RU2422144C2 - Применение солей тиотропия для лечения тяжелых форм персистирующей астмы - Google Patents
Применение солей тиотропия для лечения тяжелых форм персистирующей астмы Download PDFInfo
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- RU2422144C2 RU2422144C2 RU2008108302/15A RU2008108302A RU2422144C2 RU 2422144 C2 RU2422144 C2 RU 2422144C2 RU 2008108302/15 A RU2008108302/15 A RU 2008108302/15A RU 2008108302 A RU2008108302 A RU 2008108302A RU 2422144 C2 RU2422144 C2 RU 2422144C2
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- Prior art keywords
- treatment
- present
- tiotropium
- asthma
- inhalation
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Emergency Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US7250426B2 (en) | 2002-11-29 | 2007-07-31 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Tiotropium-containing pharmaceutical combination for inhalation |
| WO2007077162A1 (en) * | 2006-01-04 | 2007-07-12 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of moderate persistent asthma |
| MX2012005711A (es) * | 2009-11-17 | 2012-10-05 | Cipla Ltd | Soluciones de inhalacion. |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2073677C1 (ru) * | 1989-09-16 | 1997-02-20 | Берингер Ингельгейм КГ | Сложные эфиры тиенилкарбоновой кислоты и аминоспиртов, способ их получения и фармацевтическая композиция, обладающая антихолинергической активностью |
| US5610163A (en) * | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| WO2002030928A1 (de) * | 2000-10-12 | 2002-04-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels |
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| US6156503A (en) * | 1997-03-03 | 2000-12-05 | The Regents Of The University Of California | Diagnosing asthma patients predisposed to adverse β-agonist reactions |
| GB9902689D0 (en) * | 1999-02-08 | 1999-03-31 | Novartis Ag | Organic compounds |
| GB0009583D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
| US6908928B2 (en) * | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
| US6919325B2 (en) * | 2001-09-14 | 2005-07-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts |
| DE10216036A1 (de) * | 2002-04-11 | 2003-10-23 | Boehringer Ingelheim Pharma | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
| WO2004014293A2 (en) * | 2002-06-12 | 2004-02-19 | Epigenesis Pharmaceuticals, Inc. | Combination of anti-muscarinic agents and non-glucocorticoid steroids |
| EP1531866A1 (en) * | 2002-08-29 | 2005-05-25 | Cipla Ltd. | Pharmaceutical products and compositions comprising specific anticholinergic agents, beta-2 agonists and corticosteroids |
| US7968717B2 (en) * | 2003-11-03 | 2011-06-28 | Boehringer Ingelhein International Gmbh | Crystalline anhydrate with anticholinergic efficacy |
| SE0303571D0 (sv) * | 2003-12-03 | 2003-12-22 | Microdrug Ag | Medical product for moisture-sensitive medicaments |
| SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
| AU2006244683A1 (en) * | 2005-05-10 | 2006-11-16 | Synergenz Bioscience Limited | Methods and compositions for assessment of pulmonary function and disorders |
| AU2006248189A1 (en) * | 2005-05-20 | 2006-11-23 | Synergenz Bioscience Limited | Methods of analysis of polymorphisms and uses thereof |
| US20070167480A1 (en) * | 2005-12-19 | 2007-07-19 | Sicor Inc. | Pure and stable tiotropium bromide |
| WO2007077162A1 (en) | 2006-01-04 | 2007-07-12 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of moderate persistent asthma |
-
2006
- 2006-08-02 CA CA2617717A patent/CA2617717C/en not_active Expired - Fee Related
- 2006-08-02 NZ NZ566399A patent/NZ566399A/en unknown
- 2006-08-02 JP JP2008525548A patent/JP2009504604A/ja active Pending
- 2006-08-02 MX MX2008001506A patent/MX2008001506A/es active IP Right Grant
- 2006-08-02 CN CNA2006800288506A patent/CN101237872A/zh active Pending
- 2006-08-02 RU RU2008108302/15A patent/RU2422144C2/ru active
- 2006-08-02 EP EP20060792647 patent/EP1915158A1/en not_active Ceased
- 2006-08-02 BR BRPI0614394-6A patent/BRPI0614394A2/pt not_active Application Discontinuation
- 2006-08-02 WO PCT/EP2006/064958 patent/WO2007017438A1/en not_active Ceased
- 2006-08-02 AU AU2006277968A patent/AU2006277968A1/en not_active Abandoned
- 2006-08-02 KR KR1020087005564A patent/KR20080039974A/ko not_active Ceased
- 2006-08-03 US US11/462,139 patent/US20070032516A1/en not_active Abandoned
- 2006-08-04 TW TW095128580A patent/TWI409072B/zh active
- 2006-08-04 AR ARP060103410A patent/AR055597A1/es unknown
-
2008
- 2008-01-08 ZA ZA200800186A patent/ZA200800186B/xx unknown
- 2008-02-04 IL IL189248A patent/IL189248A0/en unknown
-
2009
- 2009-02-19 US US12/388,879 patent/US20090163531A1/en not_active Abandoned
-
2012
- 2012-09-24 US US13/625,589 patent/US20130245059A1/en not_active Abandoned
Patent Citations (3)
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|---|---|---|---|---|
| RU2073677C1 (ru) * | 1989-09-16 | 1997-02-20 | Берингер Ингельгейм КГ | Сложные эфиры тиенилкарбоновой кислоты и аминоспиртов, способ их получения и фармацевтическая композиция, обладающая антихолинергической активностью |
| US5610163A (en) * | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
| WO2002030928A1 (de) * | 2000-10-12 | 2002-04-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels |
Non-Patent Citations (1)
| Title |
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| Noveck R et al. "Bronchodilator effect of tiotropium in moderate-severe asthmatics", American Journal of respiratory and critical care medicine, Mar 1999, vol. 159, №3, А625. * |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ566399A (en) | 2011-07-29 |
| CA2617717C (en) | 2014-02-11 |
| TW200744606A (en) | 2007-12-16 |
| US20130245059A1 (en) | 2013-09-19 |
| WO2007017438A1 (en) | 2007-02-15 |
| CA2617717A1 (en) | 2007-02-15 |
| RU2008108302A (ru) | 2009-09-20 |
| EP1915158A1 (en) | 2008-04-30 |
| ZA200800186B (en) | 2009-04-29 |
| IL189248A0 (en) | 2008-08-07 |
| KR20080039974A (ko) | 2008-05-07 |
| US20070032516A1 (en) | 2007-02-08 |
| AU2006277968A1 (en) | 2007-02-15 |
| MX2008001506A (es) | 2008-04-07 |
| BRPI0614394A2 (pt) | 2011-03-29 |
| AR055597A1 (es) | 2007-08-29 |
| TWI409072B (zh) | 2013-09-21 |
| JP2009504604A (ja) | 2009-02-05 |
| US20090163531A1 (en) | 2009-06-25 |
| CN101237872A (zh) | 2008-08-06 |
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