RU2670106C2 - Фармацевтическая композиция - Google Patents
Фармацевтическая композиция Download PDFInfo
- Publication number
- RU2670106C2 RU2670106C2 RU2014147674A RU2014147674A RU2670106C2 RU 2670106 C2 RU2670106 C2 RU 2670106C2 RU 2014147674 A RU2014147674 A RU 2014147674A RU 2014147674 A RU2014147674 A RU 2014147674A RU 2670106 C2 RU2670106 C2 RU 2670106C2
- Authority
- RU
- Russia
- Prior art keywords
- insulin
- combination
- subject
- compound
- glu
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title description 12
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims abstract description 303
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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| EP12166251.4 | 2012-05-01 | ||
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| EP12166251 | 2012-05-01 | ||
| EP12166252.2 | 2012-05-01 | ||
| US201261641540P | 2012-05-02 | 2012-05-02 | |
| US201261641544P | 2012-05-02 | 2012-05-02 | |
| US61/641,544 | 2012-05-02 | ||
| US61/641,540 | 2012-05-02 | ||
| PCT/EP2013/059073 WO2013164375A1 (en) | 2012-05-01 | 2013-05-01 | Pharmaceutical composition |
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| RU2014147674A RU2014147674A (ru) | 2016-06-27 |
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| EP1969004B1 (en) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| US20160296602A1 (en) * | 2013-03-20 | 2016-10-13 | Novo Nordisk A/S | Dosing Regimen |
| EP2991672A1 (en) * | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
| WO2016001185A1 (en) * | 2014-07-02 | 2016-01-07 | Novo Nordisk A/S | Dosage regimen for the treatment of diabetes |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| CN114096269B (zh) | 2019-07-12 | 2024-06-11 | 诺和诺德股份有限公司 | 高浓度胰岛素制剂 |
| WO2025104600A1 (en) * | 2023-11-15 | 2025-05-22 | Ambio, Inc. | Insulin analogs for the treatment of human metabolic disorder and disease |
Citations (3)
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|---|---|---|---|---|
| EP0925792A2 (en) * | 1997-12-23 | 1999-06-30 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
| WO2010049488A1 (en) * | 2008-10-30 | 2010-05-06 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| RU2010138656A (ru) * | 2008-02-19 | 2012-03-27 | Байокон Лимитид (IN) | Способ получения очищенного биологически активного гетерологичного белка (варианты), очищенный биологически активный гетерологичный белковый продукт и очищенный инсулин гларгин (варианты) |
Family Cites Families (14)
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| NZ222907A (en) | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
| HUT56857A (en) | 1988-12-23 | 1991-10-28 | Novo Nordisk As | Human insulin analogues |
| IL93282A (en) | 1989-02-09 | 1995-08-31 | Lilly Co Eli | Insulin analogues |
| ATE300519T1 (de) | 1989-04-19 | 2005-08-15 | Enzon Inc | Verfahren zum herstellen von modifizierten polypeptiden die eine polypeptid und ein polyalkylenoxid enthalten |
| NZ273285A (en) | 1993-09-17 | 1997-10-24 | Novo Nordisk As | Insulin derivatives and compositions thereof |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
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| AU2004261353B2 (en) | 2003-08-05 | 2009-12-10 | Novo Nordisk A/S | Novel insulin derivatives |
| EP1969004B1 (en) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| AU2007247109B2 (en) | 2006-05-09 | 2012-03-15 | Novo Nordisk A/S | Insulin derivative |
| JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー／エス | インスリン誘導体を含有する薬学的製剤 |
| KR20130139297A (ko) * | 2010-10-27 | 2013-12-20 | 노보 노르디스크 에이/에스 | 다양한 주사 간격으로 투여된 인슐린 주사를 이용한 진성 당뇨병의 치료 |
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2013
- 2013-05-01 EP EP13721650.3A patent/EP2844274B1/en active Active
- 2013-05-01 JP JP2015509430A patent/JP6262206B2/ja active Active
- 2013-05-01 MX MX2014013091A patent/MX363119B/es unknown
- 2013-05-01 US US14/398,018 patent/US9884094B2/en active Active
- 2013-05-01 WO PCT/EP2013/059073 patent/WO2013164375A1/en not_active Ceased
- 2013-05-01 AU AU2013255880A patent/AU2013255880B2/en active Active
- 2013-05-01 RU RU2014147674A patent/RU2670106C2/ru active
- 2013-05-01 BR BR112014026442A patent/BR112014026442A8/pt not_active Application Discontinuation
- 2013-05-01 CA CA 2872083 patent/CA2872083A1/en not_active Withdrawn
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| EP0925792A2 (en) * | 1997-12-23 | 1999-06-30 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
| RU2010138656A (ru) * | 2008-02-19 | 2012-03-27 | Байокон Лимитид (IN) | Способ получения очищенного биологически активного гетерологичного белка (варианты), очищенный биологически активный гетерологичный белковый продукт и очищенный инсулин гларгин (варианты) |
| WO2010049488A1 (en) * | 2008-10-30 | 2010-05-06 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2013164375A1 (en) | 2013-11-07 |
| RU2014147674A (ru) | 2016-06-27 |
| EP2844274B1 (en) | 2019-03-20 |
| US20150126439A1 (en) | 2015-05-07 |
| AU2013255880A1 (en) | 2014-10-16 |
| BR112014026442A8 (pt) | 2018-01-16 |
| MX363119B (es) | 2019-03-11 |
| JP2015517458A (ja) | 2015-06-22 |
| AU2013255880B2 (en) | 2017-07-20 |
| BR112014026442A2 (pt) | 2017-06-27 |
| US9884094B2 (en) | 2018-02-06 |
| CA2872083A1 (en) | 2013-11-07 |
| MX2014013091A (es) | 2014-12-08 |
| JP6262206B2 (ja) | 2018-01-17 |
| EP2844274A1 (en) | 2015-03-11 |
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