RU2704271C1 - Agent for treating chicken diseased with mallophagosis - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: invention refers to veterinary medicine, particularly to an agent for treating chicken diseased with mallophagosis. Agent contains potassium polysulphide, citric acid and distilled water. All components are taken at specified ratio.

EFFECT: use of the invention enables effective treatment of chicken mallophagosis.

1 cl, 2 dwg, 7 ex

Description

The invention relates to the field of veterinary medicine, in particular, to an agent for treating chickens with malophagosis and can be used in agriculture for treating poultry with parasitic diseases.

State of the art

A known drug according to the method of treatment of parasitic diseases of agricultural and carnivorous animals, including oral administration of the drug from the group of avermectins, while the animals are given orally with water for drinking a 4% solution of ivermectin on polyethylene glycol 400 at a dose of 0.01-0.03 ml per kg masses, individually or in a group way, while preparing the prepared treatment solution for arachnoentomiasis - twice with an interval of 14 days. If necessary, carnivores additionally carry out non-specific and immunocorrection therapy (see Pat. RU 2568906, IPC A61K 31/35, A61P 33/00, published on 11/20/2015).

The disadvantages of this drug is that slaughter for poultry meat is allowed no earlier than after 9 days. Also, this drug is not allowed to be used for laying hens and repairing young chickens less than 14 days before egg laying, due to the accumulation of ivermectin in the eggs.

A known composition for the treatment of parasitic diseases in farm animals and birds, carnivores, including oral administration of a drug from the group of avermectins - aversectin C, polyethylene oxide, perlite filtered powder, (see Instructions for use of the Department for the treatment and prevention of nematodoses and arachnoentomoses of farm animals, including birds, fur animals and rabbits, approved 04.24.2012).

The disadvantages of this composition is that slaughter for poultry is allowed no earlier than 5 days later. Also, this composition is not allowed to be used by laying hens.

The closest in technical essence and the achieved positive effect and adopted by the authors for the prototype is an anti-pediculosis treatment for pediculosis, consisting of permethrin, citric acid, ethyl alcohol 95% and perfume (see US Pat. RU 2077315, IPC A61K 7/40, A01N 25 / 3, published on 04/20/1997).

The disadvantages of this tool is that the presence of permethrin in the composition limits its use for laying hens, so it will stand out with the egg within 6 days after processing.

Disclosure of invention

The objective of the invention is to develop a tool for the treatment of chickens with malophagosis, with high treatment efficiency, environmental safety and obtaining products of high sanitary quality.

The technical result that can be achieved using the proposed invention is to increase the effectiveness of treatment and improve environmental safety and product quality.

The technical result is achieved using the means for treating chickens with malophagosis, including citric acid and distilled water, while it additionally contains potassium polysulfide, with the following ratio of components in wt. %:

potassium polysulfide - 1.0

citric acid - 12.8

distilled water - the rest

Thus, malophagosis is a parasitic disease caused by insects. Around 4,000 species of down-eaters are known in the world; most of them are bird parasites. Mallofagosis is widespread, both in industrial type poultry farms, and in poultry farming in private households. The most harmful are: the downy-eaters Menopon gallinae and Eomenacanthus stramineus of the Menoponidae family and Goniocotes gallinae of the Philopteridae family. These insects are distributed almost everywhere, and from them annually farms suffer enormous economic damage, while the skin and feather are disturbed in the bird; resistance decreases, weight gain, egg production decreases by 3-8%. Around 4,000 species of down-eaters are known in the world; most of them are bird parasites. Mallofagosis is widespread, both in industrial type poultry farms, and in poultry farming in private households. The most harmful are: the downy-eaters Menopon gallinae and Eomenacanthus stramineus of the Menoponidae family and Goniocotes gallinae of the Philopteridae family.

Since poohoedov eat fluff, feather, skin flakes, in the treatment of this disease it is necessary to use cutaneous applications, and not injectable systemic drugs.

Ectoparasites are pathogens that quickly develop resistance to insecticides and therefore many insecticides can act on them only in high doses. This creates a risk of poisoning the bird. When using modern insecticides, restrictions on the use of products are imposed, while to eliminate the above listed disadvantages, a means is proposed for treating poultry with patients with malophagosis, which includes:

- citric acid, the chemical formula is C ₆ H ₈ O ₇ , which is a white crystalline substance, soluble in ethyl alcohol and water, which is found in Chinese magnolia vine, lemon, citrus fruits, berries, needles, and it is produced on an industrial scale by synthesis mold fungus strains and sugar or sugar substances and which has antitumor and antibacterial agents (see Citric acid - characteristics, composition, application, https: // products. propto / ru / article / limonnaya - kislota 01/06/2019);

- potassium polysulfide are solid crystals of yellow to yellow-orange color with the formula K ₂ S _n , where n = 2-6 is highly soluble in water, higher polysulfides are dissolved in ethanol.

Chemical properties of potassium polysulfide: - decompose with the release of sulfur with the release of sulfur; - aqueous solutions have an alkaline reaction due to anion hydrolysis; - at room temperature decompose with dilute acids with the release of sulfur; - at low temperature and concentrated acid, polysulfanes can be obtained; - in a humid environment and in the light, potassium polysulfides are oxidized by atmospheric oxygen; - without water, the oxidation reaction is different. Potassium polysulfide in one of the applications is used for the treatment of skin diseases “Sulfuric liver” (see Chemical Encyclopedia / Editorial: Knunyants I.L. et al. - M .: Soviet Encyclopedia, 1990, - T.2 - 671 pp. - ISBN5-82270-035-5).

The essence of the implementation of obtaining funds for the treatment of poultry patients with malophagosis, is as follows.

The remedy for treating chickens with malofagosis patients includes citric acid and distilled water, while it additionally contains potassium polysulfide, in the following ratio of components in wt. %:

potassium polysulfide - 1.0

citric acid - 12.8

distilled water - the rest.

Treatment with the proposed tool consists in bathing a bird suffering from malophagosis in a warm (38 ° C) solution of 1.0% potassium polysulfide combined with a 0.1N citric acid solution in a 1: 1 ratio to form sulfur particles and release hydrogen sulfide. The resulting tool is prepared by extempore. Patients with malophagosis are bathed twice with an interval of 25 days. The tool is highly effective against pathogens of mallophagosis and does not have side effects on the body of poultry.

Brief description of drawings and other materials

In FIG. 1 given a tool for the treatment of chickens with mallophagosis, the results of a test of potassium polysulfide on insects of the order Mallorhaga. Table 1.

In FIG. 2, the same, the effectiveness of the treatment of chickens with malophagosis. Table 2.

The implementation of the invention

Examples of specific performance of obtaining funds for the treatment of chickens with malophagosis.

Example 1. Test means invitro on mallophages collected from chickens. For this, potassium polysulfide is used in vitro in 3 concentrations: 0.1%, 0.5%, 1%. A 0.1N citric acid solution is always used to precipitate potassium polysulfide.

The fluff-eaters are placed in a Petri dish with filter paper, on which 1.5 ml of potassium polysulfide in various concentrations are preliminarily applied: 0.1% (group 1), 0.5% (group 2), 1% (group 3), and then 1.5 ml of a 0.1N citric acid solution are poured into each Petri dish.

Only 1.5 ml of a 0.1 N citric acid solution (group 4) is poured into a control Petri dish. Analysis is carried out every 6-12 hours.

The results are presented in figure 1, table 1.

The insect effectiveness index of potassium polysulfide of the Mallophaga order was everywhere 100%.

Production tests of the claimed funds are carried out in an individual farm on chickens of the brama breed spontaneously sick with malophagosis.

Examples of specific tests of the proposed funds for the treatment of chickens with malophagosis.

Example 2. When examining 50 chickens, clinical signs were revealed: anxiety, feather loss in the back and cesspools, excoriation and redness of the skin, the presence of ectoparasites.

To establish the type of ectoparasites, the chickens were examined by the method of Fomicheva E.G., 2014: cotton wool moistened in medical ether is placed in a plastic bag, then the chicken, leaving only its head outside, is tightly closed. The feathers are tousled for 0.5 minutes, the chicken is removed, and the collected material is viewed under a microscope. In the obtained material, Menopon gallinae, Eomenacanthus stramineus and Goniocotes gallinae were found in the amount of 80-100 insects per bird.

For the treatment of chickens with patients with malophagosis in a plastic bowl, a preparation is prepared in the following ratio of components, wt. %:

potassium polysulfide - 0.3

citric acid - 7.0

distilled water - the rest

In the prepared solution bathe sick chickens. Then, mollophages were counted daily on chickens, according to the results of which it was established that the greatest effectiveness of this ratio of components is achieved by 14 days after the first treatment and is 92% (see Fig. 2, table 2).

Studies have shown that the most effective concentration of potassium polysulfide is 1%

Example 3. The number of examined chickens was 50 goals. Clinical signs, number and composition of ectoparasites were similar to example No. 1. In contrast to the first example, 0.5% potassium polysulfide solution and 0.1 N citric acid solution were taken as a treatment solution. The composition of the substance is presented:

potassium polysulfide - 0.5%

citric acid - 10.0%

distilled water - the rest

According to the results of daily calculations, it was found that the greatest efficiency of this ratio of components is achieved by 10 days after the first treatment and is 94% (see Fig. 2, table 2).

Example 4. The number of examined chickens of patients with malophagosis 50 goals. Clinical signs and the number and composition of ectoparasites were similar to example No. 1. Unlike the first example, a 1% potassium polysulfide solution and a 0.1 N citric acid solution were taken as a treatment solution. The composition is presented:

potassium polysulfide - 1.0%

citric acid - 12.8%

distilled water - the rest

According to the results of daily calculations, it was found that the greatest efficiency of this ratio of components is achieved by 5 days after the first treatment and is 100% (see Fig. 2, table 2).

Example 5. The number of examined chickens of patients with malophagosis 50 goals. Clinical signs and the number and composition of ectoparasites were similar to example No. 1. In contrast to the first example, 1.5% potassium polysulfide solution and 0.1 N citric acid solution were taken as a treatment solution. The composition is presented:

potassium polysulfide - 1.5%

citric acid - 15.0%

distilled water - the rest

According to the results of daily calculations, it was found that the greatest efficiency of this ratio of components is achieved by 5 days after the first treatment and is 100%. The effectiveness of this ratio of the components of the substance is equal to the efficiency from example 4, but this significantly increases the consumption of the used means and, accordingly, the cost.

Example 6. Squash solutions were tested for toxicity in mice. The toxicity of the drug is determined with a single cutaneous application of the solution to sexually mature, heterosexual white mice weighing 18-20 g. and on clinically healthy chickens of Brama breed aged 6-7 months.

Assessment of the toxicity of solutions of potassium polysulfide and citric acid in white mice was as follows. In the group of experimental animals there were 10 mice. Using a spray gun, a solution of potassium polysulfide and citric acid is applied to the skin of mice. The animals are treated with a tool containing 1% potassium polysulfide. After treatment, within 2 weeks of observation, the general condition of the experimental animals did not change. Not a single animal has died.

Example 7. Conduct a toxicity test of this substance on chickens. Apply bathing birds in containers with the above ratios of the funds, consisting of the ratio of components, in wt. %:

potassium polysulfide - 1.0

citric acid - 12.8

distilled water - the rest

The finished solution is heated to a temperature of 36-38 ° C. The product is tested on 10 chickens of the breed of bramah. None of the experimental birds died.

Thus, the most optimal is a tool consisting of the following components in wt. %:

potassium polysulfide - 1.0

citric acid - 12.8

distilled water - the rest,

which contributes to the release of chickens from mallophages, and as a result helps to increase the weight gain and egg production of birds.

Thus, in the course of testing the proposed tool on the poultry of patients with malophagosis, in particular, chickens, it was proved to be highly effective as a therapy, environmental safety and, as a consequence, to obtain products of high sanitary quality. Buying poultry in a 1% solution of potassium polysulfide and 0.1N citric acid solution in order to precipitate sulfur and release hydrogen sulfide can eliminate small-phagous invasion, it does not have side effects on the birds.

The invention in comparison with the prototype and other known technical solutions has the following advantages:

- high treatment efficiency;

- environmental safety of the substance;

- obtaining products of high sanitary quality.

Claims (2)

An agent for treating chickens with malofagosis, including citric acid and distilled water, characterized in that it additionally contains potassium polysulfide, in the following ratio of starting components, wt. %: potassium polysulfide  1,0 lemon acid  12.8 distilled water  rest

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