RU2404773C2 - Pharmaceutical composition based on acridonacetic acid and its compounds for treatment of suppurative-destructive lesions of mucous membrane and skin, general system diseases in case of immunodeficiency states - Google Patents

Pharmaceutical composition based on acridonacetic acid and its compounds for treatment of suppurative-destructive lesions of mucous membrane and skin, general system diseases in case of immunodeficiency states Download PDF

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RU2404773C2
RU2404773C2 RU2008147792/15A RU2008147792A RU2404773C2 RU 2404773 C2 RU2404773 C2 RU 2404773C2 RU 2008147792/15 A RU2008147792/15 A RU 2008147792/15A RU 2008147792 A RU2008147792 A RU 2008147792A RU 2404773 C2 RU2404773 C2 RU 2404773C2
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pharmaceutical composition
composition according
substance
gram
acid
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RU2008147792/15A
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RU2008147792A (en
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Евгений Вольфович Межбурд (RU)
Евгений Вольфович Межбурд
Нинель Ивановна Косякова (RU)
Нинель Ивановна Косякова
Аркадий Николаевич Мурашев (RU)
Аркадий Николаевич Мурашев
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Закрытое акционерное общество "Биологические исследования и системы"
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Abstract

FIELD: medicine, pharmaceutics.
SUBSTANCE: pharmaceutical composition contains acridonacetic acid or its therapeutically active compound, target additive and base, at the same time it contains at least one substance selected from the following row as additional target additive: immunomodulator, substance having antibacterial activity in respect of gram-positive and/or gram-negative bacteria, antimycotic agent, anesthetic agent, biogenic element, vitamin, preservative or their mixture at a certain ratio of components. Therapeutically active compound of acridonacetic acid - cyclopherone or cridanimod or anandin - is used. Composition is arranged in the form of suppositories or capsules for rectal and vaginal use or in the form of soft dosage form: ointment, cream, gel or in the form of fluid dosage form for topical and local administration.
EFFECT: composition of invention has immunomodulatory action, antiviral and antibacterial effect, higher therapeutical activity and preservation of therapeutical activity during long service life.
13 cl, 6 tbl, 37 ex

Description

Текст описания приведен в факсимильном виде.

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Claims (13)

1. Фармацевтическая композиция местного и наружного применения для лечения гнойно-деструктивных поражений слизистой и кожи, а также общесистемных заболеваний при иммунодефицитных состояниях, содержащая акридонуксусную кислоту или ее терапевтически активное соединение, липофильную или гидрофильную основу и при необходимости, по крайней мере, одну целевую добавку, выбранную из ряда: анальгетик, антиоксидант, вещество, обладающее антибактериальной активностью в отношении грамположительных и грамотрицательных бактерий в виде антибиотика, стимулятор репаративных процессов, консервант, стабилизатор, отличающаяся тем, что она содержит в качестве дополнительной целевой добавки, по крайней мере, одно вещество, выбранное из ряда: иммуномодулятор, вещество, обладающее антибактериальной активностью в отношении грамположительных и/или грамотрицательных бактерий, кроме антибиотика, антимикотик, анестетик, биогенный элемент, витамин или их смесь при следующем содержании компонентов, мас.%:
акридонуксусная кислота или   ее терапевтически активное соединение 0,005-25,00 иммуномодулятор 0,000005-25,0 вещество, обладающее антибактериальной   активностью в отношении грамположительных   и грамотрицательных бактерий 0,01-3,00 антимикотик 0,50-3,00 анестетик 0,50-4,00 биогенный элемент 0,000001-5,50 витамин 0,30-5,00 целевые добавки и основа остальное
1. A pharmaceutical composition for local and external use for the treatment of purulent-destructive lesions of the mucous membrane and skin, as well as systemic diseases in immunodeficiency states, containing acridone acetic acid or its therapeutically active compound, lipophilic or hydrophilic base and, if necessary, at least one target additive selected from the series: analgesic, antioxidant, a substance with antibacterial activity against gram-positive and gram-negative bacteria in the form of an antibiotic ka, stimulator of reparative processes, preservative, stabilizer, characterized in that it contains as an additional target additive at least one substance selected from the series: immunomodulator, a substance with antibacterial activity against gram-positive and / or gram-negative bacteria, except antibiotic, antimycotic, anesthetic, biogenic element, vitamin or their mixture with the following components, wt.%:
acridonoacetic acid or its therapeutically active compound 0.005-25.00 immunomodulator 0.000005-25.0 antibacterial substance activity against gram-positive and gram-negative bacteria 0.01-3.00 antimycotic 0.50-3.00 anesthetic 0.50-4.00 nutrient element 0.000001-5.50 vitamin 0.30-5.00 targeted supplements and base rest
2. Фармацевтическая композиция по п.1, отличающаяся тем, что она выполнена в виде мази, крема, геля, жидкой лекарственной формы для наружного и местного применения, суппозиториев и капсул для ректального и вагинального применения, заполненных композицией в жидкой или мазевой форме.2. The pharmaceutical composition according to claim 1, characterized in that it is made in the form of an ointment, cream, gel, liquid dosage form for external and local use, suppositories and capsules for rectal and vaginal administration, filled with the composition in liquid or ointment form. 3. Фармацевтическая композиция по п.1, отличающаяся тем, что в качестве дополнительного иммуномодулятора она содержит вещество, выбранное из ряда: тилорон, трекрезан, полиоксидоний, глутоксим, галавит, имунофан, рекомбинантный интерлейкин-1b, рекомбинантный интерлейкин-2, миелопид, лизоцим или их смесь.3. The pharmaceutical composition according to claim 1, characterized in that as an additional immunomodulator it contains a substance selected from the series: tilorone, trecrezan, polyoxidonium, glutoxim, galavit, imunofan, recombinant interleukin-1b, recombinant interleukin-2, myelopid, lysozyme or a mixture thereof. 4. Фармацевтическая композиция по п.1, отличающаяся, тем, что в качестве вещества, обладающего антибактериальной активностью в отношении грамположительных и/или грамотрицательных бактерий, она содержит вещество, выбранное из ряда: лизоамидаза, трилон Б, мираместин.4. The pharmaceutical composition according to claim 1, characterized in that as a substance having antibacterial activity against gram-positive and / or gram-negative bacteria, it contains a substance selected from the series: lysoamidase, trilon B, miramestine. 5. Фармацевтическая композиция по п.1, отличающаяся тем, что в качестве антимикотика она содержит клотримазол или циклопироксоламин.5. The pharmaceutical composition according to claim 1, characterized in that it contains clotrimazole or cyclopiroxolamine as an antimycotic. 6. Фармацевтическая композиция по п.1, отличающаяся тем, что в качестве анестетика она содержит вещество, выбранное из ряда: тримекаин, пиромекаин, лидокаин, анестезин, дибукаин.6. The pharmaceutical composition according to claim 1, characterized in that as an anesthetic it contains a substance selected from the series: trimecaine, pyromecaine, lidocaine, anestezin, dibucaine. 7. Фармацевтическая композиция по п.1, отличающаяся тем, что в качестве биогенного элемента она содержит цинк или марганец в виде физиологически приемлемых соединений или их физиологически приемлемую смесь.7. The pharmaceutical composition according to claim 1, characterized in that as a biogenic element it contains zinc or manganese in the form of physiologically acceptable compounds or their physiologically acceptable mixture. 8. Фармацевтическая композиция по п.1, отличающаяся тем, что в качестве витамина она содержит вещество, выбранное из ряда: аскорбиновая кислота, токоферола ацетат или их смесь.8. The pharmaceutical composition according to claim 1, characterized in that as a vitamin it contains a substance selected from the series: ascorbic acid, tocopherol acetate or a mixture thereof. 9. Фармацевтическая композиция по п.2, отличающаяся тем, что суппозитории выполнены двухслойными в виде стержня, окруженного оболочкой, при этом в зависимости от целевых добавок акридонуксусную кислоту или ее терапевтически активное соединение содержат или стержень, или оболочка.9. The pharmaceutical composition according to claim 2, characterized in that the suppositories are made in two layers in the form of a rod surrounded by a shell, while depending on the target additives acridonoacetic acid or its therapeutically active compound contain either a rod or a shell. 10. Фармацевтическая композиция по п.9, отличающаяся тем, что стержень и оболочка суппозитория содержат гидрофильные основы.10. The pharmaceutical composition according to claim 9, characterized in that the core and suppository shell contain hydrophilic bases. 11. Фармацевтическая композиция по п.9, отличающаяся тем, стержень и оболочка суппозитория содержат липофильные основы.11. The pharmaceutical composition according to claim 9, characterized in that the core and suppository shell contain lipophilic bases. 12. Фармацевтическая композиция по п.9, отличающаяся тем, что стержень суппозитория содержит гидрофильную основу, а оболочка - липофильную основу.12. The pharmaceutical composition according to claim 9, characterized in that the suppository rod contains a hydrophilic base, and the shell contains a lipophilic base. 13. Фармацевтическая композиция по п.9, отличающаяся тем, что стержень суппозитория содержит липофильную основу, а оболочка - гидрофильную основу. 13. The pharmaceutical composition according to claim 9, characterized in that the suppository rod contains a lipophilic base, and the shell is a hydrophilic base.
RU2008147792/15A 2008-12-04 2008-12-04 Pharmaceutical composition based on acridonacetic acid and its compounds for treatment of suppurative-destructive lesions of mucous membrane and skin, general system diseases in case of immunodeficiency states RU2404773C2 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2713943C1 (en) * 2019-10-28 2020-02-11 Александр Ливиевич Ураков Gel for children's skin
RU2714503C1 (en) * 2019-06-06 2020-02-18 Общество с ограниченной ответственностью "Современные Технологии Качества" Antiseptic composition containing potassium permanganate

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA031933B1 (en) * 2016-08-05 2019-03-29 Общество С Ограниченной Ответственностью "Научно-Производственный Центр Пробиотех" Veterinary biological preparation, method of producing the same (embodiments), and method for treatment of nodular dermatitis in bovine cattle (embodiments)
RU2704354C1 (en) * 2019-07-10 2019-10-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр реабилитации и курортологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ РК" Минздрава России) Method for preventing development of corneal opacity in case of mechanical injuries

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* Cited by examiner, † Cited by third party
Title
ИНСТРУКЦИЯ ПО МЕДИЦИНСКОМУ ПРИМЕНЕНИЮ ПРЕПАРАТА ЦИКЛОФЕРОН; Найдено 20.07.2009. Найдено из Интернет: <URL: http://www.polysan.ru/pdf/instl_liniment_cicloferon.pdF. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2714503C1 (en) * 2019-06-06 2020-02-18 Общество с ограниченной ответственностью "Современные Технологии Качества" Antiseptic composition containing potassium permanganate
RU2713943C1 (en) * 2019-10-28 2020-02-11 Александр Ливиевич Ураков Gel for children's skin

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