RU2472514C1 - Method for metabolic syndrome correction with use of mare's milk and hypobarotherapy - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine and represents a method of treating the patients with metabolic syndrome involving patient's staying in the low atmospheric pressure environment at heights of 1000, 1500 m above sea level with underlying basic therapy combined with the oral administration of a therapeutic beverage, differing by the fact that a hypoxia adaptation course is two-staged; the first stage involves staged climbing at height of 1000, 1500, 2000 and 2500 m above sea level; at the second stage, from the fifth session, a "working height" is 2500 metres with climbing up and down at speed 4-5 m/s at partial oxygen pressure 20-35 mm Hg, chamber pressure 75.5 kPa for 15-20 minutes within the therapeutic course of 12-14 daily procedures; the therapeutic beverage is mare's milk of weak or medium strength of permanent Turner acidity 71-100° in dose of 200-250 ml three times a day before meals of the length of 24 days.

EFFECT: invention provides improved clinical values, haemodynamics, carbohydrate and lipid metabolism, higher tolerance to physical activity.

2 cl, 2 ex, 5 tbl

Description

The invention relates to medicine, namely to restorative medicine and physiotherapy, and can be used for the prevention and comprehensive treatment of patients with diseases of the cardiovascular system in medical diagnostic and sanatorium institutions.

In recent years, interest has significantly increased in the study of the pathogenesis of metabolic syndrome (MS), as well as the development of methods for its treatment and prevention. According to the WHO, about 30% of the world's inhabitants are overweight and the number of obese people is progressively increasing every 10 years by an average of 10% (W. Kannel, D. McGee, 2007).

The combination of insulin resistance with abdominal obesity, dyslipidemia, and arterial hypertension (AH) makes up the MS cluster, which contributes to the formation of atherosclerotic processes and becomes a pathological basis for the occurrence, primarily, myocardial infarction, circulatory failure, cerebral stroke, determining high disability and mortality (Chazova I. E., 2004; Oganov R.G. et al., 2005).

The existing principles for the treatment of patients with MS are mainly aimed at normalizing blood pressure without exacerbating insulin resistance and metabolic disorders or that can positively affect the sensitivity of tissues to insulin (Demidova T.Yu., 4004).

Recent studies have shown that some natural physical factors used in the treatment of various diseases can activate the insulin regulation of metabolism by increasing the number of insulin receptors and increasing tissue sensitivity. Despite the widespread use of pharmacological agents, the development of corrective technologies based on natural and preformed physical factors remains relevant. The use of non-pharmacological correction activates sanogenetic reactions, increases the body's regulatory capabilities, its functional reserves in the conditions of a developing pathology (V.K. Frolov, I.P. Bobrovnitsky, 2007).

It is known that some mineral waters (MB) are able to activate the insulin regulation of metabolism, positively affect hemodynamics, lipid metabolism and other disorders in the metabolic syndrome (Georgiadi-Avdinko K.A. et al., 2005: V.K. Frolov et al. , 2005).

A known method of treating a metabolic syndrome using the technology of the integrated use of phytocorrection with mineral waters externally and in the form of baths, as well as inside in the form of cocktails and inhalations (Mikhaylenko L.V. Complex use of phytotherapy and mineral waters for the correction of metabolic syndrome at the stage of spa treatment Abstract of dissertation for the degree of Doctor of Medical Sciences. - Moscow, 2011. - 24 p.). Patients on the background of basic treatment used various phytocompositions, which included medicinal plants, widely used in the treatment of metabolic diseases and the cardiovascular system in the form of phytococtails, inhalations, and also added to mineral baths. For inhalation, a decoction of herbs (20 ml) (decoction of motherwort, marjoram sage, red beet leaves, beet pulp) was used in an ultrasonic inhaler, the procedure lasting 10 minutes, the treatment course consisted of 12 daily procedures. For external use, phytoextract (decoction of motherwort, oregano, sage, red beet leaves, beet pulp) was added to mineral water, at the rate of 5 liters per bath with sodium bicarbonate-chloride water, at a temperature of 35-37 ° C, lasting 15 minutes, 10 procedures - 5 daily and 2 days of rest. For internal use, a herbal cocktail was used from herbs (motherwort, hawthorn and rosehip berries, peppermint leaves). The various phytocompositions used do not affect all components of MS (blood pressure and dyslipoproteinemia), do not have a therapeutic effect on MS complications (IHD, heart failure, etc.), and have side effects in the form of individual intolerance and anaphylactic shock.

The prototype of the invention is a method for the comprehensive treatment and prevention of MS using, against the background of basic treatment, the physical factors of the Kislovodsk resort: low-altitude conditions (hypoxia) corresponding to altitudes of 500, 1000 and 1500 meters, intake of Narzan sulfate inside (1.5 ml per 100 grams of body weight) and physical activity of varying intensity (swimming with a weight) (Elizarov AN, Federal State Institution “Russian Scientific Center for Restorative Medicine and Balneology”. Roszdrav. - Moscow, 2009). It is difficult to use these physical factors for complications of MS (coronary heart disease, decompensated diabetes mellitus, high arterial hypertension, severe obesity), in old age, because there is evidence that exceeding the optimal intensity of physical activity contributes to increased blood pressure (Fang CL. Sherman M., Grouse SF, Tolson H. // Med. Sci. Sports Exercise. - 1988 .-- Vol. 20. - P.455-462).

The above method is not effective enough, since it does not provide for the maximum individualization of treatment, sparing effect on the main links of the pathogenetic mechanism of the metabolic syndrome.

One of the non-pharmacological methods used in the sanatorium therapy of many diseases in Bashkiria is a natural therapeutic product - natural koumiss from mare's milk. Koumiss is a healing fermented milk drink of the nomadic peoples of the East, a most valuable dietary and therapeutic product containing the optimal amount of vitamins, trace elements, antibiotic substances, amino acids, lactic acid bacteria, necessary factors of cellular and humoral immunity, steroid and thyroid hormones. The main nutritional components of koumiss are absorbed almost completely (up to 95%). Despite its widespread use in sanatorium practice, the possibility of using it, as well as the mechanisms of the therapeutic effect of this unique product in the metabolic syndrome, have not yet been disclosed.

There are no data on the use of hypobarotherapy in MS. Meanwhile, the most promising direction in the course of reconstructive correction of impaired functions in patients with MS is the technology of complex exposure. This approach has a number of advantages and allows you to influence the main links of the pathogenesis and hormonal regulation of metabolic processes of MS.

A fundamentally new way of treating MS is the use of a treatment complex using the method of adaptation to stress hypoxia in combination with koumiss.

Hypobarotherapy is a method of therapeutic use of air under low atmospheric pressure. It has the ability to restore the balance of sympathetic and parasympathetic influences of the autonomic nervous system, stimulates non-specific adaptive reactions, and increases the body's resistance. It allows you to affect most of the clinical symptom complex of the disease due to adaptive, hemostimulating, metabolic, detoxification, immunomodulating, angioprotective effects (Bogolyubov V.M., Ponomarenko G.N. General physiotherapy. - M., 1998. - P.269-271; Karash Yu.M., Strelkov R.V., Chizhov A.Ya. Normobaric hypoxia in treatment, prophylaxis and rehabilitation. - M .: Medicine, 1988).

The objective of the invention is to develop a method for the complex treatment of metabolic syndrome, which allows to influence the main links in the pathogenesis of this pathology.

The technical result of the proposed method is to improve clinical indicators, hemodynamic parameters, correction of carbohydrate, lipid metabolism, antioxidant system, indicators of the functional state of vascular endothelium, increased exercise tolerance.

The proposed method is carried out as follows: against the background of basic treatment, a course of adaptation to hypoxia is used, which is carried out in two stages, while at the first stage, a stepwise rise to a height of 1000, 1500, 2000, 2500 meters above sea level, i.e. from the first to the fourth session. At the second stage of treatment, from the fifth session, the “working” height is 2500 meters, on which patients are 15-20 minutes. "Ascent" and "descent" is carried out at a speed of 4-5 m / s and the doctor adjusts the pressure chambers from the medical salon, the pressure in the cabin at an altitude of 2500 m is -75.5 kPa, the partial oxygen pressure is 20-35 mm Hg. (at a rate of 159 mmHg). The course of treatment includes 12-14 sessions. The air entering the chamber is preliminarily prepared as follows: it is passed through a Chizhevsky chandelier (saturated with negatively charged oxygen ions), treated with a bactericidal lamp, and cleaned with a hydraulic filter. At the same time, koumiss treatment is carried out as follows: use koumiss of weak and medium strength with constant acidity of 71-100 ° according to Turner 200-250 ml three times before meals. Mare's milk koumiss is used with starter culture based on the microorganisms Lactobacterium bulgaricum and yeast type Torula. The duration of the koumiss treatment course is 24 days.

The proposed method treated 66 men with metabolic syndrome at the age of 47.2 ± 1.3 years who were treated in the sanatorium "Green Grove" RB.

According to the therapy, patients are divided into groups using simple randomization. The first group consisted of 32 patients who received only basic therapy (comparisons). The second group (main) included 34 patients with metabolic syndrome who, against the background of basic therapy, took koumissotherapy in combination with hypobarotherapy.

Basic therapy included: lipid-lowering diet, climatotherapy, psychotherapy, intake of Nurly mineral water (low mineralized hydrocarbonate sulfate-calcium-magnesium, M = 2.4 g / l), physiotherapy exercises, dosed walking, background drug therapy. Metoprolol (Corvitol) at a daily dose of 50 mg was used as an antihypertensive drug.

Adaptation to hypoxia in patients of the main group against the background of basic therapy was carried out using the Taganay hypobaric complex. The course was conducted in two stages and included 12-14 sessions, while at the first stage it began with "step" climbs to a height of 1000, 1500, 2000, 2500 meters above sea level. From the fifth session, the “working” height was 2500 meters, on which the patients were 15-20 minutes. "Ascent" and "descent" was carried out at a speed of 4-5 m / s. The pressure in the chamber at an altitude of 2500 m was 75.5 kPa. The air entering the chamber underwent staged preparation: ionization, filtration, disinfection and moisturizing.

Adaptation of patients for the treatment of patients with metabolic syndrome was carried out using the Taganay-2 hypobaric complex (approved for use in medical practice, certificate No. 000120, registration certificate of the State Register of Medical Products 29/09020302 / 4818-03 of January 23, 2003), established in the sanatorium "Green Grove".

The hypobaric complex "Taganay" includes:

- a hermetic cabin of reduced pressure, equipped with chairs to accommodate 6 patients;

- control device and control modes of the treatment session (control panel);

- a pumping system consisting of liquid ring pumps and designed to create the necessary vacuum (vacuum):

- piping system;

- gangway and control panel.

The principle of operation is based on the creation in the cabin, with the patients in it, of lowered pressure (vacuum) while supplying ventilation air and maintaining this regimen throughout the treatment session.

To ensure comfortable conditions for patients in the pressure chamber installed 6 seats with adjustable backrest. Personal responsibility for the operation of the pressure chamber, the selection and examination of patients, evaluation of treatment results is provided for in the "Regulation on the Department of Hypobarotherapy."

Koumiss treatment was carried out by taking koumiss of weak and medium strength with constant acidity of 71-100 ° according to Turner 200-250 ml three times before meals. Koumiss was used from mare's milk with starter culture based on the microorganisms Lactobacterium bulgaricum and yeast type Torula. The duration of the koumiss treatment course was 24 days.

Before treatment, all patients underwent clinical, laboratory and instrumental studies. Determination of blood glucose, insulin resistance, blood plasma lipid spectrum, lipid peroxidation state (LPO), endothelial functional state, systolic blood pressure (SBP), diastolic blood pressure (DBP), average blood pressure (SRP), pulse blood pressure (PAD), heart rate, respiration, their intersystem ratio (HR / BH), body mass index, ECG, echocardiography, bicycle ergometry test.

After the course of treatment, all patients with metabolic syndrome in the main group showed a positive dynamics of clinical symptoms. Headaches, dizziness disappeared, shortness of breath decreased, sleep recovery, increased efficiency, decreased irritability, and normalization of blood pressure were noted.

As a result of the course of hypobarotherapy and koumiss treatment in patients with primary group MS, there was a significant decrease in the levels of SBP by 22.1% (p <0.05), DBP by 17.4% (p <0.05), and systolic blood pressure by 16.2 % (p <0.05), pAD by 26.8% (p <0.05), heart rate by 12.4% (p <0.05) compared with the initial data, which indicated an improvement in overall hemodynamics with antihypertensive effect. In the comparison group, significant changes in similar indicators were not observed (table 1).

Against the background of the treatment, in patients with MS of the main group, lipid status correction was noted. The decrease in the level of cholesterol was 24.5% (p <0.05), LDL cholesterol - 31.8% (p <0.05), TG - 17.8% (p <0.05), against the background of an increase in the level of cholesterol HDL by 18.7% (p <0.05), with less significant biases in the comparison group (table 2).

Analysis of the state of LPO processes and the antioxidant defense system showed that sanatorium therapy using hypobarotherapy and koumiss helps to suppress LPO processes and activate antioxidant enzymes in patients with MS. At the same time, a significant decrease in the concentration of malondialdehyde (MDA) was noted by 34.9% (p <0.05), indicating inhibition of the initially increased activity of LPO processes, an increase in the activity of blood plasma catalase by 29.8% (p <0.05) ), superoxide dismutase (SOD) by 37.5% (p <0.05) from the initial values, which is associated with the positive effect of the combined use of hypobarotherapy and koumiss therapy in patients with MS. Moreover, the shifts in the parameters of the main groups significantly differed from the values of the comparison group. Antioxidant effects were enhanced by direct exposure to koumiss ingredients, such as vitamin C and E, polyunsaturated fatty acids, carotene, the antioxidant activity of which was previously proven in experimental and clinical studies. One of the main mechanisms for increasing the activity of antioxidant enzymes may be the elimination of the inhibitory effect of lipid peroxidation on the functional state of the catalytic center of enzymes (table 3).

In the course of the study, it was found that the combined effects of hypobarotherapy and koumiss treatment are effective on the indicators of the functional state of vascular endothelium. A decrease in the content of ET-1 in blood plasma in patients of the main groups by 39.7% with a decrease in P-selectin by 31.6% from the initial values in the presence of a significant difference with the comparison group. Toward the end of the course of treatment, patients of the main group showed a more significant increase in the diameter of the brachial artery (p <0.05), including at the 30th and 60th second of reactive hyperemia (p <0.05). Values according to the ultrasound data of the brachial artery of endothelium-dependent vasodilation (EDVD) increased by 46.3% (p <0.05) and independent (ENZVD) - by 31.5% (p <0.05) with a significant difference with the group comparisons. Therefore, the results of the study showed that the complex effect improves endothelial function in patients of the main group with an increase in vasodilating and a decrease in vasoconstrictor properties (table 4).

The study revealed that the complex effect in patients with MS of the main group favorably affects carbohydrate metabolism. At the same time, a significant decrease in the basal concentration of insulin and glucose was noted. Fasting insulin levels against hypobarotherapy and koumiss treatment decreased by 25% (p <0.05), while basal glucose levels decreased by 14% (p <0.05) and the insulin resistance index by 17.1%, which indicated the corrective effect of hypobarotherapy and koumiss for insulin resistance and carbohydrate metabolism. The dynamics of the parameters of carbohydrate metabolism in the comparison group against the background of standard sanatorium therapy was insignificant.

In patients with MS of the main group, against the background of hypobarotherapy and koumiss therapy, they decreased during the observation period: body weight by 15.9% (p <0.05), patient weight by 2.3 kg. In patients of the comparison group, against the background of basic sanatorium therapy, insignificant shifts in the parameters of anthropometric indicators were revealed (table 5).

In the available scientific, medical and patent literature, there is information about the popularity of a method of treating patients with metabolic syndrome, characterized in that, against the background of basic treatment, an adaptation to stress hypoxia is carried out, which is carried out in two stages, while in the first stage the first four procedures are carried out by step "ascents to a height of 1000, 1500, 2000 and 2500 meters above sea level, at the second stage of treatment, from the fifth session, the" working "height is 2500 meters for 15-20 minutes, with" rise "and" descent "at a speed of 4- 5 m / s, pressure in the cabin at an altitude of 2500 m - 75.5 kPa (103 mmHg), a partial oxygen pressure of 20-35 mmHg, a course of treatment of 12-14 daily sessions, at the same time koumiss treatment is carried out, using mild koumiss and average strength with constant acidity 71-100 Turner 200-250 ml three times before a meal with a course of 24 days, was not found. Thus, the claimed invention meets the criterion of "novelty."

The authors' studies proved that the course of adaptation to stress hypoxia, which is carried out in two stages, while in the first stage the first four procedures are carried out by "step" rises to a height of 1000, 1500, 2000 and 2500 meters above sea level, in the second stage of treatment , from the fifth session, the “working” height is 2500 meters for 15-20 minutes, with “rise” and “descent” at a speed of 4-5 m / s, the pressure in the cabin at an altitude of 2500 m is 75.5 kPa (103 mm RT .st.), a partial oxygen pressure of 20-35 mm Hg, a course of treatment of 12-14 daily sessions, simultaneous pr conducting kymyz using koumiss weak and medium strong acidity constant by Turner 71-100 200-250 ml three times before a meal duration of the course of the day 24, provides improved clinical parameters, hemodynamic parameters, carbohydrate, lipid metabolism, increased exercise tolerance. Thus, the claimed invention meets the criterion of "inventive step".

The proposed method is illustrated by the following clinical examples.

Example 1. Patient A., 45 years old, was admitted to a spa treatment with a diagnosis of Hypertension stage II, II degree, risk 3. Metabolic syndrome: Obesity II degree. Dyslipidemia. Insulin resistance.

Complaints of headaches with predominant localization in the occipital region, dizziness, shortness of breath, increased fatigue, psychoemotional lability. Sick for 8 years. Antihypertensive therapy was carried out irregularly. On an ECG: Sinus rhythm with a heart rate of 76 beats per minute, impaired repolarization in the antero-apical-lateral region of the left ventricle, signs of left ventricular myocardial hypertrophy. HELL 162/102 mm Hg Blood biochemical analysis: total cholesterol 6.20 mmol / L, LDL cholesterol 4.10 mmol / L, HDL cholesterol 0.92 mmol / L, triglycerides 2.39 mmol / L, atherogenic coefficient 5.54, SOD 2.85 sr units / ml, catalase 14.4, ml.cat / l, MDA 4.49 μmol / l. Fasting glucose - 5.71 mmol / l, after 2 hours - 8.37 mmol / l, fasting insulin - 21.38 mced / ml, insulin after 2 hours - 39.88 mcd / ml, insulin resistance index - 5.32. BMI was 30.9, according to VEM - samples - exercise tolerance - 58.5 watts. The indices of endothelial function were as follows: according to the ultrasound data of the brachial artery-ESVD-6.22%, ENZVD-11.4%, the blood content of ET-1 was 1.86 fmol / ml, P-selectin was 367.08 ng / ml .

The basic treatment included: lipid-lowering diet, climatotherapy, psychotherapy, intake of Nurly mineral water (low mineralized hydrocarbonate sulfate-calcium-magnesium, M = 2.4 g / l), exercise therapy, dosed walking. Metoprolol (Corvitol) at a daily dose of 50 mg was used as an antihypertensive drug.

Treatment was prescribed according to the claimed method: against the background of basic treatment, hypoxic therapy sessions were used in the hypobarocamera. The course of adaptation to hypoxia was carried out in two stages, while at the first stage it began with "step" climbs to a height of 1000, 1500, 2000 and 2500 meters above sea level, i.e. from the first to the fourth session, at the second stage of treatment, from the fifth session, the “working” height was 2500 above sea level, on which the patient spent 15-20 minutes. “Ascent” and “descent” was carried out at a speed of 4-5 m / s, the pressure in the cabin at an altitude of 2500 m was 75.5 kPa, the partial pressure of oxygen was 20-35 mm Hg. (at a rate of 159 mmHg). The course of treatment included 12 daily sessions.

At the same time, koumiss of weak and medium strength with a constant acidity of 71-100 ° according to Turner was taken 200-250 ml three times before meals for 24 days.

At the end of the course of treatment, there was a positive trend: improvement of well-being, sleep, reduction of headaches. HELL decreased to 135/85 mm Hg By the end of treatment, headaches in the back of the head disappeared, heart rate was 68 beats per minute. Blood biochemical analysis was close to normal: total cholesterol 4.61 mmol / L, LDL 2.65 mmol / L, HDL 1.14 mmol / L, triglycerides 1.8 mmol / L, atherogenicity coefficient 4.02, SOD 3, 92 conventional units / ml, catalase 18.7, ml.cat / l, MDA 2.92 μmol / l. Fasting glucose - 4.9 mmol / l, after 2 hours 7.14 mmol / l, fasting insulin - 16.0 mcd / ml, insulin after 2 hours 28.12 mcd / ml, insulin resistance index 4.41. The daily dose of the drug (Corvitol) was halved. On the ECG, the processes of repolarization in the myocardium of the left ventricle improved. According to the VEM test, the exercise tolerance increased by 18.9% (p <0.05), the body mass index decreased to 27.9, and the patient lost 2.3 kg. According to the ultrasound data of the brachial artery-ESVD - 9.2%, ENZVD - 14.9%, decreased vasoconstriction and increased vasodilation of the brachial artery. Indices of endothelial function were close to normal: ET-1 - 1.12 fmol / ml, P-selectin - 249.69 ng / ml.

Example 2. Patient N., 56 years old, was admitted to a spa treatment with a diagnosis of Hypertension of the II stage, II degree, risk 3. Metabolic syndrome: Obesity of I degree. Dyslipidemia. Insulin resistance.

Complaints of headaches, dizziness, shortness of breath, fatigue, psycho-emotional lability. Sick for 7 years with a crisis, a frequency of 1 time in 3 months. Blood pressure ranged from 140/90 to 160/100 mm Hg. ECG: Sinus rhythm with a heart rate of 78 beats per minute, horizontal EOS, signs of left ventricular myocardial hypertrophy. Blood biochemical analysis: total cholesterol 7.9 mmol / l, LDL cholesterol 4.5 mmol / l, HDL cholesterol 0.8 mmol / l, triglycerides - 2.7 mmol / l, SOD 2.86 srvc / ml, catalase 14.5, ml.cat / l, MDA 4.50 μmol / l. Fasting glucose - 5.72 mmol / l, after 2 hours - 8.38 mmol / l, fasting insulin - 21.39 mced / ml, insulin after 2 hours - 40.12 mcd / ml, insulin resistance index - 5.30. BMI was 31.2, according to VEM - samples - exercise tolerance - 55.5 watts. According to the Doppler ultrasonography of the brachial artery-ESVD - 6.11%, ENZVD - 11.1%. Indicators of endothelial function were as follows: ET-1 - 1.85 fmol / ml, P-selectin-368.09 ng / ml.

The drug treatment was: metoprolol Corvitol in a daily dose of 50 mg. The basic treatment included: lipid-lowering diet, climatotherapy, psychotherapy, intake of Nurly mineral water (low mineralized hydrocarbonate sulfate-calcium-magnesium, M = 2.4 g / l), back massage, exercise therapy, dosed walking.

Treatment was prescribed according to the claimed method: against the background of basic treatment, koumiss treatment was taken in combination with hypobarotherapy sessions. The course of adaptation to hypoxia was carried out in two stages, while at the first stage it began with "step" climbs to a height of 1000, 1500, 2000 and 2500 meters above sea level, i.e. from the first to the fourth session, at the second stage of treatment, from the fifth session the “working” height was 2500 meters, on which the patient spent 15-20 minutes. "Ascent" and "descent" was carried out at a speed of 4-5 m / s and was regulated by the doctor’s chamber from the medical salon, the pressure in the cabin at an altitude of 2500 m was 75.5 kPa, the partial pressure of oxygen was 20-35 mm Hg. at a rate of 159 mmHg). The course of treatment included 14 sessions.

At the same time I took koumiss of weak and medium strength with constant acidity of 71-100 according to Turner, 200-250 ml three times before meals for 24 days.

By the end of treatment, headaches disappeared, blood pressure 125/79 mm Hg, heart rate was 68 beats per minute. Biochemical blood tests were close to normal: total cholesterol 5.3 mmol / L, LDL 3.5 mmol / L, HDL 1.2 mmol / L, triglycerides 1.7 mmol / L, atherogenic coefficient 4.02, SOD 3, 91 conventional units / ml, catalase 18.6, ml.cat / l, MDA 2.91 μmol / l. Fasting glucose - 4.8 mmol / l, after 2 hours - 7.10 mmol / l, fasting insulin - 16.2 mcd / ml, insulin after 2 hours - 28.10 mcd / ml, insulin resistance index - 4.39. The daily dose of the drug was halved. The ECG improved myocardial contractility of the left ventricle. Exercise tolerance increased by 19.1% (p <0.05), the body mass index decreased to 26.6, the patient lost 2.2 kg. According to the ultrasound data of the brachial artery-ESVD - 9.4%, ENZVD - 15.2%, decreased vasoconstriction and increased vasodilation of the brachial artery. Endothelial function indices were close to normal: ET-1 - 1.13 fmol / ml, P-selectin - 250.68 ng / ml.

The proposed method is easily reproducible in the conditions of medical diagnostic and sanatorium institutions. Thus, the claimed invention meets the criterion of "industrial applicability".

Table 1 The effect of GBT and koumiss treatment on hemodynamic parameters in patients with MS (M ± m) Hemodynamic parameters (mmHg) Patients with MS The main group (n = 34) Comparison Group (n = 32) before treatment after treatment before treatment after treatment GARDEN 162.1 ± 2.2 126.1 ± 1.7 * 162.0 ± 2.1 144.0 ± 1.8 DBP 101.2 ± 1.4 83.5 ± 1.3 101.3 ± 1.5 94.4 ± 1.4 Wed 151.8 ± 2.3 127.1 ± 1.5 * 151.7 ± 2.3 144.8 ± 1.4 PAD 59.9 ± 1.3 43.8 ± 0.9 * 59.6 ± 1.2 50.3 ± 0.9 Heart rate 78.2 ± 1.3 68.5 ± 0.9 * 78.2 ± 1.4 75.1 ± 1.2 * - significance of differences in indicators before and after treatment, p <0.05

table 2 The dynamics of lipid metabolism in patients with MS on the background of GBT and koumiss treatment (M ± m) Groups The main group (n = 34) Comparison Group (n = 32) Indicators before treatment after treatment before treatment after treatment OHS, mmol / l 6.10 ± 0.08 4.61 ± 0.07 * 6.11 ± 0.07 5.90 ± 0.06 HDL cholesterol, mmol / l 0.96 ± 0.02 1.14 ± 0.02 * 0.94 ± 0.02 0.98 ± 0.03 LDL cholesterol mmol / l 3.89 ± 0.04 2.65 ± 0.03 * 3.91 ± 0.04 368 ± 0.05 TG, mmol / l 2.19 ± 0.03 1.80 ± 0.01 * 2.20 ± 0.03 2.14 ± 0.02 * - significance of differences in indicators before and after treatment, p <0.05

Table 3 Dynamics of indicators of LPO processes in patients with MS on the background of GBT and koumiss treatment (M ± m) Groups The main group (n = 34) Comparison Group (n = 32) Indicators before treatment after treatment before treatment after treatment SOD, conventional units / ml 2.85 ± 0.11 3.92 ± 0.13 * 2.82 ± 0.14 2.91 ± 0.12 Catalase, ml. cat / l 14.4 ± 0.38 18.7 ± 0.33 * 14.5 ± 0.34 15.1 ± 0.30 MDA, μmol / L 4.49 ± 0.11 2.92 ± 0.10 * 4.43 ± 0.12 3.97 ± 0.11 * - significance of differences in indicators before and after treatment, p <0.05

Table 4 The dynamics of endothelial function in patients with MS on the background of GBT and koumiss treatment (M ± m) Groups The main group (n = 34). Comparison Group (n = 32) Indicators before treatment after treatment before treatment after treatment ET-1, fmol / ml 1.86 ± 0.14 1.12 ± 0.09 * 1.85 ± 0.11 1.62 ± 0.12 R-selectin, ng / ml 367.08 ± 8.6 249.69 ± 6.75 * 365.1 ± 8.0 339.22 ± 8.04 EDVD,% 6.22 ± 0.09 9.1 ± 0.10 * 6.20 ± 0.08 6.8 ± 0.09 ENZVD,% 11.4 ± 0.1 15.0 ± 0.12 * 11.5 ± 0.1 11.9 ± 0.1 * - significance of differences in indicators before and after treatment, p <0.05

Table 5 The dynamics of carbohydrate metabolism in patients with MS on the background of GBT and koumiss treatment (M ± m) Indicators The main group (n = 34) Comparison Group (n = 32) before treatment after treatment before treatment after treatment Fasting insulin, mced / ml 21.38 ± 0.03 16.0 ± 0.02 * 21.35 ± 0.04 20.4 ± 0.03 Insulin after 2 hours, mced / ml 39.88 ± 0.41 28.12 ± 0.42 * 39.7 ± 0.06 38.12 ± 0.03 Fasting glucose, mol / L 5.71 ± 0.02 4.90 ± 0.03 * 5.65 ± 0.02 5.60 ± 0.04 Glucose after 2 hours, mol / l 8.37 ± 0.01 7.14 ± 0.08 * 8.36 ± 0.06 7.65 ± 0.08 Insulin resistance index 5.32 ± 0.01 4.41 ± 0.01 * 5.31 ± 0.01 5.21 ± 0.01 Body mass index, conv. 31.1 ± 0.04 26.5 ± 0.03 * 30.9 ± 0.02 30.2 ± 0.04 * - significance of differences in indicators before and after treatment, p> 0.05

Claims (2)

1. A method of treating patients with metabolic syndrome, including, against the background of basic treatment, finding the patient under conditions of low atmospheric pressure at an altitude of 1000, 1500 meters above sea level, simultaneous oral administration of a therapeutic drink, characterized in that the course of adaptation to hypoxia in two stages, in this case, at the first stage, by stepwise ascents to a height of 1000, 1500, 2000 and 2500 m above sea level, at the second stage of treatment, from the fifth session, the "working height" is 2500 m, while the "rise" and "descent" are carried out at a speed four -5 m / s at a partial oxygen pressure of 20-35 mm Hg, a pressure in the chamber of 75.5 kPa for 15-20 minutes in a course of 12-14 daily procedures, and a weak and medium strength koumiss is introduced as a therapeutic drink with a constant acidity of 71-100 ° according to Turner, 200-250 ml three times before meals, a course of 24 days. 2. The method according to claim 1, characterized in that the air entering the chamber is previously passed through the Chizhevsky chandelier, treated with a bactericidal lamp, and cleaned with a hydraulic filter.