RU2558302C2 - Новая дельта-9-элонгаза для получения масел, обогащенных полиненасыщенными жирными кислотами - Google Patents

Новая дельта-9-элонгаза для получения масел, обогащенных полиненасыщенными жирными кислотами Download PDF

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RU2558302C2
RU2558302C2 RU2012103248/10A RU2012103248A RU2558302C2 RU 2558302 C2 RU2558302 C2 RU 2558302C2 RU 2012103248/10 A RU2012103248/10 A RU 2012103248/10A RU 2012103248 A RU2012103248 A RU 2012103248A RU 2558302 C2 RU2558302 C2 RU 2558302C2
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delta
elongase
nucleic acid
seq
acid molecule
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RU2012103248A (ru
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Сюзетт ПЕРЕЙРА
Тапас ДАС
Падмавати КРИШНАН
Прадип МУКЕРДЖИ
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Эбботт Лэборетриз
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)

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  • Plant Pathology (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Fats And Perfumes (AREA)
  • Edible Oils And Fats (AREA)
RU2012103248/10A 2009-07-17 2010-07-14 Новая дельта-9-элонгаза для получения масел, обогащенных полиненасыщенными жирными кислотами RU2558302C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/505,293 2009-07-17
US12/505,293 US8188335B2 (en) 2009-07-17 2009-07-17 Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
PCT/US2010/041893 WO2011008803A2 (en) 2009-07-17 2010-07-14 Novel δ9-elongase for production of polyunsaturated fatty acid-enriched oils

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RU2012103248A RU2012103248A (ru) 2013-08-27
RU2558302C2 true RU2558302C2 (ru) 2015-07-27

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RU2012103248/10A RU2558302C2 (ru) 2009-07-17 2010-07-14 Новая дельта-9-элонгаза для получения масел, обогащенных полиненасыщенными жирными кислотами

Country Status (15)

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US (1) US8188335B2 (https=)
EP (1) EP2454365A2 (https=)
JP (1) JP2012533303A (https=)
CN (1) CN102782124B (https=)
AR (1) AR077763A1 (https=)
AU (1) AU2010273508B2 (https=)
BR (1) BR112012001125A2 (https=)
CA (1) CA2768318A1 (https=)
IN (1) IN2012DN00469A (https=)
MX (1) MX2012000825A (https=)
MY (1) MY160166A (https=)
NZ (1) NZ597679A (https=)
RU (1) RU2558302C2 (https=)
UA (1) UA107468C2 (https=)
WO (1) WO2011008803A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1756280T3 (en) 2004-04-22 2015-02-02 Commw Scient Ind Res Org SYNTHESIS OF CHAIN, polyunsaturated fatty acids BY RECOMBINANT CELLS
CA3056110C (en) 2004-04-22 2020-07-14 Surinder Pal Singh Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
CN101578363A (zh) 2006-08-29 2009-11-11 联邦科学技术研究组织 脂肪酸的合成
NO2358882T3 (https=) 2008-11-18 2017-12-23
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
US8293790B2 (en) 2011-10-19 2012-10-23 Dignity Sciences Limited Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof
JP2015500639A (ja) * 2011-11-29 2015-01-08 ディグニティ サイエンシス リミテッド 20−炭素脂肪酸を含む組成物ならびにその製造方法および使用方法
PL2861059T3 (pl) 2012-06-15 2017-10-31 Commw Scient Ind Res Org Wytwarzanie długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach roślinnych
NZ721036A (en) 2013-12-18 2023-07-28 Grains Res & Dev Corp Lipid comprising long chain polyunsaturated fatty acids
PH12016502586B1 (en) 2014-06-27 2023-07-19 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
SG11201708106TA (en) * 2015-04-08 2017-10-30 Euglena Co Ltd Suppressive agent for rheumatoid arthritis, prophylactic agent for rheumatoid arthritis, therapeutic agent for rheumatoid arthritis, and food for suppressing rheumatoid arthritis
WO2017208173A1 (en) 2016-06-01 2017-12-07 National Research Council Of Canada Winter aconite fatty acid elongase and uses thereof in the production of fatty acids
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136877A2 (en) * 2006-05-17 2007-11-29 E. I. Du Pont De Nemours And Company Delta-5 desaturase and its use in making polyunsaturated fatty acids
WO2008124048A2 (en) * 2007-04-03 2008-10-16 E. I. Du Pont De Nemours And Company Multizymes and their use in making polyunsaturated fatty acids
WO2008128240A1 (en) * 2007-04-16 2008-10-23 E. I. Du Pont De Nemours And Company Delta 9 elongases and their use in making polyunsaturated fatty acids

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63907A0 (en) 1980-09-24 1981-12-31 Cetus Corp Diagnostic method and antibody probe for use therein
US4582788A (en) 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
ATE53862T1 (de) 1982-01-22 1990-06-15 Cetus Corp Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US4943674A (en) 1987-05-26 1990-07-24 Calgene, Inc. Fruit specific transcriptional factors
US5420034A (en) 1986-07-31 1995-05-30 Calgene, Inc. Seed-specific transcriptional regulation
GB8507058D0 (en) 1985-03-19 1985-04-24 Efamol Ltd Pharmaceutical & dietary compositions
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8524276D0 (en) 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
GB8524275D0 (en) 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5107065A (en) 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5188958A (en) 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US5004863B2 (en) 1986-12-03 2000-10-17 Agracetus Genetic engineering of cotton plants and lines
US5416011A (en) 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
US5116871A (en) 1988-09-13 1992-05-26 Efamol Holdings Plc Fatty acid therapy and compositions for the treatment of myalgic encephalomyelitis
US5231020A (en) 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5106739A (en) 1989-04-18 1992-04-21 Calgene, Inc. CaMv 355 enhanced mannopine synthase promoter and method for using same
US5175095A (en) 1989-07-19 1992-12-29 Calgene, Inc. Ovary-tissue transcriptional factors
WO1991018985A1 (en) 1990-05-25 1991-12-12 E.I. Du Pont De Nemours And Company Nucleotide sequence of soybean stearoyl-acp desaturase gene
US5518908A (en) 1991-09-23 1996-05-21 Monsanto Company Method of controlling insects
PH31293A (en) 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
CA2124673C (en) 1991-12-04 2008-08-05 John Browse Fatty acid desaturase genes from plants
EP0616645B1 (en) 1991-12-06 2001-08-22 Genentech, Inc. Prohormone convertase transformed cells
US5912120A (en) 1992-04-09 1999-06-15 The United States Of America As Represented By The Department Of Health And Human Services, Cloning, expression and diagnosis of human cytochrome P450 2C19: the principal determinant of s-mephenytoin metabolism
DK0668919T3 (da) 1992-11-17 2003-09-15 Du Pont Gener for mikorsomale delta-12-fedtsyredesaturaser og beslægtede enzymer fra planter
DK0686197T3 (da) 1993-02-26 2000-09-04 Calgene Llc Geminivirusbaseret genekspressionssystem
AU692841B2 (en) 1994-03-09 1998-06-18 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
US5750176A (en) 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
WO1995024494A1 (en) 1994-03-09 1995-09-14 Abbott Laboratories Humanized milk
US5654402A (en) 1994-10-26 1997-08-05 Michigan State University Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase
US5631152A (en) 1994-10-26 1997-05-20 Monsanto Company Rapid and efficient regeneration of transgenic plants
DK1951866T3 (da) 2005-11-23 2014-10-27 Du Pont Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer
US8389808B2 (en) 2007-02-12 2013-03-05 E.I. Du Pont De Nemours And Company Production of arachidonic acid in oilseed plants
CA2739836A1 (en) 2008-10-06 2010-04-15 Tapas Das Delta-8 desaturase genes, enzymes encoded thereby and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136877A2 (en) * 2006-05-17 2007-11-29 E. I. Du Pont De Nemours And Company Delta-5 desaturase and its use in making polyunsaturated fatty acids
WO2008124048A2 (en) * 2007-04-03 2008-10-16 E. I. Du Pont De Nemours And Company Multizymes and their use in making polyunsaturated fatty acids
WO2008128240A1 (en) * 2007-04-16 2008-10-23 E. I. Du Pont De Nemours And Company Delta 9 elongases and their use in making polyunsaturated fatty acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SINGH S.P. et al., Metabolic engineering of new fatty acids in plants, Curr Opin Plant Biol, 2005, Vol. 8, N.2, pp.197-203. ЛОСЬ Д. А., Структура, регуляция экспрессии и функционирование десатураз жирных кислот, Успехи биологической химии, т. 41, 2001, с. 163-198 *

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CA2768318A1 (en) 2011-01-20
NZ597679A (en) 2013-06-28
AU2010273508B2 (en) 2015-02-05
MY160166A (en) 2017-02-28
EP2454365A2 (en) 2012-05-23
US8188335B2 (en) 2012-05-29
AR077763A1 (es) 2011-09-21
IN2012DN00469A (https=) 2015-06-05
US20110016585A1 (en) 2011-01-20
CN102782124A (zh) 2012-11-14
WO2011008803A3 (en) 2011-04-07
CN102782124B (zh) 2015-04-22
JP2012533303A (ja) 2012-12-27
WO2011008803A2 (en) 2011-01-20
MX2012000825A (es) 2012-04-19
UA107468C2 (uk) 2015-01-12
RU2012103248A (ru) 2013-08-27
BR112012001125A2 (pt) 2015-09-01
AU2010273508A1 (en) 2012-02-09

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