RU2570731C2 - Композиции, включающие финафлоксации, и способы лечения офтальмологических, ушных или назальных инфекций - Google Patents

Композиции, включающие финафлоксации, и способы лечения офтальмологических, ушных или назальных инфекций Download PDF

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RU2570731C2
RU2570731C2 RU2012103458/15A RU2012103458A RU2570731C2 RU 2570731 C2 RU2570731 C2 RU 2570731C2 RU 2012103458/15 A RU2012103458/15 A RU 2012103458/15A RU 2012103458 A RU2012103458 A RU 2012103458A RU 2570731 C2 RU2570731 C2 RU 2570731C2
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composition
finfloxacin
compositions
concentration
finafloxacin
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RU2012103458/15A
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English (en)
Russian (ru)
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RU2012103458A (ru
Inventor
Дэвид У. СТРОМАН
Масуд А. ЧОВХАН
Кеннет К. АППЕЛЛ
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Алькон Рисерч, Лтд.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2012103458/15A 2009-07-02 2010-07-02 Композиции, включающие финафлоксации, и способы лечения офтальмологических, ушных или назальных инфекций RU2570731C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22262509P 2009-07-02 2009-07-02
US61/222,625 2009-07-02
PCT/US2010/040956 WO2011003091A1 (en) 2009-07-02 2010-07-02 Compositions comprising finafloxacin and methods for treating ophthalmic, otic, or nasal infections

Publications (2)

Publication Number Publication Date
RU2012103458A RU2012103458A (ru) 2013-08-10
RU2570731C2 true RU2570731C2 (ru) 2015-12-10

Family

ID=42752088

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RU2012103458/15A RU2570731C2 (ru) 2009-07-02 2010-07-02 Композиции, включающие финафлоксации, и способы лечения офтальмологических, ушных или назальных инфекций

Country Status (17)

Country Link
US (3) US8536167B2 (enExample)
EP (1) EP2448587B1 (enExample)
JP (2) JP5784012B2 (enExample)
KR (1) KR101541823B1 (enExample)
CN (2) CN105687111A (enExample)
AR (1) AR077372A1 (enExample)
AU (1) AU2010266120B2 (enExample)
BR (1) BRPI1016257B8 (enExample)
CA (1) CA2765852C (enExample)
CL (1) CL2011003327A1 (enExample)
ES (1) ES2694775T3 (enExample)
MX (1) MX2012000136A (enExample)
RU (1) RU2570731C2 (enExample)
TW (1) TWI460181B (enExample)
UY (1) UY32758A (enExample)
WO (1) WO2011003091A1 (enExample)
ZA (1) ZA201109492B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2570731C2 (ru) * 2009-07-02 2015-12-10 Алькон Рисерч, Лтд. Композиции, включающие финафлоксации, и способы лечения офтальмологических, ушных или назальных инфекций
US20150174137A1 (en) * 2010-06-02 2015-06-25 Alcon Research, Ltd. Compositions for treating microbial infections
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
PL3517541T3 (pl) 2012-05-08 2020-12-28 Nicox Ophthalmics, Inc. Postać polimorficzna propionianu flutykazonu
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
AU2014306781A1 (en) * 2013-08-12 2015-12-24 Merlion Pharmaceuticals, Pte., Ltd. Method for treating otic infections after tympanostomy tube placement
DE102014115951A1 (de) * 2014-11-03 2016-05-04 Merlion Pharmaceuticals Pte Ltd. Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de) * 2015-01-06 2016-07-07 Merlion Pharmaceuticals Pte Ltd. Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
US11529309B2 (en) * 2016-04-29 2022-12-20 University Of Houston System Compositions, methods and kits for treating a contact lens
US10282607B2 (en) 2016-10-28 2019-05-07 The Nielsen Company (Us), Llc Reducing scale estimate errors in shelf images

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2001089496A2 (en) * 2000-05-19 2001-11-29 Alcon Laboratories, Inc. Compositions and methods for treating otic, ophthalmic and nasal infections comprising quinolone antibiotics

Family Cites Families (11)

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JP2832535B2 (ja) * 1989-04-04 1998-12-09 富山化学工業株式会社 キノロンカルボン酸またはその塩の可溶化法
US5421818A (en) * 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
US6156728A (en) 1996-11-01 2000-12-05 Genentech, Inc. Treatment of inner ear hair cells
DE19652239A1 (de) * 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
US6440964B1 (en) * 1998-09-30 2002-08-27 Alcon Manufacturing, Ltd. Compositions and methods for treating ophthalmic and otic infections
AR020661A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
JP2006289070A (ja) * 2005-03-18 2006-10-26 Santen Pharmaceut Co Ltd キノロン系抗菌化合物含有製品
DK1901749T3 (en) * 2005-05-18 2016-10-24 Raptor Pharmaceuticals Inc Aerosolized fluoroquinolones AND USES THEREOF
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
RU2570731C2 (ru) * 2009-07-02 2015-12-10 Алькон Рисерч, Лтд. Композиции, включающие финафлоксации, и способы лечения офтальмологических, ушных или назальных инфекций

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001089496A2 (en) * 2000-05-19 2001-11-29 Alcon Laboratories, Inc. Compositions and methods for treating otic, ophthalmic and nasal infections comprising quinolone antibiotics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GOH CY et al. Antibacterial Activity And Resistance Potential Of The Investigational Fluoroquinolone Finafloxacin and Moxifloxacin Against Clinical Isolates of Community Associated Methicillin Resistant Staphylococcus aureus. Program and abstracts of the interscience conference on antimicrobial agents and chemotherapy (ICAAC), vol.49, 01.01.2009, p.74. ENDERMANN R et al. In Vivo Efficacy of Finafloxacin in Difficult to Treat Animal Models of Infection. Program and abstracts of the interscience in antimicrobial agents and chemotherapy (ICAAC), vol.48, 01.01.2008, pp.306-307. WOHLERT S-E et al. New Fluoroquinolone Finafloxacin HCl (FIN): Route of Synthesis, Physicochemical Characteristics and Activity under Neutral and Acid Conditions. Vivo Efficacy of Finafloxacin in Difficult to Treat Animal Models of Infection. Program and abstracts of the interscience in antimicrobial agents and chemotherapy (ICAAC), vol.48, 2008, F1-2036. *

Also Published As

Publication number Publication date
BRPI1016257B1 (pt) 2021-03-16
US9119859B2 (en) 2015-09-01
US20150328229A1 (en) 2015-11-19
TWI460181B (zh) 2014-11-11
CA2765852A1 (en) 2011-01-06
ZA201109492B (en) 2013-03-27
TW201102395A (en) 2011-01-16
JP2015134827A (ja) 2015-07-27
CA2765852C (en) 2014-08-26
US8536167B2 (en) 2013-09-17
US20130331385A1 (en) 2013-12-12
CN105687111A (zh) 2016-06-22
EP2448587A1 (en) 2012-05-09
AU2010266120A1 (en) 2012-02-02
CL2011003327A1 (es) 2013-01-25
KR101541823B1 (ko) 2015-08-04
KR20120114211A (ko) 2012-10-16
US20110003803A1 (en) 2011-01-06
BRPI1016257A2 (pt) 2016-07-12
CN102470139A (zh) 2012-05-23
JP5784012B2 (ja) 2015-09-24
BRPI1016257B8 (pt) 2021-05-25
US9993483B2 (en) 2018-06-12
UY32758A (es) 2010-10-29
JP2012532115A (ja) 2012-12-13
ES2694775T3 (es) 2018-12-27
AU2010266120B2 (en) 2014-02-06
AR077372A1 (es) 2011-08-24
MX2012000136A (es) 2012-02-08
RU2012103458A (ru) 2013-08-10
EP2448587B1 (en) 2018-08-22
WO2011003091A1 (en) 2011-01-06

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