RU2626829C2 - Means for polyps treatment in sinuses and prevention of their repeated growth, and method of its application - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method for polyps treatment in the sinuses is proposed. The method is characterized by application of aqueous solutions of acetic acid in concentrations of 3-6% as means or drug component for the treatment of polyps in the nose sinuses, and 1-2 drops of solution are injected into each sinus within 1-2 weeks, 3-5 times a day.

EFFECT: improved safety and effectiveness of polyps treatment in the sinuses, prevention of repeated growth, reduced duration and costs of treatment.

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Description

The claimed object relates to medicine, namely to means and methods for the treatment of polyps in the sinuses.

A known method of treating polyps in the sinuses of the nose, proposed in the invention of the Russian Federation No. 2197966 (A61K 31/44; A61K 31/415), based on the use of inhibitors of H ⁺ , K ⁺ -ATPase, which (specifically) can be used, for example, omeprazole or an alkaline salt of omeprazole, (-) - the enantiomer of omeprazole or its alkaline salt. The drug is used in the form of a suspension, liquid solution or aerosol by injecting it into each nostril twice a day for at least two weeks.

The disadvantage of this method is its insufficiently high efficiency. In addition, this tool is difficult to manufacture and therefore has a high cost.

There is also a method of treating polyps in the sinuses of the nose, based on the use of corticosteroids - see, for example, publication www.zdravotvet.ru/polipy-v-nosu-lechenie-narodnymi-sredstvami-bez-operacii/.

Treatment is carried out in this case by taking these chemicals inside or by injecting them directly into polyps.

However, after a possible (not always happening) improvement, the polyps grow again almost always (see the publication mentioned above). In addition, corticosteroids cause harmful side effects and have many contraindications for their use.

Closest to the claimed object is a method based on the use of hormonal agents, namely flixonase, polydex, nazarez, aldecine, beclomethazole, avamis, benorin, nasobek, nazonex, etc. - see, for example, publication www.zdravotvet.ru/polipy -v-nosu-lechenie-narodnymi-sredstvami-bez-operacii /. They are used after operations to remove polyps in the form of aerosols, spraying them for six months to a year in the sinuses. Moreover, these hormones are absorbed into the blood.

A significant drawback of these drugs (and the corresponding method of treating polyposis) is the fact that they cause a number of dangerous consequences for human health: suppression of local immunity, atrophy of the mucous membranes, inhibition of adrenal gland function, perforation of the nasal septum and other harmful systemic side effects. In addition, they are expensive.

The objectives of the claimed object are to increase the safety and effectiveness of the treatment of polyps in the sinuses, to prevent their repeated growths, to reduce the treatment time and reduce the financial cost of treatment (i.e., reduce the cost of treatment).

These goals are achieved due to the fact that as an agent or component of such an agent intended for the treatment of polyps in the sinuses of the nose, aqueous solutions of acetic acid are used in concentrations, for example, from 3 to 6 percent.

The use of this agent for the treatment of polyps in the sinuses of the nose and to prevent their repeated growths is carried out due to the following method: prepare a 3-6% aqueous solution of acetic acid and instill 1-2 drops of the solution into each sinus of the nose for 1-2 weeks by 3-5 times a day.

The patent search (for the novelty of the claimed one) showed the following.

It is known to use acetic acid (and the corresponding methods) as food additives to various (and extremely numerous!) Dishes and food products: salads, dumplings, barbecue, various meat and fish dishes, etc. - see, for example, pp. 66-67, 80-82, 86, 263-264 and many others in the book “Russian Culinary” (authors Kovalev N.I. et al .; Publishing House “Business Literature”; M ., year 2000).

The use of acetic acid (and the corresponding methods) in the food industry is known - see, for example, the invention of the Russian Federation No. 2465788 (A23L 1/29; C12J 1/08), the invention of the Russian Federation No. 2142002 (C12G 3/06), publication http: // kepk-uksus.ru/primenenie_uksusnoy_kisloty and many other print and other publications.

The use of acetic acid in the chemical industry is also known for the production of plastics, various dyes, artificial fibers, drugs, as a reaction medium for the oxidation of various organic substances - see, for example, publication http://kepk-uksus.ru/primenenie_uksusnoy_kisloty.

The patent search performed (as of the filing date of the original (No. 2014153181) application) did not lead to the discovery of publications and inventions that would suggest the use of the claimed method for the treatment of polyposis.

Examples of the claimed method of treatment.

Example 1

In patient V., approximately one year after the surgical removal of polyps from the sinuses of the nose, their repeated growth was noticed. In accordance with the stated, he was prescribed: 1) during the first week of treatment 3-5 times a day to instill in the nostrils of the nose 1 drop of a 3-4% aqueous solution of acetic acid; 2) during the second week, 3-5 times a day, instill 1-2 drops of a 4-6% aqueous solution of acetic acid into the nostrils of the nose. The disappearance of polyps occurred after 12 days.

Example 2

Patient F. was assigned the same treatment as in Example 1. However, he had an increase in polyps after surgery to remove them significantly more than patient B. Therefore, after the end of the first treatment cycle (which led to a decrease in the size of the polyps), after a week he was assigned to repeat the treatment within 3 weeks. After its completion, it was found that the polyps in F. completely disappeared.

Example 3

Patient K. suffers from almost 100 percent closure of all lumens in the sinuses of the nose of polyps for more than 6 years. He refused surgery for their surgical removal. In accordance with the stated, he was prescribed: 1) during the first week of treatment 3-5 times a day to instill in the nostrils of the nose 1 drop of a 3-4% aqueous solution of acetic acid; 2) during the second week, 3-5 times a day, instill 1-2 drops of a 4-6% aqueous solution of acetic acid into the nostrils of the nose. After the completion of the second week of treatment, K. was given a repeated cycle of treatment, namely, for another 2-3 weeks, instill 1-2 drops of a 4-6% aqueous solution of acetic acid into the nostrils of the nose. By the time of filing this application, a significant (about 70 percent) decrease in the size of polyps was noted and almost full breathing through the nose was already possible. The dynamics of getting rid of polyps and the prognosis of treatment are positive.

Many patients noted that within 1.5-2 weeks after the start of treatment, they (when spitting out secretions from the sinuses of the nose) saw fragments of polyps that began to separate.

The proposed method can also be used to prevent (prevent) the growth of polyps in the sinuses.

With repeated use of the claimed method for the treatment of polyps in the sinuses of the nose, the author unexpectedly discovered (and was confirmed by observations of different patients) that aqueous solutions of acetic acid in the indicated concentrations and in its other compositions, when using the proposed method, also positively and effectively affect the treatment of rhinitis and acute respiratory infections (ARI). The technique (method) of application in this case is (is) the same as in the above examples.

The advantages of the proposed method are the high efficiency of treatment and prophylaxis (a positive effect was observed in all cases), a wide range of its possible applications for all types of polyposis and for various features of the individual course of this type of disease (both in treatment and in prevention), its simplicity application, as well as extremely low cost and high availability.

Unlike the substances indicated as analogues and prototype, the proposed method does not lead to any adverse side effects or complications in its application, has no contraindications and can be used repeatedly and arbitrarily often.

The basis for the above statement is more than a thousand-year history of the completely safe (and useful!) Use of the claimed funds in the highest degree of numerous and varied food dishes. Over the past centuries, the widest use of acetic acid for cooking and in the food industry, no contraindications to its use have been identified. Therefore, there is no and cannot be any doubt about the possibility and safety of its use also for getting rid of polyps in the sinuses and to prevent their re-growth.

The main advantage of the proposed method is the real possibility of getting rid of polyps in the nose without surgical removal, which is often even unacceptable due to intolerance by patients of certain anesthetics and because of a wide range of various other contraindications.

Claims (1)

A method of treating polyps in the sinuses and preventing re-growths, characterized in that a 3-6 percent aqueous solution of acetic acid is prepared and 1-2 drops of the solution are instilled into each sinus of the nose for 1-2 weeks 3-5 times a day .