RU2731160C2 - Способы и композиции для усиления противовоспалительных эффектов интерлейкина 10 - Google Patents

Способы и композиции для усиления противовоспалительных эффектов интерлейкина 10 Download PDF

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RU2731160C2
RU2731160C2 RU2018140988A RU2018140988A RU2731160C2 RU 2731160 C2 RU2731160 C2 RU 2731160C2 RU 2018140988 A RU2018140988 A RU 2018140988A RU 2018140988 A RU2018140988 A RU 2018140988A RU 2731160 C2 RU2731160 C2 RU 2731160C2
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vector
peptide
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Джон ФОРСЭЙЕТ
Рэймонд ЧАВЕС
Линда УОТКИНЗ
Питер ГРЭЙС
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Ксалюд Терапьютикс, Инк.
Дзе Риджентс Оф Дзе Юниверсити Оф Колорадо, Э Боди Корпорейт
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12N2710/10011—Adenoviridae
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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RU2018140988A 2016-04-22 2017-04-21 Способы и композиции для усиления противовоспалительных эффектов интерлейкина 10 RU2731160C2 (ru)

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US201662326082P 2016-04-22 2016-04-22
US62/326,082 2016-04-22
PCT/US2017/028755 WO2017184933A1 (en) 2016-04-22 2017-04-21 Methods and compositions to enhance the anti-inflammatory effects of interleukin 10

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RU2018140988A RU2018140988A (ru) 2020-05-22
RU2018140988A3 RU2018140988A3 (enExample) 2020-05-25
RU2731160C2 true RU2731160C2 (ru) 2020-08-31

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SI3021873T1 (sl) 2013-07-18 2018-12-31 Xalud Therapeutics, Inc. Sestavek za zdravljenje vnetne sklepne bolezni
CA3087238A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
EP3803866A4 (en) 2018-05-24 2022-03-16 Nureva Inc. METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS
CN111989068B (zh) 2018-05-24 2024-10-25 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
CN112779285B (zh) * 2019-11-11 2023-01-06 百奥赛图(北京)医药科技股份有限公司 人源化il-10和il-10ra基因改造动物的构建方法和应用
EP4329734A4 (en) 2021-04-26 2025-04-02 Celanese EVA Performance Polymers LLC Implantable device for the delayed release of a macromolecular drug compound
KR102466921B1 (ko) * 2021-06-29 2022-11-14 주식회사 오에이티씨 인터루킨-4를 암호화하는 유전자를 포함하는 신경병증성 통증의 예방 또는 치료용 약학적 조성물
WO2023114958A1 (en) * 2021-12-16 2023-06-22 Xalud Therapeutics, Inc. Dosing regimen for il-10 encoding expression construct

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DE602006011311D1 (de) * 2005-05-31 2010-02-04 Univ Colorado Il-10 mutante
EP2550359B1 (en) * 2010-03-23 2017-08-09 Intrexon Corporation Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
US9315825B2 (en) * 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
WO2013103966A1 (en) * 2012-01-06 2013-07-11 The Regents Of The University Of Colorado, A Body Corporate Methods for the treatment of multiple sclerosis and other demyelinating disorders

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CREPALDI et al., Up-Regulation of IL-10R1 Expression Is Required to Render Human Neutrophils Fully Responsive to IL-10, The Journal of Immunology, 2001, v.167, p.2312 - 2322. МЯГКОВ А.В., Использование аденовирусного вектора для доставки и регулируемой экспрессии гена интерлейкина-10 in vivo, АВТОРЕФЕРАТ ДИССЕРТАЦИИ, 1998, 23с. *
SUNG IL YOON ET AL., Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling Properties, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, v.287, n.32, p.26586 - 26595. *
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TAMASSIA N. ET AL, Circulating neutrophils of septic patients constitutively express IL-10R1 and are promptly responsive to IL-10, INTERNATIONAL IMMUNOLOGY, 2008, v.20, n.4, p.535 - 541. SUNG IL YOON ET AL., Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling Properties, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, v.287, n.32, p.26586 - 26595. WALTER M.R., The Molecular Basis of IL-10 Function: from Receptor Structure to the Onset of Signaling, Curr. Top. Microbiol. Immunol., 2014, v.380, p.191-212. *
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EP3445849A4 (en) 2019-09-25
RU2018140988A (ru) 2020-05-22
JP2019518003A (ja) 2019-06-27
WO2017184933A1 (en) 2017-10-26
KR102430455B1 (ko) 2022-08-05
JP2022169585A (ja) 2022-11-09
US20240352089A1 (en) 2024-10-24
AU2017252327A1 (en) 2018-11-15
CN109477085B (zh) 2023-08-01
EP3445849B1 (en) 2024-06-05
JP7163189B2 (ja) 2022-10-31
US20190112354A1 (en) 2019-04-18
EP3445849A1 (en) 2019-02-27
KR20190021211A (ko) 2019-03-05
DK3445849T3 (da) 2024-08-05
IL262195B1 (en) 2023-05-01
CA3019846A1 (en) 2017-10-26
IL262195A (en) 2018-11-29
CN109477085A (zh) 2019-03-15
IL262195B2 (en) 2023-09-01
AU2017252327B2 (en) 2023-05-25
RU2018140988A3 (enExample) 2020-05-25

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