RU2728867C2 - Способ совместного кондиционирования и хемоселекции за один цикл - Google Patents

Способ совместного кондиционирования и хемоселекции за один цикл Download PDF

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RU2728867C2
RU2728867C2 RU2017104621A RU2017104621A RU2728867C2 RU 2728867 C2 RU2728867 C2 RU 2728867C2 RU 2017104621 A RU2017104621 A RU 2017104621A RU 2017104621 A RU2017104621 A RU 2017104621A RU 2728867 C2 RU2728867 C2 RU 2728867C2
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hprt
subject
deficient
transplantation
cells
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RU2017104621A
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Russian (ru)
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RU2017104621A (ru
RU2017104621A3 (https=
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Нориюки КАСАХАРА
Роберт Х. ШИСТЛ
Катрин ХАКЕ
Акош ШАКМАРИ
Гай М. КРУКС
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Де Реджентс Оф Де Юниверсити Оф Калифорния
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017104621A 2011-04-20 2012-04-20 Способ совместного кондиционирования и хемоселекции за один цикл RU2728867C2 (ru)

Applications Claiming Priority (2)

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US201161477440P 2011-04-20 2011-04-20
US61/477,440 2011-04-20

Related Parent Applications (1)

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RU2013151632A Division RU2611396C2 (ru) 2011-04-20 2012-04-20 Способ совместного кондиционирования и хемоселекции за один цикл

Publications (3)

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RU2017104621A RU2017104621A (ru) 2018-08-15
RU2017104621A3 RU2017104621A3 (https=) 2020-06-04
RU2728867C2 true RU2728867C2 (ru) 2020-07-31

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RU2017104621A RU2728867C2 (ru) 2011-04-20 2012-04-20 Способ совместного кондиционирования и хемоселекции за один цикл
RU2013151632A RU2611396C2 (ru) 2011-04-20 2012-04-20 Способ совместного кондиционирования и хемоселекции за один цикл

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US (1) US9439928B2 (https=)
EP (3) EP3384912B1 (https=)
JP (4) JP5997257B2 (https=)
AU (3) AU2012245269B2 (https=)
CA (1) CA2861440C (https=)
DK (1) DK2699247T3 (https=)
ES (1) ES2672693T3 (https=)
PL (1) PL2699247T3 (https=)
RU (2) RU2728867C2 (https=)
TR (1) TR201808037T4 (https=)
WO (1) WO2012145723A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2699247T3 (en) * 2011-04-20 2018-06-14 Univ California PROCEDURE FOR COMBINED CONDITIONING AND CHEMOS SELECTION IN A SIMPLE CYCLE
US9682106B2 (en) * 2011-04-20 2017-06-20 The Regents Of The University Of California Method for combined conditioning and chemoselection in a single cycle
US20170209447A1 (en) * 2014-08-07 2017-07-27 Nitor Therapeutics Use of PNP Inhibitor to Treat Relapse of Malignancy after Hematopoietic Stem Cell Transplant
US20180140606A1 (en) * 2016-11-18 2018-05-24 Calimmune, Inc. In Vivo Chemoselection with Low Dose Thioguanine
JP6783674B2 (ja) 2017-01-20 2020-11-11 株式会社日立ハイテク 自動分析装置、自動分析装置における廃液方法、及び、三方電磁弁
JP7410856B2 (ja) * 2017-07-18 2024-01-10 シーエスエル・ベーリング・ジーン・セラピー・インコーポレイテッド ドナー改変細胞の選択のための調節可能スイッチ
CN111164211B (zh) * 2017-07-18 2024-08-02 杰特贝林基因治疗股份有限公司 用于治疗β-血红蛋白病的组合物和方法
CN111511376B (zh) 2017-10-09 2025-02-25 斯托瓦斯医学研究所 用于扩增细胞群的方法和组合物
KR20210118833A (ko) * 2018-12-23 2021-10-01 씨에스엘 베링 엘엘씨 킬 스위치를 갖는 공여 t 세포
EP3897745A1 (en) * 2018-12-23 2021-10-27 CSL Behring LLC Haematopoietic stem cell-gene therapy for wiskott-aldrich syndrome

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030032003A1 (en) * 2000-02-02 2003-02-13 Schiestl Robert H. In vivo selection
US20030073649A1 (en) * 2001-10-12 2003-04-17 Dimartino Jorge Composition and method for treating graft-versus-host disease
RU2216336C2 (ru) * 1999-02-24 2003-11-20 Реньюрон Лимитед Трансплантация гемопоэтических клеток
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965126A (en) 1996-03-25 1999-10-12 The Penn State Research Foundation use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents
WO1997043900A1 (en) 1996-05-24 1997-11-27 The President And Fellows Of Harvard College In vivo selection
AU7605796A (en) 1996-11-04 1998-05-29 Saint Jude Children's Research Hospital (in vivo) selection of primitive hematopoietic cells
AU1585799A (en) * 1997-11-14 1999-06-07 General Hospital Corporation, The Treatment of hematologic disorders
WO2002040049A2 (en) * 2000-11-14 2002-05-23 The General Hospital Corporation Blockade of t cell migration into epithelial gvhd target tissues
DK2699247T3 (en) * 2011-04-20 2018-06-14 Univ California PROCEDURE FOR COMBINED CONDITIONING AND CHEMOS SELECTION IN A SIMPLE CYCLE

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2216336C2 (ru) * 1999-02-24 2003-11-20 Реньюрон Лимитед Трансплантация гемопоэтических клеток
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US20030032003A1 (en) * 2000-02-02 2003-02-13 Schiestl Robert H. In vivo selection
US20030073649A1 (en) * 2001-10-12 2003-04-17 Dimartino Jorge Composition and method for treating graft-versus-host disease

Also Published As

Publication number Publication date
TR201808037T4 (tr) 2018-06-21
AU2016259368B2 (en) 2017-12-14
US20140154225A1 (en) 2014-06-05
CA2861440A1 (en) 2012-10-26
US9439928B2 (en) 2016-09-13
EP3799876A1 (en) 2021-04-07
JP6266716B2 (ja) 2018-01-24
JP2017008090A (ja) 2017-01-12
CA2861440C (en) 2022-11-15
ES2672693T3 (es) 2018-06-15
JP2014512391A (ja) 2014-05-22
JP6560332B2 (ja) 2019-08-14
RU2017104621A (ru) 2018-08-15
JP6799117B2 (ja) 2020-12-09
JP2018044007A (ja) 2018-03-22
AU2012245269B2 (en) 2016-09-29
AU2012245269A1 (en) 2013-12-05
AU2018200967B2 (en) 2019-08-15
EP3384912A1 (en) 2018-10-10
RU2013151632A (ru) 2015-05-27
EP3384912B1 (en) 2020-11-11
JP2019199476A (ja) 2019-11-21
EP2699247B1 (en) 2018-03-07
HK1256048A1 (en) 2019-09-13
WO2012145723A1 (en) 2012-10-26
JP5997257B2 (ja) 2016-09-28
AU2018200967A1 (en) 2018-03-01
EP2699247A1 (en) 2014-02-26
DK2699247T3 (en) 2018-06-14
RU2017104621A3 (https=) 2020-06-04
AU2016259368A1 (en) 2016-12-08
RU2611396C2 (ru) 2017-02-21
PL2699247T3 (pl) 2018-09-28
EP2699247A4 (en) 2014-11-19

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