JP2010508306A - 眼障害を治療するためのpai−1結合調節因子 - Google Patents

眼障害を治療するためのpai−1結合調節因子 Download PDF

Info

Publication number
JP2010508306A
JP2010508306A JP2009534946A JP2009534946A JP2010508306A JP 2010508306 A JP2010508306 A JP 2010508306A JP 2009534946 A JP2009534946 A JP 2009534946A JP 2009534946 A JP2009534946 A JP 2009534946A JP 2010508306 A JP2010508306 A JP 2010508306A
Authority
JP
Japan
Prior art keywords
pai
agent
binding
glaucoma
volume percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009534946A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010508306A5 (enExample
Inventor
デブラ フリーノーア,
イォク−ホー パン,
アボット クラーク,
Original Assignee
アルコン リサーチ, リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルコン リサーチ, リミテッド filed Critical アルコン リサーチ, リミテッド
Publication of JP2010508306A publication Critical patent/JP2010508306A/ja
Publication of JP2010508306A5 publication Critical patent/JP2010508306A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009534946A 2006-10-31 2007-10-31 眼障害を治療するためのpai−1結合調節因子 Pending JP2010508306A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86371506P 2006-10-31 2006-10-31
PCT/US2007/083170 WO2008055205A2 (en) 2006-10-31 2007-10-31 Pai-1 binding modulators for the treatment of ocular disorders

Publications (2)

Publication Number Publication Date
JP2010508306A true JP2010508306A (ja) 2010-03-18
JP2010508306A5 JP2010508306A5 (enExample) 2011-06-30

Family

ID=39345074

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009534946A Pending JP2010508306A (ja) 2006-10-31 2007-10-31 眼障害を治療するためのpai−1結合調節因子

Country Status (11)

Country Link
US (2) US20080107644A1 (enExample)
EP (1) EP2077829A2 (enExample)
JP (1) JP2010508306A (enExample)
KR (1) KR20090082401A (enExample)
CN (1) CN101588798A (enExample)
AU (1) AU2007313684A1 (enExample)
CA (1) CA2666316A1 (enExample)
MX (1) MX2009004792A (enExample)
RU (1) RU2465898C2 (enExample)
WO (1) WO2008055205A2 (enExample)
ZA (1) ZA200902453B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013073191A1 (ja) * 2011-11-15 2013-05-23 国立大学法人浜松医科大学 プラスミノゲンアクチベータインヒビター-1による流産、早産治療薬
JP2018528169A (ja) * 2015-08-19 2018-09-27 ジェニヴィジョン インク. 眼科用薬物の定量的な眼窩周囲への適用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100158897A1 (en) * 2006-10-31 2010-06-24 Alcon Research, Ltd. Pai-1 modulators for the treatment of ocular disorders
US20090202524A1 (en) * 2007-10-31 2009-08-13 Alcon Research, Ltd. Pai-1 expression and activity inhibitors for the treatment of ocular disorders
US10946076B2 (en) 2013-02-13 2021-03-16 The Research Foundation For The State University Of New York Glaucoma treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024121A1 (fr) * 1992-05-22 1993-12-09 Senju Pharmaceutical Co., Ltd. Medicament pour le glaucome
AR002194A1 (es) * 1997-03-17 1998-01-07 Sanchez Reynaldo Alemany Instrumento computarizado para el analisis del movimiento.
WO2000035439A1 (en) * 1998-12-11 2000-06-22 Bakulesh Mafatlal Khamar The process for manufacturing formulation of topical beta blockers with improved efficacy
CA2358400C (en) * 1999-01-05 2012-05-15 Nancy A. Noble Methods for treating conditions associated with the accumulation of excess extracellular matrix
CA2476761A1 (en) * 2002-02-19 2003-08-28 Vanderbilt University Therapeutic methods employing pai-1 inhibitors and transgenic non-human animal for screening candidate pai-1 inhibitors
KR20040104566A (ko) * 2002-04-30 2004-12-10 알콘, 인코퍼레이티드 안압 저하 및 녹내장성 망막병증/시신경병증 치료를 위한특유의 수단으로서의 결합 조직 성장 인자 (ctgf)의활성 및/또는 발현 조절, 저해, 또는 변조제

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6012034521; Arch Ophthalmol vol.123, no.2, 200502, p.220-4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013073191A1 (ja) * 2011-11-15 2013-05-23 国立大学法人浜松医科大学 プラスミノゲンアクチベータインヒビター-1による流産、早産治療薬
JPWO2013073191A1 (ja) * 2011-11-15 2015-04-02 国立大学法人浜松医科大学 プラスミノゲンアクチベータインヒビター−1による流産、早産治療薬
US9448234B2 (en) 2011-11-15 2016-09-20 National University Corporation Hamamatsu University School Of Medicine Therapeutic agent for preterm delivery or abortion using plasminogen activator inhibitor-1
JP2018528169A (ja) * 2015-08-19 2018-09-27 ジェニヴィジョン インク. 眼科用薬物の定量的な眼窩周囲への適用

Also Published As

Publication number Publication date
EP2077829A2 (en) 2009-07-15
CA2666316A1 (en) 2008-05-08
ZA200902453B (en) 2010-07-28
MX2009004792A (es) 2009-05-21
WO2008055205A2 (en) 2008-05-08
CN101588798A (zh) 2009-11-25
WO2008055205A3 (en) 2008-07-17
US20080107644A1 (en) 2008-05-08
AU2007313684A1 (en) 2008-05-08
KR20090082401A (ko) 2009-07-30
US20100260784A1 (en) 2010-10-14
RU2465898C2 (ru) 2012-11-10
RU2009120545A (ru) 2010-12-10

Similar Documents

Publication Publication Date Title
CN100425241C (zh) 由Rho激酶抑制剂和前列腺素类物质构成的青光眼治疗剂
JP4934653B2 (ja) Rhoキナーゼ阻害剤とβ遮断薬からなる緑内障治療剤
US20040213782A1 (en) Compositions of an aquaporin modulating agent and an aqueous humor modulating agent for the treatment of elevated intraocular pressure
Krauss et al. Update on the mechanism of action of bimatoprost: a review and discussion of new evidence
CN101505744A (zh) 用于预防和治疗眼部病症的内皮分化基因亚家庭3(edg-3,s1p3)受体的拮抗剂
US20080153903A1 (en) Inhibitors of protein kinase c-delta for the treatment of glaucoma
JP2010508306A (ja) 眼障害を治療するためのpai−1結合調節因子
JP2004107335A (ja) Rhoキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤
US20110105574A1 (en) Pai-1 expression and activity inhibitors for the treatment of ocular disorders
Ormrod et al. Topical Dorzolamide 2%/Timolol 0.5% A Review of its Use in the Treatment of Open-Angle Glaucoma
Ellis Guanylate cyclase activators, cell volume changes and IOP reduction
CA2622952A1 (en) Apoe4 domain interaction inhibitors and methods of use thereof
US20100158897A1 (en) Pai-1 modulators for the treatment of ocular disorders
US20090181896A1 (en) Use of Natriuretic Peptide Receptor Antagonists to Treat Ocular, Otic and Nasal Edemetous Conditions
US20170027936A1 (en) Abl1 inhibitor for treating and preventing ocular neovascularisation
AU2007234903B2 (en) Prenyltransferase inhibitors for ocular hypertension control and the treatment of glaucoma
US9872863B2 (en) Targeting primary cilia to treat glaucoma
Roddy et al. 7. Stanniocalcin-1, a novel ocular hypotensive agent with capacity for sustained intraocular pressure reduction
US20060134171A1 (en) Agents which regulate, inhibit, or modulate the activity and/or expression of formyl peptide receptors as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies
US6534475B1 (en) Use of TIMP-3 inducers of TIMP-3 expression, and TIMP-3 mimetics to treat ocular neovascularization
JP2000264847A (ja) 角膜障害治療剤
JP2004189735A (ja) Limキナーゼ阻害作用を有する化合物を有効成分とする緑内障治療剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100511

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100511

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110428

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121002

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121010

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130110