RU2651474C2 - Фосфодиэстераза 4d7 как маркер рака предстательной железы - Google Patents

Фосфодиэстераза 4d7 как маркер рака предстательной железы Download PDF

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RU2651474C2
RU2651474C2 RU2011150279A RU2011150279A RU2651474C2 RU 2651474 C2 RU2651474 C2 RU 2651474C2 RU 2011150279 A RU2011150279 A RU 2011150279A RU 2011150279 A RU2011150279 A RU 2011150279A RU 2651474 C2 RU2651474 C2 RU 2651474C2
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pde4d7
expression
prostate cancer
hormone
level
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RU2011150279A
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RU2011150279A (ru
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Ральф ХОФФМАНН
Майлз Д. ХАУСЛЭЙ
Дэвид Дж. П. ХЕНДЕРСОН
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Конинклейке Филипс Электроникс Н.В.
Дзе Юниверсити Корт Оф Дзе Юниверсити Оф Глазго
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RU2011150279A 2009-05-12 2010-05-11 Фосфодиэстераза 4d7 как маркер рака предстательной железы RU2651474C2 (ru)

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Application Number Priority Date Filing Date Title
EP09159960 2009-05-12
EP09159960.5 2009-05-12
PCT/IB2010/052073 WO2010131195A1 (en) 2009-05-12 2010-05-11 Phosphodiesterase 4d7 as prostate cancer marker

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RU2011150279A RU2011150279A (ru) 2013-06-20
RU2651474C2 true RU2651474C2 (ru) 2018-04-19

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US (1) US8753892B2 (cg-RX-API-DMAC7.html)
EP (2) EP2430191B1 (cg-RX-API-DMAC7.html)
JP (4) JP6148007B2 (cg-RX-API-DMAC7.html)
KR (1) KR101778036B1 (cg-RX-API-DMAC7.html)
CN (2) CN107267482A (cg-RX-API-DMAC7.html)
BR (1) BRPI1007093A2 (cg-RX-API-DMAC7.html)
DK (1) DK2430191T3 (cg-RX-API-DMAC7.html)
ES (1) ES2700877T3 (cg-RX-API-DMAC7.html)
RU (1) RU2651474C2 (cg-RX-API-DMAC7.html)
WO (1) WO2010131195A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2793635C2 (ru) * 2018-10-11 2023-04-04 Конинклейке Филипс Н.В. Предоперационная стратификация риска на основании экспрессии PDE4D7 и DHX9

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3343647B2 (ja) 1997-07-22 2002-11-11 株式会社岡田建築デザインルーム 木造軸組在来構法による既存建物を、外部より鋼製受け梁と鋼製筋かいフレームにより耐震補強をなす架構
JP6148007B2 (ja) * 2009-05-12 2017-06-14 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 前立腺癌マーカーとしてのホスホジエステラーゼ４ｄ７
EP2430190B1 (en) * 2009-05-12 2018-11-21 Koninklijke Philips N.V. Phosphodiesterase 4d7 as marker for malignant, hormone-sensitive prostate cancer
US8791508B2 (en) 2010-04-13 2014-07-29 Gan Systems Inc. High density gallium nitride devices using island topology
GB201322034D0 (en) 2013-12-12 2014-01-29 Almac Diagnostics Ltd Prostate cancer classification
GB201504763D0 (en) 2015-03-20 2015-05-06 Mironid Ltd Compounds and uses
DK3303616T3 (da) 2015-05-29 2021-03-01 Koninklijke Philips Nv Fremgangsmåder til prognose af prostatakræft
CN105893782A (zh) * 2016-05-26 2016-08-24 江苏省人民医院 前列腺癌风险预测装置
GB201616439D0 (en) 2016-09-28 2016-11-09 Mironid Limited Compounds and uses
CN106544430A (zh) * 2016-11-04 2017-03-29 叶伟亮 一种检测前列腺癌的分子标记物及其应用
US20210277479A1 (en) * 2016-12-01 2021-09-09 Koninklijke Philips N.V. Risk scores based on human phosphodiesterase 4 d variant 7 expression
EP3450981A1 (en) * 2017-08-28 2019-03-06 Trizell GmbH Btnl8 as a marker for tregs
KR102885025B1 (ko) * 2017-11-03 2025-11-11 옥스포드 바이오다이나믹스 피엘씨 유전적 조절
DE102017125780B3 (de) * 2017-11-05 2018-12-13 Dimo Dietrich Verfahren zur Bestimmung des Ansprechens einer malignen Erkrankung auf eine Immuntherapie
KR102080887B1 (ko) * 2017-11-07 2020-02-24 고려대학교 산학협력단 Gcc2 유전자 또는 단백질을 과발현하는 엑소좀 기반 폐암 진단 또는 예후 예측용 마커 조성물
WO2019158825A1 (en) * 2018-02-16 2019-08-22 Tampereen Korkeakoulusäätiö SR Xrcc5 as biomarker for prostate cancer
GB201805527D0 (en) 2018-04-04 2018-05-16 Mironid Ltd Compounds and their use as pde4 activators
KR20220008175A (ko) * 2020-07-13 2022-01-20 가톨릭대학교 산학협력단 전립선암 환자의 예후 진단 및 치료 전략 결정용 병리등급 특이적 마커
CN112779348B (zh) * 2020-12-31 2022-05-20 四川农业大学 一种小麦单位面积穗数主效qtl位点及紧密连锁的kasp引物和应用
EP4608430A1 (en) 2022-10-27 2025-09-03 Koninklijke Philips N.V. Treatment of prostate cancer by promoting pde4d7
EP4360711A1 (en) * 2022-10-27 2024-05-01 Koninklijke Philips N.V. Treatment of prostate cancer by promoting pde4d7
WO2025016918A1 (en) 2023-07-18 2025-01-23 Koninklijke Philips N.V. Prediction of an outcome of a subject suffering from a glioma
EP4600377A1 (en) 2024-02-12 2025-08-13 Koninklijke Philips N.V. Prediction of an outcome of a subject suffering from a glioma
EP4620461A1 (en) 2024-03-22 2025-09-24 Koninklijke Philips N.V. Treatment of prostate cancer by inhibiting short pde4d isoforms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003044170A2 (en) * 2001-11-15 2003-05-30 Memory Pharmaceuticals Corporation Cyclic amp phosphodiesterase 4d7 isoforms and methods of use
RU2005136013A (ru) * 1997-10-16 2007-05-27 Айкос Корпорейшен (Us) Фосфодиэстераза 8а
WO2007134451A1 (en) * 2006-05-19 2007-11-29 Topigen Pharmaceuticals Inc. Oligonucleotides affecting expression of phosphodiesterases

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090176722A9 (en) 2000-01-28 2009-07-09 Shiv Srivastava Androgen-regulated PMEPA1 gene and polypeptides
OA12540A (en) * 2001-01-31 2006-06-05 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes.
US20030220273A1 (en) * 2002-05-15 2003-11-27 Isis Pharmaceuticals Inc. Antisense modulation of phosphodiesterase 4D expression
AU2003283303A1 (en) 2002-11-08 2004-06-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4b (pde4b)
WO2004042389A2 (en) * 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)
EP1426767A1 (en) 2002-12-04 2004-06-09 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4c (PDE4C)
CA2458085A1 (en) * 2003-03-21 2004-09-21 F. Hoffmann-La Roche Ag Transcriptional activity assay
CN100372944C (zh) * 2003-04-10 2008-03-05 弗·哈夫曼-拉罗切有限公司 Pde4d在筛选治疗动脉粥样硬化的药物中的用途
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US9939441B2 (en) 2006-07-21 2018-04-10 Epigenomics Ag Methods and nucleic acids for analyses for cellular proliferative disorders
EP2518163B1 (en) 2006-10-10 2014-08-06 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Prostate cancer specific alterations in erg gene expression and detection methods based on those alterations
US20110136115A1 (en) * 2007-11-23 2011-06-09 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
JP6148007B2 (ja) * 2009-05-12 2017-06-14 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 前立腺癌マーカーとしてのホスホジエステラーゼ４ｄ７
EP2430190B1 (en) * 2009-05-12 2018-11-21 Koninklijke Philips N.V. Phosphodiesterase 4d7 as marker for malignant, hormone-sensitive prostate cancer
CN109100288A (zh) * 2013-03-15 2018-12-28 艾瑞思国际股份有限公司 用于血液样品中的粒子分析的鞘流体系统和方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005136013A (ru) * 1997-10-16 2007-05-27 Айкос Корпорейшен (Us) Фосфодиэстераза 8а
WO2003044170A2 (en) * 2001-11-15 2003-05-30 Memory Pharmaceuticals Corporation Cyclic amp phosphodiesterase 4d7 isoforms and methods of use
WO2007134451A1 (en) * 2006-05-19 2007-11-29 Topigen Pharmaceuticals Inc. Oligonucleotides affecting expression of phosphodiesterases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHANG L., Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia, Proc Natl Acad Sci U S A., 2008, 105(49), pp.19532-19537. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2793635C2 (ru) * 2018-10-11 2023-04-04 Конинклейке Филипс Н.В. Предоперационная стратификация риска на основании экспрессии PDE4D7 и DHX9

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