RU2496535C1 - Method for correction of age-related changes in face skin - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to medical cosmetology and physiotherapy, and may be used for correction of the age-related changes in face skin. The patient is exposed to monochromatic non-coherent visible radiation at average wave length 650+-20 nm. Radiation dose is 500-600 J/cm², power density is 7.5 mWt/cm². The exposure is contact and stable, and sequentially covers the skin of right and left upper half of cheek-bone, the skin of right and left lower half of cheekbone, the skin of right and left region of chin for 7-8 minutes. The therapeutic course is 10-12 procedures every second day.

EFFECT: method enables the more effective correction of the age-related changes in the face skin ensured by reduction of transdermal water loss, increase of epidermal corneal humidity, activation of blood microcirculation, improvement of skin elasticity.

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Description

The invention relates to medicine, in particular medical cosmetology and physiotherapy, and can be used to correct various age-related changes in the skin of the face with the help of light radiation, namely monochrome incoherent radiation of the red spectrum.

Currently, in the arsenal of medical cosmetology, methods of correction and prevention of age-related changes in facial skin, which are based on the use of physical factors, occupy far from the last place.

The method of prevention and correction of age-related changes in facial skin using microcurrent therapy is widely known (N. Imaeva. Comparative evaluation of vibration-plastic massage and microcurrent therapy in the correction of involutional skin changes. Abstract of dissertation for the candidate of medical sciences ., Moscow, 2008). The active factor of this method is rectangular bipolar and monopolar impulse currents of low intensity, affecting mainly the superficial muscles of the skin of the face and the muscle membrane of the vessels of the skin. Realization of the rejuvenating effect of microcurrent therapy is carried out mainly due to the vasodilating and lymphatic drainage effects.

Among the disadvantages of this method, the impossibility of carrying out the procedure with individual intolerance to the patient by an electric current, the limitation of the use of the technique for various diseases of the thyroid gland, inflammatory diseases of the skin of the face can be noted. Considering the fact that microcurrent therapy significantly increases the amount of sebum, the use of the technique is not recommended for patients with oily, combined type of facial skin, which makes up a significant percentage of people using cosmetologist services.

There is a method of correction of involutional changes in the skin of the face using selective pulsed phototherapy (Belysheva T.S. Influence of selective pulsed phototherapy on involutional changes in the skin (pathogenetic substantiation of effectiveness. Abstract of dissertation for the candidate of medical sciences - Moscow , 2007). The method is based on the use of high-energy bursts of incoherent light waves of the visible and near infrared parts of the spectrum (515-1200 nm), causing the effect of photothermolysis in the skin due to absorption by target chromophores (hemogl bin, melanin) light waves. The main observed clinical effect of this method is the regression of pigmentation and telangiectasia on the back of improved turgor and align overall skin color.

Among the disadvantages of this method, one can distinguish a long course of treatment (up to 6 months), carried out mainly in the autumn-winter period of the year, given the mandatory exclusion of insolation. In addition, the procedures are accompanied by pain, often severe facial swelling, which persists in the rehabilitation period.

The closest analogue of the proposed method, we have chosen as a prototype, is a method for correcting age-related changes in the skin of the face using low-intensity laser radiation (LLLT) in the infrared spectrum. (Kiryanova V.V., Maksimov A.V., Skuratova Yu.G. Laser and barolaser therapy in cosmetology, St. Petersburg Publishing House SPbMAPO, 2002; Moskvin S.V., Antipov E.V., Zarubina E.G. . et al. Low-intensity laser radiation and laser phoresgialuronic acid as methods of correction of age-related skin changes. Cosmetics and Medicine 2/2011, p. 34-39). According to this method, face skin is irradiated with low-intensity continuous laser radiation with an average wavelength of 780-785 nm, an average power of 40-50 mW, translational movements along massage lines at an average speed of 1-2 cm / s for 10 minutes for 8-10 procedures carried out every other day.

As the main disadvantages of this method, the following can be noted:

1. LLLT of the infrared range does not affect the structure and number of collagen and elastin fibers in the dermis (Moskvin SV, Antipov EV, Zarubina EG et al. Low-intensity laser radiation and laser phoresgialuronic acid as methods for correcting age-related skin changes Cosmetics and Medicine 3/2011) and, therefore, does not affect the main mechanism of pathogenesis of involutional skin changes, namely, thinning of the structure of dermal fibers, slowing down their synthesis by fibroblasts.

2. The depth of penetration of infrared laser radiation is about 5-6 cm and, therefore, the implementation of the main biological effects occurs mainly in deeply located tissues. (Bogolyubov V.M. / edition /. Physiotherapy and balneology, volume 1. - Moscow: BINOM publishing house, 2008. - 408 p.).

3. The cost of devices for low-intensity laser therapy is significantly higher than the equipment that generates monochrome light radiation, which represents in a favorable light the commercial component of the issue (Veselovsky AB, Kiryanova VV, Mitrofanov AS Development trends, development and study of physiotherapy equipment for photochromotherapy Optical and laser technologies, collection of articles, Issue 1. - SPB, 2001. - 251 p.).

The technical result of the invention is:

- expansion of the arsenal of tools used for the correction of age-related changes in facial skin;

- increasing the efficiency of correction of age-related changes in the skin of the face due to the specific effect at the level of the main layers of the skin, manifested in a decrease in transepidermal water loss, increased moisture in the stratum corneum of the epidermis, increased blood circulation at the level of microcirculation, increased skin elasticity;

- reducing the cost of treatment, and, as a result, expanding the patient population.

The technical result of the invention is achieved by the fact that they carry out exposure to monochrome incoherent radiation of the visible spectrum with an average wavelength of 650 + -20 nm, an irradiation dose in the range of 500-600 J / cm ² , a radiation power density of 7.5 mW / cm ² contact, stable, consistently on the skin of the right and left upper cheekbones, the skin of the right and left lower half of the cheekbones, the skin of the right and left chin area for 7-8 minutes for 10-12 procedures performed at intervals of 1 day.

The method is as follows:

The source of light radiation is the “Spectrum I” apparatus. The exposure to the LED matrix is carried out with an irradiation dose in the range of 500-600 mJ / cm ² , a radiation power density of 7.5 mW / cm ² on the skin of the left and right half of the face in contact, stably sequentially in three zones: the upper half of the cheekbone, the lower half of the cheekbone region during the established therapeutic time of the procedure, calculated as the ratio of the radiation dose (mJ / cm ² ) to the power density of the acting radiation (mW / cm ² ) and amounted to 1 min 7 sec - 1 min 20 sec. The total exposure time is 7-8 minutes.

$$T\left(c\right)=\frac{500-600{\text{mJ / cm}}^{\text{2}}}{7.5{\text{mJ / cm}}^{\text{2}}}$$

T (s) = 67-80

The therapeutic course is 10-12 procedures performed at intervals of 1 day.

Distinctive features of the invention are:

Exposure is performed monochrome incoherent radiation of the visible spectrum with a center wavelength of 650 + -20 nm, the irradiation dose in the range of 500-600 m Joules / ^cm2 of radiation power density 7.5 mW / cm ² contact stably, successively to the skin of the right and left the upper half of the cheekbone, the skin of the right and left lower half of the cheekbone, the skin of the right and left chin area for 7-8 minutes for 10-12 procedures performed at intervals of 1 day.

A causal relationship between the salient features and the result achieved:

As a result of the histological study, the relationship between the wavelength of the monochrome incoherent radiation of the visible spectrum and the nature of morphofunctional changes in the cellular and fibrous skin structures was first discovered. As a result of histological examination, optimal parameters of light radiation were titrated, the effectiveness of which was confirmed in the clinical part of the study. It was found that monochrome incoherent red spectrum radiation has a specific effect on the state of collagen and elastic fibers of the dermis, causing their structural and quantitative changes. In the analysis of histological preparations, a more compact, dense, ordered arrangement of collagen, elastin fibers was noted, which was confirmed later in the analysis of changes in skin elasticity after exposure to the studied light radiation.

As a result of a clinical study, a significantly significant increase in indicators such as corneometry (an indicator of the water content in the stratum corneum of the epidermis), mexametry (an indicator characterizing the state of microcirculation), a decrease in tevometry (an indicator reflecting the level of transepidermal water loss) after exposure to the skin of monochrome incoherent radiation of the red region of the spectrum. The above changes can be explained by the effect of light radiation on the permeability of cell membranes, as well as the specific effect on photoacceptors such as catalase, DNA molecule, molecular oxygen, cytochrome oxidase, superoxide dismutase, through which a cascade of photobiological reactions is triggered in cells.

The results of the study of the condition of the skin of the face before and after exposure to monochrome incoherent radiation of the red spectrum are presented in table 1.

Table 1 Test indicator Mean value before exposure Post exposure value Tevometry 11.21 9.48 Mexametria (erythema) 249.05 278.02 corneometry 58.64 68,43 Elastometry (R0) 0.332 0.28 Elastometry (R2) 0.586 0.684 Elastometry (R4) 0.174 0.139 Elastometry (R6) 0.743 0.603 Elastometry (R8) 0.292 0.217 Elastometry (F0) 0.108 0,074 Elastometry (F1) 0.06 0.04

As can be seen from the table, after exposure to monochrome incoherent radiation in the red region of the spectrum, the following is observed: 1) a 15.4% decrease in the average value of the tevometry parameter (transepidermal water loss);

2) an increase in the average value of the mexametric index (erythema), which reflects the hemoglobin content in the skin by 10.5%;

3) an increase in the average value of corneometry, reflecting the water content in the stratum corneum of the epidermis by 14.3%;

4) a decrease in the average value of the elastometry index R0, which characterizes the elongation of the skin by 15.6%;

5) an increase in the average value of the elastometry index R2, characterizing the elasticity of the skin by 16.7%;

6) a decrease in the average value of the elastometry index R4 (characterizes the “skin fatigue effect”) by 20.1%;

7) a decrease in the average value of the elastometry index R6, characterizing the elastic-viscous part of the elastometric curve by 18.8%;

8) a decrease in the average value of the elastometry index R8 (is inversely related to the ability of the skin to return to its original state) by 25.6%;

9) a decrease in the average value of the elastometry index F0 (for an elastic material, the value tends to zero) by 31.4%;

10) a decrease in the average value of the elastometry index F1 (for an elastic material, the value tends to zero) by 33.3%.

Our changes in the above indicators confirm the positive dynamics of the state of the skin of the face after exposure to monochrome incoherent radiation in the red region of the spectrum.

In the available literature, we did not find information on the use of monochrome incoherent radiation in the red region of the spectrum to correct various age-related changes in the skin of the face.

We give an example of a specific implementation of the method:

Example 1. Patient E., aged 40, complained of dryness, decreased turgor, facial skin elasticity, the formation of fine wrinkles in the outer corner of the eye, and deepening of the nasolabial folds of the right and left half of the face. A course of photochromotherapy (red visible light) was prescribed sequentially on the skin of the right and left upper cheekbones, the skin of the right and left lower cheekbones, the skin of the right and left chin region for 8 minutes for 10 procedures performed at intervals of 1 day. The radiation dose was 600 mJ with a radiation power density of 7.5 mW / cm ² The exposure was carried out according to a contact stable method, the exposure time of one zone 1 minute 20 seconds. The total exposure time is 8 minutes. The course was 10 procedures performed every other day. The skin condition of the face was evaluated after the first, fifth and tenth procedure according to the indicators presented in tables 2-10.

table 2 Dynamics of tevametry indicators (characterizes the index of transepidermal water loss (TEPV) by the skin) Impact zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 15.4 14.5 12.1 10.9 Lower cheekbone 16 15.7 10.9 8.2 Chin area 13 11.7 10.7 8.8

Table 3 Dynamics of mexametric indicators (a method for quantitative determination of hemoglobin (erythema) in the skin) Impact zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 345.3 352.67 383.33 385.33 Lower cheekbone 250.1 254.33 335.67 339.67 Chin area 350,4 363.0 390.67 375.67

Table 4 Dynamics of corneometry (international capacitive method for measuring skin moisture) Irradiated zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 59.12 62.3 79.23 75.6 Lower cheekbone 60.3 64.13 70,2 73.1 Chin area 50.1 65.63 65.75 67.1

Table 5 The dynamics of elastometry R0 (the first maximum amplitude of the elastometric curve. Determines the elongation of the skin) Irradiated zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 0.219 0.220 0.250 0.192 Lower cheekbone 0.400 0.409 0.313 0.262 Chin area 0.204 0.2 0.216 0.205

Table 6 Dynamics of elastometry indicators R2 (relationship between the value of permanent deformation and the maximum amplitude of deformation (elasticity) Impact zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 0.66 0.679 0.826 0.838 Lower cheekbone 0.551 0.566 0.783 0.79 Chin area 0.680 0.688 0.861 0.946

Table 7 Dynamics of indicators of elastometry R4 (characterizes the ability to reduce residual deformation with each new absorption, determines the so-called "effect of fatigue" of the skin) Impact zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 0.193 0.179 0.151 0.150 Lower cheekbone 0.168 0.125 0.11 0.104 Chin area 0.177 0.174 0,099 0,072

Table 7 Dynamics of R6 elastometry indicators (elastic-viscous part on the elastic part of the elastometric curve) Impact zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 1.12 1,1188 0.9339 0.7771 Lower cheekbone 0.730 0.7358 0.4786 0.4394 Chin area 0.4153 0.3043 0.3058 0.2851

Table 8 Dynamics of R8 elastometry indicators (characterizes the plastic component, the value of which is inversely related to the elasticity value) Irradiated zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 0.148 0.129 0.127 0.09 Lower cheekbone 0.257 0.151 0.138 0.19 Chin area 0.489 0.428 0.313 0.26

Table 9 Dynamics of elastometry indices F0 (a parameter calculated from the total area of the absorption curve, for an elastic material its value tends to zero) Irradiated zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 0,083 0.0816 0,080 0,079 Lower cheekbone 0,096 0.0946 0,0772 0,0700 Chin area 0.105 0.1041 0,0896 0.09

Table 10 Dynamics of elastometry indices F1 (a parameter calculated from the total area of the absorption curve, for an elastic material its value tends to zero) Irradiated zone Baseline After the 1st procedure After the 5th procedure After the 10th procedure Upper cheekbone 0.04 0,0458 0,0442 0,03 Lower cheekbone 0,07 0,0785 0.0467 0,0323 Chin area 0,078 0.0947 0,0538 0,0486

At the end of the course of treatment, the patient noted a decrease in dry skin, smoothing small wrinkles, increasing skin elasticity, reducing the depth of the nasolabial folds.

The method was tested in 33 patients. All patients showed improvement in skin quality and increased vitality. Negative dynamics, deterioration in patients were not observed in any case.

Thus, we have developed a method that allows you to expand the arsenal of tools used to correct age-related changes in the skin of the face, and also, compared with the prototype, increases the efficiency of correction of age-related changes in the skin of the face due to the specific effect at the level of the main layers of the skin, manifested in a decrease in transepidermal loss water, increasing the hydration of the stratum corneum of the epidermis, activating blood circulation at the level of microcirculation, increasing the elastic properties of the skin. Compared with the prototype, the invention also reduces the cost of treatment.

Claims (1)

A method of correcting age-related changes in the facial skin, which consists in exposing the face skin to light radiation, characterized in that the exposure is effected by monochrome incoherent radiation of the visible spectrum with an average wavelength (650 ± 20) nm, an irradiation dose in the range of 500-600 mJ / cm ² , the radiation power density of 7.5 mW / cm ² contact, stable, sequentially on the skin of the right and left upper cheekbones, the skin of the right and left lower cheekbones, the skin of the right and left chin areas for 7-8 minutes for 10-12 procedures you olnyaemyh with an interval of 1 day.