RU2239404C1 - Method for preventing human body aging - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: hormonal modulation should be conducted due to doing physical exercises to overcome resistance and/or strengthen cardio-vascular system and/or improve flexibility, and, also, introduction of biologically active substances chosen out of the group consisting of arginine, ornithine and carnitine. Moreover, the mode of physical exercises and the dosages of the above-mentioned substances should be matched so to provide increased level of somatotropic hormone. The present innovation provides prophylaxis of aging processes in human body due to the impact upon different aging mechanisms with participation of hormones.

EFFECT: higher efficiency of prophylaxis.

3 cl, 3 ex

Description

The invention relates to medicine and can be used to prevent premature aging of the body by developing an individual anti-aging program.

Aging is a complex phenomenon of the whole organism, the result of the implementation of hereditary programs for its development and multidirectional changes throughout life.

From the point of view of modern ideas, the body is an extremely complex, self-governing and self-regulating system that restores its integrity during self-renewal processes and is in equilibrium with constantly changing environmental conditions - a fundamentally open system.

The principle of openness of the system (constant interaction with the environment surrounding the body) indicates that a decrease in the openness of the system (and this is the most characteristic sign of aging, manifested in a decrease in the adaptive capacity of the body over time) is sufficient for its degradation.

The lack and change of regulatory influences is the basis of aging for the skin, mucous membranes, internal organs, many types of tissues. For aging people, this is a leading factor. In this regard, it is necessary to maintain a sufficient level of tissue renewal, only slightly different from that which is formed by the end of puberty and growth of the body.

In many respects, aging indicators are determined by the hormonal profile - the level and ratio of those hormones that directly or indirectly control tissue renewal. A number of morphological and neurochemical changes in the suprachiasmal nuclei of the brain have been identified in the aging organism, partially responsible for the age-related decrease in blood levels of somatotropic hormone / insulin-like growth factor-I (STG / IGF-1) (somatopause), testosterone (andropause), estrogen and gestagens (menopause), dehydroepiandrosterone and its sulfate (adrenopause), melatonin and thyroid hormones. In an average man, these changes develop at about 50 years old. A concomitant increase in the concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is observed. The level of free biologically active testosterone is also reduced due to an increase in the content of sex hormone binding globulin. With an increase in life expectancy, its third part in both men and women can pass with some form of hormonal deficiency.

Research and treatment, for example, menopause, have long and widely been carried out in medicine. Recently, hormone replacement therapy of andropause has also become increasingly popular. It has also been known for a long time that an imbalance in thyroid status leads to results that accelerate aging. Research and practical application of knowledge about other types of age-related hormonal deficiency are at different levels; information on most types of this deficiency began to accumulate relatively recently.

A known method of treating diseases associated with aging of the body, using stimulants of secretion of growth hormone (STH) [US Patent No. 6313140, class. 514/303].

A known method of preventing aging of the body, in which use food additives that stimulate the synthesis of growth hormone [US Patent No. 6461634, class. 424/439].

There is a method of slowing the aging of an organism in men using male sex hormones [US Patent No. 6451782, cl. 514/182].

All of these methods are not effective enough, because they affect only one of the many aging mechanisms.

The closest in technical essence and the achieved result to the proposed one is a method for the prevention of aging of the human body, including the determination and dynamic control of biological age based on measuring a set of indicators for five biological systems: cardiovascular, respiratory, nervous, sensory, musculoskeletal, conducting a health course, including multivitamin preparations, special nutritional supplements, psychotherapeutic effects and physical exercises Niya [RF Patent No. 2166278, 06/27/2001]. The biological age in the known method is determined before the treatment and rehabilitation course and after it.

When determining the biological age, at least two indicators are determined that are characteristic of each of the five biological systems:

1) for cardiovascular: systolic blood pressure, diastolic blood pressure, pulse blood pressure, pulse wave velocity in muscle vessels, pulse wave velocity in elastic vessels, recovery time of heart rate in a step test, cholesterol level;

2) for the respiratory system, at least two indicators are determined from the list: Stange test (or Gencha test), chest excursion, lung capacity, forced expiratory volume in 1 s;

3) for the nervous system: the Wexler symbol-digital test, a test with Schulge tables (or proofreading test), the time of a simple visual-motor reaction, the time of a simple visual-motor reaction, the time of a complex visual-motor reaction, a short-term memory test;

4) for the sensory system: balance test, accommodation, hearing acuity at 4000 Hz (or the frequency threshold for sound perception);

5) for the musculoskeletal system: weight-bearing index, contraction force of the hands, torso angles of the body forward, sideways, backward, mobility test in the shoulder joints.

The known method is not effective enough, since it does not take into account changes in the metabolism associated with aging, that is, hormonal or biochemical parameters.

The objective of the present invention is to increase the effectiveness of the prevention of aging.

The problem is solved in that in the proposed method for the prevention of aging of the human body by determining and dynamically controlling the biological age based on measuring a set of indicators for the biological systems of the patient’s body and conducting a therapeutic course including a combination of drug and non-drug methods of influencing the body, when determining biological age determine the functional capabilities of the body, the level of activity of vital organs and g a hormonal profile, and during the treatment and rehabilitation course hormonal modulation is carried out, physical exercises that stimulate the endogenous synthesis of growth hormone are used as physical exercises, food additives with an individual composition of biologically active substances selected in accordance with indicators of biological systems of the body are used as food additives specific person (patient).

The problem is also solved by the fact that to correlate the importance of different indicators and calculate directly the biological age, expertly determined weight coefficients are used that lie within:

- the functionality of the body - from 0.8 to 1.3;

- hormonal profile - from 0.9 to 1.35;

- the level of activity of organs - from 0.9 to 1.7.

The problem is also solved by the fact that hormonal modulation is carried out to replenish the level of hormones, the content of which decreases with aging, such as growth hormone, adrenal steroids, sex hormones, thyroid hormones, melatonin, to physiological values characteristic of the age at which the content of these hormones as much as possible.

The problem is also solved by the fact that hormonal modulation is carried out by hormone replacement therapy and / or by stimulating the synthesis or secretion of a hormone lacking in the body.

The problem is also solved by the fact that food additives are additionally used as food additives, which include biologically active substances (BAA) that stimulate the endogenous synthesis of hormones, the level of which in the body decreases with age.

The problem is also solved by the fact that as biologically active substances that stimulate the endogenous synthesis of hormones, biologically active substances are used to stimulate the synthesis and secretion of growth hormone, for example arginine, ornithine, carnitine.

The problem is also solved by the use of food additives, which include biologically active substances with antioxidant properties, such as vitamins C, E, selenium, iron.

The problem is also solved by the fact that the material composition of individual food additives is based on determining the individual usefulness of biologically active substances. The individual usefulness of each biologically active substance is presented in the form of a utility indicator, which is calculated taking into account the system of coefficients for various dietary supplements determined by experts and parameters reflecting deviations from the normal functioning of the body.

The proposed method for the prevention of human aging is carried out by individual selection of anti-aging programs.

First, the biological age of the body is determined, taking into account the totality of all indicators of a physical, laboratory and instrumental examination that change with age, namely:

1. Functional (physiological) capabilities of the body:

- the power of visual accommodation;

- response time to auditory and visual stimuli;

- coordination of movements;

- short-term memory;

- vibration sensitivity;

- forced expiratory volume;

- muscle strength;

- maximum frequency of perceived sound.

2. Hormonal profile - the content in the blood / urine of the following hormones, the level of which is associated with age:

- growth hormone and proteins formed under its action (for example, insulin-like growth factor-I);

- thyroid-stimulating hormone;

- thyroxine and triiodothyronine;

- melatonin;

- parathyroid hormone;

- cortisol;

- precursors of the synthesis of sex hormones (dehydroepiandrosterone, pregnenolone, androstenedione);

- androgens;

- estrogens;

- gestagens.

3. The level of activity of vital internal organs (not related to the endocrine system), determined by the content in the blood / urine of the enzymes of these organs and other substances, the level of which depends on the work of these organs:

- liver (ALT, ACT, bilirubin, cholesterol);

- pancreas (lipase, amylase, insulin, glucagon);

- heart (CPK);

- kidneys (creatinine, urea);

- bones (osteocalcin, pyridinoline, deoxypyridinoline, b-Cross Laps).

Biological age is determined by the following formula:

where BV is the biological age;

(k _1i × a _1i ) - the sum of the products of the analyzed parameters determined during the examination;

k _f is the weight coefficient of the functional capabilities of the body;

k _h is the weight coefficient of the hormonal profile;

k _a - weight coefficient of internal organs.

To correlate the importance of different parameters and calculate directly biological age, weights are used:

body functionality - from 0.8 to 1.3;

hormonal profile - from 0.9 to 1.35;

the level of organ activity is from 0.9 to 1.7.

Weights are determined by expert judgment.

Then a treatment and health course is carried out, which is a combination of drug and non-drug methods of influencing the body, that is, a combination of hormonal modulation, taking special nutritional supplements and physical exercises.

The fundamental principle of hormonal modulation is to replenish the level of hormones, the content of which decreases with aging, to physiological values characteristic of the age of the maximum content of these hormones - approximately 35 years.

Treatment, as a rule, includes the appointment of hormone replacement therapy.

In those cases where there are real, from the point of view of modern medicine, possibilities to stimulate the synthesis or secretion of one or another hormone, this approach is also used.

An important component of the proposed method for the prevention of aging is the development of a special regime of physical activity that contributes to the correction of hormonal status and the elimination of some external signs of aging. Such a scheme of physical activity includes the following main types of exercises:

- exercises to overcome resistance (power);

- exercises to strengthen the cardiovascular system;

exercises to improve flexibility.

Each type of exercise has a positive effect on the body. The meaning of exposure to exercise as part of an anti-aging program is an increase in the level of growth hormone controlled by laboratory tests. A decrease in this level is responsible for many external manifestations of aging: the amount of adipose tissue, muscle mass, skin elasticity, working capacity, mental activity.

As a rule, a combination of exercises from all categories provides the most balanced program of physical activity and, accordingly, the best results, that is, an increase in the secretion of growth hormone.

The complex of the treatment course includes the use of a number of biologically active substances that can have a direct or indirect effect on the aging process of the human body. Supplements can be used for two main purposes:

- for targeted impact on the aging process at the cellular and organismic levels;

- to eliminate the adverse effects of environmental conditions that reduce the duration and quality of life.

In the course of treatment, individual nutritional supplements are prescribed in which the highest coefficients are received by the substances:

1) stimulating the synthesis of hormones, the level of which decreases with age, for example arginine, ornithine, carnitine - to stimulate the synthesis and secretion of growth hormone;

2) acting on the aging process by preventing oxidative damage to tissues - antioxidants (vitamins C, E, selenium, iron).

Individual nutritional supplements with biologically active substances that are most shown to a particular person are compiled. In this case, the individual usefulness of each biologically active substance is presented in the form of a utility indicator, which is calculated by a system of coefficients given to this substance, and parameters reflecting deviations from the normal functioning of the body.

In this case, special attention is paid to the hereditary history. All available information about the state of health of the patient’s closest relatives is taken into account in the analysis, which makes it possible to give the developed anti-aging complexes a preventive focus, especially in the absence of pronounced pathological manifestations.

When choosing and prescribing a specific complex of a health-improving course, specific goals formulated by the doctor together with the patient are taken into account, for example, a more active lifestyle, enhancing mental activity, improving skin condition, reducing the amount of adipose tissue in the body, improving sexual life, and strengthening immunity.

Each parameter taken into account corresponds to a specific list of biologically active substances with a certain coefficient reflecting the significance of this substance in the presence of this parameter in humans.

The calculation of the value of a substance, expressed as an indicator of utility, is used.

For example, when examining a patient revealed:

- frequent stresses,

- myopathy,

- hypercholesterolemia,

- a history of myocardial infarction in the mother.

The first item - frequent stresses - corresponds to the following substances with the coefficients attached to them:

- vitamin B1 (5),

- vitamin B6 (4),

- folic acid (5).

The second point - myopathies - correspond to:

- calcium (6),

- magnesium (5),

- vitamin B1 (4),

- vitamin B6 (4).

Hypercholesterolemia correspond to:

- cellulose (6),

- lecithin (6).

Myocardial infarction correspond to:

- lecithin (6) - the coefficient is multiplied by 0.3, because the symptom is not in the patient, but in the hereditary history - in the mother: 6 × 0.3 = 1.8,

- vitamin E (5) - 5 × 0.3 = 1.5,

- vitamin C (4) - 4 × 0.3 = 1.2.

By summing up, utility indicators of all the substances shown are calculated:

Vitamin B1 - 9 (5 + 4),

Vitamin B6 - 8 (4 + 4),

lecithin - 7.8 (6 + 1.8),

cellulose - 6,

calcium - 6,

folic acid - 5,

magnesium - 5,

vitamin E - 1.5,

Vitamin C - 1.2.

The threshold for the utility indicator is set to 5. (The use of such a threshold is necessary to avoid drug polypharmacy).

This means that the individual dietary supplement for this patient includes: vitamin B1, vitamin B6, lecithin, cellulose, calcium.

After the course of treatment, the biological age is re-determined by the described method.

The following are specific examples of the use of the proposed method.

EXAMPLE 1

Patient V.A., 56 years old.

Turned in connection with an increase in the amount of subcutaneous fat in the abdomen - one of the characteristic early signs of aging.

In laboratory studies, eosinophilia, a borderline decrease in the concentration of somatomedin C (an indicator of somatotropic status) and free testosterone, an abnormal oxidant-antioxidant profile (in particular, a decrease in the concentration of homocysteine) were detected.

Based on a comprehensive analysis of the survey data, examination and laboratory tests, the patient is recommended an anti-aging program containing the following complex of biologically active substances:

- growth hormone,

- testosterone gel,

- melatonin,

- vitamin E (antioxidant),

- selenium (antioxidant),

- arginine (in doses, as a stimulator of the secretion of growth hormone),

- lysine (a stimulator of secretion of growth hormone).

Individual recommendations on the correction of nutrition and physical activity are given (a combination of strength exercises and exercises to improve flexibility is prescribed).

After 6 months of taking an individual anti-aging complex. Repeated dual-energy X-ray absorptiometry revealed a decrease in the content of adipose tissue in the abdomen by 8%. Homocysteine levels decreased by 21%.

EXAMPLE 2

Patient V.P., 43 years old.

Complains of depressed mood over the past 2 years, fatigue, rapid appearance of fine wrinkles on the face.

Smokes for 25 years.

In laboratory studies, a moderate increase in the levels of LH and FSH, a decrease in the concentration of progesterone in the second phase of the cycle.

The developed anti-aging program, in addition to recommendations regarding lifestyle, included hormonal drugs:

- progesterone gel,

- dehydroepiandrosterone in tablets.

The following biomodulators are also recommended:

- vitamin C (antioxidant),

- Ornithine (in doses, as a stimulator of the secretion of growth hormone).

Recommended exercises to overcome resistance.

After 6 months of taking an individual anti-aging complex, the overall tone and working capacity significantly increased, fatigue decreased, facial wrinkles became less deep. The levels of hemoglobin and iron in the blood increased statistically significantly, the atherogenic coefficient decreased by 25%, the level of ionized calcium in the blood reached normal values.

EXAMPLE 3

Patient A. B., 54 years old.

Complaints of overweight, rapidly increasing after the onset of menopause, as well as the characteristic manifestations of menopause.

Up to 25 years old, she lived in an area with severe iodine deficiency, currently lives in Moscow.

During the examination, the sexual hormonal profile corresponds to the postmenopausal one. Increased blood cholesterol, low density lipoproteins, copper deficiency.

Ultrasound of the liver - signs of fatty hepatosis.

Hormone replacement therapy was prescribed from the following components:

- estradiol gel,

- progesterone gel,

- Growth hormone injection.

In addition, a complex is recommended that contains:

- selenium (antioxidant),

- carnitine (in doses to stimulate lipolysis, secretion of growth hormone and a protective effect on hepatocytes).

Assigned a set of exercises to strengthen the cardiovascular system. After 6 months of taking the individual anti-aging complex, there was a significant relief of the cardiac, vasomotor and urogenital symptoms of menopause, body weight decreased by 8 kg, blood cholesterol decreased by 12%, LDL cholesterol by 20%.

Upon repeated examination of biological age, all patients had a positive result (a decrease in biological age by 1-3 years).

Claims (4)

1. A method for the prevention of aging, which consists in providing hormonal modulation by conducting physical exercises to overcome resistance and / or to strengthen the cardiovascular system and / or improve the flexibility and administration of biologically active substances selected from the group consisting of arginine, ornithine and carnitine, while the regime of physical exercise and the dose of biologically active substances are selected in such a way as to provide an increase in the level of growth hormone. 2. The method according to claim 1, characterized in that it further conduct hormone replacement therapy. 3. The method according to claim 1, characterized in that they use food additives, which include these biologically active substances. 4. The method according to claims 1 to 3, characterized in that it additionally uses food additives, which include antioxidant substances.