RU2705099C1 - Preventive-therapeutic silver-containing coating composition for agents used in oral cavity treatment - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to public health services and may be used for preventive-therapeutic treatment of oral cavity. Preventive-therapeutic coating for agents used in oral treatment contains silver ions. To obtain a coating, a composition is used which contains the following components, wt%: mineral osmous iridium in moomiyo (1:1,000), dispersed to size of not more than 0.1 mm 3÷5, copper hydrophosphate, CP 1÷3, iron phosphate (II), disubstituted, CP 1÷3, potassium phosphate, monosubstituted, CP 1÷3, 2-chloroethanesulphonic acid sodium salt, monohydrate, CP 5÷15, silver nitric acid (AgNO₃) or ammonium (NH₄Ag) 10÷20, water – balance. When making the composition, it is activated by pulsed current of ultrahigh frequencies from 30 MHz to 100 GHz for 30 minutes at temperature 40+5 °C. Forming a coating from said composition on the working surface of the agents used in treating the oral cavity, galvanically with silver anode and cathode pulse current of said parameters for 40 minutes at temperature 30±5 °C.

EFFECT: oral cavity treatment by means (toothbrush, toothpick, linen thread and tampon), having said coating, enables to provide prevention and treatment in inflammatory processes passing in oral cavity, by disinfection with saturation of humoral-fluid medium of oral cavity with components possessing bactericidal properties.

1 cl, 1 tbl, 1 ex

Description

The invention relates to healthcare and can be used in prophylactic treatment of the oral cavity.

Known antiseptic colloidal preparation of silver protargol containing 7.8 ÷ 8.3% silver, which has a pronounced antimicrobial effect by silver ions as a result of inactivation of their enzyme systems [Big Medical Encyclopedia, t. 21, p. 173].

The disadvantage of this drug is that silver ions are inactivated by active singlet oxygen, and it loses its preventive and therapeutic properties.

Known antiseptic colloid preparation collargon containing 70% silver, causing the death of microorganisms by silver ions of systems [Big Medical Encyclopedia, vol. 11, p. 140].

The disadvantage of this drug is that silver ions are to some extent inactivated by active singlet oxygen, and it loses its preventive and therapeutic properties.

The disinfectant effect of an ultrahigh-frequency pulse current (from 30 MHz to 30 GHz) is known [Big Medical Encyclopedia, vol. 7, p. 56/150] directly on the product.

The disadvantage of this action is that it is effective directly on the tool and does not have preventive and therapeutic properties.

The purpose of the invention is to increase the duration of antiseptic properties when acquiring the prophylactic and therapeutic properties of the composition.

The problem is achieved in that the composition of the drug contains the following components in wt. %:

moreover, in the manufacture of the composition it is activated by a pulsed current of ultrahigh frequencies from 30 MHz to 100 GHz for 30 min at a temperature of 40 + 5 ° C and the formation of a coating from this composition on the working surface of the means used in the treatment of the oral cavity is performed galvanically with a silver anode and cathode pulsed current of the same parameters for 40 minutes at a temperature of 30 ± 5 ° C.

Obviously, the body’s high resistance to infectious lesions is a balanced course of biochemical processes in the human body, especially for the oral cavity open to various microbes, and the specific susceptibility of the body (CBO) is a violation of the balance of biochemical processes, most often depending on the image life (food, hygiene, etc.).

SVO is manifested in the oral cavity with a decrease in the content of antiseptic agents, especially in hard-to-reach places (between the teeth), which increases the activity of bacteria, viruses and spores associated with many factors that cause various disorders.

As a suppression of this activity, the preparation of 2-chloroethanesulfonic acid sodium salt, 1 aqueous salt (IMP), h, as well as exposure to the composition by a pulsed microwave current, which ensures the transition of the singlet state of water oxygen to the triplet state, i.e. less active, which ensures a long life of ions, including silver.

Introduction to the composition:

- osmist iridium with mummy (1: 1000) less than 3% - the effectiveness of the antiseptic effect decreases, and more than 5% - the cost of the composition unreasonably increases;

- copper hydrogen phosphate; iron phosphate (II), two-substituted, two-water; potassium phosphate, monosubstituted each less than 1% - the effectiveness of the antiseptic effect is reduced, and more than 3% - the manufacturing process is complicated;

- 2-chloroethanesulfonic acid sodium salt, one-water less than 5% - the antiseptic effect is not ensured, and more than 15% - the manufacturing process is complicated;

- silver nitrate (AgNO ₃ ) or ammonia (NH ₄ Ag) less than 10% - the antiseptic effect is not ensured for a period of at least 30 days, and more than 20% - the manufacturing process is complicated;

- activation of the composition for less than 20 minutes at a temperature of less than 20 ° C does not ensure the quality of the coating, and more than 60 minutes at a temperature of more than 60 ° C are technologically and economically unreasonable;

- the use of silver anode and cathode provides: economical consumption of the composition and obtaining a better coating, due to a change in polarity during the manufacture of the composition, and applying it to the working surface of these funds.

An example of a specific application.

A composition was made containing the following components in mass%:

mineral osmisty iridium in the mummy (1: 1000), dispersed to a particle size of not more than 0.1 mm four copper hydrogen phosphate 2 iron phosphate (II), bisubstituted, hch 2 potassium phosphate, monosubstituted, hch 2 2-chloroethanesulfonic acid sodium salt, single-water, hh 10

silver nitrate (AgNO ₃ ) or ammonia (NH ₄ Ag) fifteen

water rest,

moreover, in the manufacture of the composition it was activated by a pulsed current of ultrahigh frequencies from 30 MHz to 100 GHz (the power source of which used a direct current of 0.5 A with a voltage of 12 V), for 30 minutes at a temperature of 40 + 5 ° C.

The formation of a coating from this composition on the funds used in the treatment of the oral cavity (flax filaments with a thickness of approximately 0.2 mm; toothpicks from wood - aspen; toothbrushes; swabs from gauze) was performed galvanically with a silver anode and cathode by a pulsed current of the same parameters for 40 minutes at a temperature of 30 ± 5 ° C.

Studies have shown that in an area not less than 3 mm from the surface of the hair of a toothbrush, floss or toothpick, the antiseptic effect (microorganisms die) worked for 60 days at a temperature of 25 ÷ 30 ° C, relative humidity 80-90%. Further studies were discontinued.

Studies have confirmed that the composition has antiseptic properties, manifested for at least 60 days.

This composition was used with the laying of tampons impregnated with it for periodontal disease and the presence of inflammation of the gums and even periosteum (see table) for 30 days. All patients recovered.

The proposed solution allows for the prevention and treatment of inflammatory processes in the oral cavity. This is ensured by disinfection during saturation of the humoral-liquid environment of the oral cavity with the components of the composition, which strengthens the periodontium and provides hygienic care.

Claims (3)

Preventive and therapeutic coating for the means used in the treatment of the oral cavity, including silver ions, characterized in that for its preparation using a composition comprising the following components, wt. %: mineral osmisty iridium in the mummy (1: 1000), dispersed to fineness not more than 0.1 mm 3 ÷ 5 copper hydrogen phosphate 1 ÷ 3 iron phosphate (II), bisubstituted, hch 1 ÷ 3 potassium phosphate, monosubstituted, hch 1 ÷ 3 2-chloroethanesulfonic acid sodium salt, one-water, hch   5 ÷ 15 silver nitrate (AgNO ₃ ) or ammonia (NH ₄ Ag) 10 ÷ 20 water rest moreover, in the manufacture of the composition it is activated by a pulsed current of ultrahigh frequencies from 30 MHz to 100 GHz for 30 min at a temperature of 40 + 5 ° C and the formation of a coating from this composition on the working surface of the means used in the treatment of the oral cavity is performed galvanically with a silver anode and cathode pulsed current of the same parameters for 40 minutes at a temperature of 30 ± 5 ° C.