RU2470676C2 - Method of treating patients with craniocerebral injury with underlying hypertension syndrome during rehabilitation - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely efferent therapy, neurology and neurosurgery, and may be used in treating patients with a craniocerebral injury with underlying hypertension syndrome during rehabilitation. That is ensured by blood sampling from a patient with erythrocyte 50 ml recovered. Then erythrocytes are saturated with nootropil 3 ml and injected back into the patient's blood-vascular system. The procedure is performed once a day every 2-3 days. The therapeutic course is 5 procedures.

EFFECT: method provides higher clinical effectiveness of treating said category of patients due to provided more complete delivery of the nootropic preparation.

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Description

The invention relates to medicine, and specifically to methods for treating patients with traumatic brain injury.

There is a method of treating patients with traumatic brain injury on the background of hypertension syndrome by taking blood from patients, mixing it with medicinal solutions and returning it to the patient’s circulatory system (1) (Doronin B.M. et al. Mexidol in the prevention of intracranial hypertension syndrome with consequences closed craniocerebral trauma No. 19, 2006, sections: introduction, materials and methods, conclusion); (RU 2289405 C2, 12.20.2006, Formula); (RU 2008133449 A, 02.20.2010, abstract); (O. Zolotukhin et al. Extracorporeal saturation of blood cells with antibiotics for targeted transport. VSU Bulletin, series: Chemistry. Biology. Pharmacy, No. 1, 2009, p. 2 Abs. 2, p. 64 Fig. 2,3).

The disadvantages of this method are the lack of effectiveness and the long duration of treatment.

The aim of the invention is to increase efficiency and reduce treatment time. This goal is achieved by extracting 50 ml of red blood cells from the patient’s blood, mixing red blood cells with 3 ml of nootropil when exposed to a laser, and returning it to the patient’s circulatory system once a day after 2-3 days with 5 treatments.

Comparison of the proposed method with methods known in the field of medicine showed its compliance with the criteria of the invention.

The proposed method differs:

- patients with a history of hypertension syndrome are treated, and then received a head injury during rehabilitation;

- 50 ml of red blood cells and 3 ml of nootropil are isolated from the patient’s blood and mixed with laser exposure by stirring on a vibrating table for 15 minutes;

- incubation and storage of red blood cells mixed with nootropil is not necessary, because introduced into the body of the victim after mixing.

The method is implemented as follows.

One of the known methods is that 120 ml of blood is taken from a patient, from which 50 ml of red blood cells are isolated by centrifugation. Washed from plasma in an isotonic solution of 0.9% sodium chloride. Red blood cells are isolated and, when exposed to a laser, they are mixed with 3 ml of nootropil in a standard manner on a vibrating table for 15 minutes, after which the red blood cells return to the patient’s circulatory system. The criterion for mixing red blood cells with nootropil when exposed to a laser is the formation of a homogeneous red blood cell mass. The process is controlled by microscopic examination, confirming the integrity of red blood cells. The ratio of 50 ml of red blood cells and 3 ml of nootropil and a mixing time of 15 minutes were obtained empirically and are optimal.

Nootropilum mixes well with red blood cells, fixes on them and gets to the right place.

Clinical example.

The patient, 37 years old, was admitted to the department with a diagnosis of: The consequences of severe traumatic brain injury in the form of left-sided central hemiparesis. Cerebral growth. Hypertension syndrome. The rehabilitation period, 5 months have passed since the injury.

In addition to standard treatment. One of the known methods for taking blood from a patient, from which 50 ml of red blood cells is isolated by centrifugation. Washed from plasma in an isotonic solution of 0.9% sodium chloride. Red blood cells are isolated and mixed with 3 ml of Nootropil in a standard procedure, after which the red blood cells are returned to the circulatory system of the patient.

Nootropilum mixes well with red blood cells, fixes on them and gets to the right place.

This patient underwent five procedures with 3 ml Nootropilum with an interval of 2-3 days.

After treatment, the clinical picture changed for the better: stability in the Romberg position, a less pronounced Mann-Gurevich symptom, the disappearance of tremor of the fingers, the asymmetry of the face disappeared, the frontal and nasolabial folds were compared, and the strength of the muscles of the hands was equalized. The course of treatment of this patient was reduced by a third, and 5 ampoules of nootropil in 3 ml were consumed.

The treatment cycle is 5 procedures once a day after 2-3 days.

Using the proposed method can improve efficiency and reduce treatment time, as well as reduce treatment costs.

Information sources

1. Doronin B.M. et al. Mexidol in the prevention of intracranial hypertension syndrome in the aftermath of closed traumatic brain injury. №19, 2006, sections: introduction, materials and methods, conclusion.

2. RU 2289405 C2, 12.20.2006, Formula.

3. RU 2008133449 A, 02.20.2010, abstract.

4. Zolotukhin OV and other extracorporeal saturation of blood cells with antibiotics for targeted transport. Bulletin of VSU, series: Chemistry. Biology. Pharmacy, No. 1, 2009, p. 62 col. 2 paragraph 3, p. 63 col. 2 paragraph 2, p. 64 fig. 2, 3.

5. Abel J.J., Rowntree L.G., Turner B.B. Plasma removal with return of corpuscles (plasmapheresis) // J. Pharmacol. Exp. Ther. - 1913-1914. - Vol. 5 - P.625.

6. Yurevich V.A., Rosenberg N.K. To the question of washing blood outside the body and the vitality of red blood balls // Russian doctor. - 1914. - T.13, No. 18. - S. 637-639.

Claims (1)

A method of treating patients with traumatic brain injury on the background of hypertension syndrome during the rehabilitation period by taking blood, saturating it with a drug and returning it to the patient's circulatory system, characterized in that 50 ml of red blood cells are isolated from the patient’s blood, saturated with 3 ml of nootropil and returned into the circulatory system of the patient 1 time a day after 2-3 days with a course of treatment of 5 procedures.