RU2712140C2 - Композиции для лечения фиброза и связанных с фиброзом состояний - Google Patents
Композиции для лечения фиброза и связанных с фиброзом состояний Download PDFInfo
- Publication number
- RU2712140C2 RU2712140C2 RU2017135950A RU2017135950A RU2712140C2 RU 2712140 C2 RU2712140 C2 RU 2712140C2 RU 2017135950 A RU2017135950 A RU 2017135950A RU 2017135950 A RU2017135950 A RU 2017135950A RU 2712140 C2 RU2712140 C2 RU 2712140C2
- Authority
- RU
- Russia
- Prior art keywords
- fibrosis
- compound
- heterocyclyl
- alkyl
- optionally substituted
- Prior art date
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- 206010016654 Fibrosis Diseases 0.000 title claims abstract description 44
- 230000004761 fibrosis Effects 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title description 65
- 150000001875 compounds Chemical class 0.000 claims abstract description 121
- -1 pyrrolidinylidene, dihydropyrrolyl Chemical group 0.000 claims abstract description 40
- 238000011282 treatment Methods 0.000 claims abstract description 25
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 16
- 229910052736 halogen Chemical group 0.000 claims abstract description 8
- 150000002367 halogens Chemical group 0.000 claims abstract description 8
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 7
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims abstract description 6
- 125000001041 indolyl group Chemical group 0.000 claims abstract description 6
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims abstract description 6
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims abstract description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims abstract description 3
- 125000002632 imidazolidinyl group Chemical group 0.000 claims abstract description 3
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract description 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims abstract description 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims abstract description 3
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Classifications
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/42—One oxygen atom attached in position 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015900979 | 2015-03-18 | ||
| AU2015900979A AU2015900979A0 (en) | 2015-03-18 | Compositions for the treatment of fibrosis | |
| PCT/AU2016/000095 WO2016145479A1 (en) | 2015-03-18 | 2016-03-18 | Compositions for the treatment of fibrosis and fibrosis-related conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017135950A RU2017135950A (ru) | 2019-04-18 |
| RU2017135950A3 RU2017135950A3 (enExample) | 2019-08-16 |
| RU2712140C2 true RU2712140C2 (ru) | 2020-01-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017135950A RU2712140C2 (ru) | 2015-03-18 | 2016-03-18 | Композиции для лечения фиброза и связанных с фиброзом состояний |
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| EP (1) | EP3271320B1 (enExample) |
| JP (1) | JP6734294B2 (enExample) |
| KR (1) | KR102591689B1 (enExample) |
| CN (1) | CN107531598B (enExample) |
| AU (1) | AU2016232978B2 (enExample) |
| BR (1) | BR112017019824B1 (enExample) |
| CA (1) | CA2979413C (enExample) |
| DK (1) | DK3271320T3 (enExample) |
| ES (1) | ES2766769T3 (enExample) |
| IL (1) | IL254505A0 (enExample) |
| MX (1) | MX375918B (enExample) |
| MY (1) | MY182818A (enExample) |
| NZ (1) | NZ736164A (enExample) |
| PH (1) | PH12017501694B1 (enExample) |
| RU (1) | RU2712140C2 (enExample) |
| SG (1) | SG11201707561RA (enExample) |
| WO (1) | WO2016145479A1 (enExample) |
| ZA (1) | ZA201706985B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2747801C2 (ru) * | 2016-07-28 | 2021-05-14 | Вектус Байосистемс Лимитед | Композиции для лечения легочного фиброза |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3353147B1 (en) * | 2015-09-22 | 2021-01-13 | Vectus Biosystems Limited | Synthesis of terphenyl compounds |
| CN118994235A (zh) * | 2023-05-19 | 2024-11-22 | 南京工业大学 | 一种β-三氟甲基取代α,β-不饱和磷酸酯及膦氧化合物的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110082109A1 (en) * | 2009-10-02 | 2011-04-07 | Ajinomoto Co., Inc. | Novel acyl guanidine derivatives |
| EA016352B1 (ru) * | 2006-08-11 | 2012-04-30 | Санофи-Авентис | Производные 5,6-бис-арил-2-пиридинкарбоксамида, их получение и их применение в терапии в качестве антагонистов рецепторов уротензина ii |
| RU2635564C2 (ru) * | 2013-09-17 | 2017-11-14 | Вектус Байосистемс Лимитед | Композиция для лечения гипертензии и/или фиброза |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1976548E (pt) * | 2005-12-09 | 2014-10-13 | Vectus Biosystems Ltd | Fragmentos de vip e suas composições |
| ES2694375T3 (es) | 2013-09-17 | 2018-12-20 | Vectus Biosystems Limited | Composiciones para el tratamiento de la hipertensión y/o de la fibrosis |
-
2016
- 2016-03-18 RU RU2017135950A patent/RU2712140C2/ru active
- 2016-03-18 AU AU2016232978A patent/AU2016232978B2/en active Active
- 2016-03-18 CN CN201680028430.1A patent/CN107531598B/zh active Active
- 2016-03-18 MY MYPI2017001348A patent/MY182818A/en unknown
- 2016-03-18 JP JP2017548980A patent/JP6734294B2/ja active Active
- 2016-03-18 NZ NZ736164A patent/NZ736164A/en unknown
- 2016-03-18 KR KR1020177030092A patent/KR102591689B1/ko active Active
- 2016-03-18 WO PCT/AU2016/000095 patent/WO2016145479A1/en not_active Ceased
- 2016-03-18 EP EP16764055.6A patent/EP3271320B1/en active Active
- 2016-03-18 ES ES16764055T patent/ES2766769T3/es active Active
- 2016-03-18 PH PH1/2017/501694A patent/PH12017501694B1/en unknown
- 2016-03-18 MX MX2017011904A patent/MX375918B/es active IP Right Grant
- 2016-03-18 SG SG11201707561RA patent/SG11201707561RA/en unknown
- 2016-03-18 US US15/557,762 patent/US10035775B2/en active Active
- 2016-03-18 BR BR112017019824-0A patent/BR112017019824B1/pt active IP Right Grant
- 2016-03-18 DK DK16764055.6T patent/DK3271320T3/da active
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2017
- 2017-09-14 IL IL254505A patent/IL254505A0/en active IP Right Grant
- 2017-10-16 ZA ZA2017/06985A patent/ZA201706985B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA016352B1 (ru) * | 2006-08-11 | 2012-04-30 | Санофи-Авентис | Производные 5,6-бис-арил-2-пиридинкарбоксамида, их получение и их применение в терапии в качестве антагонистов рецепторов уротензина ii |
| US20110082109A1 (en) * | 2009-10-02 | 2011-04-07 | Ajinomoto Co., Inc. | Novel acyl guanidine derivatives |
| RU2635564C2 (ru) * | 2013-09-17 | 2017-11-14 | Вектус Байосистемс Лимитед | Композиция для лечения гипертензии и/или фиброза |
Non-Patent Citations (3)
| Title |
|---|
| Peters, M. et al. A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 1: Synthesis of Core Fragments with Two Electronically Differentiated Leaving Groups. Chemistry A-European Journal, 2013, 19(7), 2442-2449. * |
| RU 2635564 C2, дата приоритета 17.09.2013. * |
| дата приоритета 17.09.2013. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2747801C2 (ru) * | 2016-07-28 | 2021-05-14 | Вектус Байосистемс Лимитед | Композиции для лечения легочного фиброза |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2979413C (en) | 2023-08-01 |
| MY182818A (en) | 2021-02-05 |
| ES2766769T3 (es) | 2020-06-15 |
| ZA201706985B (en) | 2019-04-24 |
| MX2017011904A (es) | 2018-11-09 |
| AU2016232978A1 (en) | 2017-10-26 |
| PH12017501694B1 (en) | 2022-06-15 |
| NZ736164A (en) | 2022-07-01 |
| KR20170129244A (ko) | 2017-11-24 |
| WO2016145479A1 (en) | 2016-09-22 |
| DK3271320T3 (da) | 2020-02-03 |
| BR112017019824A2 (pt) | 2018-05-29 |
| CN107531598B (zh) | 2020-10-16 |
| EP3271320A1 (en) | 2018-01-24 |
| US10035775B2 (en) | 2018-07-31 |
| BR112017019824B1 (pt) | 2023-02-23 |
| AU2016232978B2 (en) | 2019-05-02 |
| PH12017501694A1 (en) | 2018-03-19 |
| US20180072682A1 (en) | 2018-03-15 |
| IL254505A0 (en) | 2017-11-30 |
| RU2017135950A (ru) | 2019-04-18 |
| EP3271320B1 (en) | 2019-10-23 |
| KR102591689B1 (ko) | 2023-10-18 |
| MX375918B (es) | 2025-03-07 |
| EP3271320A4 (en) | 2018-11-14 |
| JP2018512406A (ja) | 2018-05-17 |
| CA2979413A1 (en) | 2016-09-22 |
| CN107531598A (zh) | 2018-01-02 |
| RU2017135950A3 (enExample) | 2019-08-16 |
| JP6734294B2 (ja) | 2020-08-05 |
| SG11201707561RA (en) | 2017-10-30 |
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