RU2514318C2 - Ингалятор со звуковыми индикаторными средствами - Google Patents
Ингалятор со звуковыми индикаторными средствами Download PDFInfo
- Publication number
- RU2514318C2 RU2514318C2 RU2011113439/14A RU2011113439A RU2514318C2 RU 2514318 C2 RU2514318 C2 RU 2514318C2 RU 2011113439/14 A RU2011113439/14 A RU 2011113439/14A RU 2011113439 A RU2011113439 A RU 2011113439A RU 2514318 C2 RU2514318 C2 RU 2514318C2
- Authority
- RU
- Russia
- Prior art keywords
- inhaler
- opening mechanism
- latch
- locking device
- ethyl
- Prior art date
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- 230000007246 mechanism Effects 0.000 claims abstract description 180
- 238000009826 distribution Methods 0.000 claims abstract description 44
- 239000003814 drug Substances 0.000 claims abstract description 27
- 229940079593 drug Drugs 0.000 claims abstract description 24
- 230000000903 blocking effect Effects 0.000 claims abstract description 15
- 239000011888 foil Substances 0.000 claims description 81
- -1 4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl Chemical group 0.000 claims description 38
- 230000004913 activation Effects 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 26
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 7
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims description 6
- QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 5
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 5
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- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 4
- STTGOFBGRUQUOE-NDEPHWFRSA-N 2-[(4-chlorophenyl)methoxy]ethyl-[[2-[(r)-cyclohexyl-hydroxy-phenylmethyl]-1,3-oxazol-5-yl]methyl]-dimethylazanium Chemical compound C=1N=C([C@@](O)(C2CCCCC2)C=2C=CC=CC=2)OC=1C[N+](C)(C)CCOCC1=CC=C(Cl)C=C1 STTGOFBGRUQUOE-NDEPHWFRSA-N 0.000 claims description 4
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 4
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 4
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 4
- 229960005012 aclidinium bromide Drugs 0.000 claims description 4
- XLAKJQPTOJHYDR-QTQXQZBYSA-M aclidinium bromide Chemical compound [Br-].C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 XLAKJQPTOJHYDR-QTQXQZBYSA-M 0.000 claims description 4
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- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims description 3
- 229960001117 clenbuterol Drugs 0.000 claims description 3
- STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 claims description 3
- 229960000265 cromoglicic acid Drugs 0.000 claims description 3
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims description 3
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 3
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- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
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- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims description 3
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- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims description 3
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- WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 claims description 3
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- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 claims description 3
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims description 3
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Natural products CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 3
- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 claims description 2
- 229950004432 rofleponide Drugs 0.000 claims description 2
- RATSWNOMCHFQGJ-TUYNVFRMSA-N (e)-but-2-enedioic acid;n-[2-hydroxy-5-[(1s)-1-hydroxy-2-[[(2s)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;dihydrate Chemical compound O.O.OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 RATSWNOMCHFQGJ-TUYNVFRMSA-N 0.000 claims 2
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- FNYFFCOCVNTJCD-NNMXADRKSA-N [(3r)-1-[2-(4-fluorophenyl)ethyl]-1-azoniabicyclo[2.2.2]octan-3-yl] (2s)-2-phenyl-2-piperidin-1-ylpropanoate Chemical compound N1([C@](C)(C(=O)O[C@@H]2C3CC[N+](CC3)(CCC=3C=CC(F)=CC=3)C2)C=2C=CC=CC=2)CCCCC1 FNYFFCOCVNTJCD-NNMXADRKSA-N 0.000 claims 2
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Landscapes
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| US61/103,600 | 2008-10-08 | ||
| PCT/SE2009/051114 WO2010042036A1 (en) | 2008-10-08 | 2009-10-07 | Inhaler with audible indicator means |
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| US6082358A (en) | 1998-05-05 | 2000-07-04 | 1263152 Ontario Inc. | Indicating device for aerosol container |
| JP2011507593A (ja) | 2007-12-20 | 2011-03-10 | アストラゼネカ・アクチエボラーグ | 粉末８５４を脱凝集解体する装置ならびに方法 |
| ES2579902T3 (es) * | 2008-10-08 | 2016-08-17 | Astrazeneca Ab | Dispositivo de inhalación para administrar un medicamento |
| FR2944902B1 (fr) * | 2009-04-28 | 2011-12-30 | Valois Sas | Compteur pour dispositif de distribution de produit fluide ou pulverulent. |
| NZ597009A (en) | 2009-07-01 | 2014-05-30 | Astrazeneca Ab | Dispenser and method for entraining powder in an airflow |
| EP2595684B1 (en) * | 2010-07-21 | 2015-03-04 | AstraZeneca AB | Inhaler |
| GB201115874D0 (en) * | 2011-09-14 | 2011-10-26 | Astrazeneca Ab | Inhaler |
| JP5969051B2 (ja) * | 2012-01-23 | 2016-08-10 | サノフィ・ソシエテ・アノニム | 吸入デバイス用の用量カウント機構（Ｄｏｓｅ Ｃｏｕｎｔｉｎｇ Ｍｅｃｈａｎｉｓｍ）および吸入デバイス |
| US20150306322A9 (en) * | 2012-01-23 | 2015-10-29 | Sanofi Sa | Inhalation Device |
| GB201306709D0 (en) * | 2013-04-12 | 2013-05-29 | Clement Clarke Int Ltd | Training device |
| DE102014114462A1 (de) * | 2013-10-15 | 2015-04-16 | Alfred Von Schuckmann | Zählwerk und Handgerät mit Zählwerk |
| RU2664624C2 (ru) | 2014-03-25 | 2018-08-21 | Конинклейке Филипс Н.В. | Ингалятор с двумя микрофонами для обнаружения вдыхаемого потока |
| GB2538285B (en) * | 2015-05-14 | 2017-10-11 | Consort Medical Plc | A fluid delivery device with an auditory indicator |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996028202A1 (en) * | 1995-03-10 | 1996-09-19 | Weston Medical Limited | Spring-powered dispensing device |
| US6422236B1 (en) * | 2000-09-25 | 2002-07-23 | Microdrug Ag | Continuous dry powder inhaler |
| EP1386630A1 (en) * | 2002-07-31 | 2004-02-04 | CHIESI FARMACEUTICI S.p.A. | Powder inhaler |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL297349A (cg-RX-API-DMAC7.html) * | 1962-08-31 | |||
| FR2550452B1 (fr) * | 1982-10-08 | 1992-05-22 | Glaxo Group Ltd | Dispositif pour administrer des medicaments a des patients |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| GB9026191D0 (en) * | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
| US5217004A (en) * | 1990-12-13 | 1993-06-08 | Tenax Corporation | Inhalation actuated dispensing apparatus |
| US5284133A (en) * | 1992-07-23 | 1994-02-08 | Armstrong Pharmaceuticals, Inc. | Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means |
| FR2701399B1 (fr) * | 1993-02-16 | 1995-03-31 | Valois | Dispositif portatif de pulvérisation à actionnement déclenché par l'inhalation. |
| US5497763A (en) * | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
| CA2172537A1 (en) * | 1993-09-22 | 1995-03-30 | Gage Garby | Indicator device responsive to axial force |
| NL1008031C2 (nl) * | 1998-01-15 | 1999-07-21 | Pharmachemie Bv | Inrichting voor het inhaleren van medicament. |
| FI108518B (fi) * | 1999-04-23 | 2002-02-15 | Orion Yhtymae Oyj | Jauheinhalaattori yhdistelmälääkkeelle |
| AUPR020400A0 (en) * | 2000-09-19 | 2000-10-12 | Glaxo Wellcome Australia Ltd | Inhalation device |
| US20020189615A1 (en) * | 2001-06-13 | 2002-12-19 | Henry Adam S. | Inhaler with dose control |
| CA2460904C (en) * | 2001-09-19 | 2011-03-22 | Advent Pharmaceuticals Pty Ltd | An inhaler for delivering metered doses of powdered medicament |
| GB0201677D0 (en) * | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| GB0216831D0 (en) * | 2002-07-19 | 2002-08-28 | Glaxo Group Ltd | Medicament dispenser |
| US7621273B2 (en) * | 2003-10-28 | 2009-11-24 | Trudell Medical International | Indicating device with warning dosage indicator |
| BRPI0507714B8 (pt) * | 2004-02-16 | 2021-07-27 | Glaxo Group Ltd | contador de dose para uso com um dispensador de medicamento, e, dispensador de medicamento |
| WO2005110519A1 (en) * | 2004-05-17 | 2005-11-24 | Sun Pharmaceutical Industries Limited | Dry powder inhaler |
| SE0401654D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | A support structure for a medicament |
| GB0428169D0 (en) * | 2004-12-23 | 2005-01-26 | 3M Innovative Properties Co | Pressurized inhalation devices |
| US8226610B2 (en) * | 2005-02-01 | 2012-07-24 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
| GB0515584D0 (en) * | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
| DE102006023662A1 (de) * | 2006-05-18 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
| EP2142239B1 (en) * | 2007-04-30 | 2017-06-07 | Sun Pharma Advanced Research Company Limited | Inhalation device |
| EP1992375A1 (en) * | 2007-05-16 | 2008-11-19 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
| GB0719299D0 (en) * | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
-
2009
- 2009-10-07 BR BRPI0920671A patent/BRPI0920671A2/pt not_active IP Right Cessation
- 2009-10-07 WO PCT/SE2009/051114 patent/WO2010042036A1/en not_active Ceased
- 2009-10-07 NZ NZ591854A patent/NZ591854A/xx not_active IP Right Cessation
- 2009-10-07 CA CA2738739A patent/CA2738739A1/en not_active Abandoned
- 2009-10-07 MX MX2011003799A patent/MX2011003799A/es unknown
- 2009-10-07 US US13/123,105 patent/US20110253138A1/en not_active Abandoned
- 2009-10-07 KR KR1020117010401A patent/KR20110083651A/ko not_active Ceased
- 2009-10-07 CN CN200980139890.1A patent/CN102176939B/zh not_active Expired - Fee Related
- 2009-10-07 EP EP09819490.5A patent/EP2341966A4/en not_active Withdrawn
- 2009-10-07 RU RU2011113439/14A patent/RU2514318C2/ru not_active IP Right Cessation
- 2009-10-07 JP JP2011530996A patent/JP5841429B2/ja not_active Expired - Fee Related
- 2009-10-07 AU AU2009302959A patent/AU2009302959B2/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996028202A1 (en) * | 1995-03-10 | 1996-09-19 | Weston Medical Limited | Spring-powered dispensing device |
| RU2161511C2 (ru) * | 1995-03-10 | 2001-01-10 | Вестон Медикал Лимитед | Раздаточное устройство с пружинным приводом |
| US6422236B1 (en) * | 2000-09-25 | 2002-07-23 | Microdrug Ag | Continuous dry powder inhaler |
| EP1386630A1 (en) * | 2002-07-31 | 2004-02-04 | CHIESI FARMACEUTICI S.p.A. | Powder inhaler |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2738739A1 (en) | 2010-04-15 |
| WO2010042036A1 (en) | 2010-04-15 |
| EP2341966A1 (en) | 2011-07-13 |
| AU2009302959A1 (en) | 2010-04-15 |
| KR20110083651A (ko) | 2011-07-20 |
| CN102176939A (zh) | 2011-09-07 |
| RU2011113439A (ru) | 2012-11-20 |
| EP2341966A4 (en) | 2016-07-13 |
| MX2011003799A (es) | 2011-06-16 |
| AU2009302959B2 (en) | 2013-05-16 |
| JP5841429B2 (ja) | 2016-01-13 |
| CN102176939B (zh) | 2015-03-04 |
| NZ591854A (en) | 2013-07-26 |
| US20110253138A1 (en) | 2011-10-20 |
| BRPI0920671A2 (pt) | 2019-07-09 |
| JP2012505020A (ja) | 2012-03-01 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20151008 |