RU2761249C2 - Человеческие генетические маркеры, ассоциированные с ответом на средства для лечения, которые целенаправленно воздействуют на токсин b clostridium difficile - Google Patents
Человеческие генетические маркеры, ассоциированные с ответом на средства для лечения, которые целенаправленно воздействуют на токсин b clostridium difficile Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1282—Clostridium (G)
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/109900 | 2016-12-14 | ||
| PCT/CN2016/109900 WO2018107388A1 (en) | 2016-12-14 | 2016-12-14 | Human genetic markers associated with response to treatments that target clostridium difficile toxin b |
| US201762508066P | 2017-05-18 | 2017-05-18 | |
| US62/508,066 | 2017-05-18 | ||
| PCT/US2017/064985 WO2018111662A1 (en) | 2016-12-14 | 2017-12-07 | Human genetic markers associated with response to treatments that target clostridium difficile toxin b |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019122099A RU2019122099A (ru) | 2021-01-15 |
| RU2019122099A3 RU2019122099A3 (https=) | 2021-04-16 |
| RU2761249C2 true RU2761249C2 (ru) | 2021-12-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019122099A RU2761249C2 (ru) | 2016-12-14 | 2017-12-07 | Человеческие генетические маркеры, ассоциированные с ответом на средства для лечения, которые целенаправленно воздействуют на токсин b clostridium difficile |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12071666B2 (https=) |
| EP (1) | EP3555303B1 (https=) |
| JP (3) | JP2020502179A (https=) |
| CN (1) | CN110088300A (https=) |
| AU (1) | AU2017375590A1 (https=) |
| BR (1) | BR112019012203A2 (https=) |
| MX (1) | MX2019007012A (https=) |
| RU (1) | RU2761249C2 (https=) |
| WO (1) | WO2018111662A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12071666B2 (en) * | 2016-12-14 | 2024-08-27 | Merck Sharp & Dohme Llc | Human genetic markers associated with response to treatments that target clostridium difficile toxin B |
| CN112481395B (zh) * | 2019-09-12 | 2024-10-18 | 深圳华大生命科学研究院 | 艰难梭菌耐药/低敏感进化分支snp标记及菌株类别鉴定方法和应用 |
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| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| CA2044591C (en) | 1989-02-13 | 2002-08-13 | James Langham Dale | Detection of a nucleic acid sequence or a change therein |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| ATE198358T1 (de) | 1992-04-27 | 2001-01-15 | Dartmouth College | Detektion von gensequenzen in biologischen flüssigkeiten |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| IL108159A (en) | 1993-12-23 | 1998-02-08 | Orgenics Ltd | Apparatus for separation, concentration and detection of target molecules in liquid sample |
| EP0754240B1 (en) | 1994-02-07 | 2003-08-20 | Beckman Coulter, Inc. | Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis |
| US6300063B1 (en) | 1995-11-29 | 2001-10-09 | Affymetrix, Inc. | Polymorphism detection |
| AU710425B2 (en) | 1995-12-18 | 1999-09-23 | Washington University | Method for nucleic acid analysis using fluorescence resonance energy transfer |
| ES2215241T3 (es) | 1996-11-06 | 2004-10-01 | Sequenom, Inc. | Procedimiento de espectrometria de masa. |
| DE19782097T1 (de) | 1996-11-06 | 1999-10-14 | Sequenom Inc | Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger |
| JP2010522560A (ja) * | 2007-03-27 | 2010-07-08 | デューク ユニバーシティ | Hiv疾患制限に関連する遺伝的変異体 |
| US20100035265A1 (en) | 2008-07-18 | 2010-02-11 | Aris Floratos | Biomarkers for Drug-Induced Liver Injury |
| WO2010050829A1 (en) | 2008-10-31 | 2010-05-06 | Vialactia Biosciences (Nz) Limited | Marker assisted selection of a mammalian subject for desired immunoglobulin phenotype |
| PE20120056A1 (es) | 2009-02-24 | 2012-02-05 | Merck Sharp & Dohme | Derivados de indol como antagonistas del receptor crth2 |
| HUE029098T2 (en) * | 2009-08-21 | 2017-02-28 | Novartis Ag | To treat lapatinib cancer |
| SG10201701055WA (en) * | 2011-09-16 | 2017-03-30 | Ucb Pharma Sa | Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile |
| AU2012328524B2 (en) * | 2011-10-28 | 2017-05-18 | Excelse Bio, Inc. | Protein formulations containing amino acids |
| AR089797A1 (es) * | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| US10280470B2 (en) * | 2013-01-11 | 2019-05-07 | Baylor College Of Medicine | Biomarkers of recurrent Clostridium difficile infection |
| EP3004386B1 (en) * | 2013-05-29 | 2019-08-07 | Immunexpress Pty Ltd | Microbial markers and uses therefor |
| US9181632B1 (en) * | 2013-09-09 | 2015-11-10 | Merck Sharp & Dohme Corp. | C.difficile toxin B CROP domain peptides, antibodies and complexes thereof |
| CN103665141B (zh) * | 2013-12-31 | 2015-09-16 | 北京大学 | 与艰难梭菌细胞毒素b相互作用的蛋白 |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| US12071666B2 (en) * | 2016-12-14 | 2024-08-27 | Merck Sharp & Dohme Llc | Human genetic markers associated with response to treatments that target clostridium difficile toxin B |
| WO2018107388A1 (en) | 2016-12-14 | 2018-06-21 | Merck Sharp & Dohme Corp. | Human genetic markers associated with response to treatments that target clostridium difficile toxin b |
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2017
- 2017-12-07 US US16/468,982 patent/US12071666B2/en active Active
- 2017-12-07 CN CN201780077861.1A patent/CN110088300A/zh active Pending
- 2017-12-07 JP JP2019532806A patent/JP2020502179A/ja active Pending
- 2017-12-07 MX MX2019007012A patent/MX2019007012A/es unknown
- 2017-12-07 RU RU2019122099A patent/RU2761249C2/ru active
- 2017-12-07 EP EP17881986.8A patent/EP3555303B1/en active Active
- 2017-12-07 BR BR112019012203-6A patent/BR112019012203A2/pt active Search and Examination
- 2017-12-07 WO PCT/US2017/064985 patent/WO2018111662A1/en not_active Ceased
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2022
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2025
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Non-Patent Citations (5)
| Title |
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| Deepika V. L. et al., Implications from predictions of HLA-DRB1 binding peptides in the membrane proteins of Corynebacterium diphtheriae, Bioinformation, 2008, Т. 3, No. 3, pp. 111. * |
| Deepika V. L. et al., Implications from predictions of HLA-DRB1 binding peptides in the membrane proteins of Corynebacterium diphtheriae, Bioinformation, 2008, Т. 3, No. 3, pp. 111. Schmitt-Egenolf M. et al., Oligonucleotide Typing Reveals Association of Type I Psoriasis with the HLA-DRB1* 0701/2,-DQA* 0201,-DQB1* 0303 Extended Haplotype, Journal of investigative dermatology, 1993, Т. 100, No. 6, pp. 749-752. Неретин В. Я. и др. HLA-DR, dq-генотипы и предрасположенность к миастении, Альманах клинической медицины 2001, номер. 4, стр. 176-178. Hernandez LD, Racine F, Xiao L, DiNunzio E, Hairston N, Sheth PR, Murgolo NJ, Therien AG. Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling. Antimicrob Agents Chemother. 2015 Feb; 59(2):1052-60. doi: 10.1128/AAC.04433-14. Epub 2014 Dec 1. PMID: 25451052; PMCID: PMC4335902. * |
| Hernandez LD, Racine F, Xiao L, DiNunzio E, Hairston N, Sheth PR, Murgolo NJ, Therien AG. Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling. Antimicrob Agents Chemother. 2015 Feb; 59(2):1052-60. doi: 10.1128/AAC.04433-14. Epub 2014 Dec 1. PMID: 25451052; PMCID: PMC4335902. * |
| Schmitt-Egenolf M. et al., Oligonucleotide Typing Reveals Association of Type I Psoriasis with the HLA-DRB1* 0701/2,-DQA* 0201,-DQB1* 0303 Extended Haplotype, Journal of investigative dermatology, 1993, Т. 100, No. 6, pp. 749-752. * |
| Неретин В. Я. и др. HLA-DR, dq-генотипы и предрасположенность к миастении, Альманах клинической медицины 2001, номер. 4, стр. 176-178. * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3555303A4 (en) | 2020-06-24 |
| AU2017375590A1 (en) | 2019-06-13 |
| CN110088300A (zh) | 2019-08-02 |
| MX2019007012A (es) | 2019-11-28 |
| RU2019122099A3 (https=) | 2021-04-16 |
| JP2025061120A (ja) | 2025-04-10 |
| RU2019122099A (ru) | 2021-01-15 |
| JP2023055222A (ja) | 2023-04-17 |
| US20200017909A1 (en) | 2020-01-16 |
| WO2018111662A1 (en) | 2018-06-21 |
| EP3555303B1 (en) | 2022-12-21 |
| US12071666B2 (en) | 2024-08-27 |
| BR112019012203A2 (pt) | 2019-11-12 |
| EP3555303A1 (en) | 2019-10-23 |
| JP2020502179A (ja) | 2020-01-23 |
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