-09-27 |
| ES2902885T8 (es) | 2022-04-06 |
| MX394556B (es) | 2025-03-24 |
| CN110475771A (zh) | 2019-11-19 |
| SG11201906681PA (en) | 2019-08-27 |
| US11999721B2 (en) | 2024-06-04 |
| NZ755447A (en) | 2023-05-26 |
| KR20190115017A (ko) | 2019-10-10 |
| CN110475771B (zh) | 2022-09-02 |
| US20200354340A1 (en) | 2020-11-12 |
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