RU2713943C1 - Gel for children's skin - Google Patents

Abstract

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmacy, particularly to cosmetic agents, pediatric dermatology, pharmacology, and is intended for emergency prevention of skin burns of children with accidental contact with parts of stinging plants, particularly nettle. Invention consists in that the agent at temperature of +45 °C and pH 8.0–8.5 consists of water, 0.75–1 % of hydrogen peroxide, 2 % of lidocaine hydrochloride and cation-active surfactants in an amount providing gel-like consistency at temperature of +24…+26 °C.

EFFECT: protection of skin of children against itching, pain, swelling, blisters, burns, infection, local inflammation of allergic and physical-chemical nature at the point of contact with stifling plants due to local hyperthermic alkaline skin stripping and deactivation of organic acids, oxidative deactivation of histamine and other biogenic amines, inhibition of all receptors in skin in conditions excluding stab wound skin, blood vessels of skin and subcutaneous fat, external and intradermal bleeding, bruise, non-specific and allergic inflammation, anaphylactic shock and sepsis.

1 cl

Description

The invention relates to pharmacy, in particular to cosmetics, pediatric dermatology, pharmacology, and is intended for emergency prevention of skin burns of children in case of accidental contact with parts of burning plants, in particular, nettle.

Known cosmetic composition against itching and redness on the skin after insect bites for use in cosmetics, which is a mixture based on sea buckthorn oil with essential oils of fir, thyme, cedar and snakehead, with a certain ratio of these components (RU 2646789).

The disadvantage of the tool is a narrow scope, low efficiency, speed and safety, since the tool is an extract from combined vegetable raw materials in vegetable oil and has an allergenic effect. The fact is that the product is an extract of many plants in vegetable oil (most likely in olive or sunflower oil) with essential oils of fir, thyme, cedar, and snakehead. Due to the presence of plant extracts, a well-known remedy in some people causes a local allergic skin reaction, which is manifested by itching, swelling and hyperthermia. Particularly high probability of the development of this negative effect in children with problem skin and / or violation of the integrity of the skin. In particular, such a negative effect can develop in some children with diathesis, acne, with other local purulent-inflammatory foci, scratches and abrasions of the skin, as well as with some systemic diseases of connective tissue and some other skin diseases. The local inflammatory effect is not prevented by the agent itself, since it does not contain a local anesthetic, which easily penetrates the skin and blocks histamine receptors in it.

In addition, the known agent does not contain a mild surfactant (detergent) with non-specific (physicochemical) washing and dissolving activity due to moderate alkalinity and the ability to inactivate organic acids, in particular formic acid. Therefore, the tool does not provide effective washing of the skin from the remnants of the poison of burning plants, in particular nettles. On the contrary, the well-known product stains the skin and clothing of children, leaves poorly washable greasy spots on the skin of children and their clothes, because it contains vegetable oil. Therefore, the known tool does not provide express skin cleansing in places of burn plants. Moreover, a well-known tool itself pollutes these places.

In addition, the vegetable oil contained in the known product promotes the bonding of toxic residues of cauterizing plants to the skin and lengthens their presence on it, which prolongs and enhances their cauterizing effect. In addition, vegetable oils are not alkalis, therefore they do not inactivate organic acids, such as formic acid, which are part of cauterizing plant poisons.

Another disadvantage of the known tool is that it does not contain hydrogen peroxide, so the tool does not oxidize or inactivate biogenic amines, in particular histamine, which is a mediator of inflammation.

A further disadvantage of the known agent is that it does not contain a mild surfactant (detergent) with a non-specific physicochemical washing and dissolving activity, due to the ability to transform proteins and protein-lipid complexes into soluble metabolites and providing a saponifying effect on biological tissues. In this regard, the tool does not provide a high rate of deactivation of plant poisons and skin washing from poisons.

And finally, the known agent does not contain a local anesthetic with high penetrating activity. Therefore, the known agent does not discolor fast and effective surface anesthesia of the skin, the rapid elimination of itching and pain, and also does not provide a rapid inhibition of histamine receptors in the skin.

In this regard, the tool does not provide rapid elimination of itching and pain in the skin when it is burned by burning plants, especially in the presence of skin diseases and allergic predisposition of children. The product does not protect the skin of children from burns by burning plants during diathesis, skin wounds, cracks, abrasions and scratches.

Known bleaching powder for dried blood to remove dressings adhered to the wound, which is an aqueous solution containing 0.75-1% hydrogen peroxide, 1.2% sodium bicarbonate and 0.5% lidocaine hydrochloride (RU 2653465).

A disadvantage of the known agent is the narrow scope, low speed, effectiveness and safety, since the agent is not intended to protect the skin of children with burns caused by cauterizing plants, such as nettles.

In addition, the tool does not provide thermal steaming of the skin, so it does not provide removal of the upper layer of the epidermis together with the poisonous hairs and spikes stuck in it.

In addition, the known product contains low concentration of lidocaine hydrochloride, therefore, when applied to hard skin with a thick layer of the epidermis located in such parts of the body as the soles and palms, they do not provide effective analgesia and inhibition of all receptors in some children. Especially low washing efficiency of the known means in the contamination of such areas of the skin of the body of children with earth and other dirt. In addition to this, it should be added that the known product does not contain surface-active substances (surfactants), therefore it does not provide high efficiency in removing the upper layer of the epidermis with poisonous hairs and spikes stuck in it, especially when all of this is covered with dirt on top.

In addition, the well-known tool is not intended for emergency elimination of itching and pain of the skin of children with its burns by plants at the stage of self and mutual assistance in the field.

In this regard, the known tool for cutaneous use does not provide a high rate of elimination of itching, pain and inflammatory reaction in the skin when it is burned with plant poison containing biogenic amines.

Known eye drops, consisting of a colorless or slightly colored aqueous solution of 2% lidocaine hydrochloride (20 mg in 1 ml of solution) and produced in 5 ml dropper bottles (found on the Internet: http://mosglaz.ru/blog/item/ 1142-lidokain-glaznye-kapli.html. Access date 10/17/2019).

The disadvantage of this tool is the narrow scope, low speed, efficiency and safety, because the tool does not contain alkali, inactivating formic acid and other acids that are part of the poisons of cauterizing plants. In addition, the known product does not contain hydrogen peroxide and other oxidizing agents, therefore, it does not oxidize or inactivate biogenic amines, in particular histamine, which are part of poisons of burning plants. Therefore, the known tool does not provide a quick elimination of the local inflammatory reaction of the skin during burns by burning plants containing histamine, formic acid and other organic acids in the composition of the burning poison.

In addition, the known tool is not intended for treating the skin of children in the field with the aim of urgently eliminating itching and skin pain during burns by plants at the stage of self-help and mutual assistance.

In this regard, the known remedy for skin application does not eliminate itching and pain in the skin of children with its burns by plants, in particular, with nettle burns.

Known bleaching agent for injection, which is an aqueous solution for injection under the mucous membrane, under the skin or inside the skin, containing 0.25% sodium ethylenediaminetetraacetate, 0.01-0.03% hydrogen peroxide, 1.7% sodium bicarbonate and 0.125- 0.25% lidocaine hydrochloride (RU 2589682).

The disadvantage of this product is that it is not intended for the rehabilitation of skin contaminated with plant products, including poisonous spines and hairs. The product is not intended for steaming the skin, therefore it does not provide removal of the upper layer of the epidermis together with the hairs and thorns stuck in it.

A disadvantage of the known agent is the narrow scope, low speed, effectiveness and safety, since the agent contains low concentrations of hydrogen peroxide and lidocaine hydrochloride, therefore, the known agent for external use does not provide effective disinfection, anesthesia and inhibition of all receptors in the contaminated skin of children at the stage of - and mutual assistance in the field.

In addition, the known tool contains hydrogen peroxide in a very low concentration, so the tool does not provide fast and effective oxidative deactivation of histamine and other biogenic amines that are part of the poisons of burning plants.

In addition, the well-known tool is not intended for emergency elimination of itching and pain of the skin of children with its burns by plants at the stage itself? and mutual assistance in the field.

In this regard, the known tool for cutaneous use does not provide a high rate of elimination of itching, pain and inflammatory reaction in the skin when it is burned with plant poison containing biogenic amines.

Known means for thinning thick and sticky pus, which is an aqueous solution of 2.7 ± 3.3% hydrogen peroxide and 5-10% sodium bicarbonate (RU 2360685).

A disadvantage of the known tool is a narrow scope, low speed, efficiency and safety, since the tool does not provide skin application. The product does not provide thermal steaming, loosening and removal of the epidermis together with the spines of plants stuck in it.

In addition, the well-known tool is not intended for emergency elimination of itching and skin pain during burns by plants at the stage of self and mutual assistance in the field.

In this regard, the known remedy for skin application does not provide a high rate of elimination of itching, pain and inflammatory; reactions in the skin during burns with cauterizing herbal products.

Alkaline cosmetics with a pH of 8.0 are known [1].

Known alkaline cosmetics with a pH of 8.0-8.5, used to neutralize the acidity of the skin during psoriasis (Found on the Internet: https://www.wonderzine.com/wonderzine/beauty/otherbeauty/228560-what-is-ph. Date of treatment 22.10. 2019).

A disadvantage of the known alkaline cosmetics is the narrow scope, low speed, effectiveness and safety, since the products are not intended for the emergency elimination of itching and skin pain during burns by plants at the stage of self and mutual assistance in the field, as they do not contain hydrogen peroxide and lidocaine hydrochloride. In addition, the known means for external use do not provide high speed and effectiveness of anesthesia and inhibition of all receptors in the skin, and also do not provide thermal, steaming of the skin, therefore they do not provide removal of the upper layer of the epidermis with hairs and spines of cauterized plants stuck in it.

In this regard, the known means for skin application do not provide a high rate of elimination of itching, pain and inflammatory reaction in the skin during its burns by cauterizing means of plant origin.

The objective of the invention is to increase the efficiency, speed, safety and expand the scope of application due to the means containing hydrogen peroxide, lidocaine hydrochloride and cationic surfactants with a gel-like consistency at room temperature that provides at + 45 ° С disinfection and steaming of the skin, removing poisonous spikes stuck in it and hairs, alkaline deactivation of organic acids, oxidative deactivation of biogenic amines, inhibition of all receptors in the skin and elimination of local ospaleniya allergic and physico-chemical nature.

The technical result is to protect the skin from itching, pain, swelling, blisters, burns, suppuration at the site of contact with burning plants due to local hyperthermic and alkaline steaming of the epidermis, loosening it and removing the epidermis along with spikes and hairs of burning plants stuck in it during infiltration and cold boiling due to thermal alkaline deactivation of organic acids, oxidative deactivation of histamine and other biogenic amines, which are components of plant poisons, and for due to inhibition of all receptors in the skin under conditions excluding artificial injury to the skin, blood vessels, local bleeding, allergic inflammation, anaphylactic shock and sepsis. '

The goal is achieved by means of water, a local anesthetic that quickly diffuses into the skin and eliminates itching, pain and all kinds of sensitivities, hydrogen peroxide, which releases oxygen gas as a result of the catalase reaction, deactivates inflammatory mediators, deodorizes, disinfects and loosens the epidermis and releasing spines of a burning plant stuck in it due to cold boiling, and surfactants; washing the surface of the skin from loosened epidermis with stuck thorns.

The essence of the proposed gel for the skin of children, designed to protect the skin from burns by cauterizing plants, is characterized in that it at a temperature of + 45 ° C and pH 8.0-8.5 includes hydrogen peroxide, lidocaine hydrochloride and cationic surfactants in the following ratio of these components, mass. %:

Hydrogen Peroxide - 0.75-1.0

Lidocaine hydrochloride - 2.0

Cationic surfactants - in an amount that provides a gel-like consistency at a temperature of +24 - + 26 ° С

Water - the rest

The claimed tool has an optimal antiseptic, deodorizing, analgesic, antiallergic,

anti-inflammatory and detergent activity. The fact is that an alkaline gel heated to + 45 ° C, containing 0.75-1.0% hydrogen peroxide, 2% lidocaine hydrochloride and cationic surfactants, is contained in an amount that provides a gel-like consistency at room temperature (at a temperature of +24 - + 26 ° С ), has isotonic, wetting, colloidal, emollient, penetrating, macerating and foaming activity, which provides it with skin application in conditions of local hyperthermia, rapid wetting, soaking, steaming, softening and loosening of the epidermis and release ix stuck it rough from the burning plant. Moreover, the claimed gel causes alkaline saponification and oxygen “micro-explosion” (due to cold boiling due to the conversion of hydrogen peroxide by the action of the catalase enzyme into gas, oxygen and water) of protein and protein-lipid complexes located on the skin surface and represented by a thin layer of a mixture of such biomaterials like epidermal cells, sweat, pus, living and dead blood cells and microorganisms.

In addition, the claimed gel dilutes the surface layers of the skin and reduces the friction between the poisonous hairs and thorns that have sunk into the skin, on the one hand, and the skin itself, surrounding them on the outside and squeezing them, on the other hand. At the same time, thermal steaming of the skin softens it, so it squeezes the hairs and spines that have stuck into it with less force. Subsequent rubbing of the skin contributes to the easy removal of the thorns outward along with the epidermis.

The claimed tool contains 0.75-1% hydrogen peroxide, which at pH 8.0-8.5 and a temperature of + 45 ° C provides high speed and efficiency of loosening of thick and dry biological tissues, including such tissues as sweat, pus and blood, due to saponification , destructive, flotation and suspension action. Alkaline properties due to cationic surfactants provide chemical saponification of the biological mass at the interface between the media and safe diffusion penetration of the liquid gel into the skin without damaging it. The presence of hydrogen peroxide provides interstitial release of molecular oxygen, the formation of gas bubbles in the thickness of the liquefied biological mass, which loosens from this, and then the gas bubbles adhere diluted and crushed particles of blood, pus, groups of glued cells of the epidermis and tear them off due to adhesion from the layer live skin.

Moreover, the indicated range of concentrations of hydrogen peroxide is optimal for effective and safe disinfection, deodorization, foaming, express loosening and discoloration of thick and dry biological masses and peeling them off the skin surface, since at a concentration of less than 0.75%, the product loses its necessary activity, and at a concentration higher 1% solution acquires an excessively high foaming activity, which leads to the ejection of splashes on the sides of the skin, which stains the child’s clothes and surrounding objects Children and worsens the aesthetic result.

Such local action of the claimed agent provides high speed and efficiency of the subsequent removal of the epidermis together with the poisonous hairs and spikes stuck in it by wiping the skin, for example with a sanitary napkin. Moreover, the high speed, efficiency and safety of their removal (washing activity) is ensured by the alkaline and surface-active properties of the claimed gel, which contains cationic surfactants that acquire high fluidity and washing activity when the temperature rises above + 37 ° C. In this regard, the claimed gel at a temperature of +37 - + 45 ° C becomes liquid and more active, therefore, it is easily removed along with the steamed epidermis and spines released “from the epidermis captivity” when wiping the treated skin area with a tissue.

In addition, the claimed tool due to the presence of 2% lidocaine hydrochloride in its composition provides the gel with safety for the cells of our body, since the gel has isosmotic activity within 280 mosmol / l of water. In other words, the claimed agent is isotonic. Thanks to this, the product has high penetrating ability, easily soaks the skin with itself and quickly causes effective local anesthesia in it, quickly deprives the skin of all types of sensitivity. Anesthesia, in turn, provides not only a local analgesic effect, but also a local antihistamine effect, since it is accompanied by inhibition of histamine receptors.

It is especially important that the local anesthetic effect of 2% lidocaine hydrochloride provides the ability to eliminate other symptoms of inflammation, that is, have a local anti-inflammatory effect. Therefore, the claimed tool also has a pronounced local anti-inflammatory effect. At the same time, due to the presence of 2% lidocaine hydrochloride in its composition, it prevents the local irritating effect of itself. The fact is that in some people the claimed product can cause skin irritation due to individual hypersensitivity to its individual ingredients and / or to local heating.

The proposed composition of the ingredients and the ratio of their concentration are optimal for skin application in the form of a warm gel application, since they provide disinfection, deodorization, rapid anesthesia of the skin, rapid steaming, softening and subsequent removal of the epidermis along with the poisonous hairs and thorns inside it without injecting skin punctures, sections of blood vessels in the skin, additional bleeding, hemorrhage, and also without the formation of post-injection hematomas, bruising s, abscesses and sepsis.

The claimed tool has a high penetrating ability. Therefore, immediately after application to the skin, it immediately begins to penetrate the skin, impregnates, macerates and loosens it. In this case, a sequential diffusion of the claimed agent from the epidermis to the deeper layers of the skin occurs.

With the skin application of warm gel, a quick disinfection of the surface, steaming, soaking, loosening of the epidermis and the release of thorns from it initially occur.

High efficiency and safety of the product is due to the fact that the composition provides optimal alkaline saponification and "boiling" loosening of dense biological tissues, including sweat, pus, blood, epidermis, blood cells and microorganisms, as well as food debris and / or various plant products [2 , 3.4].

At the same time, the presence in the claimed agent of cationic surfactants in an amount that provides a gel-like consistency at a temperature of +24 - + 26 ° C creates comfortable conditions both for applying the product to the skin of children, and for the subsequent preservation of the gel on the applied bare skin surface due to its pronounced adhesive properties. The fact is that the local temperature of the gel on the exposed surface of the skin is always lower than the total temperature of the human body due to evaporation of water and sweat. In particular, it is always below + 37 ° C due to external cooling of the exposed surface of the body with air and evaporation of water. Therefore, in the absence of an external heater, the claimed agent retains a gel-like consistency on the exposed skin area.

Therefore, the proposed composition of the claimed gel for the skin of children provides the maximum possible local alkaline physico-chemical interaction of the claimed funds with the epidermis and all layers of the skin. This feature of the pharmacokinetics of the drug provides it with a pronounced penetrating, macerating, saponifying and loosening effect with cutaneous application. This creates the conditions for rapid loosening of the epidermis and the release of thorns from its captivity. The high speed and efficiency of loosening the epidermis, the release of thorns and deactivation of the poison is ensured by the presence in the claimed tool 0.75-1.0% hydrogen peroxide.

In turn, loosening of the epidermis and its detachment from the skin ensures the removal of hairs and spines together with the epidermis itself, which is achieved by optimal alkalinity and interstitial cold boiling due to the release of oxygen gas from hydrogen peroxide as a result of a catalase reaction.

The claimed means for skin application can be used to quickly prevent symptoms of skin irritation in the area of contact with a cauterizing plant, regardless of the presence of wounds, scratches, abrasions and blood stains on the surface of the skin. To protect the skin from burning plants, warm gel is applied to the skin with a thin layer, after which it can immediately be covered with a layer of wax paper or plastic wrap, and can a heating pad be applied on top of this layer? In this case, disinfection, deodorization, steaming, maceration and cleansing of the skin from dirt and “dirty” epidermis occur. Under such conditions, the epidermis swells very quickly, softens, loosens and discolors, so after 5-10 seconds the skin becomes light in color. After 20-30 seconds after the onset of local interaction under conditions of local hyperthermia, the film is removed and the skin surface in the burn area is wiped with a napkin and the remaining gel is removed along with the softened and loosened epidermis with thorns.

The composition of the product (the ingredients that make up the product) eliminates human poisoning when applied to the skin.

We have conducted a study of the scope, speed, effectiveness and safety of the claimed funds for artificial burns of nettle skin.

Before this, the claimed gel was prepared for the skin, which at a temperature of + 45 ° C and pH 8.5 contained water, 0.75% hydrogen peroxide, 2% lidocaine hydrochloride and cationic surfactants in an amount providing a gel-like consistency at a temperature of + 24 ° C.

In parallel, a comparison tool (prototype) was made. For this, a composition was introduced into a standard cream formulation. The amount of composition in the cream was 1% of the total mass. The composition was a mixture based on sea buckthorn oil with essential oils of fir, thyme, cedar and snakehead according to the invention RU 2646789. As a result, the final product turned yellow-orange and the cream acquired a more intense aroma of essential oils.

For an artificial burn, the inner surface of the skin of the hand of the author of the claimed invention was selected. For this purpose, equal segments of the green stem of the freshly picked nettle were once and densely applied to the distal and proximal parts of the forearm. In this case, the researcher immediately noted the appearance of a burning sensation in the skin in both places of contact with nettles.

1 minute after this, the declared gel heated to + 45 ° C was applied to the proximal area, which was applied with a flat elastic spatula by lubricating the skin with a continuous layer at the site of contact with nettles, after which the treated area of the skin was covered with a plastic film and a heating pad was placed on top of it with water at a temperature of + 45 ° C.

Immediately, the skin in the distal part of the forearm was smeared with cold (at a temperature of + 26 ° С) cream, in which the mixture created on the basis of sea buckthorn oil with essential oils of fir, thyme, cedar and snakehead was contained in a concentration of 1%.

In the proximal area, the heating pad and film were removed after 20 seconds. Immediately, the treated area of the skin was wiped with a dry sanitary napkin and the remaining gel was removed completely along with the exfoliated epidermis layer. Then this area was covered with the claimed gel repeatedly. At the same time, after half a minute, the feeling of pain in this area of the skin almost disappeared, and after 1 minute it disappeared completely. Further monitoring of the dynamics of the skin condition of this area lasted 60 minutes. During the observation period, no visible skin inflammation symptoms were detected.

In the distal part of the forearm, the effect of the cream with a mixture of sea buckthorn oil in combination with essential oils did not artificially stop. However, in this area, the feeling of pain persisted continuously throughout the entire period of studying the dynamics of the skin condition, namely, for 60 minutes. Moreover, in this skin area, in addition to soreness, the following symptoms of local inflammation were revealed: itching, swelling and local hyperthermia. The site of inflammation had an elongated shape about 7 mm wide and 37 mm long. Then 3 blisters appeared in this area, filled with a clear, colorless liquid.

Thus, a single application of the declared gel containing hydrogen peroxide, lidocaine hydrochloride and cationic surfactants to the skin prevents local irritation and inflammation of the skin at the point of contact with the prickly stalk of nettles and burns of nettle skin.

Therefore, the claimed agent is intended for emergency prevention and elimination of symptoms of local inflammation of the skin of children with burns by burning plants, in particular nettle, which is an agent that consists of water at a temperature of + 45 ° C and pH 8.0-8.5, 0.75-1% hydrogen peroxide, 2% lidocaine hydrochloride and cationic surfactants in an amount that provides a gel-like consistency at a temperature of 24-26 ° C, provides quick and complete prevention of symptoms of local irritation and inflammation without injuring the skin, enosnyh vessels in the skin and subcutaneous fat, without external and intradermal bleeding, bruising, inflammation and anaphylactic shock, therefore, expands the scope of application, increases the speed, efficiency and security protection of the skin from the irritating burning plants.

List of references

1. Kim E., Kim S., Nam G.W., Lee N., Moon S., Chang I. The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation. Int J Cosmet Sci. 2009 Aug; 31 (4): 263-269.

2. Urakov A., Urakova N., Reshetnikov A., Kopylov M., Chernova L. Solvents of pus-medicines with physical-chemical aggressive action. IOP Conf. Series: Journal of Physics: Conf. Series. 2017. V. 790. N 012033.

3. Urakov A.L., Urakova H.A., Urakova T.B. A new group of drugs: pus solvents. International Journal of Applied and Basic Research. 2016. No6 (5). S.881-884.

4. Urakov A., Urakova N., Reshetnikov A. Oxygen alkaline dental's cleaners from tooth plaque, food debris, stains of blood and pus: A narrative review of the history of inventions. Journal of International Society of Preventive & Community Dentistry. 2019.V. 9.N 5.P. 427-433.

Claims (6)

Gel for children's skin, designed to protect the skin from burns by cauterizing plants, is characterized by the fact that it at a temperature of + 45 ° C and a pH of 8.0-8.5 includes hydrogen peroxide, lidocaine hydrochloride and cationic surfactants with the following ratio of these components, mass. %: Hydrogen Peroxide - 0.75-1.0; Lidocaine hydrochloride - 2.0; Cationic surfactants - in an amount that provides gel-like consistency at a temperature of +24 - + 26 ° С; Water is the rest.