ES2902885T3 - Derivados de N1-(4-(5-(ciclopropilmetil)-1-metil-1H-pirazol-4-il)piridin-2-il)ciclohexano-1,4-diamina y compuestos relacionados como inhibidores de CK1 y/o IRAK1 para el tratamiento del cáncer - Google Patents
Derivados de N1-(4-(5-(ciclopropilmetil)-1-metil-1H-pirazol-4-il)piridin-2-il)ciclohexano-1,4-diamina y compuestos relacionados como inhibidores de CK1 y/o IRAK1 para el tratamiento del cáncer Download PDFInfo
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- ES2902885T3 ES2902885T3 ES18705024T ES18705024T ES2902885T3 ES 2902885 T3 ES2902885 T3 ES 2902885T3 ES 18705024 T ES18705024 T ES 18705024T ES 18705024 T ES18705024 T ES 18705024T ES 2902885 T3 ES2902885 T3 ES 2902885T3
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Classifications
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762453192P | 2017-02-01 | 2017-02-01 | |
| PCT/IL2018/050100 WO2018142393A1 (en) | 2017-02-01 | 2018-01-30 | N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2902885T3 true ES2902885T3 (es) | 2022-03-30 |
| ES2902885T8 ES2902885T8 (es) | 2022-04-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18705024T Active ES2902885T3 (es) | 2017-02-01 | 2018-01-30 | Derivados de N1-(4-(5-(ciclopropilmetil)-1-metil-1H-pirazol-4-il)piridin-2-il)ciclohexano-1,4-diamina y compuestos relacionados como inhibidores de CK1 y/o IRAK1 para el tratamiento del cáncer |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11072599B2 (instruction) |
| EP (1) | EP3577108B1 (instruction) |
| JP (1) | JP7142646B2 (instruction) |
| KR (1) | KR20190115017A (instruction) |
| CN (1) | CN110475771B (instruction) |
| AU (1) | AU2018215809B2 (instruction) |
| CA (1) | CA3052247A1 (instruction) |
| ES (1) | ES2902885T3 (instruction) |
| IL (1) | IL268128B2 (instruction) |
| MX (1) | MX394556B (instruction) |
| NZ (1) | NZ755447A (instruction) |
| RU (1) | RU2761457C2 (instruction) |
| SG (1) | SG11201906681PA (instruction) |
| TW (1) | TW201837027A (instruction) |
| WO (1) | WO2018142393A1 (instruction) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| LT3331877T (lt) * | 2015-08-04 | 2022-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Pirazolpirimidino dariniai ir jų panaudojimas |
| US20200383984A1 (en) * | 2018-02-08 | 2020-12-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Heteroaryl compounds, pharmaceutical compositions thereof, and their therapeutic use |
| WO2021000957A1 (zh) * | 2019-07-04 | 2021-01-07 | 北京国鸿生物医药科技有限公司 | 一种杂环化合物、其药物组合物及用途 |
| CA3189703A1 (en) * | 2020-09-17 | 2022-03-24 | Terry Patrick LEBOLD | Casein kinase 1 delta modulators |
| US20240239774A1 (en) * | 2021-04-28 | 2024-07-18 | Cornell University | Soluble adenylyl cyclase (sac) inhibitors and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| JP5985473B2 (ja) | 2010-07-13 | 2016-09-06 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ＩＲＡＫ４モジュレーターとしてのピラゾロ［１，５ａ］ピリミジン及びチエノ［３，２ｂ］ピリミジン誘導体 |
| CN103298460B (zh) | 2010-12-14 | 2016-06-01 | 电泳有限公司 | 酪蛋白激酶1δ(CK1δ)抑制剂 |
| JP6215832B2 (ja) | 2011-11-04 | 2017-10-18 | ジャスコ ファーマスーティカルズ エルエルシーＪａｓｃｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， ＬＬＣ | アミノピリミジンキナーゼ阻害剤 |
| MX2016003843A (es) | 2013-09-27 | 2017-02-15 | Nimbus Iris Inc | Inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. |
| CA2927920A1 (en) * | 2013-10-18 | 2015-04-23 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7) |
| JP6787892B2 (ja) * | 2014-11-20 | 2020-11-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｉｒａｋインヒビターとしてのヘテロアリール化合物及びその使用 |
| CN113350353A (zh) * | 2015-03-23 | 2021-09-07 | 墨尔本大学 | 呼吸性疾病的治疗 |
| LT3331877T (lt) | 2015-08-04 | 2022-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Pirazolpirimidino dariniai ir jų panaudojimas |
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2018
- 2018-01-30 SG SG11201906681PA patent/SG11201906681PA/en unknown
- 2018-01-30 TW TW107103255A patent/TW201837027A/zh unknown
- 2018-01-30 RU RU2019127038A patent/RU2761457C2/ru active
- 2018-01-30 CN CN201880022829.8A patent/CN110475771B/zh not_active Expired - Fee Related
- 2018-01-30 US US16/482,199 patent/US11072599B2/en active Active
- 2018-01-30 WO PCT/IL2018/050100 patent/WO2018142393A1/en not_active Ceased
- 2018-01-30 ES ES18705024T patent/ES2902885T3/es active Active
- 2018-01-30 KR KR1020197025024A patent/KR20190115017A/ko not_active Ceased
- 2018-01-30 AU AU2018215809A patent/AU2018215809B2/en not_active Ceased
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| CN110475771A (zh) | 2019-11-19 |
| KR20190115017A (ko) | 2019-10-10 |
| IL268128A (en) | 2019-09-26 |
| WO2018142393A1 (en) | 2018-08-09 |
| SG11201906681PA (en) | 2019-08-27 |
| MX2019009083A (es) | 2019-09-10 |
| AU2018215809B2 (en) | 2021-12-23 |
| RU2019127038A (ru) | 2021-03-02 |
| JP7142646B2 (ja) | 2022-09-27 |
| US11072599B2 (en) | 2021-07-27 |
| TW201837027A (zh) | 2018-10-16 |
| NZ755447A (en) | 2023-05-26 |
| MX394556B (es) | 2025-03-24 |
| US20200354340A1 (en) | 2020-11-12 |
| AU2018215809A1 (en) | 2019-08-15 |
| CN110475771B (zh) | 2022-09-02 |
| CA3052247A1 (en) | 2018-08-09 |
| US20220017493A1 (en) | 2022-01-20 |
| IL268128B (en) | 2022-11-01 |
| US11999721B2 (en) | 2024-06-04 |
| RU2019127038A3 (instruction) | 2021-03-17 |
| RU2761457C2 (ru) | 2021-12-08 |
| EP3577108A1 (en) | 2019-12-11 |
| EP3577108B1 (en) | 2021-10-20 |
| ES2902885T8 (es) | 2022-04-06 |
| JP2020505468A (ja) | 2020-02-20 |
| IL268128B2 (en) | 2023-03-01 |
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