RU2757417C2 - Композиции для лечения патологических состояний кальцификации и способы их применения - Google Patents

Композиции для лечения патологических состояний кальцификации и способы их применения Download PDF

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RU2757417C2
RU2757417C2 RU2017144183A RU2017144183A RU2757417C2 RU 2757417 C2 RU2757417 C2 RU 2757417C2 RU 2017144183 A RU2017144183 A RU 2017144183A RU 2017144183 A RU2017144183 A RU 2017144183A RU 2757417 C2 RU2757417 C2 RU 2757417C2
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Деметриос БРАДДОК
Рональд ОЛБРАЙТ
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Йейл Юниверсити
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
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    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A—HUMAN NECESSITIES
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    • A01K2227/00—Animals characterised by species
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    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/03—Animal model, e.g. for test or diseases
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K—PEPTIDES
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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RU2017144183A 2015-05-19 2016-05-19 Композиции для лечения патологических состояний кальцификации и способы их применения RU2757417C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562163500P 2015-05-19 2015-05-19
US62/163,500 2015-05-19
PCT/US2016/033236 WO2016187408A1 (en) 2015-05-19 2016-05-19 Compositions for treating pathological calcification conditions, and methods using same

Related Child Applications (1)

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RU2021129201A Division RU2021129201A (ru) 2015-05-19 2016-05-19 Композиции для лечения патологических состояний кальцификации и способы их применения

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RU2017144183A RU2017144183A (ru) 2019-06-19
RU2017144183A3 RU2017144183A3 (enExample) 2019-11-25
RU2757417C2 true RU2757417C2 (ru) 2021-10-15

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RU2017144183A RU2757417C2 (ru) 2015-05-19 2016-05-19 Композиции для лечения патологических состояний кальцификации и способы их применения
RU2021129201A RU2021129201A (ru) 2015-05-19 2016-05-19 Композиции для лечения патологических состояний кальцификации и способы их применения

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RU2021129201A RU2021129201A (ru) 2015-05-19 2016-05-19 Композиции для лечения патологических состояний кальцификации и способы их применения

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US (10) US10064917B2 (enExample)
EP (2) EP4414028A3 (enExample)
JP (3) JP6995627B2 (enExample)
KR (2) KR20250078598A (enExample)
AU (3) AU2016264364B2 (enExample)
CA (2) CA3176123A1 (enExample)
ES (1) ES2983910T3 (enExample)
MX (2) MX391074B (enExample)
PL (1) PL3298140T3 (enExample)
RU (2) RU2757417C2 (enExample)
WO (1) WO2016187408A1 (enExample)

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TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
ES2981606T3 (es) * 2014-12-19 2024-10-09 Inozyme Pharma Inc NPP1 soluble para su uso en un método para el tratamiento del pseudoxantoma elástico
RU2757417C2 (ru) * 2015-05-19 2021-10-15 Йейл Юниверсити Композиции для лечения патологических состояний кальцификации и способы их применения
EP3377105A4 (en) 2015-11-20 2019-04-24 Yale University COMPOSITIONS FOR THE TREATMENT OF ECTOPIC CALIBRATION DISORDERS AND METHODS THEREWITH
US11364284B2 (en) 2016-06-16 2022-06-21 Inozyme Pharma, Inc. Methods of treating myointimal proliferation
WO2018027024A1 (en) 2016-08-05 2018-02-08 Yale University Compositions and methods for stroke prevention in pediatric sickle cell anemia patients
WO2018201090A1 (en) 2017-04-28 2018-11-01 Exicure, Inc. Synthesis of spherical nucleic acids using lipophilic moieties
EP3687565A1 (en) * 2017-09-27 2020-08-05 Alexion Pharmaceuticals, Inc. Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (npp1)
JP2021523139A (ja) 2018-05-08 2021-09-02 イエール ユニバーシティ 腎石症の進行を遅らせるための組成物および方法
CN112930397B (zh) * 2018-08-31 2025-05-09 耶鲁大学 Enpp1多肽及其使用方法
CN113631033B (zh) * 2019-01-18 2024-10-15 依诺兹梅制药公司 与enpp1或enpp3缺乏有关的疾病的治疗
BR112021020037A2 (pt) * 2019-04-05 2021-12-07 Univ Yale Polipeptídeos enpp1 e métodos para o uso dos mesmos
MX2022014717A (es) * 2020-05-27 2023-02-23 Inozyme Pharma Inc Composiciones y metodos para tratar la enfermedad arterial periferica.
CN116157145A (zh) 2020-06-09 2023-05-23 依诺兹梅制药公司 可溶性enpp1或enpp3蛋白及其用途
TW202229557A (zh) * 2020-10-08 2022-08-01 美商伊諾臻醫藥公司 Enpp1或enpp3之肝臟特異性生產
WO2022109344A1 (en) * 2020-11-19 2022-05-27 Inozyme Pharma, Inc. Treatment of enpp1 deficiency and abcc6 deficiency
WO2023049864A1 (en) * 2021-09-24 2023-03-30 Inozyme Pharma, Inc. Lyophilized enpp1 polypeptide formulations and uses thereof
WO2025042995A1 (en) * 2023-08-22 2025-02-27 Inozyme Pharma, Inc. Treatment of enpp1 deficiency and abcc6 deficiency in children

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WO2014126965A2 (en) * 2013-02-13 2014-08-21 Yale University Compositions and methods for treating pathological calcification and ossification
US20140377859A1 (en) * 2010-03-12 2014-12-25 Synageva Biopharma Corp. Npp1 fusion proteins
RU2013142583A (ru) * 2011-03-11 2015-04-20 Синаджива Байофарма Корп Гибридные белки npp1

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