RU2747788C2 - Комбинированная терапия ингибиторами notch и cdk4/6 для лечения рака - Google Patents
Комбинированная терапия ингибиторами notch и cdk4/6 для лечения рака Download PDFInfo
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- RU2747788C2 RU2747788C2 RU2018138627A RU2018138627A RU2747788C2 RU 2747788 C2 RU2747788 C2 RU 2747788C2 RU 2018138627 A RU2018138627 A RU 2018138627A RU 2018138627 A RU2018138627 A RU 2018138627A RU 2747788 C2 RU2747788 C2 RU 2747788C2
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| RU2747788C2 (ru) | 2016-04-12 | 2021-05-14 | Эли Лилли Энд Компани | Комбинированная терапия ингибиторами notch и cdk4/6 для лечения рака |
| EP3442528B1 (en) * | 2016-04-12 | 2021-05-26 | Eli Lilly and Company | Combination therapy with notch and pi3k/mtor inhibitors for use in treating ovarian cancer |
| JP7194022B2 (ja) | 2016-05-20 | 2022-12-21 | イーライ リリー アンド カンパニー | Ｎｏｔｃｈ阻害剤とＰＤ－１またはＰＤ－Ｌ１阻害剤との併用療法 |
| US11376259B2 (en) | 2016-10-12 | 2022-07-05 | Eli Lilly And Company | Targeted treatment of mature T-cell lymphoma |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| BR112020008812A2 (pt) | 2017-11-06 | 2020-10-27 | Juno Therapeutics Inc | combinação de terapia celular e um inibidor de gama secretase |
| IL257225A (en) * | 2018-01-29 | 2018-04-09 | Yeda Res & Dev | Treatment of sarcoma |
| BR112020022654A2 (pt) | 2018-05-06 | 2021-03-09 | Ayala Pharmaceuticals Inc. | Composições de combinação que compreendem compostos de bisfluoroalquil-1,4-benzodiazepinona e métodos de uso das mesmas |
| WO2019226667A1 (en) * | 2018-05-25 | 2019-11-28 | Nantomics, Llc | Comprehensive molecular profiling with proteomic and genomic analyses |
| CN112535686B (zh) * | 2019-09-20 | 2022-06-14 | 山东轩竹医药科技有限公司 | 激酶抑制剂的新用途 |
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| WO2010075074A1 (en) * | 2008-12-22 | 2010-07-01 | Eli Lilly And Company | Protein kinase inhibitors |
| WO2012097039A1 (en) * | 2011-01-14 | 2012-07-19 | Eli Lilly And Company | Imidazo [4, 5 -c] quinolin- 2 -one compound and its use as pi3 kinase / mtor dual inhibitor |
| WO2013016081A1 (en) * | 2011-07-27 | 2013-01-31 | Eli Lilly And Company | Notch pathway signaling inhibitor compound |
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| EP1117778A2 (en) | 1998-10-02 | 2001-07-25 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| US8633179B2 (en) | 2007-03-13 | 2014-01-21 | The Trustees Of Columbia University In The City Of New York | Synergistic interaction of NOTCH-1 inhibitors with glucocorticoids |
| EA017286B1 (ru) | 2007-08-14 | 2012-11-30 | Эли Лилли Энд Компани | Ингибиторы гамма-секретазы |
| WO2011060051A1 (en) | 2009-11-12 | 2011-05-19 | University Of Massachusetts | Methods for treating glioblastoma |
| CN102085372A (zh) | 2009-12-04 | 2011-06-08 | 中国医学科学院基础医学研究所 | Notch通路抑制剂用于治疗mTOR活化导致的肿瘤的用途 |
| WO2014193898A1 (en) | 2013-05-31 | 2014-12-04 | Merck Sharp & Dohme Corp. | Combination therapies for cancer |
| EP3035964B1 (en) | 2013-08-20 | 2020-09-23 | Merck Sharp & Dohme Corp. | Treating cancer with a combination of a pd-1 antagonist and dinaciclib |
| US10092645B2 (en) | 2014-06-17 | 2018-10-09 | Medimmune Limited | Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy |
| JP6681905B2 (ja) | 2014-09-13 | 2020-04-15 | ノバルティス アーゲー | Ａｌｋ阻害剤の併用療法 |
| US20180140602A1 (en) | 2015-04-07 | 2018-05-24 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
| TWI609687B (zh) | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
| EP3442528B1 (en) * | 2016-04-12 | 2021-05-26 | Eli Lilly and Company | Combination therapy with notch and pi3k/mtor inhibitors for use in treating ovarian cancer |
| RU2747788C2 (ru) | 2016-04-12 | 2021-05-14 | Эли Лилли Энд Компани | Комбинированная терапия ингибиторами notch и cdk4/6 для лечения рака |
| JP7194022B2 (ja) | 2016-05-20 | 2022-12-21 | イーライ リリー アンド カンパニー | Ｎｏｔｃｈ阻害剤とＰＤ－１またはＰＤ－Ｌ１阻害剤との併用療法 |
| SG10202107832UA (en) | 2016-08-31 | 2021-09-29 | Lilly Co Eli | Dosage regimen for treatment of solid tumors |
| US11376259B2 (en) | 2016-10-12 | 2022-07-05 | Eli Lilly And Company | Targeted treatment of mature T-cell lymphoma |
| EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| BR112020008812A2 (pt) | 2017-11-06 | 2020-10-27 | Juno Therapeutics Inc | combinação de terapia celular e um inibidor de gama secretase |
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| WO2010075074A1 (en) * | 2008-12-22 | 2010-07-01 | Eli Lilly And Company | Protein kinase inhibitors |
| WO2012097039A1 (en) * | 2011-01-14 | 2012-07-19 | Eli Lilly And Company | Imidazo [4, 5 -c] quinolin- 2 -one compound and its use as pi3 kinase / mtor dual inhibitor |
| WO2013016081A1 (en) * | 2011-07-27 | 2013-01-31 | Eli Lilly And Company | Notch pathway signaling inhibitor compound |
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| WO/2013/016081, 31.01.2013. WO/2010/075074, 01.07.2010. WO/2012/097039, 19.07.2012. BENDER М. et al. Novel inhibitor of Notch signaling for the treatment of cancer. // In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1131. doi:10.1158/1538-7445.AM2013-1131, реферат. * |
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| JP7288482B2 (ja) | 2023-06-07 |
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| CN109310684A (zh) | 2019-02-05 |
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| CN109310684B (zh) | 2021-11-19 |
| EP3442529B1 (en) | 2021-05-26 |
| JP2021176858A (ja) | 2021-11-11 |
| JP2019511526A (ja) | 2019-04-25 |
| US11298362B2 (en) | 2022-04-12 |
| MX380779B (es) | 2025-03-12 |
| AU2017249078A1 (en) | 2018-11-01 |
| KR102418765B1 (ko) | 2022-07-08 |
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