RU2438668C1 - Preparation for treating acute postnatal endometritis in cows and method for using it - Google Patents

Abstract

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to veterinary gynaecology. A preparation for treating acute postnatal endometritis in cows involves antimicrobial and antiprotozoal agents, and as the antimicrobial agent the preparation contains enrophlone, as the antiprotozoal agent - trichopol (metronidazole), in addition, the preparation contains DMSO, sodium hydroxide and distilled water in the following proportions, g/l of the solution: enrophlone 8.0-12.0; trichopol (metronidazole) 4.0-6.0; DMSO 150.0-250.0; sodium hydroxide pH 10-11; distilled water - the rest. The method of treating acute postnatal endometritis consists in introduction of the specified preparation 50-100 ml once a day for 3-5 days. ^ EFFECT: invention provides higher clinical effectiveness. ^ 2 cl, 2 ex

Description

The invention relates to the field of veterinary medicine, in particular to antimicrobial and antiprotozoal drugs used to treat acute postpartum endometritis in cows, and methods for their use.

A known method of treating intrauterine furazolidone sticks in combination with injections of a 7% solution of ichthyol (Veterinary obstetrics, gynecology and biotechnology of reproduction. - M .: Kolos, 2000. - S. 326).

The disadvantages of this method of treatment include significant labor and working time, as well as the need to replace during treatment of intrauterine sticks with a liquid drug due to the gradual closure of the cervical canal.

The closest solution adopted for the prototype is the well-known drug levoerythrocycline and the method of treatment with this drug (Veterinary obstetrics, gynecology and biotechnology of reproduction. - M .: Kolos, 2000. - P.327).

The basis of the invention is the task of creating such a drug for the treatment of acute postpartum endometritis in cows and the method of its use with such active substances, solvent and auxiliary components, which, acting in combination, can have an effective antimicrobial and antiprotozoal effect in the uterus of the cow.

The problem is solved in that the drug for the treatment of acute postpartum endometritis in cows contains antimicrobial and antiprotozoal substances, according to the invention, contains enroflon as an antimicrobial substance, contains trichopolum (metranidazole), DMSO and distilled water are used as solvents, in sodium hydroxide was used as an auxiliary component in the following ratio of components, g / l of solution:

enroflon 8.0-12.0 trichopolum (metranidazole) 4.0-6.0 DMSO 150.0-250.0 sodium hydroxide up to pH 10-11 distilled water rest.

The problem is also solved by the fact that in the known method for the treatment of acute postpartum endometritis in cows, which consists in the intrauterine administration of an antimicrobial preparation, according to the invention, the drug is administered intrauterine 50-100 ml once a day for 3-5 days.

The proposed drug and method of treatment are simple and convenient to use and do not require large labor costs from veterinarians.

The inventive preparation is prepared and used as follows.

To get 1.0 l of the drug:

1. In 150-250 g of DMSO suspend antimicrobial and antiprotozoal substances in quantities, g:

enroflon 8.0-12.0 trichopolum (metranidazole) 4.0-6.0

2. To the resulting suspension add 700-800 ml of distilled water.

3. To the resulting suspension add 10% sodium hydroxide solution to a pH of 10-11.

4. The volume of the drug is adjusted with distilled water to 1.0 liters.

The resulting preparation is a light yellow solution.

A test of the therapeutic effectiveness of the known and claimed drugs was conducted on cows with acute postpartum endometritis.

Example 1. In the experiment there were 200 goals of black-motley breed with clinical signs of acute postpartum endometritis. The diagnosis was made on the basis of clinical and rectal studies. Conditionally pathogenic microflora was isolated from the uterus of animals - St. aureus, St. albus, Str. fecalis, P. vulgaris, E. coli.

The animals of the experimental group (120 animals) were injected with the claimed drug in a dose of 50-100 ml intrauterine device once a day for 3-5 days, depending on the nature of the inflammation. During treatment with the claimed drug, 83.3% of the animals showed a decrease in the size of the uterus, restoration of its stiffness, a sharp increase in vaginal discharge on days 5-6 and a gradual decrease by the eighth day. Epithelial cells dominated in the cytogram of cervical mucus (88%). The duration of the service period was 35-45 days. Therapeutic efficacy on the 11-12th day of the experiment is 95.6%.

The animals of the control group (80 animals) were treated at the farm: levoerythrocycline according to the instructions for use.

Positive dynamics was noted on days 15-16 of the experiment. It was characterized by a restoration of the size of the uterus to normal size, a change in the nature and cytological composition of the lochia. Of 120 cows, 102 (85%) recovered on 20-25 days. The duration of the service period was 60-70 days.

Thus, the claimed drug in comparison with the closest analogue increased the recovery rate of animals by 10.6%, reduced the recovery time by 2 times, the service period - by 1.6 times.

Example 2. In the experiment used 110 cows of black-motley breed with clinical signs of acute postpartum purulent-catarrhal endometritis. The diagnosis was made on the basis of clinical and rectal studies.

The animals of the experimental group (70 animals) were injected with the claimed drug in a dose of 50-80 ml intrauterine device once a day for 3-5 days.

Recovery was observed in 89.7% of cows on 7-9 days of experience. The service period was 35-40 days; 89.7% of cows were fertilized in 1-2 sexual hunts.

In the control group (40 cows), the treatment was taken on the farm at the time of the study: antibiotics, oxytocin, intrauterine sticks with furazolidone or ichthyol according to the instructions for their use.

Clinical recovery was observed in 27 cows (64.2%) at 16-20 days of experience. The duration of the service period was 60-65 days, 64.2% of the cows were fertilized in the first or second sexual hunt.

Thus, the use of the claimed drug in acute postpartum purulent-catarrhal endometritis ensured recovery and subsequent fruitful insemination in the first and second hunts of 89.7% of cows.

The use of this treatment method allows to increase the cost-effectiveness of treatment by reducing labor costs, reducing treatment time by 1.8-2.0 times and the number of days of infertility by 1.4 times.

Claims (2)

1. The drug for the treatment of acute postpartum endometritis in cows, including antimicrobial and antiprotozoal substances, characterized in that the drug includes enroflon as an antimicrobial substance, includes trichopolum (metranidazole), and DMSO, sodium hydroxide as additional components distilled water, in the following ratio of components, g / l of solution:
enroflon 8.0-12.0 trichopolum (metranidazole) 4.0-6.0 DMSO 150.0-250.0 sodium hydroxide up to pH 10-11 distilled water rest 2. A method of treating acute postpartum endometritis in cows, comprising administering a preparation comprising an antimicrobial and antiprotozoal substance, characterized in that the preparation according to claim 1 is used as a preparation comprising an antimicrobial substance, the administration of which is carried out in a dose of 50-100 ml once per day for 3-5 days.