RU2509575C2 - Disinfectant "desophor" - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to disinfection, and can be used for disinfection of livestock buildings, vehicles, various equipment and equipment. The disinfectant represents a micronised powder of a particle size up to 20 mcm, containing phosphogypsum (CaSO₄*2H₂O) - 25-70%, calcium carbonate (CaCO₃) - 15-30%, kaolin (Al₂Si₂O₇*2H₂O) - 10-40%, zinc sulphate (ZnSO₄*7H₂O) - 0.1-1%, copper sulphate (CuSO₄*5H₂O) - 0.1-1%, ferric sulphate (FeSO₄*7H₂O) - 0.2-2%, chloramine (C₆H₅SO₂N(Na)Cl*3H₂O) - 0.1-0.5% and natural essential oils - 0.1-0.5%.

EFFECT: invention enhances the bactericidal activity of the disinfectant on gram-positive and gram-negative microorganisms with reducing the concentrations of the active substances and increasing the storage period of the ready product.

Description

The invention relates to the field of disinfection: for veterinary disinfection; to disinfect livestock and poultry facilities; to disinfect vehicles, equipment and inventory.

When keeping animals and birds, litter is always emitted, during the accumulation and storage of which toxic gases (ammonia, methane, hydrogen sulfide) are released into the environment in the premises and on the street. Litter is also a favorable environment for the reproduction and vital activity of harmful microorganisms and fungi.

Excessive concentrations of ammonia and hydrogen sulfide in rooms where animals and poultry are kept lead to an outbreak of various intestinal and respiratory diseases, a decrease in weight gain, productivity and safety of the livestock, increasing feed conversion.

To reduce the emission of ammonia, various chemicals are used: acids, zeolites, peat, etc.

Currently, many disinfectants are known, but most of them contain active chlorine compounds, peroxides, phenols, etc. They provide the necessary degree of disinfection, but at the same time adversely affect the processed products and personnel, have increased toxicity and have limited scope.

Many traditional disinfectants have a relatively limited spectrum of biocidal activity, which is especially characteristic of phenolic preparations. Only a few disinfectants have a direct sporocidal effect, almost all of them are effective in the disinfection of spore-forming microorganisms in a vegetative form. The traditional disinfectants in the doses used are strong toxicants for humans and the beneficial biosphere, and therefore the search for effective compounds that have biocidal action against certain representatives of opportunistic microflora and are safe for warm-blooded animals, which would allow the use of these compounds in the presence of animals and birds, is extremely relevant.

Known disinfectant composition containing hydrogen peroxide, magnesium lauryl sulfate, glycerin, sodium oleate, disodium salt of ethylenediaminetetraacetic acid (EDTA), sodium benzoate and water (RF patent No. 2108810 C1, 1998). This composition is intended for the disinfection of surfaces of premises, sanitary equipment, linen, medical devices, but does not have sufficient effectiveness and is toxic to humans and animals.

A disinfectant is known for use in veterinary practice. [Patent RU No. 2158140, A61L 2/16; 2000.10.27.

The product includes glutaraldehyde, water and a quaternary ammonium compound (QAS) - N- [alkylphenoxypoly (ethyleneoxy) carbonylmethyl] ammonium chloride in the following ratio, wt.%: Glutaraldehyde - 20.0-26.0; HOUR - 4.0-20.0; water is the rest.

For disinfection in veterinary practice, alkalis, acids, oxidizing agents, phenols, cresols and xylenols, salts of heavy metals, etc. are used. A.A. Poles. Veterinary sanitation. Kolos, 1979, p. 17

A technical solution is known in which a 3% alkaline formaldehyde solution is used as a disinfectant at the rate of 1 liter per m ^{2 of the} treated surface. However, this drug has low bactericidal activity (see Zharov V.G. "On the resistance of tuberculosis mycobacteria to certain disinfectants." Tr. VNIIVS, M., 1986, p. 52-56). To enhance the bactericidal action, the formaldehyde working solution must be heated to 70 ° C. In addition, the disinfectant has strong corrosion activity and is unstable during storage.

It is known that various disinfectants are used for disinfection using the irrigation method, including: 10-20% suspension of freshly slaked lime, 5% hot solution of soda ash, 3% hot emulsion of disinfecting creolin, 2% hot emulsion xylonaphtha, 5% emulsion of naphthalisole, 3% hot solution of causticized potash mixture, 1% formaldehyde solution, 2% sodium hydroxide solution, bleach solution containing 2% active chlorine, 5% chloramine solution et al., the rate of 1-2 liters per 1 m ² disinfected overhnosti depending on its density. Hot solutions should have a temperature not lower than 70 ° C, and solutions of soda ash not lower than 90 ° C. If disinfection is carried out by the aerosol method, then apply: 6% hydrogen peroxide solution, formalin-kalalinovy mixture or formalin (36-40% aqueous formaldehyde solution) (Veterinary law. - M .: Kolos, 1973).

The disadvantage of this disinfectant is: a long disinfection time, which is 3 hours at a 3% concentration of the solution. When the concentration is reduced to 2.5 wt.%, The exposure time increases to 6 hours, and in some cases the disinfection was not effective.

The known composition "sulfochlorantin" (Ovchinnikov VG, Gudz OV Antimicrobial properties and the use of sulfochlorantin. Literature review // Doctor. Case. - 1990. - No. 2. - P.108-113), including the organic chlorine compound and having a bactericidal effect against a wide range of gram-positive and gram-negative microflora. However, this composition is not intended for use in livestock and poultry facilities, since it has a short-term bactericidal effect.

The bulk of these compounds are used in the absence of animals as they are poisonous to them. Also, the disadvantage of almost all formulations is that they have a liquid form of application.

The disadvantages of existing formulations and preparations include a relatively short shelf life of them in a ready-to-use form.

During the period of livestock cultivation, in the course of their life, a huge amount of moisture is released, which, in turn, is a place for the rapid development of microorganisms, bacteria, fungi, flies, ticks, etc.

The present invention is the creation of a disinfectant that provides high quality disinfection, while reducing humidity in the room and when this substance gets on the skin or inside the body of animals and people did not cause serious harm, with an acceptable processing time and minimum effective concentration of the disinfectant.

The technical result is:

1. In the selection of the composition of the substance, which has the properties of an absorbent and disinfectant properties.

2. In increasing the bactericidal activity of the disinfectant due to the activation of the antibacterial properties that make up the components

3. The decrease in the concentration of active substances

4. The increase in the duration of storage of the finished product.

A disinfectant is proposed, which is a micronized powder with a particle size of up to 20 microns, including the following components, in%:

phosphogypsum CaSO ₄ * 2H ₂ O 25.00-70.00 a piece of chalk CaCO3 15.00-30.00 kaolin Al ₂ Si ₂ O ₇ * 2H ₂ O 10.00-40.00 zinc sulfate ZnSO ₄ * 7H ₂ O 0.10-1.00 copper sulfate CuSO ₄ * 5H ₂ O 0.10-1.00 iron sulfate FeSO ₄ * 7H ₂ O 0.20-2.00 Chloramine B C ₆ H ₅ SO ₂ N (Na) Cl * 3H ₂ O 0.10-0.50 natural essential oils 0.10-0.50

Essential oil of eucalyptus and conifers have pronounced phytoncidal properties. Volatile phytoncides (LAV) are able to exert their effect at a distance, for example volatile phytocides of eucalyptus leaves, pine and other conifers kill many species of protozoa, bacteria and lower fungi in the first minutes of action. Volatile phytoncides kill many insects in a fairly short time. Thus, fir phytoncides kill pertussis bacillus (Bordetella pertussis pertussis pathogen); pine phytoncides are fatal for Koch's bacillus (the causative agent of tuberculosis Mycobacterium tuberculosis) and for E. coli E. coli).

Essential oil of eucalyptus and conifers also has a positive effect on humans, possessing anti-inflammatory, antiseptic, anti-infectious properties and is used in medicine for colds accompanied by cough, runny nose, throat and respiratory infections, as well as with flu, bronchitis and tuberculosis.

The floating dosage of the ingredients of the disinfectant composition is due to the fact that the composition is selected according to the analysis for the content of certain bacteria, fungi, microorganisms located on the territory of livestock, poultry and other application complexes.

For what reasons this composition was chosen:

Phosphogypsum:

1. It is a high moisture absorbent from the application surface. A piece of chalk:

1. Dry chalk is both a high moisture absorbent from the application surface and a feed additive necessary for animals for normal development.

Kaolin:

1. The main property of cosmetic clay is the cleansing and drying of the skin. It absorbs excess sebum and secretions of sweat glands, eliminates pollution that is on the skin.

2. Kaolin enhances the bactericidal effect of substances.

INKSTONE

1. It has a pronounced local effect depending on the concentration: a 0.1% solution exhibits an astringent, 3.5% irritant, and in high concentrations, a cauterizing effect. It acts antimicrobial and deodorizing. When administered orally, it irritates the mucous membranes of the stomach and intestines, enhances secretion. After absorption, it stimulates erythropoiesis, improves metabolism.

2. Outwardly used as cauterizing arrows in cancer arrows (powder or concentrated solutions). Inside, they are administered in the form of a 0.2-1% solution in case of exhaustion, anemia, postpartum hemoglobinuria of cows, leukemia, myocardosis along with other means.

3. Doses: horses and cattle 2-5 g; small cattle and pigs 0.5-1 g; dogs 0.05-0.2 g; cats and birds 0.02-0.1 g.

4. As an astringent and disinfectant, the intestines are administered orally in the form of a 1% solution in doses: 10–25 g for horses and cattle; donkeys 5-10 g; small cattle and pigs 2-5 g; dogs 0.1-0.5 g; cats 0.05-0.3 g; bird 0.01-0.2 g.

5. For the prevention and treatment of anemia in suckling piglets, when they reach 3-5 days of age, the sows' nipples are sprayed with a 0.25% solution or solution containing 0.25% iron sulfate and 0.1% copper sulfate before sucking. Subsequently, before weaning, the same solutions are added to concentrated feed at the rate of 10 ml per piglet per day.

6. Apply as a herbicide, fungicide and insecticide, in the form of 3-5% solutions by spraying.

ZINC SULFATE.

1. 0.1-1% zinc sulfate solution on wounds and mucous membranes acts astringently, vasoconstrictor, antiseptic and anti-inflammatory; 5-10% solution irritates, and 20% - cauterizes tissue.

2. As an antiseptic and anti-inflammatory drug, it is prescribed for conjunctivitis, keratitis, ulcers of the cornea and edges of the eyelids (0.25-2% solution). A 1% solution is used to rinse the lacrimal-nasal canal. With vaginitis, metritis, urethritis, douching is prescribed with a 0.2-1% solution of the drug. Dogs are given a 2% solution as an emetic. In microdoses, zinc sulfate is recommended to be added to the diet of animals in biogeochemical zones and provinces with zinc deficiency in feed and water. It is used as a treatment for parakeratosis in pigs.

3. Daily prophylactic doses of zinc sulfate, g: manufacturing bulls 0.1-0.15; cows 0.06-0.07; young cattle weighing 100-300 kg 0.025-0.045; calves up to 6 months 0,001-0,025; sheep and goats 0.006-0.009; lambs 0.002-0.004; pigs (per 100 kg of animal weight) - 0.05; chickens and chickens 0.012 per 1 kg of dry food.

COPPER SULFATE

1. Action and application. It has a pronounced local irritant effect. The drug is used as an antiseptic and astringent in the form of 0.25% solutions.

2. The drug has an anthelmintic effect on moniesia, gemonkhov and neoaskarid, as well as molluscicidal and antimicrobial. In addition, it is an antidote for poisoning animals with phosphorus.

3. Copper sulphate is the main drug used to combat sheep and goat moniesiosis and tisaniesiosis. Deworming is carried out twice with 1% copper sulfate solution. The solution is prepared in boiled rain or well water. To enhance the effect on 1 liter of solution, 2-4 ml of pure undiluted hydrochloric acid are added. When working with copper sulfate solutions, do not use easily oxidized metal utensils. The most effective is pre -aginal deworming, which is carried out twice: the first - after 25-30 and the second after 35-40 days after the animals are pastured into the pasture. All young growths that have reached the age of one month are subjected to predominantly deworming; adult animals are treated only in foci of intense infection. In addition, deworming of all sheep in the stall period is not earlier than a month after the animals are placed in a stall. A 1% solution of copper sulfate to sheep and lambs is dosed in the following quantities: 15-80 ml to lambs aged 1 to 10 months; sheep older than 10 months 81-100 ml; adult goats no more than 60 ml; calves aged 3 to 6 months 120-150 ml. Before deworming, sheep, goats and calves are kept on a hungry diet for 12-15 hours.

4. In addition, copper sulfate gives a good effect in drepanidoteniosis of geese and ducks, as well as in hymenolepidoses and duck polymorphism. It is prescribed in the form of 0.1-0.15% aqueous solutions by free evaporation at the rate of 100-150 ml of solution per bird per day, 3-5 days in a row.

5. Copper sulfate is also effective in pre-maginal forms of polymorphus: it releases up to 60% of ducks from cestodes. Small doses of copper sulfate are sometimes prescribed to enhance erythropoiesis in case of anemia (5-15 ml of a 1% solution 2-3 times a day during feeding).

6. The drug has low toxicity for animals and birds in therapeutic doses. So, long-term evaporation of a 0.1% copper sulfate solution of 100-150 ml per day does not cause any changes in the clinical, hematological, biochemical and physiological parameters of the bird's body. Their meat is edible.

7. It is advisable to prepare a solution of copper sulfate in soft or boiled water on the day of its use. It is advisable to appoint a salt laxative (6-10% solution of glauber's salt) 1-2 hours after giving the drug, which helps to cleanse the intestines from cestodes.

8. Apply in powder by pollination, solutions by spraying in a concentration of 1-6%. Active against a number of insects: pests of fruit trees, aphids, thrips, lice, fleas, mosquitoes, some ticks, spiders, etc.

The use of all ingredients of ultra-high purity (PSA) with a basic substance content of at least 99% can reduce the concentration of active substances in the composition of the disinfectant.

The tool is obtained as follows:

The ingredients are dried to a residual moisture content of 0.15%, then crushed to a particle size of up to 20 microns, the ingredients are mixed until uniform in the ratio according to the claims. The obtained, environmentally friendly, grayish powder with the aromatic smell of grass or needles is used for disinfection and sanitization of premises at facilities for keeping all kinds of animals and birds in their presence.

The tool is used for disinfection and sanitization of livestock buildings (poultry houses, cowsheds, pigsties, stables, aviaries, nurseries, zoos), slaughterhouses, equipment and inventory of feed production, road transport used to transport animals, poultry, meat, meat products:

in pig breeding:

- pregnant sows: 100 g / m ² 2-3 times in the first week, then 40-50 g / m ²

Once a week

- after birth: piglets are individually treated with a dry shower (bathed in a bucket or basin with a product) - 100 g per head once

- in the nest after birth: 40-50 g / m ² 1-2 times a week until weaning

- after weaning: it is applied at the rate of 100 g / m ² 2-3 times a week. Then 40-50 g / m ²

Once a week

- after castration: treat a wound, 20 g per head, once

- sows and boars: 40-50 g / m ² 1 time per week constantly;

in cattle breeding:

- in the dispensary: it is introduced into the litter 100 g / m ² 2-3 times in the first week, then 40-50 g / m ² once a week

- in the calf: 100 g / m ^{2 of the} floor 2-3 times in the first week, then 40-50 g / m ² once a week

- with the tethered content of dairy cows: 40-50 g / m ² 1 time per week constantly

- with loose housing: 40-50 g / m ² 1 time per week constantly;

in poultry farming:

Before entering the animals into the premises at the rate of 100 g / m ² sex 2-3 times in the first week, then 40-50 g / m ² once a week constantly.

- at floor keeping of the bird: it is brought on a laying, on 40-50 g / m ² once a week constantly

- with the cellular content of the bird: applied to the conveyor belt at 40-50 g / m ² .

To disinfect a feed production line:

1) pre-clean accessible work surfaces from a layer of dust, caked materials, feed, etc., to increase the effectiveness of disinfection and better penetration of the product.

2) prepare a mixture consisting of 150-200 kg of the product and 800 kg of grain or wheat bran (preferably). This proportion is recommended for a 1000 kg receiving tank.

3) 2-3 tons of such a mixture (for the best filling of the conveyor line it is recommended to use just such an amount of the mixture) to pass through the entire production line, starting from the receiving tank, through all conveyors, small containers, up to the mixer (crusher).

4) such disinfection should be carried out regularly, at least 1 time per month.

5) the mixture used (grain, bran plus product) can be used for feed production or for distribution to animals.

The product has a wide spectrum of antibacterial, antiviral and fungicidal effects, reduces the microbial contamination of rooms by pathogenic bacteria (Haemophilus spp. E. Coli, Staphylococcus aureus. Salmonella spp., Pasteurella spp.), Viruses (Enterovirus, Coronavirus, Parvovirus, cocavirus, Rotav) and helminths, exhibits a fungicidal effect (Aspergillus niger, Aspergillus amstelodami, Aspergillus flavus), repels adult flies and destroys their larvae.

Possessing excellent absorbing properties, the product reduces the humidity in the rooms for animals and birds, preventing the formation of ammonia, methane and hydrogen sulfide, fills the air with a pleasant smell of freshness.

The advantages of the claimed funds:

- more pronounced than their analogues antibacterial, antiviral, fungicidal actions;

- hypoallergenic microelements included in the preparation, essential oils;

- used in the presence of animals and birds;

- increases the resistance of young animals and birds;

- reduces mortality of animals and birds;

- increases the productivity of animals and birds;

- eliminates the transmission of infection with the cellular content of pigs and birds;

- makes it possible to conduct early weaning of piglets from sows;

- reduces humidity in rooms;

- non-toxic and completely safe for animals and people;

- significantly reduces the formation of ammonia, methane, hydrogen sulfide;

- neutralizes unpleasant odors;

- aromatizes air in rooms;

- does not require special equipment for its use;

- reduces the use of litter;

- increases the content of free nitrogen in manure of manure storages.

The versatility of the product allows you to use the same preparation, both for local regular disinfection of rooms in the presence of animals, and for disinfection of equipment and feed production equipment, as well as for disinfection of vehicles and filling deoksrikov in all production areas of the economy. After such processing, the production line does not require any additional disinfectants and disinfection measures.

The use of the product in a mixture with several tons of feed,

significantly increases the disinfection efficiency of the upper parts of the conveyors and their covers on the inside. Freely sprinkled product also gets into hard-to-reach places - in the line of bucket conveyors, the so-called soles.

Vehicle disinfection:

It has been established that the most effective way to process the wheels (tires) of a car is to pass all cars, both entering and leaving, through a properly organized barrier.

1. A tank is needed to handle the car. As such, the usual shallow prepared pit with fortified walls is used. The dimensions of the pit should be 10-12 meters long, 4-5 meters wide.

2. Sawdust is mixed with the product in the ratio: 1 ton of sawdust per 200 kg of product.

3. A “pillow” is made for their mixture, 15–20 cm high, DEZOFOR is introduced from above, at the rate of 200-300 g / m ² once, in the future, before transport arrives, 100 g / m ² each.

4. The car enters a pit, rolls several times back and forth, so that the tires “capture” the powder. An indicator of proper processing will be tires that are completely dyed white.

5. Next, the car remains in the pit for 15-20 minutes - the time for which the maximum bactericidal effect is achieved.

This time can be effectively used, for example, for registration of shipping documents in accounting.

The product is environmentally friendly. Shelf life is 2 years. Store in the original packaging at a temperature of 0 ° C to + 25 ° C in a dry place.

The test results show that the use of the claimed means in terms of disinfecting ability exceeds the prototype and can reduce the concentration of the solution by 15 times (0.28 wt.%), And the exposure time by 1.5 times (120 min).

The invention allows to expand the arsenal of agents exhibiting bactericidal activity against gram-positive and gram-negative microorganisms. This provides a wide range of use with good tolerance and duration of the effect due to its use.

In addition, a decrease in outbreaks of various intestinal and respiratory diseases leads to an increase in weight gain, productivity and preservation of the livestock.

Claims (1)

A disinfectant, characterized in that it is a micronized powder with a particle size of up to 20 microns, including phosphogypsum (CaSO ₄ · 2H ₂ O), chalk (CaCO ₃ ), kaolin (Al ₂ Si ₂ O ₇ · 2H ₂ O), sulfate zinc (ZnSO ₄ · 7H ₂ O), copper sulfate (CuSO ₄ · 5H ₂ O), iron sulfate (FeSO ₄ · 7H ₂ O), chloramine (C ₆ H ₅ SO ₂ N (Na) Cl · 3H ₂ O) and natural essential oils in the following ingredients,%:
phosphogypsum CaSO ₄ · 2H ₂ O 25.00-70.00 a piece of chalk CaCO ₃ 15.00-30.00 kaolin Al ₂ Si ₂ 0 ₇ · 2H ₂ O 10.00-40.00 zinc sulfate ZnSO ₄ · 7H ₂ O 0.10-1.00 copper sulfate CuSO ₄ · 5H ₂ O 0.10-1.00 iron sulfate FeSO ₄ · 7H ₂ O 0.20-2.00 chloramine C ₆ H ₅ SO ₂ N (Na) Cl · 3H ₂ O 0.10-0.50 natural essential oils 0.10-0.50