RU2729630C2 - Терапевтическое средство для фиброза - Google Patents
Терапевтическое средство для фиброза Download PDFInfo
- Publication number
- RU2729630C2 RU2729630C2 RU2017145271A RU2017145271A RU2729630C2 RU 2729630 C2 RU2729630 C2 RU 2729630C2 RU 2017145271 A RU2017145271 A RU 2017145271A RU 2017145271 A RU2017145271 A RU 2017145271A RU 2729630 C2 RU2729630 C2 RU 2729630C2
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- Russia
- Prior art keywords
- fibrosis
- amino
- present
- interstitial pneumonia
- acid
- Prior art date
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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| WO2007139608A1 (en) | 2006-03-14 | 2007-12-06 | Ceres, Inc. | Nucleotide sequences and corresponding polypeptides conferring modulated growth rate and biomass in plants grown in saline conditions |
| US12152246B2 (en) | 2006-03-14 | 2024-11-26 | Ceres, Inc. | Nucleotide sequences and corresponding polypeptides conferring modulated growth rate and biomass in plants grown in saline conditions |
| KR102323255B1 (ko) | 2017-02-15 | 2021-11-08 | 다이호야쿠힌고교 가부시키가이샤 | 의약 조성물 |
| AU2018329881B2 (en) | 2017-09-08 | 2021-12-02 | Taiho Pharmaceutical Co., Ltd. | Antitumor agent and antitumor effect potentiator |
| EP3854395A4 (en) | 2018-09-18 | 2022-06-15 | Taiho Pharmaceutical Co., Ltd. | POLYTHERAPY COMBINING AN ACYLTHIOUREA COMPOUND AND ABIRATERONE |
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| CN115177636A (zh) * | 2022-07-18 | 2022-10-14 | 陕西科美致尚生物科技有限公司 | 一种用于治疗前列腺钙化的组合物及其制备方法与应用 |
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| RU2494470C1 (ru) * | 2012-04-04 | 2013-09-27 | Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "Саентифик Фьючер Менеджмент") | Способ лечения фиброза легких |
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| EP1896461A2 (en) | 2005-06-30 | 2008-03-12 | Amgen Inc. | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer |
| KR20080080584A (ko) | 2005-11-30 | 2008-09-04 | 버텍스 파마슈티칼스 인코포레이티드 | c-Met의 억제제 및 이의 용도 |
| ZA200804681B (en) * | 2005-11-30 | 2009-11-25 | Vertex Pharma Inc | Inhibitors of C-Met and uses thereof |
| EP2114898A2 (en) | 2007-02-16 | 2009-11-11 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors |
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| ES2608329T3 (es) | 2010-02-03 | 2017-04-07 | Incyte Holdings Corporation | Imidazo[1,2-b][1,2,4]triazinas como inhibidores de c-Met |
| JP5960688B2 (ja) | 2010-05-17 | 2016-08-02 | インコゼン セラピューティクス プライベート リミテッド | プロテインキナーゼ調節物質としての新規3,5−二置換−3h−[1,2,3]トリアゾロ[4,5−b]ピリジン化合物 |
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| US9149471B2 (en) | 2013-09-30 | 2015-10-06 | National University Corporation Tokyo University Of Agriculture And Technology | Therapeutic agent for osteoporosis |
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2023
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1466624A1 (en) * | 2001-12-13 | 2004-10-13 | Japan Tobacco, Inc. | Drug for regenerating tissue and vessel and method therefor |
| WO2009125597A1 (ja) * | 2008-04-10 | 2009-10-15 | 大鵬薬品工業株式会社 | アシルチオウレア化合物又はその塩、及びその用途 |
| RU2494470C1 (ru) * | 2012-04-04 | 2013-09-27 | Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "Саентифик Фьючер Менеджмент") | Способ лечения фиброза легких |
Non-Patent Citations (1)
| Title |
|---|
| ZHAO L.U. et al. Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer // CANCER SCIENCE. - 2013. - Vol. 104, No. 12. - P. 1640-1646. * |
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