RU2465898C2 - Модуляторы связывания pai-1 для лечения глазных болезней - Google Patents
Модуляторы связывания pai-1 для лечения глазных болезней Download PDFInfo
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- RU2465898C2 RU2465898C2 RU2009120545/15A RU2009120545A RU2465898C2 RU 2465898 C2 RU2465898 C2 RU 2465898C2 RU 2009120545/15 A RU2009120545/15 A RU 2009120545/15A RU 2009120545 A RU2009120545 A RU 2009120545A RU 2465898 C2 RU2465898 C2 RU 2465898C2
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- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
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- Biomedical Technology (AREA)
- Diabetes (AREA)
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- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US86371506P | 2006-10-31 | 2006-10-31 | |
| US60/863,715 | 2006-10-31 |
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| RU2009120545A RU2009120545A (ru) | 2010-12-10 |
| RU2465898C2 true RU2465898C2 (ru) | 2012-11-10 |
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| RU2009120545/15A RU2465898C2 (ru) | 2006-10-31 | 2007-10-31 | Модуляторы связывания pai-1 для лечения глазных болезней |
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| US (2) | US20080107644A1 (enExample) |
| EP (1) | EP2077829A2 (enExample) |
| JP (1) | JP2010508306A (enExample) |
| KR (1) | KR20090082401A (enExample) |
| CN (1) | CN101588798A (enExample) |
| AU (1) | AU2007313684A1 (enExample) |
| CA (1) | CA2666316A1 (enExample) |
| MX (1) | MX2009004792A (enExample) |
| RU (1) | RU2465898C2 (enExample) |
| WO (1) | WO2008055205A2 (enExample) |
| ZA (1) | ZA200902453B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20100158897A1 (en) * | 2006-10-31 | 2010-06-24 | Alcon Research, Ltd. | Pai-1 modulators for the treatment of ocular disorders |
| US20090202524A1 (en) * | 2007-10-31 | 2009-08-13 | Alcon Research, Ltd. | Pai-1 expression and activity inhibitors for the treatment of ocular disorders |
| EP2790023B1 (en) | 2011-11-15 | 2018-07-04 | National University Corporation Hamamatsu University School of Medicine | Therapeutic and diagnostic agent for early delivery or abortion using plasminogen activator inhibitor-1 |
| US10946076B2 (en) | 2013-02-13 | 2021-03-16 | The Research Foundation For The State University Of New York | Glaucoma treatment |
| US9820954B2 (en) * | 2015-08-19 | 2017-11-21 | Jenivision Inc. | Quantitative peri-orbital application of ophthalmology drugs |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2102069C1 (ru) * | 1992-05-22 | 1998-01-20 | Сендзю Фармасьютикал Ко., Лтд. | Фармацевтическая композиция для лечения глаукомы |
| RU2197970C2 (ru) * | 1997-03-17 | 2003-02-10 | Новартис Аг | Композиции и способы, предназначенные для снижения глазной гипертензии |
| US20030217371A1 (en) * | 2002-02-19 | 2003-11-20 | Vanderbilt University | Therapeutic methods employing PAI-1 inhibitors and transgenic non-human animal for screening candidate PAI-1 inhibitors |
| RU2218156C2 (ru) * | 1998-12-11 | 2003-12-10 | Бакулиш Мафатлал Хамар | Способ изготовления состава местных бета-блокаторов улучшенного действия |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2358400C (en) * | 1999-01-05 | 2012-05-15 | Nancy A. Noble | Methods for treating conditions associated with the accumulation of excess extracellular matrix |
| KR20040104566A (ko) * | 2002-04-30 | 2004-12-10 | 알콘, 인코퍼레이티드 | 안압 저하 및 녹내장성 망막병증/시신경병증 치료를 위한특유의 수단으로서의 결합 조직 성장 인자 (ｃｔｇｆ)의활성 및/또는 발현 조절, 저해, 또는 변조제 |
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2007
- 2007-10-31 AU AU2007313684A patent/AU2007313684A1/en not_active Abandoned
- 2007-10-31 US US11/931,393 patent/US20080107644A1/en not_active Abandoned
- 2007-10-31 CA CA002666316A patent/CA2666316A1/en not_active Abandoned
- 2007-10-31 MX MX2009004792A patent/MX2009004792A/es not_active Application Discontinuation
- 2007-10-31 WO PCT/US2007/083170 patent/WO2008055205A2/en not_active Ceased
- 2007-10-31 CN CNA2007800407976A patent/CN101588798A/zh active Pending
- 2007-10-31 ZA ZA200902453A patent/ZA200902453B/xx unknown
- 2007-10-31 RU RU2009120545/15A patent/RU2465898C2/ru not_active IP Right Cessation
- 2007-10-31 KR KR1020097010021A patent/KR20090082401A/ko not_active Withdrawn
- 2007-10-31 EP EP07868631A patent/EP2077829A2/en not_active Withdrawn
- 2007-10-31 JP JP2009534946A patent/JP2010508306A/ja active Pending
-
2010
- 2010-06-25 US US12/823,773 patent/US20100260784A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2102069C1 (ru) * | 1992-05-22 | 1998-01-20 | Сендзю Фармасьютикал Ко., Лтд. | Фармацевтическая композиция для лечения глаукомы |
| RU2197970C2 (ru) * | 1997-03-17 | 2003-02-10 | Новартис Аг | Композиции и способы, предназначенные для снижения глазной гипертензии |
| RU2218156C2 (ru) * | 1998-12-11 | 2003-12-10 | Бакулиш Мафатлал Хамар | Способ изготовления состава местных бета-блокаторов улучшенного действия |
| US20030217371A1 (en) * | 2002-02-19 | 2003-11-20 | Vanderbilt University | Therapeutic methods employing PAI-1 inhibitors and transgenic non-human animal for screening candidate PAI-1 inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| DAN J et al. Plasminogen activator inhibitor-1 in the aqueous humor of patients with and without glaucoma // Arch Ophthalmol. - 2005; 123(2):220-4. AMY LIANG et al. Characterization of a small molecule PAI-1 inhibitor, ZK4044 // Thrombosis Research. - 2005, 115, 341-350. * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2077829A2 (en) | 2009-07-15 |
| CA2666316A1 (en) | 2008-05-08 |
| ZA200902453B (en) | 2010-07-28 |
| MX2009004792A (es) | 2009-05-21 |
| WO2008055205A2 (en) | 2008-05-08 |
| CN101588798A (zh) | 2009-11-25 |
| JP2010508306A (ja) | 2010-03-18 |
| WO2008055205A3 (en) | 2008-07-17 |
| US20080107644A1 (en) | 2008-05-08 |
| AU2007313684A1 (en) | 2008-05-08 |
| KR20090082401A (ko) | 2009-07-30 |
| US20100260784A1 (en) | 2010-10-14 |
| RU2009120545A (ru) | 2010-12-10 |
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| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20131101 |