RU2577697C2 - Remedy for getting rid of polyps in sinuses of nose and to prevent repeated development thereof, as well as method for use thereof - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: group of inventions relates to devices and methods for treating polyps in sinuses of nose. Disclosed is use of aqueous solution of acetic acid in concentration from 3 to 15% as an agent for treating polyps in sinuses of nose and for prevention of recurrent growths thereof, and related method of treating.

EFFECT: technical result is safety and efficiency of treating polyps in sinuses of nose, prevention of recurrent growths, reducing length of treatment and reduction of financial costs for treatment (id est low cost of treating).

2 cl, 3 ex

Description

The claimed object relates to medicine, namely to means and methods for the treatment of polyps in the sinuses.

Known means for the treatment of polyps in the sinuses of the nose, proposed in the invention of the Russian Federation No. 2197966 (A61K 31/44; A61K 31/415), namely, H ⁺ , K ⁺ -ATPase inhibitors, which (specifically) can be used, for example , omeprazole or an alkaline salt of omeprazole, (-) - the enantiomer of omeprazole or its alkaline salt. The drug is used in the form of a suspension, liquid solution or aerosol by injecting it into each nostril twice a day for at least two weeks.

The disadvantage of this tool is the complexity of its production and the high cost of this substance.

Corticosteroids are also known for use in treating polyps in the sinuses of the nose - see, for example, publication www.zdravotvet.ru/polipy-v-nosu-lechenie-narodnymi-sredstvami-bez-operacii/. Treatment is carried out in this case by taking these chemicals inside or by injecting them directly into polyps.

However, after a possible (not always happening) improvement, the polyps grow again almost always (see the publication mentioned above). In addition, corticosteroids cause harmful side effects and have many contraindications for their use.

The closest to the claimed object are hormonal drugs, namely: flixonase, polydex, nazarez, aldecin, beclomethazole, avamis, benorin, nasobek, nazonex, etc. - see, for example, publication www.zdravotvet.ru/polipy-v-nosu -lechenie-narodnyrm-sredstvami. They are used after operations to remove polyps in the form of aerosols, spraying them for six months to a year in the sinuses. Moreover, these hormones are absorbed into the blood.

A significant drawback of these drugs is the fact that they cause a number of dangerous consequences for human health: suppression of local immunity, atrophy of the mucous membranes, inhibition of adrenal gland function, perforation of the nasal septum and other harmful systemic side effects. In addition, they are expensive.

The objectives of the claimed object are to increase the safety and effectiveness of the treatment of polyps in the sinuses, to prevent their repeated growths, to reduce the treatment time and reduce the financial cost of treatment (i.e., reduce the cost of treatment).

These goals are achieved due to the fact that as an agent or component of such an agent intended for the treatment of polyps in the sinuses of the nose, aqueous solutions of acetic acid are used in concentrations, for example, from 3 to 15 percent.

The use of this tool for the treatment of polyps in the sinuses of the nose is carried out by the following method: prepare a 3-6% aqueous solution of acetic acid and moisten the inner surface of the nose behind the nostrils to a depth of 0.5-2 centimeters for 1-2 weeks for 3-5 once a day.

The patent search (for the novelty of the claimed one) showed the following.

It is known to use acetic acid as food additives to various (and extremely numerous!) Dishes and food products: salads, dumplings, kebabs, various meat and fish dishes, etc. - see, for example, pp. 66-67, 80-82, 86, 263-264 and many others in the book "Russian Culinary" (authors Kovalev N.I. et al .; Publishing House "Business Literature"; M .; year 2000).

The use of acetic acid in the food industry is known - see, for example, the invention of the Russian Federation No. 2465788 (A23L 1/29; C12J 1/08), the invention of the Russian Federation No. 2142002 (C12G3 / 06), publication http://kepk-uksus.ru/ primenenie_uksusnoy_kisloty and many other printed and other publications.

The use of acetic acid in the chemical industry for the production of plastics, various dyes, artificial fibers, drugs, as a reaction medium for the oxidation of various organic substances is also known - see, for example, the publication http://kepk-uksus.ru/primenenie_uksusnoy_kisloty.

The patent search carried out did not lead to the discovery of publications and inventions in which it would be proposed to use the agent claimed here for the treatment of polyposis and the method of its use (its variants).

Examples of the use of the claimed funds and the implementation of the proposed method (its options) treatment.

Example 1

In 2005, patient A. underwent surgical removal of polyps from the sinuses of the nose. After 4 years, in 2009, due to a repeated increase in polyps, he was forced to agree to a repeated operation to remove polyps in his nose. Since about 2010, polyps again (to a small extent) began to grow in the sinuses. In 2012, in accordance with the stated, he was prescribed: 1) 3-4 times a day with a 3-4% aqueous solution of acetic acid to moisten the inner surfaces of the nose behind the nostrils to a depth of not more than 0.5 centimeters; 2) during the next 2 weeks, 4-5 times a day, moisten the inner surfaces of the nostrils of the nose to a depth of not more than 1.5 centimeters, 5-6% aqueous solution of acetic acid. 2 weeks after the start of treatment, the polyps completely disappeared.

Example 2

In patient D., a year after surgical removal of polyps from the sinuses, a repeated intensive increase was observed. In accordance with the stated, he was prescribed: 1) to moisten the inner surface of the nose behind the nostrils 3-5 times a day with a 3% aqueous solution of acetic acid 3-5 times a day; 2) during the next 3-5 weeks, 5-7 times a day, wet the 5-6% aqueous solution of acetic acid of the inner surfaces of the nose behind the nostrils to a depth of not more than 0.8-1 centimeter. The disappearance of polyps occurred after 25 days.

Example 3

Patient E. was assigned the same treatment as in Example 2. However, in view of the fact that he had much less sinus overgrowth with polyps than patient D., the disappearance of polyps in E. occurred after 17 days. About 5 months after this, he noted a resumption (to a slight degree) of growth of nasal polyps. After the repeated treatment, as in Example 2, the polyps finally disappeared.

Many patients noted that within 1.5-2 weeks after the start of treatment, they (when spitting out secretions from the sinuses of the nose) saw fragments of polyps that began to separate.

The proposed tool and methods of its use can also be used to prevent (prevent) the growth of polyps in the sinuses.

With repeated use of the claimed agent for the treatment of polyps in the sinuses of the nose, the author unexpectedly discovered (and was confirmed by observations of different patients) that it positively and effectively affects the cure of colds and acute respiratory diseases (ARI). The technique (method) of its application in this case is (is) the same as in the above examples.

The advantages of the proposed tool are the high efficiency of treatment and prevention (a positive effect was observed in all cases), a wide range of its possible applications - for all types of polyposis and for various features of the individual course of this type of disease (both in treatment and prevention), is simplicity its use, as well as extremely low cost and high availability.

Unlike the substances indicated as analogues and prototype, the claimed agent does not lead to any adverse side effects or complications in its use, has no contraindications and can be used repeatedly and arbitrarily often.

The basis for the above statement is more than a thousand-year history of the completely safe (and useful!) Use of the claimed funds in the highest degree of numerous and varied food dishes. Over the past centuries, the widest use of acetic acid for cooking and in the food industry, no contraindications to its use have been identified. Therefore, there is no and cannot be any doubt about the possibility and safety of its use also for getting rid of polyps in the sinuses and to prevent their re-growth.

The main advantage of the proposed tool and method (its variants) of application is the real possibility of getting rid of polyps in the nose without surgical removal, which, often, is even unacceptable due to intolerance by patients of certain anesthetics and because of a wide range of various other contraindications.

Claims (2)

1. The use of aqueous solutions of acetic acid in concentrations, for example, from 3 to 15% for the treatment of polyps in the sinuses and to prevent re-growth. 2. The method of using the agent according to claim 1, characterized in that a 3-6% aqueous solution of acetic acid is prepared and the inner surfaces of the nose are moistened behind the nostrils to a depth of 0.5-2 cm for 1-2 weeks 3-5 times per day.