RU2564896C2 - Tannin encapsulation method - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: method includes suspending tannin in benzene and dispersing the obtained mixture into a suspension of sodium alginate in butanol in the presence of an E472c preparation while stirring at 1000 rps. Chloroform is then added. The obtained suspension is filtered out and dried at room temperature. The process of producing microcapsules is carried out at 25°C for 20 minutes.

EFFECT: simpler and faster process of producing microcapsules and reduced losses during production.

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Description

The invention relates to the field of encapsulation, in particular to the production of microcapsules containing tannin.

Previously known methods for producing microcapsules of drugs. So, in RF Patent No. 2092155 IPC A61K 047/02, A61K 009/16 published on 10/10/1997, a method of microencapsulation of drugs based on the use of ultraviolet radiation was proposed.

The disadvantages of this method are the duration of the process and the use of ultraviolet radiation, which can affect the process of formation of microcapsules.

In the RF Patent No. 2091071 IPC A61K 35/10 publ. 09/27/1997, a method for producing the drug by dispersion in a ball mill with the receipt of microcapsules.

The disadvantage of this method is the use of a ball mill and the duration of the process.

In the RF Patent No. 2101010 IPC A61K 9/52, A61K 9/50, A61K 9/22, A61K 9/20, A61K 31/19 publ. On January 10, 1998, a chewing mask of a taste-masked drug with the properties of controlled release of the drug was proposed. It contains microcapsules 100-800 μm in diameter and consists of a pharmaceutical core with crystalline ibuprofen and a polymer coating that includes a plasticizer that is flexible enough to withstand chewing. The polymer coating is a methacrylic acid based copolymer.

The disadvantages of the invention: the use of a copolymer based on methacrylic acid, as these polymer coatings can cause cancerous tumors; complexity of execution; the duration of the process.

In the RF Patent No. 2173140 IPC A61K 009/50, A61K 009/127 publ. 09/10/2001, a method for producing silicon organolipid microcapsules using a rotary-cavitation unit with high shear forces and powerful sonar phenomena of sound and ultrasonic range for dispersion is proposed.

The disadvantage of this method is the use of special equipment - rotary cavitation unit, which has an ultrasonic effect, which affects the formation of microcapsules and can cause adverse reactions due to the fact that ultrasound destructively affects polymers of a protein nature, therefore, the proposed method is applicable when work with polymers of synthetic origin.

In Patent No. 2359662 IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 publ. 06/27/2009, a method for producing microcapsules using spray cooling in a Niro spray tower is proposed under the following conditions: inlet air temperature 10 ° C, outlet air temperature 28 ° C, spray drum rotation speed of 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

The closest method is the method proposed in RF Patent 2134967 IPC A01N 53/00, A01N 25/28 publ. 08/27/1999, a solution of a mixture of natural lipids and a pyrethroid insecticide is dispersed in water in a weight ratio (2-4): 1 in an organic solvent, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining microcapsules, reducing losses when receiving microcapsules (increase in yield by mass).

The solution to the technical problem is achieved by the method of encapsulation of alkaloids, characterized in that sodium alginate is used as a shell of microcapsules when they are obtained by the physicochemical method of precipitation with a non-solvent using chloroform as a precipitant, the production process is carried out without special equipment.

A distinctive feature of the proposed method is the use of sodium alginate as a shell of microcapsules and tannin as their core, as well as the use of chloroform as a precipitant.

The result of the proposed method is to obtain microcapsules of tannin in sodium alginate at 25 ° C for 20 minutes. The output of microcapsules is 100%.

EXAMPLE 1. Obtaining microcapsules of tannin in the ratio of core / polymer 1: 3

1 g of tannin is suspended in 3 ml of benzene and the resulting mixture is dispersed into a suspension of sodium alginate in butanol containing the indicated 3 g of polymer in the presence of 0.01 g of the preparation E472c (glycerol ester with one to two molecules of food fatty acids and one to two molecules citric acid, moreover, citric acid as a tribasic acid can be esterified with other glycerides and an oxo acid with other fatty acids. Free acid groups can be neutralized with sodium with stirring at 1000 rpm. Then add 3 ml of chloro form The resulting suspension is filtered off and dried at room temperature.

Received 4 g of a white powder. The yield was 100%.

EXAMPLE 2. Obtaining microcapsules of tannin in the ratio of core / polymer 1: 1

1 g of tannin is suspended in 3 ml of benzene and the resulting mixture is dispersed into a suspension of sodium alginate in butanol containing the indicated 3 g of polymer in the presence of 0.01 g of the preparation E472c with stirring at 1000 rpm. Then pour 3 ml of chloroform. The resulting suspension is filtered and dried at room temperature.

Received 2 g of a white powder. The yield was 100%.

EXAMPLE 3. Obtaining microcapsules of tannin in the ratio of core / polymer 1: 2

1 g of tannin is suspended in 3 ml of benzene and the resulting mixture is dispersed into a suspension of sodium alginate in butanol containing the indicated 2 g of polymer in the presence of 0.01 g of the preparation E472c with stirring at 1000 rpm. Then pour 3 ml of chloroform. The resulting suspension is filtered and dried at room temperature.

Received 3 g of a white powder. The yield was 100%.

Microcapsules of tannin were obtained by physicochemical precipitation with a non-solvent using chloroform as a precipitant, which helps to increase the yield and accelerates the microencapsulation process. The process is simple to execute and lasts for 20 minutes, does not require special equipment.

The proposed technique is suitable for the pharmaceutical and veterinary industries due to minimal losses, speed, ease of preparation and isolation of microcapsules.

Claims (1)

A method of encapsulating tannin, characterized in that the tannin is suspended in benzene and the resulting mixture is dispersed in a suspension of sodium alginate in butanol in the presence of 0.01 g of the preparation E472c with stirring 1000 rps, then chloroform is poured, the resulting suspension is filtered off and dried at room temperature.