RU2759540C1 - Preparation for treatment of bovine finger dermatitis - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: invention relates to the field of veterinary medicine, namely to a preparation for the treatment of bovine finger dermatitis containing iodophor, 80% lactic acid, glycerin, dimexide and an ointment base in the following ratios, by wt. %: 5.5% iodophor 70.0; 80%-lactic acid 5.0; glycerin 5.0; dimexide 5.0; ointment base being the rest.

EFFECT: invention provides an increase in the analgesic effect of an antiseptic ointment containing active iodine.

1 cl, 1 tbl, 1 ex

Description

The invention relates to the field of veterinary medicine, in particular to substances used for the treatment of digital dermatitis in cattle.

Digital dermatitis is one of the most important problems of modern dairy farming and animal husbandry in general, as a widespread and economically significant disease. In herds with obvious signs of limb lesions, from 20 to 35% of animals are detected, but it is also possible with a low level of preventive and therapeutic measures to damage up to 70% of the herd. The disease is accompanied by lameness, severe pain in the affected area. Even with a small lesion area, the animal is not able to stand on a diseased limb.

In recent years, iodophores have been used as an aseptic component in the composition of ointments. 66l0); The use of iodophores in veterinary surgical practice / Chuvakova E.A., Kurochkina N.G. // Youth and Science. 2019. No. 7-8. P. 24) [1, 2].

A known composition containing iodophores based on ethoxylated para-n-nonylphenol with disinfecting and detergent properties (RF patent No. 2535016) [3]. However, information on the use of this active substance in the composition of an ointment for the treatment of digital dermatitis in cattle was not found in the available literature sources.

The disadvantage of the known composition is that it does not have an analgesic effect.

The objective of the invention is to provide a preparation in the form of an ointment for effective treatment of digital dermatitis in cattle.

The technical result of the proposed invention is to increase the analgesic effect of an antiseptic ointment containing active iodine.

The task and the specified technical result are achieved due to the fact that in the known preparation for the treatment of digital dermatitis of cattle, containing iodophor, according to the invention additionally contains lactic acid, glycerin, dimexide and an ointment base in the following ratios, wt. %: iodophore (C _Io = 5.5%) - 70.0; lactic acid (80%) - 5.0; glycerin - 5.0; dimexide - 5.0; ointment base - the rest.

Iodophores are complex compounds of iodine with high molecular weight surfactants. Iodophor and compositions based on it are used as a disinfectant for the treatment of the surgical field, various medical products, etc. Active iodine, which is part of the ointment, has a bactericidal effect against gram-positive, gram-negative bacteria, pathogenic fungi, yeast, mycoplasma and others. The mechanism of the antimicrobial action of active iodine lies in the interaction of iodine with structural and functional proteins of microorganisms. The resulting iodamines lead to a change in the conformation of protein molecules with the loss of their initial physical, chemical and biological properties. Due to this, the destruction of membrane structures and blocking of biocatalytic processes in microbial cells is carried out.

Iodophores are most effective in an acidic environment (pH 2 to pH 5) (https://ru.qaz.wiki/wiki/Iodophor, https://web.archive.org/web/20140214181533/http://www.daff .gov.au / animal-plant-health / aquatic / aquavetplan / operational_procedures_manual_-

_decontamination / contents / recommendations_for_specific_disinfecting_agents / iodophors) [4], and therefore lactic acid was used to acidify the medium.

Lactic acid is an antimicrobial and antiseptic drug. It is used to disinfect the skin and cauterize wounds. It can be used for various injuries, ulcerative and fungal skin lesions.

Glycerin is a colorless liquid that has a bacteriostatic, astringent, enveloping and emollient effect. It is used in the base of ointments with other form-building substances.

Dimexide (Dimethylsulfoxide) is an anti-inflammatory drug that inactivates hydroxyl radicals, improves metabolic processes in the focus of inflammation. Provides local anesthetic and analgesic. Promotes the acceleration of healing processes (Local treatment of purulent-inflammatory diseases of soft tissues with drugs "Roncoleukin" and "Dimexid" / Kulemin M.E., Chernova A.A., Styazhkina S.N., Bayramkulov E.D., Fedorov V.G. ., Kiryanov N.A., Emelyanova AM // Academy. 2019. No. 1 (40). S. 75-76. Https://www.elibrary.ru/item.asp?id=36727593) [5].

The complex combination of the constituent substances in the composition of the developed drug provides broad antimicrobial, anti-inflammatory and wound-healing properties, as well as an analgesic effect.

A drug for the treatment of digital dermatitis in cattle is prepared in the form of an ointment by mixing the components until a homogeneous mass is obtained. The resulting ointment is a homogeneous, viscous mass of dark brown color.

An example of using the proposed tool.

A drug for the treatment of digital dermatitis in cattle in the form of an ointment is applied to the affected skin of the limb. Enough 1-2 applications. Data on the use of the drug for the treatment of digital dermatitis in cattle are presented in the table.

The selected ratio of components in the composition of the ointment provides a slow and uniform release of active iodine, while providing a prolonged antiseptic, disinfectant and analgesic effect. When using the ointment, there were no side effects or allergic reactions.

Claims (6)

A drug for the treatment of digital dermatitis in cattle, containing iodophor, 80% lactic acid, glycerin, Dimexide and an ointment base in the following ratios, wt%: 5.5% iodophore - 70.0; 80% lactic acid - 5.0; glycerin - 5.0; dimexide - 5.0; ointment base - the rest.