RU2549667C1 - Method of correcting biological age of organism as prevention of premature ageing - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method includes carrying out complex treatment at the background of diet therapy. Intake of antihelmintic of vegetable origin and immunomodulator is carried out daily with washing down each of them with 200 ml of radon water. Intestinal lavage is performed every second day. On days of performing intestinal lavage, patient takes bath with radon water in the morning before lavage, with performing underwater hydrodynamic massage (UHM) on other days. On days, when intestinal lavage is not performed, sessions of sound therapy are carried out after UHM.

EFFECT: method provides correction of biological age of organism as prevention of premature ageing.

3 cl, 4 tbl, 2 ex

Description

The invention relates to medicine and can be used in the practice of physicians, therapists, gerontologists, specialists involved in medical activities, prevention or rehabilitation issues in the field of balneology.

Ensuring an adequate level of quality of life for an elderly person while increasing life expectancy is one of the important tasks facing modern society (25, 28, 32, 34, 35). The state program “Health Care Development” (2012) included the prevention of diseases and the formation of a healthy lifestyle as the most important priorities. Among urgent health problems and the extension of active labor activity (1, 14, 15), the need to “provide conditions for active longevity” (V.V. Putin, 2012). At the same time, insufficient attention is paid to taking into account the consequences of adverse environmental effects on public health (3, 25, 39). At the same time, the ecological component with global technogenic disturbances of ecosystems and intense pollution of all components of the human environment play a pronounced modifying and reinforcing role with respect to the characteristics of the occurrence, course, and chronicity of major diseases (25, 34, 39). This applies to diseases of the respiratory system, digestion, skin, allergic reactions and immunodeficiencies, diseases of the liver, blood and blood-forming organs, oncological processes, pregnancy complications, spontaneous abortions, congenital and genetic pathologies (12, 20, 25). Under the current conditions of life, the human body, undergoing prolonged exposure to harmful environmental factors, is forced to constantly use its compensatory-adaptive mechanisms, the reserves of which are limited and depleted over time. Exposure to exogenous and endogenous adverse factors is accompanied by overstrain and impaired adaptive mechanisms of the body, which predisposes to the development of pre-painful and chronic main pathological processes, dystrophic and degenerative diseases (Parkinson’s disease, Alzheimer's disease, dementia in general), which are increasingly acquiring features of environmental conditioning and are introducing a significant contribution to premature aging and a reduction in life expectancy (25, 29, 42).

Aging is a complex biological process that reflects the development of the body over time, combining both regressive and progressive (the acquisition of new adaptive mechanisms) trends at the genetic, molecular, cellular, organ and systemic levels, which is increasingly becoming the subject of many medical and social studies (12, 26, 37, 40). Assessing the degree of aging or the level of vitality of an organism and its elements is one of the most urgent tasks of preventive medicine, in particular gerontology. Assessment of aging is currently becoming more and more widespread with the help of the “biological age” (BV) indicator, which objectively reflects the state of the body and the general health of the body, which is necessary to develop and increase the effectiveness of measures to slow down the aging rate and prolong active aging (2, 13, 16 , 17).

The problem of biological age is the key to studying the effect of time on changes in the body at all stages of individual development from birth to death. BV is also called the age of development, the processes of which are limited or activated under the influence of a wide range of exogenous environmental factors and are kept within the normal range by endogenous regulatory mechanisms. The indicator of BV is worsened by increased body weight, a reduced index of physical activity, smoking, and alcohol abuse (3, 24, 27). The causes of premature aging are immune disorders (26, 42, 44). Inhibition of nonspecific protection, immunity, and pronounced humoral and cellular autoimmune shifts were found. The accelerated rate of aging is interconnected with neurotic and somatic manifestations, the combined action of radiation in the professional activity and factors of non-radiation nature - significant psychological and physical stress (3, 13, 14, 43). Thus, it was established that the average biological age of the Kuzbass miners exceeds the due biological age by 6 years (with an average work experience of 14.2 years) and exceeds their calendar age by more than 10 years (43). That is, the aging of miners is more pronounced in comparison with the population standard of aging and should find its solution in priority treatment and preventive measures to increase the level of vitality and overall health of the miners' body, increase their professional longevity (43).

Among the many competing theories of aging, each of which gives only a part of the overall picture, deserve attention, first of all, from the perspective of a possible correction, the mechanisms of cell aging, which are determined by the impossibility of division, a decrease in the "working capacity" of cells with age or a limited number of their divisions (26, 37 , 42). In this case, intracellular debris accumulates in the body, and biological debris interferes with the normal functioning of cells. Free radicals are one of the main factors causing molecular damage in living cells, exacerbating the body’s “slagging” of biological debris. The immune theory of aging reveals the relationship of physiological apoptosis (programmed cell death) with an adequate immune response, the role of a special subpopulation of T-lymphocytes in maintaining the level of cell growth in the body, and the importance of reducing its function for aging (26). The impact of an aggressive environment (anthropogenic factors, pressure on the uncontrolled growth of viral and parasitic diseases) can trigger pathological apoptosis and premature aging of the body, closing the vicious circle of morphological, functional and metabolic changes.

Thus, aging is a complex process of restructuring and adapting the body to the conditions of its existence changing over time, therefore it is regulated and controlled (1, 12, 26, 40).

Summarizing the mechanisms and stages of the development of ecologically driven progeria (accelerated aging): "environmental pollution - pollution of the internal environment - environmentally related increase in morbidity - accelerated aging syndrome - reduction in life expectancy" (25) as an integral solution to increase the duration of active life, rejuvenate the body by the basis of the correction of the biological age of the individual can be a deep physiological cleansing of endoecological clogging, "environmental dirt "(V.P. Kaznacheev) using unique natural factors and innovative technologies (29, 30).

Known methods for reducing biological age (rejuvenation of the body), prevention of aging, according to which: 1. To reduce the biological age (rejuvenation of the body), the immunotropic drug "Transfer factor" is used, obtained from colostrum and restores a number of indicators of immunity, reduced as a result of various reasons (Dontsov V.I., Krutko V.N., Chizhov A.Ya. RU 2404784 C2; 11/27/2010). The drug is used in foreign practice for therapeutic purposes in various diseases with immunodeficiency, not directly related to the aging process. The possibility of its influence on aging is associated with the developed theory of regulation of somatic tissue growth by special subpopulations of T-lymphocytes (V.I. Dontsov, V.N. Krutko, A.A. Podkolzin. Fundamental mechanisms of geroprophylaxis. M .: Bioinformservice. 2002. 414 p. .) and with the notion that this mechanism is central to the aging of the whole organism and many tissues (26).

2. The method of preventing aging, which consists in the fact that the body is exposed to an electromagnetic field with a varying magnetic flux density depending on the mass of the selected targets responsible for the aging of the body, in the range from 106 to 1020 G for a given time, followed by a repetition of effects until the result, manifested in noticeable changes in the body (application No. 96124379/14, 05.25.1995).

3. Slowing down premature aging is achieved (Abdrashitova AT, Belolapenko IA, Frenkel MV, RU 2465905 C2; 10.11.2012) by the fact that a cross is prescribed - a lipid-lowering drug that lowers LDL cholesterol, also significantly increases HDL cholesterol and slows the progression of the atherosclerotic process, the main cause of cardiovascular disease. Possessing an immunotropic effect, it suppresses the increased activity of physiological activators of apoptosis - pro-inflammatory cytokines. As a result, the start of the apoptosis inducer, p53 protein, is blocked and the activity of apoptosis, which plays a leading role in the development of the premature aging of the body, is reduced (1).

4. There is a comprehensive method for reducing pathologically increased biological age (patent RU 2332207, 08/27/2008 - prototype), which consists in the fact that for a long period of time an individually selected hypocaloric diet is prescribed, rationally dosed static and dynamic physical activities, metformin is administered in a dose 500 mg 2 times a day after meals, Essential Forte 2 capsules 3 times a day, tocopherol acetate 0.1 g 2 times a day and activated charcoal 1 tablet per 10 kg of weight per night. This complex, according to the developers, makes it possible to bring the biological and chronological ages within two months into account due to the normalization of DNA repair and fragility of chromosomes.

Analyzing the known methods for reducing the biological age and preventing premature aging, it should be noted that they have a selective narrow focus on any one of the aging mechanisms (apoptosis, immune response, electromagnetic effects on the target organs of aging) without taking into account the whole variety of the complex biological aging process and factors that influence on indicators of "biological age" - the degree of true aging. Treatment with an electromagnetic field has a number of contraindications for its use.

The objective of the present invention was to develop a method for correcting the biological age of the body as a prevention of premature aging at the spa stage based on an integrated approach to eliminating disorders that develop during the life of the body, improving individual health, rejuvenation, improving the quality of life, ensuring professional longevity of a person. The originality of the innovation complex lies in the prolonged and mutually reinforcing action of each of its components based on a balanced combination of patented techniques (4, 5, 6, 7, 8, 9, 10, 11), which allows to reduce the recovery time of the body's homeostasis.

The proposed method ensures the achievement of the following technical result: correction of the biological age of the body as a prevention of premature aging at the spa stage due to: elimination of toxins, allergens, release from helminths, lowering cholesterol and glucose, uric acid, and restoration of the immune status. In addition, the use of the developed complex ensures the normalization of hemodynamics of blood flow, the functional activity of the cerebral cortex, as well as the activity of higher autonomic centers, improves the elasticity of the vascular wall, and normalizes muscle tone.

The impact of the diverse endogenous or exogenous factors underlying the development of pathologies has a common basis - a violation of informational relationships, processes at the cellular level.

Discovering and studying the amazing effects of restoration, regeneration and normalization of functions not only of affected organs in certain diseases, but also of the general condition in the resort of Belokurikha V.P. Kaznacheev wrote: “This is a universal general biological action, the basic influence of the resort's water on regulatory information systems, cellular, intercellular structures. Treatment normalizes homeostasis systems, restores the vital cycle, the person’s vitality so that the defects that we characterize as separate diseases disappear, recover, have a positive long-term prognosis. In the Belokurikha resort, new prospects are opening up for further use of resort factors for the treatment of such common and serious diseases as atherosclerosis, amyotrophic lateral sclerosis, multiple sclerosis, dystrophic changes in cortical neurons (Alzheimer's syndrome), some forms of parkinsonism, and other so-called diseases of civilization. Probably a whole series of mild hereditary defects, which under normal conditions are not sufficiently restored in the Belokurikha resort due to the activation of the bioinformation system, may have positive treatment prospects ”(29, 30).

The method is as follows.

Conduct a comprehensive treatment, including the use of the following methods:

1. Detoxification of the body, correction of the parameters of homeostasis, functional disorders and intestinal microbiocenosis through the procedure "Intestinal lavage".

The necessary full-fledged cleansing of all body systems is provided by the technology of intestinal lavage developed at the Scientific Research Institute of the Joint Venture. N.V. Sklifosovsky (36). A non-invasive method removes toxins, allergens, congestive bile, cleanses blood, lymph, intestines, lowers cholesterol and glucose levels (developed by a group of scientists and authors: candidate of medical sciences Matkevich V.A., doctor of medical sciences Mashkov O. A., Doctor of Engineering Leonov B.I.). In the process of intestinal lavage, the work of the bile excretion system, intestines, and the state of its microbiocenosis improves. The processes of restoration of protective functions are included, all types of exchanges are normalized: carbohydrate, fat, protein, mineral, development is stopped and the threat of chronic diseases is eliminated. A combination of intestinal lavage and highly effective innovative technology of underwater hydrodynamic massage (PHM), for the first time in natural water, helps to increase the effectiveness of detoxification. This allows you to increase the therapeutic effect of water, to ensure the flow, overcoming the protective barriers of the skin, any of its components, especially its healing natural factors. This technology (PGM) increases the yield of toxic products, the functions of all internal organs are powerfully stimulated, the microcirculation of body fluids — blood, lymph and interstitial fluid — is enhanced, the walls of blood vessels are strengthened, and their elasticity is restored. Peripheral circulation improves, blood flow accelerates, muscle tone normalizes, scar tissue changes decrease, and the functions of the musculoskeletal system are restored for diseases of the back and joints. The skin's resistance to negative environmental influences is increased, its water-lipid balance is restored, collagen production is activated, peeling, scrubbing, lifting and barophoresis effects are provided in one procedure, stimulating renewal processes, reducing excess weight - from the general cosmetic effect to the healing effect on the whole body.

2. Sound therapy (procedures according to the program of resonant-acoustic vibrations (PRAC), reconstructive sound resonance therapy using resonators (a musical self-sounding instrument made in the form of a cup and called - singing cups)), which ensures the normalization of the functional state of the body.

One of the types of PRAC sound therapy - resonance-acoustic vibration programs (PRAC) - a method of bioresonance effects on organs and systems, provides directed remote (non-contact) and non-drug restorative effects on the patient's body, depending on the diseases he has. The PRAC methodology was approved by the Ministry of Health and Social Development of the Russian Federation (Commission Resolution on New Medical Technology of the Ministry of Health of the Russian Federation of October 9, 2002, protocol No. 3; registration certificate N229 / 03031002 / 4633-02 of December 26, 2002).

Resonance-acoustic vibration programs (PRAC) are selected by forming music audio sequences for music therapy (4), restore the body’s bio-potential, introduce it into self-regulation mode, which relieves tension, fear, motivates the feeling of emotional well-being, instills confidence in the success of treatment, restores its harmony internal environment and with the outside world, contributes to spiritualization, rejuvenation and active longevity.

Another method of sound therapy that we use in the complex is sound resonance therapy using resonators (singing bowls). The therapeutic effect of the complex is based on the principle that components of the acoustic field produced by a multilayer acoustic resonator interact with the patient’s body. As a result of this effect, the general tone of the body increases, destructive emotions, habits, programs and attitudes are eliminated. This harmonizing practice allows you to quickly relax and free yourself from blocks and clamps, from the hustle and bustle of thoughts, contributes to the equilibrium state of the right and left hemispheres. At an emotional level, relaxation occurs, peace comes, harmonization, this is an excellent anti-stress agent. Sound therapy, like a tuning fork, allows you to “properly” tune each organ, restore its harmonious functioning, is a necessary “tuner” that increases the effectiveness of each procedure (23).

3. Balneotherapy: the natural aquatic environment of Altai with unique phenomena: potentiation of three different components in the composition of the water: radon, nitrogen and silicic acid; rejuvenation when changing the individual ratio of ¹² C and ¹³ C isotopes in human tissues in the direction of ¹³ C, which characterizes the state of a young organism, and restoration of immunity (29). At the Institute of Theoretical and Experimental Biophysics (Balakin V.E., 2000) it was experimentally proved that the memory of the primary exposure, a kind of “vaccination” against radiation, lasts almost all of life. In this aspect, the effect of radon therapy can be the same “vaccination” against radiation, and based on the cross-adaptive response, it can also increase the resistance of cells to chemical mutagens, which is extremely important for prevention and recovery - the effect of d-radiation (29) in the production environment of a radiation environment (mining, processing industries, coal industry, chemical plants, X-rays, etc.).

The use of radon water (ingestion, bath, hydromassage) in the proposed method is due to the fact that under the influence of radon and its decay products, the functional activity of the cerebral cortex, the activity of higher autonomic centers are normalized: patients quickly recover sleep, irritability, headaches, dizziness decrease , noise in the head, mood improves. The hemodynamics of coronary and cerebral blood flow, lipid metabolism (cholesterol, lipoproteins, etc.), capillary permeability, nitrogen and nucleic exchanges, hormonal levels are normalized, blood anticoagulant activity is increased, fibrinolysis activity is increased, the body’s immunological reactivity, its 30 )

Radon-carrying water, taken internally, provides a significant penetration of radon into the blood (29), has a beneficial effect on the course of a number of physiological processes: the secretory and motor functions of the stomach increase, lipid metabolism improves, the carbohydrate function of the liver changes, etc. This water is a biologically active silicon supplier. in an accessible form, making up for the existing deficit of this main element of life, with a lack of which the metabolic balance is disturbed in the human body (29, 41).

The introduction of (the Altai Castle Sanatorium) innovative technology of underwater hydrodynamic massage (PHM), which is the first in a natural aquatic environment that provides its medicinal natural components to the body, enhances the therapeutic effect of radon-containing mineral thermal waters of the Belokurikha deposit. Acting (non-traumatic) on the entire surface of the body, including the head, face skin, it accelerates cellular metabolism, increases the skin's resistance to negative environmental influences, restores its water-lipid balance, strengthening the first line of immune defense.

It is worth noting that the specific used mineral radon water has an undeniable effect on the achieved result. Optimal from the point of view of penetration into the body of radon and its decay products is water with a natural temperature of about 38 ° C. It is known that when heated, radon escapes from water. At the same time, it is from warm water that a greater amount of radon enters the body than from cool water. In this connection, we used unheated radon water during the procedures, with a natural water temperature of about 38 ° C.

Water with such a characteristic can be obtained, in particular, in the resort of Belokurikha, in the sanatorium "Altai Castle". Water in the treatment rooms of the sanatorium comes from well No. 4E of the Belokurikhinsky field. The water temperature in the well + 42 ° C at an air temperature of + 15 ° C. The concentration of radon is 5.5-6.0 nKu / dm ³ . It is known that the concentration of radon undergoes drastic changes during its transportation from the source to the treatment room. So, for example, passing through pipelines, radon losses can be 65% or more. In this connection, in order to maintain the concentration of radon, and therefore, to achieve the maximum efficiency of the procedures, it is advisable to take radon therapy procedures at a minimum distance from the well from which the radon water is taken. At such a distance is the sanatorium "Altai Castle".

4. Deworming - among the many reasons that affect the state of health of a modern person, 4th place is occupied by diseases caused by parasitic worms - helminths. About 300 species of parasitic worms find refuge in the human body. One of the components of the claimed method is the patented (10) highly effective comprehensive antiparasitic program that provides the release of the body (deworming) from all types of parasites (helminths). High-tech deworming includes the use of universal natural anthelmintics (33) and a rehabilitation complex, also aimed at restoring a full-fledged immune response.

Complex deworming reflects the unique balance of the proposed method, using the therapeutic components of Belokurikha water, primarily silicon. In the body, silicon creates colloidal structures that work like a magnet with respect to the antigen-antibody complex and various pathogens (microorganisms, parasites). At the same time, typical inhabitants of the intestine, such as E. coli, lactic acid bacteria, do not possess the ability to “stick together” with silicon colloidal systems and remain in the intestine (41). The selective ability of colloidal forms of silicon (silicic acid) to “stick” viruses and other pathogens onto itself, and, in fact, neutralize and destroy them, puts it in the category of extremely important and necessary components for maintaining a person’s health and youth. It is this silicon, transported by water from the bowels of Altai in a biologically accessible form, that acts as a cleaner of organs and systems and is an important component of the patented innovative antiparasitic program and technology for deep cleansing of the body.

After deworming, the rehabilitation complex includes a natural immunotropic product, the effects of which are the basis of the invention, “Method for reducing the biological age (body rejuvenation)” (RU 2404784 C2, 11/27/2010) and compensates for the effects on the immune mechanisms of aging from the perspective of immunorehabilitation.

5. Immunorehabilitation based on an immunomodulator of natural origin (8, 22).

6. Diet therapy based on elements of separate nutrition, taking into account the blood groups of patients and physiologically sound drinking regimen (water intake at a rate of 30 ml per kg / weight per day).

The method is as follows.

Against the background of diet therapy, complex treatment is carried out, consisting of taking:

- shared baths with radon water and underwater hydrodynamic massage (PGM) performed using radon water (moreover, on the days when intestinal lavage procedures are performed, only bath procedures are taken that are taken in the morning before lavage, on the remaining days - in the morning - PGM, in the second half - bath)

- every other day of sound therapy sessions (moreover, these sessions are carried out on days when intestinal lavage procedures are not carried out, and the sessions are carried out after PGM),

- after a day of intestinal lavage procedures,

- daily anthelmintic of plant origin and immunomodulator, each of which is washed down with a glass of radon water.

Since the essence of aging is a decrease in overall vitality, i.e. resistance to a variety of external influences, the meaning of determining the biological age (BV) is to determine the degree of decrease in overall viability. Domestic and foreign researchers have proposed different methods for determining BV, which include multiple groups of tests of varying degrees of complexity, reflecting age-related physiology, age-related chronic pathology, limits of adaptation and functional reserves, physical and neuropsychic performance, tests to characterize the most important systems, their own self-esteem of health et al. (2, 17, 18, 31, 33, 38).

We determined the indicators of BV during a comparative assessment of the effectiveness of the claimed method for correcting the biological age of the body as a prevention of premature aging at the spa stage (main group) and the known method (prototype) of exposure (comparison group). The determination of BV was carried out according to the "Kiev" method of Chebotarev D.F. (1, 14, 40). It is known that aging is considered premature if the aging rate is the difference between biological (BV) and due biological age (DBV)> 0, physiological with BV-DBV = 0. Potential long-livers BV-DBV <0. A group of tests characterizing changes in regulation during aging of the organism is essential for determining BV. These, in particular, include the characteristic of mental (SD) and physical performance (RF) of a person (Table 1, 2).

Table 1 Assessment of the influence of the studied methods on the degree of aging of the central nervous system Correction Methods BW on SD, srvc. Years, shift indicator after correction I - the proposed method (n = 27) - 2,848 ± 0,329 *** II - prototype (n = 25) - 1.938 ± 0.416 * Note: * - p <0.05; ** - p <0.01; *** - p <0.001 - the reliability of the indicator shift in relation to the initial level.

An analysis of the state of mental productivity before and after therapy showed a statistically significant shift in the BV index in people who received the complex of the proposed method in comparison with the initial level and results in the comparison group. At the same time, in persons who received a placebo, significant changes in this indicator were not detected.

table 2 Assessment of the influence of the studied methods on the degree of aging of the cardiovascular system Correction Methods BV for FR, srvc. years, indicator shift after correction I - the proposed method (n = 27) - 1,999 ± 0,112 ** II - prototype (n = 25) - 1.217 ± 0.077 * Note: * - p <0.05; ** - p <0,01 - the reliability of the indicator shift in relation to the initial level.

The results obtained showed a statistically significant effect of the studied methods on the indicators of BV. Significantly the most pronounced effect was achieved in the main group.

The SF-36 questionnaire is one of the currently most used questionnaires for assessing the quality of life (21). The presented results of a comparative assessment of the indicators of each scale (Table 3) also allow us to conclude that the claimed method is more effective for correcting BV at the spa stage.

Table 3

Quality of life in patients of the main group and the comparison group after the course of treatment according to the questionnaire SF-36 $$(\overline{X}\pm m)$$

Scales SF-36 Healthy (n = 45) The main group (n = 27) Comparison Group (n = 25) Gh 74.84 ± 2.12 72.23 ± 1.90 ^^ 54.35 ± 1.52 ^^ Pf 91.82 ± 1.15 83.53 ± 2.25 ^^ 62.74 ± 1.26 ^^ RP 81.31 ± 4.05 72.94 ± 2.31 ^^ 55.43 ± 2.45 ^^ RE 54.24 ± 4.18 49.12 ± 3.16 43.13 ± 1.54 ^ SF 85.32 ± 1.17 72.35 ± 2.26 ^^ 61.67 ± 3.02 ^^ BP 82.82 ± 2.69 78.65 ± 3.05 ^^ 51.92 ± 3.24 ^^ VT 69.31 ± 1.94 63.35 ± 2.61 ^ 46.28 ± 2.07 ^ MN 82.52 ± 1.95 65.82 ± 2.14 ^ 58.91 ± 2.54 ^ Note: ^ (p <0.05), ^^ (p <0.001) - significance in patients of the main group, the comparison group with the control group of healthy individuals.

Attention is drawn to a significantly significant difference in the viability index (VT) in the compared groups. In the main group, indicators indicate a sense of vivacity and fullness of strength among respondents, in the comparison group (prototype) - a slight decrease in vital activity.

In addition, we investigated the effect of the developed complex on microcirculation indicators (Table 4). As you know, the basic point of the aging process of any organ is a violation of microcirculation.

Table 4 Dynamics of microcirculation in the thigh area before and after the course of hydromassage according to LDF (M ± m) Indicator, norm Using the complex of the prototype Using the developed complex M bases 6.20 ± 0.11 6.18 ± 0.11 6.65 ± 0.10PE 6.54 ± 0.12 ** 6.60 ± 0.12 ** Kv 8.21 ± 0.61 8.16 ± 0.64 11.43 ± 0.51% 10.40 ± 0.72 * 10.67 ± 0.61 ** TM max. 19.51 ± 1.35 19.27 ± 1.29 23.11 ± 1.19PE 22.66 ± 1.42 * 22.57 ± 1.36 * RKK, thermal test. 210.34 ± 4.83 210.18 ± 4.30 248.61 ± 13.01% 239.03 ± 5.20 ** 244.85 ± 4.75 ** Note: in the numerator - indicators before the massage course, in the denominator - after the massage course; one (*) or two (**) asterisks indicate the significance of differences by the paired t-test for repeated measurements at p <0.05 and p <0.001, respectively. Abbreviations: TM max. - the level of maximum perfusion during thermal testing, RKK - reserve capillary blood flow, Kv - coefficient of variation

According to the data obtained (table 4), people who received treatment with the complex developed by us had significantly better dynamics of microcirculation indicators than people who received treatment according to the prototype.

Thus, the obtained versatile data indicate significantly higher treatment effects by the claimed method (main group), compared with the results of the comparison group (prototype).

Clinical example 1.

Patient N., born in 1960 Diagnosis: metabolic syndrome. Obesity II tbsp. Allergic dermatitis. Asthenic syndrome.

Complaints: episodes of the appearance of a nodular rash on the upper third of the chest and back, increased blood pressure, a feeling of heaviness in the right hypochondrium, nausea in the morning, tendency to constipation, poor sleep, irritability.

Medical history: considers himself ill for 5 years. He was treated by a gastroenterologist, cardiologist, endocrinologist without a stable effect. At the insistence of his wife in the sanatorium "Altai Castle" was treated according to the claimed method. Pharmacotherapy was not used in the treatment.

During the examination, eggs Op. felineus.

Biological age (BV) 64.6 years, due biological age (DBV) 51.3 years, the rate of aging (BV-DBV) is 13.3 years.

A course of treatment was carried out, according to the developed methodology (the course was 15 days).

After the course, the patient's condition improved significantly: blood pressure stabilized, weight decreased (by 10%), cholesterol levels (from 7.2 to - 5.6 mmol / l) and glucose (from 6.3 to 5.2 mmol / l ) Test results (questionnaire SF-36) showed an increase in the quality of life. Weakness disappeared, the patient became more active, emotionally balanced. After the 10th day, the discomfort in the right hypochondrium completely disappeared, the skin condition improved.

At the end of the recovery course, the patient was given recommendations on diet, prevention of reinfection, and a healthy lifestyle.

Biological age (BV) 60.2 years, due biological age (DBV) 51.3 years, the rate of aging (BV-DBV) is 8.9 years.

A follow-up examination after 3 months did not reveal Op. felineus. Biological age (BV) is 59.8 years, the rate of aging (BV-DBV) is 8.5 years.

Clinical example 2.

Patient S., born in 1962 Diagnosis: Primary gout. Arterial hypertension 2 tbsp. Progressive alimentary-constitutional obesity 1 tbsp.abdominal type.

Complaints: episodes of sharp pain in the metatarsophalangeal joint of the big toe of the right foot with swelling and redness of the skin, decreased physical activity, poor sleep, increased blood pressure, shortness of breath, irritability.

Medical history: considers himself ill for 7 years. It is observed by a rheumatologist, cardiologist, endocrinologist without a stable effect.

Biochemical analysis of blood: glucose 6.7 mm / l, ACT 14 IU / l, ALT 24 IU / l, creatinine 0.09 mmol / l, urea 5.1 mmol / l, cholesterol 6.92 mmol / l, uric acid 578.80 mM / L.

Biological age (BV) 59.86 years, due biological age (DBV) 50.01 years, the rate of aging (BV-DBV) is 9.85 years.

He was treated according to the claimed method, the course was 18 days.

After the course, the patient's condition improved significantly: blood pressure stabilized, weight decreased (by 10%), cholesterol levels (from 6.92 to 4.95 mmol / L), glucose (from 6.7 to 5.0 mmol / L) uric acid (from 578.80 to 398, 75 mM / L). Shortness of breath disappeared, the patient became more active, emotionally balanced, normalized sleep. Test results (questionnaire SF-36) showed an increase in the quality of life.

Biological age (BV) 55.86 years, due biological age (DBV) 50.01 years, the rate of aging (BV-DBV) is 5.85 years.

Observation over the next period (repeated recovery according to the claimed method after 8 months - taking the course of treatment developed by us for 15 days) showed the preservation of the quality of life, persistent remission of gouty arthritis.

Biological age (BV) 53.7 years, due biological age (DBV) 50.01 years, the rate of aging (BV-DBV) is 3.69 years.

Bibliography

1. Abdrashitova A.T. A method of slowing premature aging in employees of a gas producer. RU 2465905 C2, 11/10/2012.

2. Abramovich S.G. and others. A method for determining the biological age of a person. Siberian medical journal. 2008. No. 1. S.46-48.

3. Alkhutova N.A. et al. Analysis of biological age and reasons for accelerating the pace of aging of participants in the liquidation of the consequences of the Chernobyl accident. Medical radiology and radiation safety. 2007. V. 52, No. 5. S.26-35.

4. Anisimov B.N. A method of forming music audio sequences for music therapy. RU 2408397, 01/10/2011.

5. Anisimov B.N. The method of complex treatment of patients with obesity I-II degree at the spa stage. RU 2458671, 08.20.2012.

6. Anisimov B.N. A method of rehabilitation treatment of women with inflammatory diseases of the pelvic organs at the spa stage. RU 2458670, 08.20.2012.

7. Anisimov B.N. A method for the comprehensive treatment of dysbiosis at the spa stage. RU 2460508, 09/10/2012.

8. Anisimov B.N. The method of complex immunorehabilitation for the restoration and preservation of health. RU 2462223, 09.27.2012.

9. Anisimov B.N. A method for the comprehensive treatment of patients with chronic gout at the spa stage. RU 2465884, 11/10/2012.

10. Anisimov B.N. A method for the complex treatment of patients with parasitic diseases. RU 2491936, 09/10/2013.

11. Anisimov B.N. A method for preventing the development and progression of Alzheimer's disease at the spa stage. RU 2496465, 10.27.2013.

12. Akhaladze N.G. and others. The relationship of some forms of chronic pathology and biological age. Problems of aging and longevity. 2009. Vol. 18, No. 2. S.187-199.

13.Balbert A.A. et al. Issues of accelerated general and cerebral aging of veterans of modern armed conflicts. Clinical Gerontology. 2009. V.15, No. 8-9, S.115.

14. Bashkireva A.S. The influence of biological age on professional performance. Message II. Biological age and physical performance. Human physiology. 2002. Vol. 28, No. 5. S.92-102.

15. Bashkireva A.S. Demographic and occupational risks of depopulation of the working population in Russia. The success of gerontology. 2010. Vol. 23, No. 1. S.30-39.

16. Belozerova L.M. et al. Method for determining biological age by spirography. Clinical Gerontology. 2006. V. 12, No. 3. S.53-56.

17. Belozerova L.M. The method of determining the psychological age according to the Kettell test. Gerontology and geriatrics. 2005. Issue 4. S.96-98.

18. Belozerova L.M. Determination of biological age by blood test. Clinical Gerontology. 2006. V. 12, No. 3. S.50-52.

19. Belozerova L.M. Determination of biological age by echocardiography. The success of gerontology. 2006. Issue 19. S.90-92.

20. Bershtein L.L. and others. Elderly age as a risk factor for the development of heart failure after acute myocardial infarction. The success of gerontology. 2008. Vol. 21, No. 2. S.265-269.

21.Brimkulov N.N. et al. Application of the SF-36 questionnaire for assessing the quality of life. Central Asian Medical Journal, 1998. No. 4-5. S.236-241.

22. Vorobyov A.A. and others. Immunorehabilitation in infectious-inflammatory and somatic diseases using transfer factors. Methodical letter of the Ministry of Health and Social Development of the Russian Federation. Moscow. 2004.32 p.

23. Khalfin R.A., Leonov B.I., Mashkov O.A., Rybkin E.A. Restoring the psychosomatic state of a person by the method of exposure to resonant-acoustic vibration programs (PRAC). A manual for doctors of the Ministry of Health and Social Development of the Russian Federation. Moscow. 2004.9 p.

24. Guzova A. V. Quality of life and indicators of the biological age of elderly people with alcohol dependence syndrome: medical and social aspects: author. dis. Cand. honey. sciences. SPb., 2010.23 s.

25. Gichev Yu.P. Biological aspects of the ecological condition of premature aging (population progeria) and reduction in life expectancy of the population of Russia. Human ecology. 2004. No. 6. S.29-33.

26. Dontsov V.I. and others. A method of reducing biological age (rejuvenation of the body). RU 2404784 C2, 11.27.2010.

27. Dubtsova E.A. Honey, its composition, properties and influence on biological age. Clinical gerontology. 2008. No. 1. S.38-41.

28. Zabolotnykh I.I. and others. Disability of elderly patients with arterial hypertension. The success of gerontology. 2009. Vol. 22, No. 3. S.496-498.

29. Kaznacheev V.P., Chernyavsky E.F. Resort Belokurikha. Novosibirsk: Publishing House of the SB RAS, 2011.204 p.

30. Kaznacheev V.P., Efendiev B.A. Problems of general balneology and its prospects in the 21st century (results, prospects, forecasts of Belokurikha resort). Belokurikha, 2000.24 p.

31. Karnaukhova E.V., Karnaukhov A.V. Determining the biological age of a person based on the parameters of the rhythmic activity of the heart. Human physiology. 2004. V. 30, No. 4. S.81-90.

32. Kishkun A.A. Biological age and aging: the possibilities of determining and ways of correction: hand-in for doctors. M., 2008.976 s.

33. Krasnov E.A. and others. Sausifol is a new antiparasitic phytopreparation. Actual problems of infectology and parasitology: Mat. First International Anniversary Conf. Tomsk, 2001. P.93.

34. Makovsky R.D. Public health and the environment of the region. Human ecology. 2006. No. 12. S.9-11.

35. Medvedev N.V., Gorshunova N.K. The value of determining biological age in assessing the body's adaptive reserves during aging. The successes of modern science. 2007. No. 12. S.148-149.

36. Khalfin R.A., Leonov B.I., Mashkov O.A., Matkevich V.A., Rybkin E.A. The method of detoxifying the body and correcting the parameters of homeostasis, functional disorders and intestinal microbiocenosis using intestinal lavage in combination with resonant-acoustic vibration programs (PRAC). A manual for doctors of the Ministry of Health and Social Development of the Russian Federation. Moscow. 2005.16 s.

37. Finger M.A. et al. Neuroimmunoendocrine mechanisms of aging. The success of gerontology. 2009. Vol. 22, No. 1. S.24-36.

38. Papayan G.V., Petrishchev N.N. A method for assessing the biological age of the skin using a fluorescent multispectral video dermatoscope. Optical Magazine. 2010. V.77, No.2. S.60-67.

39. Plakuev A.N. et al. Biological age in young people living in the European North. Human ecology. 2006. No. 11. S.17-20.

40. Ryabchikova T.V. and others. Comparison of passport and biological age. Clinical Gerontology. 2009. Vol. 15, No. 12. S.19-22.

41. Semenova N.A. Silicon is an element of life. Ecology and medicine. St. Petersburg: "Publishing house" DILA ", 2008. 448 p.

42. Khavinson V.Kh., Anisomov V.N. 35 years of research on peptide regulation of aging. The success of gerontology. 2009. No1. S.11-23.

43. Shpagina L.N. et al. Assessment of the biological age and rate of aging as an indicator of the health status of Kuzbass miners. FUNDAMENTAL RESEARCH. 2013. No. 7. S.666-669.

44. Anis L., Claudio F., Dawn M. Aging of the immune system as a prognostic factor for human longevity. Physiology. 2008. Vol. 23, N2. P.64.

Claims (3)

1. A method for correcting the biological age of the body, including complex treatment carried out against a background of diet therapy and consisting of daily intake of anthelmintics of plant origin and an immunomodulator, each of which is washed down with 200 ml of radon water; water procedures in radon water - shared baths and underwater hydrodynamic massage (PGM); intestinal lavage carried out every other day; sound therapy sessions that are carried out after PGM and on days without intestinal lavage; moreover, on the days when intestinal lavage procedures are performed, a bath with radon water is taken in the morning before lavage, PGM on the remaining days in the morning, and radon water baths in the second half. 2. The method according to claim 1, according to which the sessions of sound therapy consist in the application of procedures according to the program of resonant-acoustic vibrations (PRAC). 3. The method according to claim 1, according to which the sessions of sound therapy consist in the use of a musical self-sounding instrument made in the form of a bowl, referred to as a “singing bowl”.