RU2665172C1 - Tea for adaptation of an employee having professional contact with a heating microclimate - Google Patents

Abstract

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to the pharmaceutical industry, namely tea for adapting the condition of workers having professional contact with the heating microclimate in the work area. Tea for adapting the condition of workers having professional contact with the heating microclimate in the work area include the roots of Japanese angelica tree, roots and the above-ground part of the althea officinalis, the grass of dooryard plantain, the straw of cultivated oat, roots of common licorice, the grass of garden sage, the leaves of Chinese tea-plant, taken in a certain ratio.

EFFECT: above tea is effective for adapting the condition of workers who have professional contact with the heating microclimate in the work area.

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Description

Phyto-collection for adaptation of an employee having professional contact with a heating microclimate

The invention relates to medicine, and in particular to a method of adapting a worker who has professional contact with a heating microclimate in closed production facilities (metallurgists, foundry workers, deep mine miners, glass blowers, plastic pressers, stokers, bakers), as well as working outdoors in the southern latitudes (geologists, military, sailors) [2], to the selection and creation of medicinal fees of plant origin, and can be used in herbal medicine.

No adaptation methods have been found for patented and scientific literature for working at elevated temperatures of the working zone using phytochemicals of medicinal plants.

In folk medicine, Mongolian, or Chagir tea, from dried leaves and rhizomes of thick-leaf frankincense (1:30) in Siberia is considered a thirst-quenching drink. A folk remedy to reduce perspiration is tea from sage leaves (1:30).

Those working in a heating microclimate have a tendency to impair the tone of the autonomic nervous system, disproportionately increased sweating with the loss of minerals (sodium, calcium, potassium, phosphorus), and water-soluble vitamins (C, B1); to dehydration with loss of fluid through the kidneys, skin, lungs; violation of hemostasis, decreased daily diuresis, a tendency to acidosis, early fatigue, the development of a deficiency of irreplaceable biologically active substances in the body [2].

One of the methods to prevent occupational injuries when exposed to a heating microclimate is non-invasive saturation of the body with biological complexes of biologically active substances with a proven effect - slowing down the loss of fluids, macro- and microelements, and water-soluble vitamins; leveling the acidotic shift of metabolism; hypoxia; violation of the tone of the autonomic nervous system; preventing blood clotting, as well as antipyretic.

Medicinal plants are the sources of the most important essential nutrients: vitamins, trace elements, flavonoids, dietary fiber, chlorophyll, polyphenols, alkaloids, glycosides, fatty oils, pectins, saponins, enzymes, phytoncides, organic acids and essential oils. Plants in nutritional science are classified as sources of alkalizing components [4].

Herbal remedies have a wide range of proven therapeutic effects. The search for medicinal plants containing optimal phytochemical ratios of the necessary biologically active substances was carried out according to the data of the 2016 State Pharmacopoeia of the Russian Federation and other scientific sources. All types of medicinal raw materials are allowed for use.

Prepare infusions of phyto-crops in a ratio of 1:10, the daily dose of a mixture of dry plant materials is 50 grams. Dried medicinal raw materials are poured with boiling water, tightly closed with a lid, insisted for 15 minutes, then filtered and filtered. Reception of infusion of 500 ml once a day in the morning before work with meals. Reception of a phytobox as prescribed by a doctor. The drinking regimen of the employee is not regulated. On days off from work, collection is not recommended.

The intensity of the biological effect increases with increasing exposure.

The most common technical solution is a well-known method of optimizing a variety of violations caused by contact with a heating microclimate, by special means (mineral solutions of a special composition containing potassium chloride, calcium chloride, sodium chloride, sodium bicarbonate); taking into account the "acid" appetite for reducing tissue acidosis, workers are given multivitamin drinks with the addition of organic acids (citric, ascorbic, lactic, pyruvic). Salted tea, sparkling water, vitamins, cabbage and beetroot juices, whey, dried fruit compotes, rosehip, barberry, and cranberry infusions are used. Sugar-containing drinks, coffee, beer are not recommended [2].

For this group of workers, preparations are used with a high content of phosphorus, magnesium, potassium, calcium, copper, zinc, iodine (phosphaden, riboxin, panangin, magnesium sulfate, magnesium citrate, potassium chloride, calcium chloride, calcium gluconate, calcium lactate, zinc picolinate, zinc sulfate, copper sulfate) as indicated in concomitant somatic pathology. For everyday use, iodized edible salt, sea edible salt is applicable [3].

The closest in composition to the above biological substrates for the correction of homeostasis are medicinal plants that have a soft and polyvalent effect.

Means that help adapt in contact with the heating microclimate include, first of all, medicinal plants that interfere with heat transfer, as well as plants that reduce thermogenesis and perspiration; plants containing bioactive substances with a proven remineralizing, multivitamin, antihypoxic effect.

The objective of the invention is to expand the arsenal of modern drugs, by developing phyto-collection for the adaptation of an employee who has professional contact with a heating microclimate

The invention relates to medicine, and in particular to a method of adapting a person who has professional contact with a heating microclimate in closed production rooms (metallurgists, foundry workers, deep mine miners, glass blowers, plastic pressers, stokers, bakers), as well as working outdoors in the southern latitudes (geologists, military, sailors) [2], to the selection and creation of medicinal fees of plant origin, and can be used in herbal medicine.

This is achieved by the fact that in the medicinal collection for various disorders in contact with a heating microclimate, permitted medicinal plants are selected that simultaneously correct the functions of organs and systems that are vulnerable in workers, namely: water metabolism, sweating, hemostasis, mucociliary clearance of the respiratory tract, gastric secretory function - intestinal tract, micronutrient balance, acid-base balance, as well as the tone of the autonomic nervous system; then the selected medicinal plants are combined into a phyto-collection.

No prototypes of phyto-collection were found in patent and scientific literature. We offer phyto-collection, intended for use by working in conditions of elevated temperature of the working area.

The problem is solved by applying medicinal plants with the above effect as a part of collections.

New is the use of the complex of all the following medicinal plants: high aralia, medicinal moth, flea plantain, sowing oat, licorice, Chinese tea bush, medicinal sage in a weight ratio of 0.5: 1: 1: 1: 0.5: 2: 1 .

The plants used in the collections have the following characteristics:

1. Aralia high roots (Aralia elata) contain triterpene glycosides, alkaloids, vitamins, essential oils, selenium, molybdenum, non-radioactive strontium. It is used as an antioxidant and adaptogenic agent for asthenia, early fatigue, and intensification of lipid peroxidation.

2. Althea officinalis (Althea officinalis) - the roots and the aerial part contain mucus (up to 35%), consisting of neutral polysaccharides, glucuronic and galacturonic acids, organic acids, including ascorbic acid; steroids. The plant accumulates selenium, iron, vanadium, chromium. Use as antiulcer, expectorant, antipyretic. Medicinal marshmallow is used to treat gastritis, stomach and intestinal ulcers, enteritis, colitis; with diseases of the genitourinary system: with cystitis, pyelonephritis, diseases of the ureter.

3. Plantain flea grass (Plantago psyllium) concentrates selenium, molybdenum, zinc, copper, strontium-90 non-radioactive, as well as alkaloids, mucus, bitterness. It reduces the level of tissue acidosis, improves mucociliary clearance, has an expectorant and enveloping effect. It has a choleretic effect. Increases the secretory activity of the stomach and duodenum. Use as an anti-inflammatory and expectorant for respiratory diseases.

4. Oats sowing straw (Avena sativa) contains trace elements, vitamins, flavonoids of hepatoprotective, choleretic, hypoglycemic, hypolipidemic action.

Decoctions and infusions from oat straw are used to cleanse the body, with liver diseases; as an antidiabetic, carminative and antipyretic agent, with mental exhaustion, nervous overload and physical fatigue. It removes nicotine from the body.

5. Licorice licorice (Glycyrrhiza glabra) roots contain saponin glycyrrhizin, flavonoids (about 30), coumarins, salicylates, iron, selenium, organic acids, steroids, bitterness, essential oils. The biological effect of licorice: adaptogenic, capillarotropic, antiplatelet, anti-inflammatory, anti-allergic, stimulating the adrenal cortex, detoxifying, expectorant. The expectorant properties of licorice are due to the presence of glycyrrhizin in the roots of triterpene saponin (up to 23%), which enhances the secretory function of the upper respiratory tract and increases the activity of the ciliary epithelium in the trachea and bronchi and reduces blood cholesterol and prevents the formation of cholesterol plaques in blood vessels.

6. Chinese bush tea leaves (Chinensis tea) - green tea contains vitamins C, P, B9, PP, as well as fluorine, zinc, iodine, copper and manganese. Due to the content of vitamin C and catechins, green tea exhibits an antioxidant effect, helps to eliminate toxins, counteracts lipid peroxidation, regulates redox processes in the body, strengthens the walls of capillaries, and prevents tissue acidosis. Vitamin B9 (folic acid) affects metabolism and performance. Provitamins A (carotenes) are actively involved in the metabolism, transfer of hydrogen and oxygen in tissues and cells.

7. Sage officinalis leaves (Salvia officinalis). Sage contains alkaloids, flavonoids, essential oils, volatile, organic acids, vitamins P and PP. Concentrates iron, zinc, strontium-90 non-radioactive. Sage has a capillary-protective, disinfecting, anti-inflammatory effect; reduces perspiration; also used to increase the activity of the central nervous system. Reduces metabolic acidosis.

An identical set of medicinal plants was not found in the medical, scientific and patent literature.

Based on the foregoing, the proposed invention should be considered relevant to the conditions of patentability "Novelty", "Inventive step", "Industrial applicability".

Before compiling the collection, all medicinal plants are selected by composition and content, dried, according to the existing rules for the procurement of medicinal raw materials, crushed on a special apparatus to particles no more than 5 mm in size. Then take each component according to the specified number of grams, mix everything, get a portion of the collection of 500 grams, calculated on the course of 10 days. Ready phytobarrow is a homogeneous mixture of crushed no more than 5 mm plant particles, which is stored in kraft paper bags.

Phyto-collection is taken 1 time a day in the morning, during meals, on weekdays, in the form of an aqueous infusion prepared at the rate of 50 grams of dry raw materials per 500 ml of boiling water at one time, the duration of the courses as prescribed by the doctor.

The studies were carried out on 14 volunteers - practically healthy men aged 37 to 44 years, height 168-189 cm, with a body mass index from 26 to 30. The division into the experimental and control group was arbitrary. The test was carried out on an empty stomach, for six days, in the interval from 8 to 10-30 hours in the morning, phyto-collection was carried out in the factory cafeteria (breakfast from 8-00 to 8-30).

Statistical processing of the results was carried out according to the Student method using the packages Statistica 6.0, SPSS 11.5 and Sigma Plot 8.0. Differences were considered significant at p≤0.05.

The activity of thermoprotective phytochemical collection was tested experimentally on a model of a heating microclimate before and after staying in overalls for two hours in a hot workshop for pressing plastics with a working temperature of 42-43 degrees Celsius.

The subjects were randomly divided into 2 groups. In the first group of 7 people (control), the subjects were exposed to the heat factor and took 500 ml of boiled water at room temperature between two measurements of body temperature (at 8-30 and 10-30) in the axillary region.

In the second group of 7 people (experimental), 500 ml of water extract of phytobox at room temperature was taken orally at a daily dose of 50 grams, calculated on the dry weight of phytobox (ingestion was carried out before breakfast in the factory cafeteria). In the second (experimental) group, the infusion was taken for 3 days before staying in the hot shop and 3 days during overheating. The stay in the hot shop began on the 4th day, the observation lasted for three days.

As efficiency markers, the temperature in the axillary region was determined when taking the collection before overheating and immediately after overheating (at 8-30 and 10-30).

In subjects of the control group, which caused overheating, the temperature increased on the 4th day of the test from 34.7 ± 0.9 degrees to 37.9 ± 0.6 degrees Celsius, on the 6th day of the test - from 34.8 ± 0.6 degrees to 38.1 ± 0.9 degrees Celsius. The maximum increase was observed on the sixth day of the experiment.

When taking infusion from medicinal plants in the experimental group, a statistically significant decrease in fluctuations in body temperature was observed compared with the control group. After staying in a hot workshop, while taking phyto collection, the temperature in the axillary region of the workers increased on the 4th day from 35.1 ± 0.5 degrees to 36.7 ± 0.5 degrees Celsius, on the 6th day of the test - from 36 , 3 ± 0.4 degrees to 37.0 ± 0.5 degrees Celsius. On the 6th day of the experiment, the general tendency to decrease in fluctuations in skin temperature continued.

In one of the subjects of the experimental group, the dynamics of temperature measurements was statistically unreliable.

Phytobox activity as increasing the adaptation of the autonomic nervous system to an extreme temperature factor was tested in the experiment for six days (blood oxygenation and pulse rate were recorded with a non-invasive measurement device "Pulse Oximeter Mitsar-Pulse" FSUE "Biofizpribor" (certificate of conformity ROSS RU IM25.V00025 GOST )). Increased tissue oxygenation allows you to adjust the acid-base balance; pulse reduction indicates a more effective adaptation of the autonomic nervous system.

The subjects (14 people) were randomly divided into 2 groups. In the first (control) group of 7 people, the subjects took boiled water at room temperature without the use of infusion of phyto-collection. In the second group of 7 people (experimental), 500 ml of water extract of phyto-collection at room temperature was taken orally in a daily dose of 50 grams, calculated on the dry weight of the collection before breakfast once a day. Seven test subjects (control group), who took boiled water at room temperature, showed oxygenation of the tissues and heart rate, their heart rate increased from 73.4 ± 5.6 to 86.3 ± 3.8 beats, on the 6th day of the test - 69.4 ± 6.9 to 85.7 ± 6.5 strokes. There was a decrease in oxygenation from 95.3 ± 2.2 to 92.0 ± 2.6 on the sixth day of the test.

When taking infusion from medicinal plants in five people (experimental group), a statistically significant decrease in heart rate from 76.2 ± 4.7 to 63.7 ± 4.9 beats was observed, on the 6th day of the test - from 70.4 ± 4 , 8 to 65.9 ± 7.1 strokes. An increase in blood oxygenation was observed from 93.1 ± 1.5, to 97.0 ± 1.0 on the sixth day of the test. One subject dropped out of the test, the second person from the experimental group did not show reliable statistical results of the dynamics of the pulse and oxygenation.

This example is convincing evidence of the action of phytobarget as a stabilizing autonomic nervous system, increasing blood oxygenation in the experimental group compared to the control. An increase in oxygen supply to tissues allows accelerating the metabolic and vegetative adaptation of tissues and normalizing acid-base balance. Workers noted the absence of early fatigue on the days of taking phytobox.

Thus, the proposed method allows to obtain a persistent and pronounced therapeutic effect, since plant substances in medicinal plants have high bioavailability and digestibility. The collection of medicinal plants can be used in medical practice to adapt workers working in a heating microclimate.

Literature

1. Hygienic correction of diets in violation of heat transfer: an information-analytical review. - Federal Scientific Center for Hygiene. F.F. Erisman. M .: ACT, 2007 .-- 48 p.

2. Sadovskaya N.Yu. In the book. "Occupational diseases": a textbook for students of institutions of higher education. prof. Education / Ed. N.F. Measured. - M.: Publishing. Center "Academy". - 2011., reprint. 2013., S. 451-452.

3. Encyclopedic Dictionary of Medicinal Plants and Products of Animal Origin / Ed. G.P. Yakovleva and K.F. Pancake, 2nd ed., Rev. and add. - St. Petersburg.: Spetslit, Publishing House SPKhFA, 2002.

4. The Internet. https://www.evalar.ru/encyclopedia/

Claims (1)

Phyto-collection for adapting the condition of workers who have professional contact with a heating microclimate in the work area, including the roots of the high aralia, the roots and the aerial part of the medicinal moth, the plantain grass, the straw of oats, the licorice roots, the sage herb, the leaves of Chinese tea bush, taken in a weight ratio of 0.5: 1: 1: 1: 0.5: 1: 2.